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5607940 |
Morphine formulations for use by electromotive administration
A morphine formulation for use by electromotive administration comprising morphine citrate salts of the formula: M np Ct (3-n)p (C 6 H 5 O 7 ) p wherein M is protonated morphine, Ct is a...
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5603693 |
Three part device for the transdermic administration of drugs by electrophoresis or iontophoresis
A device in three separable modules, for the transdermic administration of drugs by electrophoresis or iontophoresis, comprises a first active module provided with at least one system of elecrodes...
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5597796 |
Transdermal insulin
Insulin analogues have been developed which are well suited for transdermal administration by iontophoresis. The insulin analogues have a negative charge at neutral pH and a reduced tendency to...
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5591219 |
Frequency modulator
A radiation device for therapeutic use in the human body allows the application of light waves to an affected area of the body. A bulb, preferrably a xenon bulb, produces light which is passed...
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5588960 |
Transurethral needle delivery device with cystoscope and method for treatment of urinary incontinence
A medical device which includes an elongate probe member sized to be able to enter a urethra of a female human body and having a length so that when the distal extremity is disposed in the vicinity...
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5582172 |
System of drug delivery to the lymphatic tissues
A substance for diagnosis or therapy of an animal. The substance includes an agent which is detectable or therapeutically active, the agent being linked to a carrier which is linked to a targeting...
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5582586 |
Drug administration and humor sampling unit and an apparatus therefor
The present invention discloses a unit and its apparatus for drug administration and humor sampling, capable of increasing the drug absorption rate with a lower voltage applied and of collecting a...
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5582587 |
Iontophoretic delivery device and method of hydrating same
A dry-state iontophoretic drug delivery device (10, 30) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. In one embodiment of...
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5571149 |
Non-intrusive analgesic neuroaugmentive and iontophoretic delivery apparatus and management system
The present invention pertains to a portable non-invasive electronic apparatus which can be used to relieve pain or alter the symptoms of certain neurological dysfunctions. A specifically contoured...
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5562608 |
Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation
An apparatus for producing a uniformly dispersed drug-containing phase within a continuous liquid delivery phase.
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5562607 |
Electrotransport device having reusable controller power saver
An electrotransport system (50) includes a reusable controller (52) having a power source (60) and a separable disposable drug-containing unit (70). The controller (52) contains a switch (62) which...
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5558632 |
Electrodes for iontophoresis
An improved electrode is disclosed for use in administering drug by means of iontophoresis, comprising a conductive element for receiving an electric current from a current source; a reticulated...
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5558633 |
Device and method for iontophoretic drug delivery
An iontophoretic device having a two-layer active electrode element is disclosed. The active element is composed of overlapping skin contact hydrogel and carrier layers. The carrier layer contains...
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5554155 |
Fiber optic pick manipulator
A multi-function pick-manipulator device that provides the functions of a vitreoretinal pick, fiberoptic illumination, and irrigation/aspiration. The manipulator may also function as a bipolar...
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5551953 |
Electrotransport system with remote telemetry link
An electrotransport system (20) for delivering a therapeutic agent (36) through a body surface (40) (eg, skin) of a patient includes a pair of electrodes (34, 38) for contacting the body surface,...
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5543098 |
Iontophoretic delivery device and method of making same
An electrically powered transdermal iontophoretic delivery device (10, 20) and a method of making same is provided. The device utilizes electrode assemblies (8, 9) composed of a substantially...
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5540669 |
Iontophoretic drug delivery system and method for using same
An iontophoretic drug delivery device of the present invention includes a power source and an electrode assembly in electrical contact with at least three reservoirs, with at least two of the...
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5540654 |
Iontophoretic electrode
The iontophoretic device of the present invention comprises (a) a source for providing an electrical signal, (b) an electrode mounting block having a plurality of separate openings formed therein...
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5538503 |
Programmable apparatus for reducing substance dependency in transdermal drug delivery
An apparatus is described for the programmable iontophoretic or iontophoretic-ultrasonic (ionosonic) transdermal delivery of medication across the skin or other biological membrane. In one...
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5533971 |
Reduction of skin irritation during electrotransport
An electrotransport delivery device utilizing reservoir buffering at a select pH ranges in order to reduce skin irritation and skin resistance is provided. Cathodic reservoirs are buffered to a pH...
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5531675 |
Micro-acupuncture needle for a finger of a hand
A micro-acupuncture needle for a finger of a hand comprises a sharp needle of a substantially cone-shaped protuberance made by molding a metal sheet of at least one of a group of aluminum and copper.
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5520680 |
Method for removing an animal organ by facilitating the atrophy thereof
A method is provided for facilitating the atrophying of a tonsil or adenoid ("organ") to cause the gradual removal thereof from the patient. A laser is positioned adjacent the organ, the wavelength...
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5520180 |
Biomedical electrodes containing solid state conductive polymer compositions
Solid state conductive polymer compositions which are ionically-conductive regardless of the amount of water present in the composition are disclosed. The compositions have solvating polymer, ionic...
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5505715 |
Iontophoretic transdermal delivery of deoxyspergualin compounds
A method and system is described for the noninvasive administration of a therapeutic concentration of a deoxyspergualin compound to a patient comprising iontophoretically passing the...
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5505726 |
Article of manufacture for the photodynamic therapy of dermal lesion
An article of manufacture for photodynamic therapy of a dermal lesion located at a dermal treatment site on skin including the stratum corneum, transparent hydrogel for covering the dermal...
