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7424199 |
Fiber tip fluid output device
A fiber tip fluid output device is provided for holding a fiber tip in an electromagnetic energy cutting apparatus and for directing water particles over a radiation delivery end of the fiber tip....
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7415302 |
Method and system for leading macromolecule substances into living target cells
A method and system for leading macromolecule substances into target cells includes an image picking unit, an image merging unit, an injection unit, and an energy conversion module. The image...
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7415306 |
Transdermal delivery system for anti-emetic medication
The present invention provides a transdermal delivery system for hydrophilic anti-emetic agents and methods of using thereof. The system includes an anti-emetic hydrophilic adhesive composition of...
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7404815 |
Tissue ablation by shear force for sampling biological fluids and delivering active agents
The present invention relates to a method and a device for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of: ablating said...
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7398121 |
Iontophoresis device
An iontophoresis device useful for administering an ionic drug by iontophoresis has an iontophoresis electrode section (active electrode section) and a ground electrode section (inactive electrode...
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7395111 |
Transdermal delivery system for water insoluble drugs
The present invention provides a system for transdermal delivery of water insoluble drugs and methods using the same. The system includes a pharmaceutical composition of a water insoluble drug and...
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7395110 |
Electrode apparatus and method for the delivery of drugs and genes into tissue
An electrode assembly for an apparatus for trans-surface molecular includes a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal...
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7392080 |
Transdermal drug delivery patch system, method of making same and method of using same
The invention provides for a transdermal drug delivery device for forming a drug delivery patch system comprising:
a) an actuator comprising:
i) an outer body defining a top of the...
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7392077 |
Method for treating a patient at risk of loss of cardiac function by cardiac ischemia
Various methods and devices for treating a patient who has lost, or is at risk of losing cardiac function by cardiac ischemia are disclosed. Treatment includes first imaging a patient's heart, or a...
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7383083 |
Transdermal delivery system (TDS) with electrode network
A transdermal delivery system (TDS) having: a carrier layer (cover layer) impermeable to the substances/active ingredients to be delivered, a membrane permeable to the substances/active ingredients...
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7364562 |
Anti-clotting apparatus and methods for fluid handling system
A method for maintaining clear passageways in an extracorporeal blood flow system. The method comprises intermittently providing one or more anti-clotting agents to a passageway of the...
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7359601 |
Device and method for delivery of long wavelength laser energy to a tissue site
A laser energy delivery device is provided that is suitable for irradiating a body tissue with relatively long wavelength laser energy in the presence of an aqueous liquid without significant...
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7356368 |
Light-activated anti-infective coatings and devices made thereof
An implantable medical device is provided including a vascular access device and a coating on at least one of an inner surface and an outer surface of the vascular access device. The coating...
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7349733 |
Iontophoretic drug delivery systems
An electrotransport device is provided for the site specific delivery of drugs or other beneficial agents across or under a skin or tissue surface. In one embodiment, the electrotransport device is...
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7346389 |
Dilation enhancer with pre-medicated contact lenses
A contact lens with a conductive outer shell (one electrode of a two-electrode electrophoresis device) and a preferably soft, preferably disposable contact lens for contacting a patient's eye,...
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7338487 |
Device for delivering localized x-ray radiation and method of manufacture
Generally, the present invention provides a device for insertion into a body of a subject being treated to deliver localized x-ray radiation, and a method for fabricating such a device. The device...
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7340297 |
Kit, device and method for controlled delivery of oxidizing agent into the skin
A kit, device and method for delivering an oxidizing agent onto and/or into the body are disclosed. Moreover, a dermal patch device, which delivers an oxidizing agent using iontophoresis and or...
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7335377 |
Transdermal delivery system for dried particulate or lyophilized medications
The present invention provides a system for transdermal delivery of dried or lyophilized pharmaceutical compositions and methods using thereof. The system comprises an apparatus for facilitating...
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7324846 |
Method of enchancing electrontransport polypeptide flux by amino acid substitution with histidine
Methods of modifying polypeptide drugs in order to enhance their transdermal electrotransport flux are provided. The polypeptide is modified by substituting a histidine residue (His) for one or...
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7302293 |
Device for transdermal electrotransport delivery of fentanyl and sufentanil
The invention provides an improved electrotransport drug delivery system for analgesic drugs, namely fentanyl and sufentanil. The fentanyl/sufentanil is provided as a water soluble salt (e.g.,...
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7294116 |
Surgical smoke plume evacuation system
Smoke evacuation apparatus designed to provide safe and efficient filtration and evacuation of smoke plume generated by laser-surgical, electrosurgical, radiosurgical, and electrocautery devices. A...
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7287319 |
Method of making a housing for drug delivery
An electrotransport reservoir housing which contains, integrally formed therein, at least one region of conductive material which allows for a liquid and moisture tight barrier, while at the same...
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7272439 |
Working electrode assembly for iontophoresis and iontophoresis device
A working electrode assembly for iontophoresis having a working electrode, a medicine-containing portion containing an ionic medicine, and an ion-exchange membrane arranged between the working...
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7252655 |
Ocular iontophoretic apparatus handle
An iontophoretic apparatus comprising a housing member, a current distribution member, a medicament containment member and at least one of a lateral and medial straddling member. The straddling...
