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5314502 |
Iontophoretic delivery device
An electrically powered iontophoretic delivery device is provided. The device includes a pair of electrode assemblies (41, 43) and a source of electrical power (30) connected thereto. Circuitry...
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5310403 |
Iontophoretic drug delivery device and circuit therefor
An iontophoresis system includes an iontophoretic drug delivery device for placement against the skin of a patient and having at least one segmented electrode, and a circuit for controlling and...
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5306235 |
Failsafe iontophoresis drug delivery system
An iontophoresis system includes an iontophoretic drug delivery device for placement against the skin of a patient and having a pair of electrodes, and a circuit for delivering and controlling the...
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5304113 |
Method of eradicating infectious biological contaminants
A method for externally eradicating by inactivation infectious pathogenic contaminants in body tissues, such as blood, so that it can be introduced into an animal comprises admixing the body...
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5301688 |
Method for localization and therapy of occult bladder cancer
Intravesical electromotive administration of specified dye substances for localisation and treatment of occult bladder cancers, is disclosed. Innocuous dye substances will provide differential...
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5302172 |
Method and composition for iontophoresis
The invention discloses methods and compositions for enhanced iontophoretic delivery of active agents. The compositions are pharmaceutically acceptable compositions for iontophoretic delivery...
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5300099 |
Gamma matched, helical dipole microwave antenna
A catheter shaft carries a coaxial cable, the terminal end of which contains a dipole antenna with opposing first and second helical elements. The first and second helical elements originate from a...
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5300019 |
Systems and methods for eradicating contaminants using photoactive materials in fluids like blood
A system and method for treating a fluid carrying a biological contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The...
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5298017 |
Layered electrotransport drug delivery system
An iontophoretic agent delivery device, having a layered structure and peripheral insulation, wherein ion transport occurs through two opposing surfaces of said device. The device is especially...
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5292346 |
Bactericidal throat gun
A bactericidal ultraviolet light radiating device for treatment of mucosal or dermal tissues, having an ultraviolet light source, an optical light-directing lens optically coupled to the...
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5290221 |
Systems for eradicating contaminants using photoactive materials in fluids like blood
Systems for treating a fluid carrying a contaminant to which a photoactive material has been bound include a treatment device that defines a relatively narrow, arcuately shaped flow path. These...
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5288605 |
Methods for inactivating bacteria in blood preparations with 8-methoxypsoralen
Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell...
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RE34544 |
Method of treatment of artherosclerosis and balloon catheter the same
A method for the treatment of atherosclerosis in a mammal by destruction of atheromatous plaque is disclosed. The disclosed method includes injecting a hematoporphyrin into the mammal for selective...
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5286254 |
Drug delivery apparatus and method
A drug delivery apparatus and method for delivering a drug locally to internal body tissue. The invention contemplates positioning a drug delivery device in a body passageway or within body tissue...
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5284471 |
Electrode and method used for iontophoresis
An iontophoretic electrode has a plurality of ion transmitters for establishing electric field lines in an area and a plurality of receivers for accepting ions flowing along the field lines. A...
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5283441 |
Low-power current mirror having feedback with optical isolation
An optically isolated current mirror provides an isolated output signal as a function of an input signal. The mirror includes first and second optical isolators and an amplifier. The amplifier is...
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5281287 |
Method of making a hydratable bioelectrode
A hydratable iontophoretic bioelectrode includes a plurality of layers of material capable of absorbing and holding an ionized fluid when placed in contact with the fluid. Adjacent layers are...
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5281196 |
Skin treatment composition and method of use
A composition and method of applying a composition of (a) between about 10 and 15 percent vitamin C, plus or minus 10 percent, by weight to volume, (b) a viscosity agent, and (c) water as the...
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5279544 |
Transdermal or interdermal drug delivery devices
A transdermal drug delivery device includes a liquid reservoir for a liquid drug to be delivered, and a drug delivery body which includes a plurality of tubular elements extending through the body,...
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5279543 |
Device for iontophoretic non-invasive sampling or delivery of substances
The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises: (a) a positive electrode; ...
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5268082 |
Actuator element
An actuator element comprises an ion exchange membrane and a pair of electrodes attached to opposite surfaces of the ion exchange membrane; the ion exchange membrane in a water-containing state...
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5257970 |
In situ photodynamic therapy
The process of photodynamic therapy (PDT) is conducted by the step of: 1) separately encapsulating at least one activation component for said photodynamic therapy process in a liposome; 2)...
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5256137 |
Biphasic power source for use in an iontophoretic drug delivery system
A biphasic power source for use in an iontophoretic system, which system includes a transdermal drug delivery device attachable to a patient and having a positive electrode and a negative...
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5254081 |
Multiple site drug iontophoresis electronic device and method
A multiple site drug iontophoresis electronic device configured for controlling infusion of ionic drugs into a patient through a plurality of electrode pairs. The device includes a plurality of...
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5250023 |
Transdermal administration method of protein or peptide drug and its administration device thereof
A transdermal administration method for protein or peptide drug that contacting and ionizing a protein or peptide drug immersed in hydrophilic polymer with ionizing solvent composition, and forming...
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5250022 |
Iontotherapeutic devices, reservoir electrode devices therefore, process and unit dose
Provided are reservoir electrodes for iontotherapeutic devices which have two chambers; the first chamber is electrically connected to the iontotherapeutic device and is designed to contain...
