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7603166 |
Method and apparatus for detection of vulnerable atherosclerotic plaque
Methods for the detection of inflammation associated with vulnerable atherosclerotic plaque to prevent heart attack and stroke are disclosed. The methods are also applicable to detection of...
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7572229 |
Probe for use in measuring a biological signal and biological signal measuring system incorporating the probe
A probe for use in photoplethysmographic (PPG) measurement includes a light source unit including a light source that contacts a predetermined site of an object and emits light onto the...
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7532920 |
Guidewire with optical fiber
Apparatus and method to perform therapeutic treatment and diagnosis of a patient's vasculature through the use of an intravascular device having an optical fiber disposed therein. In an embodiment...
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7519407 |
Optical sensing catheter system
An optical sensing catheter system for physiological measurements of vascular or arterial parameters at plurality of location deploys wavelength division multiplexing in a common optical fiber to...
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7515265 |
Imaging systems and methods to improve backscattering imaging using circular polarization memory
An optical technique to improve the imaging of a target inside suspensions of scattering particles includes the illumination of the scattering particles with circularly polarized light. The...
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7488116 |
Universal coupling of small core optical fiber to large laser foci
It is often desirable to efficiently couple laser foci that are dimensionally large to dimensionally small optical fibers. A fiber fused in a lower refractive index fiber is disclosed. The...
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7402426 |
Detection of biological molecules by differential partitioning of enzyme substrates and products
This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated...
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7385176 |
Calibration reflector device, sensor arrangement, and method for sterile packaging of a fiber-optic sensor arrangement
A tube-like reflector insert for a sensor is located in a rigid, light-absorbing sleeve that is closed on one side, and forms a two-part reflector body with the sleeve. A nut is glued onto the open...
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7349731 |
Reconstructed refractive index spatial maps and method with algorithm
The invention provides a means to produce reconstructed refractive index spatial maps that reveal and allow visual separation of normal soft tissue and certain types of tumors. Detector fiber optic...
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7329223 |
Catheter with optical fiber sensor
An apparatus and method to perform therapeutic treatment and diagnosis of a patient's vasculature through the use of an intravascular device having an optical fiber disposed therein. In an...
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7322971 |
Surgical drain with sensors for monitoring internal tissue condition by transmittance
Devices and methods of using a surgical drain, and more particularly a surgical drain having at least one sensor for monitoring and/or recording the condition of the anatomical site or fluid...
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7277740 |
Analysis system for reagent-free determination of the concentration of an analyte in living tissue
The present invention is generally directed towards a system for reagent-free determination of the concentration of an analyte in vivo. The system comprises a light transmitter for generating...
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7149562 |
Needle with fiberoptic capability
A needle with fiber optic capability for spectrophotometric analysis includes a needle assembly including a needle body having an open tip and side radiation ports. A fiber optic element is...
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7096053 |
Internal biochemical sensing device
A biosensing device for detecting biological analytes, and methods of use and manufacture, are disclosed. The device includes a biosensing element that can remain implanted for extended periods of...
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6999809 |
Central venous catheter having a soft tip and fiber optics
A multiple lumen catheter having a soft, tapered multiple lumen distal tip for insertion into a body vessel. One of the lumens is sized to pass over a guidewire such that the catheter can be...
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6999807 |
pH measuring balloon
The present invention relates to devices and methods for measuring the pH of blood in the vicinity of a vulnerable plaque. A balloon including an opto-electric device may be positioned proximate a...
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6954665 |
Catheter system
A catheter system is suitable for the simultaneous, continuous, mutually unaffected measurement of the centrovenous oxygen saturation and the local concentration of injected indocyanine green. It...
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6891984 |
Scanning miniature optical probes with optical distortion correction and rotational control
Optical probes having a diameter less than substantially 500 μm for use in scanning light from a long, highly flexible fiber to a sample. In one embodiment the probe includes a viscous damping...
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6885881 |
Device for measuring human blood sugar levels
Device for measuring human blood sugar levels with a catheter, the free end of which is positioned in a blood vessel, wherein the catheter consists of at least one optical waveguide comprising a...
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6819951 |
Peripherally inserted central catheter with continuous central venous oximetry and proximal high flow port
A peripherally inserted central catheter includes three lumens that communicate with its proximal end. A large lumen terminates short of the distal end of the catheter and is used for the infusion...
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6775565 |
Imaging apparatus for displaying concentration ratios
Imaging apparatus for representing an image of concentration ratios between a first and a second substance in a region of interest of an object, with different measuring values being represented...
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6723054 |
Apparatus and method for measuring pulse transit time
In a method of measuring pulse transit time of a living subject, first and second pulse wave signals are produced by sensing the pulse at first and second pulse points, respectively, the first and...
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6716178 |
Apparatus and method for performing thermal and laser doppler velocimetry measurements
A therapeutic intravascular device and method for performing thermal and laser Doppler velocimetry measurements. In one embodiment, the therapeutic intravascular device includes an elongated member...
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6609014 |
Use of PDT to inhibit intimal hyperplasia
Long-term dialysis requires provision of safe and reliable vascular access, often in the form of an arteriovenous (AV) fistula. The primary cause of AV fistula loss or failure is stenosis caused by...
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6594518 |
Device and method for classification of tissue
A diagnostic monitor for classifying biological tissue in which a light emitter ( 102 ) is optically coupled to the tissue to be diagnosed ( 145 ) and a light detector ( 174 ) is optically coupled...
