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7105518 |
Thiopyrane-4-ones as DNA protein kinase inhibitors
The present invention provides compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein R 1 and R 2 are independently hydrogen, an option...
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7107103 |
Full-body charger for battery-powered patient implantable device
A full-body charger for charging one or more battery-powered devices wherein such devices are configured for implanting beneath a patient's skin for the purpose of tissue, e.g., nerve or muscle,...
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7099713 |
Skin conduction and transport systems
Surfactants useful for enhancing the electrical conduction of electrodes attached to the surface of a patient. The surfactants are also useful in transport of materials in and out of the body of a...
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7089053 |
Compositions for drug administration by electroporation
The present invention relates to compositions for electroporation which are useful in elevating a percutaneous absorbability of drugs, etc. By adding polyhydric alcohols to compositions for...
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7087035 |
Device and method for enhancing skin piercing by microprotrusions
A device and method for enhancing skin piercing by microprotrusions involves pre-stretching the skin to enhance pathway formation when the microprotrusions are pressed into the skin. An expandable...
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7079886 |
Apparatus and method for programming a KVO phase and a first phase of an injection procedure as a flushing medium phase
A fluid injection arrangement in the context of patient imaging systems, in which phases of contrast medium injection and flushing medium injection can be freely and selectably ordered as to make...
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7070592 |
Medical device with array of electrode-containing reservoirs
Devices are provided for medical diagnostics comprising a substrate; an array of reservoirs; one or more electrodes located at least partially inside the reservoirs; a plurality of discrete...
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7069073 |
Electrokinetic delivery of medicaments
An electrokinetic delivery or diagnostic device for personal use and self-administration of a medicament to a treatment site is provided. The device includes a housing containing a power supply, a...
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7066930 |
Arrangement for the treatment of barrett's esophagus
A method for the treatment of Barrett's Esophagus of a patient having endothelial esophageal complications. The treatment comprises connecting a wavelength specific light source to an elongated...
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7062317 |
Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
A device for facilitating transdermal passage of a substance through skin on the body of a subject is provided. The device preferably includes afcn electrode and a control unit. In a preferred...
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7054683 |
Methods of electrotransport drug delivery
A reservoir and a family of reservoirs are provided which are designed to be used with a single controller to provide a wide range of therapeutic drug delivering regimens while maintaining many of...
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7054682 |
Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition
A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and...
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7047070 |
Valved intradermal delivery device and method of intradermally delivering a substance to a patient
An intradermal delivery device for delivery a substance into the skin of a patient has a fluid chamber for containing the substance, at least one micro skin penetrating member, and a valve...
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7047069 |
Iontophoretic fluid delivery device
A low cost, accurate, single use, disposable, iontophoretic fluid delivery device having cationic and anionic chambers separated by container structure and arranged to promote a flow of treatment...
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7043297 |
Iontophoretic drug delivery device and reservoir and method of making same
A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to...
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7036516 |
Treatment of pigmented tissues using optical energy
A method and apparatus for selectively photobleaching or killing pigmented tissues by photochemically converting pigments in the tissues using light and specifically two-photon excitation....
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7037490 |
Apparatus and method for local application of polymeric material to tissue
An apparatus is provided for applying to a surface of mammalian tissue including soft, living tissue an initially fluent material and then activating the material by exposure to an energy source....
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7031769 |
Dosage control electrode for iontophoresis device
An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species includes a base layer of conductive material which is consumed...
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7031768 |
Controlled dosage drug delivery
A planar disposable transdermal iontophoretic delivery system is disclosed which includes amounts of an oxidizable species and a reducible species connected by a common conductor forming a galvanic...
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7027859 |
Electrotransport delivery device having improved safety and reduced abuse potential
An electrotransport device ( 20 ) for delivering one or more therapeutic agents through the skin includes electrodes ( 30,32 ) for contacting the skin ( 34 ), at least one electrode containing the...
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7022115 |
Continuously conductive unipolar cannula for anesthesia
A continuously conductive unipolar cannula for anesthesia is described with an electrically conductive cannula tube ( 10 ), with a tip ( 14 ) at the distal end and a body part ( 18 ) at the...
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7018345 |
Iontophoresis system
The present invention provides an iontophoresis system for non-invasively taking a physiological substance out of the living body, the system being suitably used for the mucous membrane. The...
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7016718 |
Medical laser apparatus and diagnostic/treatment apparatus using the medical laser apparatus
In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting...
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7016723 |
Rate adjustable drug delivery system
A transdermal iontophoretic therapeutic agent delivery system which is provided with a plurality of self-contained serially connected galvanic sources.
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7016724 |
Electrokinetic delivery system for self-administration of medicaments and methods therefor
An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an...
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6985770 |
Apparatus for the controllable modification of compound concentration in a tube
Apparatus and methods for delivery of a drug or compound into a fluid flowing within a tube or catheter. In one embodiment a catheter includes an inner surface and polymer matrix such as a...
