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6263227 |
Apparatus for imaging microvascular blood flow
An apparatus for measuring and imaging blood perfusion in tissue comprises a monochromatic laser light source, means for shaping the laser light beam, means for irradiating a section of the surface...
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6263234 |
Confocal surface-measuring device
The invention concerns a device for the confocal measuring of surfaces inside cavities of the body, specially to measure the surface profile (1) of teeth (2) in the mouth cavity. Said device has a...
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6263233 |
Handheld imaging microscope
A handheld imaging microscope for imaging tissue samples substantially beneath the surface of the tissue sample. The microscope includes an objective lens and a window defining a tissue contacting...
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6259936 |
Apparatus for imaging blood flow in the microcirculation
Blood perfusion in tissue is imaged using a beam from a monochromatic laser light source that is scanned over the tissue surface in a predetermined pattern at a substantially constant speed. Light...
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6246892 |
Phase modulation spectroscopy
A spectroscopic system for quantifying in vivo concentration of an absorptive pigment in biological tissue includes an oscillator for generating a first carrier waveform of a first frequency on the...
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6243601 |
Transillumination imaging instrumentation with scattered light discrimination
Transillumination imaging instrumentation is improved by eliminating the detection of stray light beams, and facilitating the detection of light beams which pass straight through an illuminated...
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6240305 |
Method and apparatus for measuring absorption information of a scattering medium
A method characterized by making modulated light having a predetermined modulation frequency component, incident to a scattering medium, receiving the modulated light having propagated inside the...
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6240312 |
Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment
Remote-controllable, micro-scale, robotic device for use in diagnosing and/or treating abnormalities inside a human body in vivo. The device has a length from 0.1 mm to 10 mm and can be introduced...
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6236871 |
Absorption information measuring method and apparatus of scattering medium
A method characterized by making modulated light having a predetermined modulation frequency component, incident to a scattering medium, receiving the modulated light having propagated inside the...
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6236877 |
Apparatus for near simultaneous observation of directly scattered image field and multiply scattered image field
An apparatus for separating an image of a target into a directly scattered component and a multiply scattered component by providing a stationary field stop having a first region and associated...
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6236881 |
Method and apparatus for differentiating and processing images of normal benign and pre-cancerous and cancerous lesioned tissues using mixed reflected and autofluoresced light
A computerized apparatus implementing a real time detection algorithm for non drug-activated imaging diseases, e.g. in cervical and bladder tissues. The apparatus employs an ultra-bright metal...
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6233481 |
Diagnostic application of sono-chemical excitation of fluorescent photosensitizers
Disclosed is a method for generating an image of a selected area of tissue, the method includes steps of: (a) providing a fluorescent photosensitizer compound in combination with a...
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6233480 |
Methods and apparatus for optically imaging neuronal tissue and activity
The present invention provides a method and apparatus for distinguishing neuronal tissue from surrounding tissue, for distinguishing functional neuronal tissue from dysfunctional tissue, and for...
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6230046 |
System and method for enhanced visualization of subcutaneous structures
System and method for enhancing visualization of veins, arteries or other subcutaneous natural or foreign structures of the body and for facilitating intravenous insertion or extraction of fluids,...
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6230045 |
Apparatus and method for localizing an object in a turbid medium
The invention relates to a method of localizing an object in a turbid medium. The invention also relates to a device for carrying out such a method. The method can be used in optical mammography...
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6217512 |
Self-illuminated, non-invasive, visual cervical inspection apparatus and method
A visual cervical inspection apparatus for visual inspection of a cervix has a housing having a cavity. The housing has a proximal viewing aperture located in a proximal end of the housing and a...
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6212425 |
Apparatus for photodynamic diagnosis
A device for "in vivo" diagnosis by means of a photosensibilisator light-induced reaction or a reaction caused by intrinsic fluorescence in biological tissue, having an illumination system, which...
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6208887 |
Catheter-delivered low resolution Raman scattering analyzing system for detecting lesions
The present invention provides low resolution Raman spectroscopic systems and methods for in-vivo detection and analysis of a lesion in a lumen of a subject. The system uses a multi-mode laser...
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6205353 |
Time-resolved optical backscattering tomographic image reconstruction in scattering turbid media
A method for imaging objects in a highly scattering turbid medium, such as breast, brain, prostate in human body and clouds, smoke in atmosphere environment, using backscattered light. The method...
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6201989 |
Methods and apparatus for detecting the rejection of transplanted tissue
Methods and apparatus for detecting the possible rejection of a transplanted tissue by a host. The transplanted tissue is subjected to illumination with light to induce fluorescence. The light can...
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6179611 |
Dental optical coherence domain reflectometry explorer
A hand-held, fiber optic based dental device with optical coherence domain reflectometry (OCDR) sensing capabilities provides a profile of optical scattering as a function of depth in the tissue at...
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6178340 |
Three-dimensional infrared imager for subcutaneous puncture and study of vascular network
A novel three-dimensional infrared imager for study of the vascular network so as to cause blood vessels to be visualized for accurate subcutaneous puncture during insertion of a hypodermic needle....
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6169913 |
Non-invasive uterine activity sensor
Uterine activity is sensed by passing light through the patient's abdominal wall and detecting the light reflected from abdominal tissues. The intensity of the reflected light varies with the state...
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6161035 |
Fluorescence diagnostic apparatus
A fluorescence diagnostic apparatus is provided in which a site to be subjected to spectrometry can be designated in an image of a diagnostic living tissue which is taken via an endoscope, and the...