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5503632 |
Electrotransport device having improved cathodic electrode assembly
An improved cathodic iontophoresis electrode assembly (8, 38) is provided having a reducible cathodic electrode (12,22) and a drug reservoir (14, 24) containing an anionic drug. The cathodic...
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5501662 |
Implantable electroporation method and apparatus for drug and gene delivery
A method and apparatus are provided for introducing molecules such as genes and pharmacological compounds into living blood cells of a patient for therapeutic purposes. A device is implanted into...
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5499967 |
Transdermal drug delivery device with waveshape generator
The device comprises a switched-mode power supply (1) equipped with an electronic switching member (T 1 ), the closing of which controls the power supply to an inductor (L 1 ) which discharges,...
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5498235 |
Iontophoresis assembly including patch/controller attachment
An iontophoretic delivery system permits transcutaneous delivery of a drug contained on a patch. The system includes a flexible planar patch having a medicament-containing surface in contact with...
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5489279 |
Method of applying photodynamic therapy to dermal lesion
Method of applying photodynamic therapy to dermal lesion located at a dermal treatment site in skin which includes the stratum corneum, including the steps of hydrating the stratum corneum at the...
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5482828 |
Synthetic media compositions and methods for inactivating bacteria and viruses in blood preparations with 8-methoxypsoralen
Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Compositions of synthetic media are...
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5476446 |
Multi-functional inner ear treatment and diagnostic system
A therapeutic treatment apparatus for use in the middle and inner ear. The apparatus includes a tubular stem portion attached to a medicine-retaining reservoir with an internal cavity. The...
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5474529 |
Multi-functional inner ear treatment and diagnostic system
A therapeutic treatment apparatus for use in the middle and inner ear. The apparatus includes a tubular stem portion attached to a medicine-retaining reservoir with an internal cavity. The...
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5474528 |
Combination controller and patch for the photodynamic therapy of dermal lesion
Combination controller and patch for photodynamic therapy of a dermal lesion located at a dermal treatment site on skin including stratum corneum, the controller is optically connected to the patch...
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5472440 |
Apparatus and method for surgically performing a filtering operation on an eye for glaucoma
The present invention provides an apparatus and method for performing a filtering operation for glaucoma. The apparatus is a jig comprising a base for supporting the jig on the eye. An offset...
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5470307 |
Catheter system for controllably releasing a therapeutic agent at a remote tissue site
A catheter having a therapeutic agent chemically bonded to a substrate on its exterior surface using a linker which photolytically releases the agent upon exposure to light energy at an appropriate...
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5470568 |
Methods and compositions of a polymer (poloxamer) for cell repair
Novel methods for prophylaxis and treatment of tissue damage resulting from cell membrane permeabilization are disclosed. Compositions comprising a surface active copolymer are employed to prevent...
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5468223 |
Electrochemotherapy
This invention provides for methods of introducing anti-cancer agents directly into cancer cells by increasing the permeability of cell walls through the use of electric pulses.
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5466217 |
Iontophoretic drug delivery apparatus
An iontophoretic agent delivery device having a simplified structure and ease of manufacture. The device utilizes an electrical pathway comprising a source of electrical energy and an output means....
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5464386 |
Transdermal drug delivery by electroincorporation of vesicles
A method of transdermal molecular delivery comprises the steps of encapsulating molecules to be delivered in a vesicle, contacting a selected area of a tissue surface with a solution of the...
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5464387 |
Transdermal delivery device
A transdermal drug delivery device (20) is provided having both an active drug reservoir (24) and a passive drug reservoir (26). Drug is actively delivered by iontophoresis from the active drug...
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5462053 |
Stable artifact-free imaging contrast suspension agent
A contrast agent adapted for magnetic resonance imaging of a sample, the contrast agent comprising a suspension in a medium acceptable for magnetic resonance imaging of (a) coated particles of a...
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5462520 |
Transsurface drug delivery by electrofusion of microbubbles to the tissue surface
A method of transtissue molecular delivery comprises encapsulating molecules to be delivered in a microbubble carrier, contacting a selected area of a tissue surface with a solution of the...
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5458569 |
Wearable iontophoresis system
A wearable iontophoresis system includes a control housing having a connector and an iontophoretic drug delivery patch for placement against the skin of a patient. The patch has a device for...
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5459030 |
Synthetic media compositions for inactivating bacteria and viruses in blood preparations with 8-methoxypsoralen
Synthetic media formulations are disclosed for use with blood preparations intended for in vivo use, including synthetic media formulations to be employed in conjunction with the...
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5456661 |
Catheter with thermally stable balloon
An intraluminal catheter with an inflatable fluoropolymer balloon is described. The catheter, generally comprising an elongate body portion dimensioned to be inserted within a body lumen, has a...
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5454782 |
Translumenal circumferential energy delivery device
A probe for translumenal circumferential delivery of energy through a biological lumen comprises a catheter which is constructed and arranged to be placed within a particular biological lumen. A...
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5453086 |
Cardiac catheter
In a cardiac catheter comprising a tubular guide catheter having a catheter hose movably disposed therein and electrodes projecting from the hose and forming sensors which are pretensioned so as to...
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5445606 |
Indicator for iontophoresis system
Apparatus (11) for delivery of a medicament, drug or other therapeutic agent transdermally to a body by iontophoresis is provided. The apparatus (11) provides a means (13) for measuring and...
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5445609 |
Electrotransport agent delivery device having a disposable component and a removable liner
An electrotransport drug delivery device (1) including a reusable component (2), a disposable component (4), and a removable liner (8) temporarily separating the mating surfaces of the components...
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