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5248295 |
Bioelectrode seal
An iontophoretic bioelectrode includes an enclosure forming upper sheet of material having a generally planar outer section circumscribing a raised central section which defines an interior...
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5246436 |
Midinfrared laser tissue ablater
A midinfrared laser tissue ablater having an Er:YAG radiation source optically connected to a first end of a fiber optic cable, a probe with a handle and a bifurcated cannula having a first half...
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5246418 |
Iontophresis system having features for reducing skin irritation
An iontophoresis drug delivery system includes a device which is attachable to the skin of an animal and having a drug reservoir, an electrolyte reservoir, and electrodes electrically communicating...
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5240995 |
Electrotransport adhesive
A two phase adhesive matrix for use in an electrically powered iontophoretic delivery device is provided. The adhesive matrix comprises an adhesive hydrophobic polymer phase and about 15 to 60 wt %...
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5240675 |
Method for cleaning endoscope
In a method for use in cleaning a flexible endoscope, an elongate cleaning member having an embedded optical fiber, an electrical conductor, and/or a heat conductor is inserted into a biopsy...
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5236412 |
Rehydratable product and method of preparation thereof
A hydratable iontophoretic bioelectrode includes a plurality of layers of material capable of absorbing and holding an ionized fluid when placed in contact with the fluid. Adjacent layers are...
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5232441 |
Method of treating schistosomal infestations by iontophoresis
A method of treating schistosomal infestations by both adult worms and eggs-miracidia, residing in the veins, venules and nearby tissues either of the bladder and ureters or of the colorectal...
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5230703 |
Wound infection resolution utilizing antibiotic agents and electrical stimulation
A method is disclosed for promoting resolution of infection at an externally accessible wound site, such as a skin tear or ulcer, of a patient using antibiotic agents (normally comprising one or...
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5224928 |
Mounting system for transdermal drug applicator
A transdermal drug applicator (100) for application to a living body for the delivery of at least one drug through the skin (144) into the bloodstream comprising an applicator (100) including at...
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5222936 |
Intracorporeal iontophoretic method
A method of intracorporeal iontophoretic treatment of an internal hollow body organ containing a physiological ion-rich fluid environment by delivery to said hollow body organ of drug ions by means...
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5215520 |
Method for delivering an active substance topically or percutaneously
A method for the topical or percutaneous administration of a cosmetic or pharmaceutically active substance involves applying an electric current to an area of the skin, ceasing to apply the...
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5213568 |
Activity controlled electrotransport drug delivery device
The electrotransport drug delivery device includes a patient activity sensor which is used to selectively deliver drugs based upon a measured physical activity of the patient.
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5209720 |
Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
Gas filled liposomes prepared by a vacuum drying gas instillation method and/or gas filled liposomes substantially devoid of liquid in the interior thereof, are presented as novel potentiators for...
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5207752 |
Iontophoretic drug delivery system with two-stage delivery profile
A two-stage iontophoretic drug delivery system provides that iontophoretic current is delivered at a first level for a first predetermined interval to rapidly introduce a therapeutic agent into the...
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5201730 |
Tissue manipulator for use in vitreous surgery combining a fiber optic endoilluminator with an infusion/aspiration system
A surgical instrument for use in penetrating and working in the vitreous humor of an eye comprises a finger grip member and a rigid needle extending from the finger grip member, with a single...
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H001160 |
Iontophoretic delivery of peptides
The invention concerns a new system and method for iontophoretically delivering a polypeptide transdermally into animal tissue.
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5195953 |
Method of increasing skin absorption of a drug
A thin layer of a drug in a liquid form in a carrier is applied to the skin. Thereafter, 15-30 milliamps of a D.C. current is applied to the skin and drug by an iontophoresis device capable of...
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5176956 |
Biomedical apparatus having fatty acid dimer derived skin compatible adhesive composition thereon
An improved biomedical appliance having disposed on a skin-contacting, operant portion thereof, a film or layer of a skin compatible, tacky, pressure sensitive polymeric adhesive, the reaction...
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5174304 |
Electrocycloablation apparatus and method
Apparatus and non-invasive method for focal transcleral destruction of living human eye tissue. The apparatus includes a pair of conical-shaped probes, each probe filled with an ionic probe...
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5171215 |
Endermic method and apparatus
Transfer of substances through the skin at a treatment site is promoted by the combined effects of ultrasonic energy and positive and negative pressure. A device having a cup-shaped body is pressed...
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5169383 |
Control membrane for electrotransport drug delivery
A membrane capable of controlling the rate at which an agent is released from an iontophoretic delivery device is provided. The membrane inhibits agent release from the delivery device when no...
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5169384 |
Apparatus for facilitating post-traumatic, post-surgical, and/or post-inflammatory healing of tissue
A temperature variable and iontophoretic device for application to the body of a patient has an outer support member coupled to a device for selectively applying thermal energy to the body of a...
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5167617 |
Disposable electralytic transdermal drug applicator
An electrically powered transdermal drug applicator a flexible, non-conductive substrate with a plurality of conductive coated areas forming drug reservoir electrodes with a plurality of drug...
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5167616 |
Iontophoretic delivery method
An improved method for delivering a drug or beneficial agent transdermally to humans by iontophoresis is provided. The method includes selecting and iontophoretically delivering the drug through a...
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