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5445607 |
Iontophoresis device and method using a rate-controlling electrically sensitive membrane
An iontophoresis device comprising a drug reservoir containing the drug in ionic form and in communication with the skin, a skin permeation enhancing agent contained in the reservoir or in a second...
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5443441 |
Apparatus and method for transdermal delivery of cosmetic compositions
An apparatus for enhancing transdermal delivery of cosmetic compositions including an electrical power source for generating varying levels of AC and/or DC current. The power source is arranged to...
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5431625 |
Iontophoresis electronic device having a ramped output current
An iontophoresis controller is configured for connection to an iontophoresis electrode pair. The controller controls infusion of a selected dose of ionic drugs into a patient through the electrode...
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5429594 |
Extra-corporeal blood access, sensing, and radiation methods and apparatuses
Methods and apparatuses for extra corporeal access to blood for analysis of the blood and for treating it or constituents of it with force, energy, or radiation; e.g. electrical energy, heat, sound...
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5427585 |
On-demand iontophoretic system
A transdermal medication system wherein said medication is selectively dispensed on-demand from multiple reservoirs within a disposable patch so as to vary the drug choice and the drug...
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5421816 |
Ultrasonic transdermal drug delivery system
Ultrasonic energy is used to release a stored drug and forcibly move the drug through the skin of an organism into the blood stream. A housing (81) includes a cavity (67) defined by an assembly of...
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5417654 |
Elongated curved cavitation-generating tip for disintegrating tissue
An improved tip for use with a device for disintegrating tissue located in a predominantly liquid environment. The tip is connected to an oscillation generator, which results in ultrasonic...
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5417653 |
Method for minimizing restenosis
Disclosed is a light angioplasty catheter and method for exposing the interior of a body lumen to a source of light. Light exposure may be accomplished prior to, during, or following conventional...
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5415629 |
Programmable apparatus for the transdermal delivery of drugs and method
An apparatus is described for the programmable iontophoretic or iontophoretic-ultrasonic (ionosonic) transdermal delivery of medication across the skin or other biological membrane. In one...
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5415628 |
Iontophorett drug delivery
Improved methods of ionophoretic drug delivery are described. By the intentional selection of drug(s) with specific characteristics, of ionotophoresis device, components or both permits the...
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5405369 |
Photochemical ablation of gastro-intestinal tissue for augmentation of an organ
The present invention provides a method for treating a human or animal patient amenable an organ augmentation with gastro-intestinal tissue which is, or will be surgically transplanted into the...
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5405614 |
Electronic transdermal drug delivery system
A drug delivery system for transdermally delivering drugs through a given skin area is provided. The delivery system comprises a collapsible container for containing the drug. The container has a...
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5405317 |
Iontophoretic delivery device
An electrically powered iontophoretic delivery device is provided. The device utilizes electrodes composed of a preferably hydrophobic polymeric matrix. The matrix contains about 10 to 50 vol % of...
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5403275 |
Method for reducing sensation in iontophoretic drug delivery
Methods for delivering therapeutic agents by iontophoresis with reduced or mitigated sensation are disclosed. The methods generally involve the step of delivering therapeutic agent by iontophoresis...
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5401239 |
Electromotive treatment of catheter-rerelated infections
A method of treating recalcitrant indewelling catheter-associated infections including the following procedures: inserting into the lumen of the catheter, a primary electrode whose uninsulated...
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5395362 |
Methods and apparatus for distributing laser radiation
Apparatus and methods are disclosed for distributing and delivering laser radiation with substantially uniform intensity to multi-spatial locations. Laser radiation is directed into a fiber optic...
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5395310 |
Iontophoresis electrode
An improved iontophoresis electrode employing a current distributing member and a drug reservoir containing an ionic drug. The drug reservoir is applied to the skin of a patient, and includes a...
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5391195 |
Device for carrying out an iontophoresis treatment on a patient
There is disclosed a device for effecting iontophoresis treatment on a patient including a signal generator for generating the treatment signal and having an output stage including two electrodes...
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5387189 |
Electrotransport delivery device and method of making same
An apparatus for supplying power to deliver a beneficial agent or drug though a body surface of a patient is provided. In a first embodiment, the invention includes a power supply (eg, a battery...
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5385543 |
Iontophoretic delivery device and method of hydrating same
A dry-state iontophoretic drug delivery device (10, 20) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. In one embodiment of...
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5383848 |
Iontophoretic administration of drugs
Methods, formulations, and a system for improved iontophoretic administration of a drug, by, preferably, topical administration of a formulation containing an active vasodilator, rubefacient, or...
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5380272 |
Transcutaneous drug delivery applicator
A transcutaneous iontophoretic drug applicator, which includes an array of reservoirs which are electrically insulated from one another, some of which contain the drug to be administered. The...
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5380271 |
Electrotransport agent delivery device and method
An electrical circuit (21) for an electrotransport agent delivery device (10), and a method for making same, is provided. The circuit (21) generally includes a plurality of electrically conductive...
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5376107 |
Electrotherapeutic device
An electrotherapeutic device for passing a DC electric current through a living organism by applying a voltage to the living organism includes a battery with an internal resistance which is high...
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5374242 |
Iontophoretic delivery device and power supply therefor
An iontophoretic drug-delivery device incorporating a power supply which minimizes the cost of the batteries needed by operating the batteries in a series configuration at the start of delivery,...
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5372501 |
Dental aid
A toothbrush (10) for applying an electrical stimulus to the gingival region has an electrode (40) on the handle and an electrode (22) having nibs (24) at the base of the bristles (20). Electronic...
