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8409847 |
System and method for controlling the diameter of a mammilian hybrid coronary bypass graft
Systems and methods are provided for controlling the diameter of a mammalian hybrid coronary bypass graft. The system includes a controller having at least one input for receiving information and...
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8399243 |
Method of manufacturing a tissue-engineered prosthesis
Developing heart valves are exposed to dynamic strains by applying a dynamic pressure difference over the leaflets. The flow is kept to a minimum, serving only as a perfusion system, supplying the...
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8353814 |
Apparatus and method for mounting an external scaffold to a vascular graft
A method for securing a compliant scaffold to an outer surface of a vascular graft includes positioning the scaffold radially about an elongated support tube which includes first and second...
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8337554 |
Skin substitute membrane, mold, and method of evaluating external preparation for skin
A skin substitute membrane includes a surface on one side including a groove-shaped depressed portion and a planar portion, the depressed portion having a cross section having a chamfered V-letter...
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8329450 |
Methods and apparatus for organ support
An organ support apparatus includes: (a) a fluid circuit defining upstream and downstream legs adapted to be connected to an organ to be supported; (b) a circulation pump connected to the fluid...
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8318414 |
System and method to simulate hemodynamics
A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one...
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8292799 |
Biological artificial blood vessel and method of making
A prosthetic device for implantation into a human body is made by a method that includes the steps of providing a natural animal tissue that has a substrate, crosslinking and fixing the substrate,...
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8202725 |
Cell sodding method and apparatus
Tissue engineering methods and biochamber apparatus are provided for making tissue grafts for implantation into a patient. The methods include applying a sustained low magnitude pressure gradient...
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8192348 |
Engineered blood vessels
The present invention relates to engineered blood vessels and methods of making such vessels using matrices comprising endothelial and smooth muscle cells, or cells capable of differentiating into...
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8172746 |
Compliant venous graft
A venous graft for replacement of a section of an artery and methods of making the graft. The graft comprises a flexible, resilient, generally tubular external support and a vein segment carried...
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8162815 |
Method and device for preserving the vitality and function of a harvested blood vessel
A blood vessel preservation device is disclosed comprised of a vessel cannister, cannister cap, vessel alignment insert, pulsatile pump and both inlet and outlet tubing. The vessel canister is...
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8158407 |
Systems and methods of coating a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft in a mammal
Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of...
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8142991 |
Cyclic implant perfusion, cleaning and passivation process and implant produced thereby
This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the...
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8123672 |
Blood vessel preparation and preservation kit
A vessel preparation and preservation kit supports a blood vessel during processing for use in bypass graft surgery. The device comprises a clamshell base having first and second trays latchable in...
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8088060 |
Progenitor endothelial cell capturing with a drug eluting implantable medical device
A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a...
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8048442 |
Modified heparin-based coatings and related drug eluting stents
Systems comprising modified heparin-based coatings to form coatings on medical devices are provided. The systems improve the suitability of the heparin-based coatings.
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8039246 |
Systems and methods of promoting endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft in a mammal
Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of...
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RE42857 |
Method of laser cutting pericardial tissue for use with an implantable medical device
A method of cutting material for use in an implantable medical device employs a plotted laser cutting system. The laser cutting system is computer controlled and includes a laser combined with a...
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8034608 |
Systems and methods of promoting endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft in a mammal
Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of...
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7968329 |
Method of conditioning a hybrid synthetic tubular structure to yield a functional human hybrid coronary bypass graft
A method of yielding a functional human hybrid coronary bypass graft is provided. The method includes conditioning a hybrid synthetic tubular structure having stem cells and/or endothelial cells on...
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7968335 |
Cell culturing method using biomechanical stimulation loading and system therefor
A cell culturing method employing biomechanical stimulation loading and a system for applying, in in vitro culture, stimulation similar to vertical weight load stimulation or sideward shear stress...
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7964387 |
Method of conditioning a hybrid synthetic tubular structure to yield a functional human hybrid hemodialysis access graft
A method of yielding a functional human hybrid hemodialysis access graft is provided. The method includes conditioning a hybrid synthetic tubular structure having stem cells and/or endothelial...
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7959553 |
Vein harvesting system and method
A tissue illumination system and a method for harvesting a section of a blood vessel from a patient's body for further use. The tissue illumination system includes a light catheter inserted into a...
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7887558 |
Modular vessel harvesting system and method
A vessel harvesting system that is suitable for harvesting target vessels such as the saphenous vein or radial artery for cardiac artery bypass graft surgery. The system includes a vessel...
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7857748 |
Photocurable endoprosthesis methods of manufacture
Methods of manufacture of endoprostheses comprising one or more photocurable materials are disclosed. The endoprostheses may comprise regions wherein the photocurable materials are selectively...
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7851200 |
Bioreactor for growing engineered tissue
A bioreactor and a method for growing engineered tissue provide facing surfaces in a vessel for containing cell-culture media. The facing surfaces are equidistant and define a gap therebetween...