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6984655 |
Photodynamic therapy for selectively closing neovasa in eyeground tissue
A method is provided for selectively occluding neovascular vessels formed in the ocular fundus of an eye, which includes intravenously administering a mono-L-aspartyl chlorin compound to a patient;...
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6981972 |
Apparatus for treating venous insufficiency using directionally applied energy
A catheter introduces electrodes in a vein for a minimally invasive treatment of venous insufficiency by the application of energy to cause selective heating of the vein. The catheter is positioned...
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6980855 |
Microneedles for minimally invasive drug delivery
The present invention provides a microneedle incorporating a base that is broad relative to a height of the microneedle, to minimize breakage. The microneedle further includes a fluid channel and a...
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6978172 |
Method for in vivo delivery of therapeutic agents
Electroporation electrodes are laminated to a permeable membrane to form an electrode membrane. Such an electrode membrane is useful for a continuous controlled delivery of a therapeutic agent...
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6975902 |
Reservoir and a series of related reservoirs for use in an electrotransport drug delivery device and devices comprised thereof
A reservoir and a family of reservoirs are provided which are designed to be used with a single controller to provide a wide range of therapeutic drug delivering regimens while maintaining many of...
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6972013 |
Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
In vivo methods are provided for using an electric field to delivery therapeutic or immunizing treatment to a subject by applying non-invasive, user-friendly electrodes to the surface of the skin....
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6970740 |
UVC rediation therapy for leukemia
Leukocytes from leukemia patients have been found to be readily killed by ultra-violet light-C (UVC) radiation. Cells from healthy donors were minimally affected by doses of UVC 10 times higher...
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6969382 |
Method and apparatus for treating bodily tissues with medicinal substance
A therapeutic device and therapeutic method for delivering electrical energy to a polymer containing a medicament that allows release of the medicament to a body tissue or organ. The device and...
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6970739 |
Iontophoresis device
This is an iontophoresis device preferred to detect abnormal conductivity at the beginning of energization and during energization. The iontophoresis device has a device ( 50 ) as a power source...
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6961609 |
Quantitative titration of the autonomic nervous system
A non-invasive method for the objective measurement of the functional state of the autonomic nervous system, including the balance between its two divisions, sympathetic and parasympathetic. The...
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6951548 |
Blood irradiating apparatus
A blood irradiating apparatus is provided including a plurality of irradiating chambers having a base and an openable cover. Each irradiating chamber will include a number of ultraviolet light...
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6952605 |
Pneumatic release mechanism for a patient contacting article
A patient contacting assembly comprising a patient contacting member that secures to the surface of a patient by means of an adhesive disposed between the patient contacting member and the patient....
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6949081 |
Sensing and interactive drug delivery
An interactive drug delivery system includes a drug delivery module, an optical probe, a local controller, and an optional central controller. The drug delivery module is constructed and arranged...
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6947791 |
Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications
The present invention is based on the development of a method for cosmetic delivery of L-ascorbic acid-containing compositions to the layer of the skin wherein collagen formation takes place to...
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6937890 |
Nonpenetrating electroporation device
The manipulator includes a support and at least one member affixed to and extending away from the support. The member has at least two differentially activatable areas of conductivity. The members...
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RE38775 |
Electrode with improved signal to noise ratio
An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is...
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6928318 |
System and method for assessing the performance of a pharmaceutical agent delivery system
A system and method for assessing the performance of a system for delivering a pharmaceutical agent to a portion of a body. A pair of electrodes are applied to the portion of the body. A...
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6920884 |
Method of providing cosmetic/medical therapy
A method for providing medical therapy treatment includes steps for preparing an electrically activated substance, and for using and applying the electrically activated substance internally to a...
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6918901 |
Device and method for enhancing transdermal agent flux
An agent delivery or sampling device ( 2 ) comprising a member ( 6 ) having a plurality of blades ( 4 ) for piercing the skin and a connecting medium ( 65 ) covering at least a part of the skin...
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6918874 |
Attribute compensation for analyte detection and/or continuous monitoring
A system and method for detecting a measuring an analyte in a biological fluid of an animal. A harvesting device ( 10 ) is provided suitable for positioning on the surface of tissue of an animal to...
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6915159 |
Electrode structure for iontophoresis device and method of producing the same
The invention is to provide an electrode structure of an iontophoresis device and a method of producing the same, excellent in an economical property, an operational property, stability and safety....
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6912417 |
Method and apparatus for delivery of therapeutic agents
Methods and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a patient. The invention comprises means for the controlled administration of the...
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6908460 |
Apparatus for conveying a light source to an intravenous needle to kill blood pathogens
A tip of a needle is inserted into large vein of a patient. The needle is mounted in a butterfly device axially engaged to a generally cylindrical housing containing a Y-connector. A...
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6902522 |
Cardiac disease treatment and device
A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A–V groove, the device including a jacket adapted to be secured to the heart, and a...
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