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6556851 |
Detection probe for optical spectroscopy and spectrometry
The invention relates to a detection probe for spectroscopy and/or spectrometry in tissue ( 4 ) with the aid of optical fibers ( 1,2 ). At least one fiber ( 2 ) transmits light into the tissue ( 4...
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6519485 |
Minimally invasive system for assessment of organ function
A system for assessing organ function couples light emitters into an optical fiber delivery assembly of which the tip extends to or into an internal organ and illuminates tissue; the device senses...
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6445939 |
Ultra-small optical probes, imaging optics, and methods for using same
Ultra-small optical probes comprising a single-mode optical fiber and a lens which has substantially the same diameter as the optical fiber. The optical fiber and lens are positioned in a probe...
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6370406 |
Method and apparatus for analyzing a test material by inducing and detecting light-matter interactions
A method and apparatus for analyzing a test material by inducing and detecting light-matter interactions. Particles of matter are introduced into a volume bounded by reflective surfaces wherein...
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6325762 |
Method and apparatus for continuous cardiac output monitoring
An apparatus for continuous cardiac output monitoring ascertains cardiac output by measuring the cross-sectional area of the vessel and the flow rate of fluid flowing through the vessel. The...
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6298253 |
Method and device for measuring the absorption of radiation in a portion of tissue
Device and method for measuring the absorption of radiation in a portion of tissue. For monitoring tissue and/or in order to permit medical indications, it is necessary to gather parameters...
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6256522 |
Sensors for continuous monitoring of biochemicals and related method
Apparatus and method for measuring properties of certain analytes are provided. The apparatus includes a sensor capsule having a processing chamber defined by a wall which in one embodiment has a...
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6208887 |
Catheter-delivered low resolution Raman scattering analyzing system for detecting lesions
The present invention provides low resolution Raman spectroscopic systems and methods for in-vivo detection and analysis of a lesion in a lumen of a subject. The system uses a multi-mode laser...
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6178346 |
Infrared endoscopic imaging in a liquid with suspended particles: method and apparatus
A device and method for imaging an object that is situated within a fluid environment having suspended particles uses infrared illumination. In a representative application, a catheter having fiber...
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6134460 |
Spectrophotometers with catheters for measuring internal tissue
The present invention provides in various embodiments novel, wearable systems for determining the metabolic condition of an aerobically stressed portion of tissue such as the muscle tissue of an...
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6071237 |
Device and method for assessing perfusion failure in a patient during endotracheal intubation
A device and method are provided for assessing impairment of blood circulation in a patient, such as that in perfusion failure, wherein the patient requires mechanical ventilatory support. The...
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6014204 |
Multiple diameter fiber optic device and process of using the same
A multiple diameter fiber optic device comprises one or more optical fibers that are used to irradiate light onto a tissue and to detect light back-scattered by the tissue wherein each fiber is...
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5963658 |
Method and apparatus for detecting an abnormality within a host medium
The detection method and apparatus detects abnormalities having a first signal propagation property within a host medium having a second signal propagation property based upon signals which have...
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5951482 |
Assemblies and methods for advancing a guide wire through body tissue
Systems and methods for advancing a guide wire through body tissue are described. In one form, the guide wire includes an interferometric guidance system and a tissue removal member. The...
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5938595 |
Fiber optic D dimer biosensor
A fiber optic sensor for D dimer (a fibrinolytic product) can be used in vivo (e.g., in catheter-based procedures) for the diagnosis and treatment of stroke-related conditions in humans. Stroke is...
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5902247 |
Transilluminating catheter
An apparatus and method for transilluminating a tubular tissue within the body. The apparatus comprises an elongate catheter having a fiber optic substantially coextensive with the length thereof...
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5797838 |
Physical-information-image displaying apparatus
A physical-information-image displaying apparatus for use with an endoscope including an image pick-up which picks up an endoscopic image from a living subject and produces an endoscopic-image...
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5785652 |
Physical-information abnormality informing endoscope
An apparatus for informing an operator of an abnormality of a physical information obtained from a living subject, including a physical-information obtaining device which obtains the physical...
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5782771 |
Dual, fused, and grooved optical localization fibers
Optical localization fiber embodiments (200, 260, 270, 290, 310, 330, and 350) suitable for preoperative localization of soft tissue lesions by X-ray mammography, CT MRI, ultrasonography or nuclear...
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5715816 |
Oximeter probes and methods for the invasive use thereof
A probe useful for invasively monitoring the oxygen saturation level of blood in the tissue walls of an anatomical cavity generally comprises a chassis with an electrical connector extending from...
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5706808 |
Fiber optic system for measuring cardiac output
The method subject of the invention is based on fiber optic technology, and in particular on the light transmission changes at a wavelength or wavelengths λ s within an optical absorption band of...
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5704353 |
Urinary diagnostic catheter
A system for monitoring the physical and chemical properties of urine in the urinary bladder and functioning of the bladder. For example, the system can include sensors for pressure, temperature,...
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5690117 |
Ultrasonic-fiberoptic imaging ventricular catheter
A rigid ultrasonic-fiberoptic stylet situated within a modified intracranial silastic catheter allows indirect and direct real time visualization through the tip of the catheter, The stylet is...
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5678550 |
Apparatus and method for in situ detection of areas of cardiac electrical activity
An apparatus and method for detecting electrical activity in areas of tissue. The apparatus (1) includes a main catheter (5), multifibered endoscope (10), light filtering means (30, 42, 52),...
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5676145 |
Cerebral hemodynamic monitoring system
A cerebral hemodynamics monitoring device includes a catheter having an optic fiber 20 for measurement of oxygen saturation, a first thermistor 30 positioned not more than about 25 mm from the tip...
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