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7846123 |
Conduit device and system for implanting a conduit device in a tissue wall
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
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7833148 |
Lumen formation-inducible material and instrument to be inserted into the body
The present invention discloses a fistula formation-inducing material having a property of forming a fistula wherein cells are exposed on at least a portion of the fistula luminal surface. This...
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7811315 |
Implant valve for implantation in a blood vessel
An implant valve for implantation in a blood vessel is comprised of a flexible tube and a hollow, substantially cylindrical support with a casing, expandable in diameter from an initial position to...
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7785438 |
Multilayer composite vascular access graft
A multilayer composite vascular access graft and a method of constructing such a graft are disclosed. The mcVAG has improved performance characteristics, which include desirable handling...
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7775965 |
Decellularized grafts from umbilical cord vessels and process for preparing and using same
A tissue graft is disclosed that includes a decellularized umbilical vessel having a luminal surface and an ablumenal surface, wherein the decellularized umbilical vessel is prepared by an...
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7763081 |
Tissue graft
The present invention relates to a method of preparing a tissue graft material. The invention also relates to a multipurpose tissue graft material and to methods of using same as a replacement for...
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7759120 |
Seeding implantable medical devices with cells
Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a...
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7753840 |
Tissue material process for forming bioprosthesis
A biomaterial useful for bioprostheses such as bioprosthetic heart valves is provided in which the fixed tissue has improved elastic properties. The high elastin-containing biomaterial is further...
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7745105 |
Method of preparing soft tissue for a biological scaffold by lyophilizing, heating and elastase treatment
A method for preparing a scaffold material for use in the prosthesis therapy is disclosed. The method comprises (a) lyophilizing a segment of native soft tissue of mammalian origin, heating the...
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7744526 |
Bioreactor for the manufacture of tissue engineered blood vessels
The invention relates to bioreactors having an enclosed chamber, a sheet growth module, a rollable mandrel, and a clamp for holding the sheet to the mandrel for rolling for the manufacture of a...
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7736366 |
Bone graft forming guide
A bone graft forming guide for providing a bone graft and a method of forming a bone graft. The guide includes a main body including a holder for holding a graft material and guide containing a...
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7682475 |
Endovascular graft joint and method for manufacture
A joint and method for producing a joint in an endovascular graft. In one embodiment, a flap of a flexible material portion of an endovascular graft is folded about a portion of an expandable...
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7682304 |
Composite heart valve apparatus manufactured using techniques involving laser machining of tissue
Methodology for using laser machining techniques to modify a tissue for use in a medical device. In a representative mode of practice, relatively low energy laser machining is used to thin down at...
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7666134 |
System and method for transplantation of dermal tissue
A dermal tissue transplantation system combining a tissue particle harvester, a tissue particle collector, and a chambered dressing. The system provides a harvester capable of harvesting tissue...
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7637872 |
Bone marrow aspiration and biomaterial mixing system
Devices and methods for bone marrow aspiration, storage, and the combining of harvested marrow with biomaterials, therapeutic agents or medical devices are provided for the treatment or assessment...
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7611830 |
Device to lavage a blood vessel
The present invention provides for compositions and methods for the preservation of tissues and organs ex vivo and in situ. In addition, the present invention provides for kits that may be used in...
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7559953 |
Method for fixing tissue
A method of preparing a fixed biological tissue includes, shaping the biological tissue, cross-linking the biological tissue, sterilizing the biological tissue, and inactivating prions in the...
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7513866 |
Intestine processing device and associated method
A device for preparing small intestines of a vertebre is provided. The device includes a body for cooperation with the small intestines. The body defines an external periphery of the body. The...
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RE40570 |
Apparatuses and methods for treating biological tissue to mitigate calcification
An apparatus for treating fixed biological tissue to inhibit calcification of the biological tissue following implantation thereof in a mammalian body. The apparatus includes a container for...
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7438722 |
Method for treatment of restenosis
A method for inhibiting restenosis is described. The method comprises implanting a stent in a patient's vasculature and simultaneously delivering a restenosis-inhibiting medicine to the treatment...
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7429241 |
Dural graft and method of preparing the same
A dural graft is provided having improved stiffness characteristics relative to conventional dural substitutes. The dural graft can be formed from a collagen material having a stiffness between...
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7427261 |
System for preparing a craft vessel for anastomosis
A system for preparing a graft vessel for anastomosis includes one or more tools held within a functional package. The package includes a tray and tray top, either or both of which may include one...
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7353153 |
Method and system for modeling bone structure
The present invention discloses a structural and mechanical model and modeling methods for human bone based on bone's hierarchical structure and on its hierarchical mechanical behavior. The model...
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7348175 |
Bioreactor with plurality of chambers for conditioning intravascular tissue engineered medical products
A microprocessor controlled and instrumented bioreactor for conditioning intravascular tissue engineered medical products. One bioreactor design including an integrated pump to provide a relatively...
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