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6149591 |
Refractometric devices especially adapted for the in vivo detection of refractive indices of cervical mucus
Devices for detecting hydration of cervical mucus (which is indicative of the course of a female's reproductive cycle) include a detector having a light source, a photoreceptor and a light guide...
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6149589 |
On-line and real-time spectroreflectometry measurement of oxygenation in a patient's eye
In the spectroreflectometry oxygenation measuring method and device, a light source produces a light beam having a spectral bandwidth including the wavelengths from 450 nm to 850 nm. A first...
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6148226 |
Optical imaging through scattering media: fit to an inhomogeneous diffusion model for differentiation
A method of optical imaging through a scattering medium is provided in which a fit is made to an inhomogeneous diffusion model. The method facilitates good differentiation between scattering and...
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6148227 |
Diagnosis apparatus for the picture providing recording of fluorescing biological tissue regions
The diagnosis apparatus according to the invention for the picture providing recording of fluorescing biological tissue by way of an endoscope contains a stimulation light source which beams...
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6148223 |
Transilluminator device
A medical transilluminator device is disclosed. The device includes a fiberoptic cable that is interconnected at one end to a fiberoptic illuminator. The opposite end of the cable is interengaged...
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6138046 |
Dosimetry probe
A dosimetry probe for monitoring light irradiation dosages and for providing irradiance measurements to monitor the application of light during a phototherapy procedure. The dosimetry probe...
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6135965 |
Spectroscopic detection of cervical pre-cancer using radial basis function networks
An apparatus and methods for spectroscopic detection of tissue abnormality, particularly precancerous cervical tissue, using neural networks to analyze in vivo measurements of fluorescence spectra....
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6128525 |
Apparatus and method to monitor photodynamic therapy (PDT)
A method and apparatus for controlling the dosimetry of a photodynamic therapy that involves exposing a site to be treated to treatment light in order to generate toxic products at the site and...
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6112114 |
Eye examination apparatus employing polarized light probe
Apparatus is provided for determining the topography, thickness, and fiber orientation of the nerve fiber layer at the fundus of the eye by measuring the polarization shift induced in a return beam...
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6108576 |
Time-resolved diffusion tomographic 2D and 3D imaging in highly scattering turbid media
A method for imaging objects in highly scattering turbid media. According to one embodiment of the invention, the method involves using a plurality of intersecting source/detectors sets and...
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6107101 |
Method for assaying photosensitizing drug in tissue
A concentration of a photosensitizing drug in a patient, for PhotoDynamic Therapy treatment of the patient by a treatment light at a treatment light wavelength is determined by the steps of drawing...
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6104939 |
Method and apparatus for reflected imaging analysis
Method and apparatus for reflected imaging analysis. Reflected imaging is used to perform non-invasive, in vivo analysis of a subject's vascular system. A raw reflected image (110) is normalized...
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6104946 |
Measuring method and apparatus of absorption information of scattering medium
A measuring apparatus of absorption information of scattering medium, comprising a light source for generating pulsed light, a light incidence section for making the pulsed light incident to a...
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6095982 |
Spectroscopic method and apparatus for optically detecting abnormal mammalian epithelial tissue
A method and apparatus for detecting tissue abnormality, particularly precancerous cervical tissue, through fluorescence or Raman spectroscopy, or a combination of fluorescence and Raman...
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6091985 |
Detection of cancer and precancerous conditions in tissues and/or cells using native fluorescence excitation spectroscopy
A method of detecting cancer or precancerous conditions in a tissue or cell using fluorescence excitation spectroscopy. According to one embodiment of the method, a tissue is tested for cancer or a...
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6091984 |
Measuring tissue morphology
The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is...
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6088606 |
Method and apparatus for determining a duration of a medical condition
A system and method for determining a duration that a patient has been experiencing a medical condition compares characteristics of fluorescent emissions from a target tissue to expected...
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6088612 |
Method and apparatus for reflective glare removal in digital photography useful in cervical cancer detection
An apparatus is disclosed for glare removal in digital imaging of a cervix. The apparatus includes a digital camera operable to create first and second digital images having substantially the same...
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6083158 |
Real-time visualization of tissue ischemia
A real-time display of tissue ischemia which comprises three CCD video cameras, each with a narrow bandwidth filter at the correct wavelength. The cameras simultaneously view an area of tissue...
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6078833 |
Self referencing photosensor
A method and apparatus for determining parameters of a medium, preferably a highly scattering medium such as living tissue. At least two spaced light sources provide light through the tissue or...
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6072523 |
System and a method of three-dimensional imaging
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6070583 |
Optical imaging of tissue using inelastically scattered light
The present invention relates to the use of inelastically scattered light, particularly fluorescent and Raman scattered light, for determining the location and composition of material within...
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6070092 |
Method and apparatus for measuring optical properties of surface state of skin
Light Lo is allowed to be applied on the skin S, the internal scattered light Li in the region from the surface of the skin S to the microcirculation system is detected preferably in at least three...
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6061583 |
Noninvasive blood analyzer
A noninvasive blood analyzer is provided which comprises: a light source for illuminating a part of tissues of a living body including a blood vessel; an image pickup section for picking up an...
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6061591 |
Arrangement and method for diagnosing malignant tissue by fluorescence observation
The invention relates to an arrangement and method for diagnosing malignant tissue by fluorescence observation with an endoscope. A stroboscope is used as a white light source in order to...
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6045511 |
Device and evaluation procedure for the depth-selective, noninvasive detection of the blood flow and/or intra and/or extra-corporeally flowing liquids in biological tissue
A device and an evaluation procedure for the depth-selective, non-invasive detection of the blood flow and/or intra- and/or extracorporeally flowing liquids in biological tissue are described...
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