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5372579 |
Pulsating transdermal drug delivery system
An electrophoretic/electro-osmotic transdermal drug delivery system for passing at least one drug, or therapeutic compound, through the skin membrane of a patient by way of a drug reservoir or gel...
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5370608 |
Apparatus for minimizing restenosis
Disclosed is a light angioplasty catheter and method for exposing the interior of a body lumen to a source of light. Light exposure may be accomplished prior to, during, or following conventional...
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5362308 |
Disposable dosage unit for iontophoresis-facilitated transdermal delivery, related devices and processes
Provided are disposable dosage units for use in iontophoresis-facilitated transdermal delivery which have hydrophilic polymer first and second layers, the first layer having ionic resin particles...
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5358483 |
Disposable transdermal drug applicators
An electrically/battery powered transdermal drug applicator comprising a flexible nonconductive substrate with a plurality of conductive coated areas, the conductive coated areas forming drug...
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5356632 |
Transdermal drug delivery device
A transdermal drug delivery device includes anode and cathode electrodes supported on a base member in spaced relation to each other to define a gap therebetween, a gel containing a liquid drug to...
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5354790 |
Methods for the preparation of non-stringy adhesive hydrophilic gels
A method is disclosed for the preparation of non-stringy hydrogels that are comprised of a homogeneous uniform mixture of water and at least one water-soluble high molecular weight polymer....
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5352192 |
Medical device
A medical device for invasive positioning in the body comprises a liquid flow passage extending between an entry orifice (24) for admitting liquid into the device and an exit orifice from which...
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5345933 |
Implantable medical device with a protected medication layer
An implantable medical device has surfaces that are in communication with the tissue of the patient after an implantation. At least one part of these surfaces is provided with at least one layer...
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5344394 |
Iontophoretic device incorporating an electrotransport adhesive
A two phase adhesive matrix for use in an electrically powered iontophoretic delivery device is provided. The adhesive matrix comprises an adhesive hydrophobic polymer phase and about 15 to 60 wt....
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5334136 |
System for treating blood processed in a cardiopulmonary bypass machine and ultrasound filtration apparatus useful therein
A system for reducing post-cardiopulmonary bypass encephalopathy due to microembolization of the brain of a patient with gaseous microbubbles (less than 40 microns in diameter) occurring during...
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5334138 |
Method and composition for increased skin concentration of active agents by iontophoresis
The invention discloses methods and compositions for enhanced skin concentration of iontophoretic delivered active agents. The compositions are pharmaceutically acceptable compositions for...
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5334171 |
Flexible, noncollapsible catheter tube with hard and soft regions
A unitary, flexible, substantially noncollapsible catheter tube of biocompatible material is comprised of hard and soft regions. The hard regions can be ring shaped or helical. The hard regions...
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5331979 |
Iontophoretic cigarette substitute
An improved iontophoretic cigarette substitute device is disclosed having a driver unit and a disposable mouthpiece. The mouthpiece has a drug coating applied to its external surface which is...
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5331951 |
Phacoemulsification probe drive circuit
A drive for a phacoemulsification probe includes a drive circuit for supplying electrical power to the probe, circuitry for sensing the electrical power supplied by the drive circuit to the probe...
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5328453 |
Method for enhancing transdermal drug delivery of electrical drug applicators
An electrical transdermal drug applicator provides enhanced drug flow to the bloodstream of the subject by delivering a primary drug into a subject's circulatory system for therapeutic purposes,...
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5328455 |
Rehydratable product and method of preparation thereof
A hydratable iontophoretic bioelectrode including a plurality of layers of material capable of absorbing and holding an ionized fluid when placed in contact with the fluid. In one embodiment, a...
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5328451 |
Iontophoretic device and method for killing bacteria and other microbes
An apparatus and method for killing microbes, including bacteria or yeast-like fungus within or on a conductive medium, is provided including positive and negative electrodes which may be activated...
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5328452 |
Multi-signal electrical transdermal drug application
A transdermal applicator for attachment to the skin having at least one drug reservoir containing at least one drug, and having an electrical connection formed at a surface interface between said...
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5326341 |
Iontorphoretic delivery device
An iontophoretic agent delivery device having donor and counter electrodes comprised of either metal or a hydrophobic polymer loaded with a conductive filler is provided. The agent reservoir in the...
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5324275 |
Antimicrobial medical devices
A catheter assembly is described which comprises a catheter tube, an exterior portion of which is circumferentially surrounded by at least two parallel elongated helical conductive elements which...
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5323769 |
Ultrasound-enhanced delivery of materials into and through the skin
A method for enhancing the permeability of the skin or other biological membrane to a material such as a drug is disclosed. In the method, the drug is delivered in conjunction with ultrasound...
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5320731 |
Iontophoresis device for transcutaneous administration of a given total quantity of an active principle to a subject
The iontophoresis device for transcutaneous administration of the active principle to the subject comprises electrodes, at least one of which is a consumable electrode formed of an...
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5320597 |
Device and method for renewing electrodes during iontophoresis
The present invention provides an iontophoretic drug delivery device having electrode renewing features includes a housing having a first electrode, a second electrode, a circuit for providing...
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5318514 |
Applicator for the electroporation of drugs and genes into surface cells
An apparatus for implanting macromolecules such as genes, DNA or pharmaceuticals into a preselected surface tissue region of of a patient. An applicator having a plurality of electrodes is provided...
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