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7245963 |
Electrode assembly for constant-current electroporation and use
The present invention relates to a modular electrode system, and its use, for facilitating the introduction of a macromolecule into cells of a selected tissue in a body or plant. The modular...
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7235685 |
Aromatic sulfenates for type I phototherapy
The present invention discloses novel sulfenate derivatives and their bioconjugates for phototherapy of tumors and other lesions. The sulfenates of the present invention are designed to absorb...
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7229556 |
Delivery system for a composition
Devices and methods for cutaneous delivery of a composition are provided, wherein the composition is passed through an ordered nanoporous membrane in fluid communication with a reservoir. The...
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7200433 |
Transdermal or transmucosal drug delivery device
A transdermal or transmucosal drug delivery device excellent in terms of drug permeability and skin irritability and capable of reducing power consumption, is disclosed. An output control circuit (...
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7200432 |
Device for enhanced delivery of biologically active substances and compounds in an organism
A device and methods are described for a non-invasive transnasal and transocular drug delivery to the central nervous system using iontophoresis technology. By delivered through the olfactory nerve...
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7197359 |
Compositions for electroporation
The present invention relates to compositions for electroporation which are useful in elevating percutaneous absorbability of drugs, etc. By controlling electrolyte concentration of compositions...
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7195628 |
Atrial fibrillation therapy with pulmonary vein support
A system and method for treatment of paroxysmal atrial fibrillation by destruction of conductive pathways between the pulmonary veins and the left atrium. A stent is delivered by catheter to the...
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7187969 |
Electroactive pore
Electroactive pores, devices including one or more electroactive pores are described, and methods of delivering therapeutic agents using one or more electroactive pores are described.
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7184826 |
Device and method for enhancing transdermal flux of agents being delivered or sampled
A percutaneous agent delivery or sampling device comprising a sheet having a plurality of microblades for piercing and anchoring to the skin for increasing transdermal flux of an agent and for...
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7184825 |
Needless medical connector having antimicrobial agent
A needleless connector for medical use, adapted to facilitate the flow of fluid therethrough, includes a housing having an inlet port and an outlet port. The connector also includes a flex-tube...
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7181271 |
Synergism of photodynamic and electropermeation effect on cell vitality as a novel cytotoxic agent
The present invention is based on the discovery that electroporation of a photosensitive agent in a cell and subsequent activation of the agent provides more effective killing of the electroporated...
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7171264 |
Intradermal delivery of active agents by needle-free injection and electroporation
Methods are proved for introducing a biologically active agent into cells of a subject by introducing the agent in a form suitable for electrotransport into a region of tissue of the subject using...
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7164943 |
Irritation-reducing ocular iontophoresis device
The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in...
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7164942 |
Handheld apparatus and method for transdermal drug delivery and analyte extraction
A device is provided for treating skin on the body of a subject. The device includes a plurality of electrodes, which are adapted to be placed in contact with the skin and then moved across the...
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7162297 |
Apparatus and applicator patch for transdermal substance delivery
Apparatus for transdermal delivery of substances contained in a carrier fluid, comprising a power supply unit which supplies an electric signal to at least two electrodes connected thereto. The...
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7151960 |
Dilation enhancer with pre-mediated contact lenses
A contact lens with a conductive outer shell (one electrode of a two-electrode electrophoresis device) and a preferably soft, preferably disposable contact lens for contacting a patient's eye,...
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7150975 |
Hydrogel composition for measuring glucose flux
The present invention relates to compositions for use in analyte monitoring devices. These compositions are useful to increase the flux of analyte across skin, tissue or mucosal surfaces. The...
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7137975 |
Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent
An iontophoretic method for transporting compounds of interest across a body tissue is provided. The method utilizes an AC signal in conjunction with a barrier-modifying agent such as a fatty acid,...
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7137965 |
Device for the iontophoretic delivery of a drug
An iontophoretic drug delivery device storage apparatus and a method of using that device is disclosed. The device comprises a fluid reservoir, an electrode assembly and a tray apparatus. The fluid...
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7136698 |
Electrotransport agent delivery apparatus
An electrotransport agent delivery device ( 10 ) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport...
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7133717 |
Tissue electroperforation for enhanced drug delivery and diagnostic sampling
The present invention relates to a method and a device for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of: ablating said...
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7127284 |
Electroporation microneedle and methods for its use
Electroporation of cells in target tissues is performed using microneedles having integral electrode structures. In a first embodiment, a pair of electrode structures are disposed on opposite sides...
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7127285 |
Systems and methods for electrokinetic delivery of a substance
A system for delivering a substance into a body at a treatment site that includes an alternating current source and a plurality of electrodes. Circuitry is connected between the alternating current...
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7123957 |
Transdermal drug delivery and analyte extraction
A device for ablating the stratum corneum epidermidis of a subject, including a plurality of electrodes, which are applied to the subject's skin at respective points. A power source applies...
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7113821 |
Tissue electroperforation for enhanced drug delivery
The present invention relates to a method and a device for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of: ablating the membrane...
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7105518 |
Thiopyrane-4-ones as DNA protein kinase inhibitors
The present invention provides compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein R 1 and R 2 are independently hydrogen, an option...
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