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7590437 |
Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution
A system for evaluating the cardiovascular system parameters using indicator dilution and non-invasive or minimally invasive detection methods is disclosed. Intravascular indicators are stimulated,...
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7580185 |
Microscopy system, microscopy method and a method of treating an aneurysm
A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is...
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7558609 |
Cerebral-ischemia supervisory monitor
A cerebral-ischemia supervisory monitor includes: a pair of optical fibers which each have a tip part that can be placed substantially perpendicularly to an exterior surface of a cerebrum; an...
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7536213 |
Reduction in scattering from a turbid medium by photo-bleaching
A method is proposed whereby photo-bleaching is used not only to change the absorption and fluorescence of a sample but is also employed to change its scattering characteristics. When the compounds...
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7524985 |
Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor
A fluorescent monomer compound represented by the following formula (1) is provided:
wherein Q, Q′ and D 3 may be the same or different, may be combined together into a fused ring, and are...
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7500951 |
Lesion detecting system
A capsule medical apparatus includes a reaction plane on which one or more kinds of reacting substance reacting with an internal substance in the body to be examined are fixed, wherein the reacting...
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7496392 |
Fiber optic device for sensing analytes
A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is described. An optical conduit, preferably an optical fiber, has an optical system at the...
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7474906 |
Method for dye injection for the transcutaneous measurement of cardiac output
A system for evaluating the cardiovascular system parameters using indicator dilution and non-invasive or minimally invasive detection and calibration methods are disclosed. Intravascular...
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7450980 |
Intracorporeal substance measuring assembly
An intracorporeal substance measuring assembly to be provided in an embedded-type substance sensor for detecting and measuring an intercorporeal analyte includes: a detection layer containing at...
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7402426 |
Detection of biological molecules by differential partitioning of enzyme substrates and products
This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated...
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7368085 |
Analyte detector
An analyte detector including a device having a surface, wherein the device is capable of detecting a charge adjacent to the surface. The surface includes a plurality of molecules bonded thereto,...
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7289836 |
Optical-based sensing devices
An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein....
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7289835 |
Multivariate analysis of green to ultraviolet spectra of cell and tissue samples
This invention relates to methods for processing in vivo skin auto-fluorescence spectra for determining blood glucose levels. The invention also relates to methods of classifying cells or tissue...
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7286224 |
Time-multiplexed scanning light source for multi-probe, multi-laser fluorescence detection systems
An apparatus images a surface. An imager stage linearly translates the surface in a first direction. A light path has a first end defining an input aperture perpendicular to the first direction and...
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7282723 |
Methods and apparatus for processing spectral data for use in tissue characterization
The invention provides methods for processing tissue-derived spectral data for use in a tissue classification algorithm. Methods of the invention comprise application of spectral and/or image masks...
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7277210 |
Measuring spectral lines from an analyte using multiplexed holograms and polarization manipulation
An optical apparatus in which multiplexed holograms are used to achieve wavelength selectivity and polarization manipulation is used to facilitate near-normal incidence of light on the holograms....
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7248908 |
Method for measuring the concentration of a substance in a living body and device for measuring the same concentration
A fluorescence indicator is injected into a living body from a container via an injecting inlet to be chemically reacted with a substance in the living body. Then, an excitation light is irradiated...
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7248182 |
Measurement system having at least one replaceable sensor
A measurement system having an analyzer unit ( 2; 102 ) and at least one replaceable sensor ( 1; 101 ). Each sensor has a transponder ( 13 ) in which sensor-specific data is stored. The analyzer...
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7244232 |
Process for identifying cancerous and/or metastatic cells of a living organism
A process for identifying and treating cells in a living organism. The cells are labeled, circulated within the organism, detected with an implanted detector, and then either isolated or ablated.
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7236812 |
System, device and method for determining the concentration of an analyte
There are many inventions described and illustrated herein. In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid (for...
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7228160 |
System, apparatus and method for inferring glucose levels within the peritoneum with implantable sensors
A glucose sensor assembly useful in patient systems includes an oxygen sensor from which glucose levels in the vicinity of the peritoneal cavity may be inferred. The sensor assembly may be...
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7228159 |
Optical sensor containing particles for in situ measurement of analytes
The invention relates to a sensor for the in vivo measurement of an analyte, comprising a plurality of particles of suitable size such that when implanted in the body of a mammal the particles can...
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7209780 |
System and a computer program for the determination of quantities relating to the circulatory system of a patient
A system for the determination of quantifies relating to the circulatory system of a patient including a device for the non-invasive measurement of the qualitative variation over time of the local...
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7202947 |
Depth-resolved fluorescence instrument with angled excitation
A fluorescence instrument illuminates the surface of tissue with light of a selected wavelength and light emanating from the tissue due to fluorescence is collected. The angle of illumination of...
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7181096 |
Light waveguide and fluorescent sensor using the light waveguide
A light waveguide includes: a light introducing portion for introducing light coming from a light source into a waveguide main body; a light radiating surface for radiating the light introduced...
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7139598 |
Determination of a measure of a glycation end-product or disease state using tissue fluorescence
A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light,...
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7096053 |
Internal biochemical sensing device
A biosensing device for detecting biological analytes, and methods of use and manufacture, are disclosed. The device includes a biosensing element that can remain implanted for extended periods of...
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6999807 |
pH measuring balloon
The present invention relates to devices and methods for measuring the pH of blood in the vicinity of a vulnerable plaque. A balloon including an opto-electric device may be positioned proximate a...
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6984228 |
Phototherapy methods and systems
The invention features methods and systems for treating inflammatory, proliferative skin disorders, such as psoriasis, with ultraviolet phototherapy. The methods and systems use optical techniques...
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6970729 |
Method and device for determining local distribution of a measuring parameter
A system and method for determining the local distribution of measurement variables being measured relative to or present in a predefined measurement area of a biological sample wherein in a first...
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6956646 |
Direct method for the correction of pressure induced scrambling of polarized fluorescence intensities
The present invention provides a simple and direct method for the simultaneous correction of steady-state polarized fluorescence intensities, depolarized (or scrambled) by the effects of applied...
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6922576 |
Micro optical sensor device
A sensor device for measuring a concentration of a substance within a sample comprises a sensor comprising an optical transmission member having a first end and a second end, the second end having...
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6887202 |
Systems and methods for monitoring health and delivering drugs transdermally
The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the...
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6870620 |
Apparatus and method for determining tissue characteristics
An apparatus embodying the invention includes a probe head with an interrogation surface that is intended to be positioned adjacent or pushed into contact with a target material or tissue. The...
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6868285 |
Method and device for detecting substances in body fluids by Raman spectroscopy
The invention relates to a method and to a device for the non-invasive detection or determination, by Raman spectroscopy, of the concentration of substances in body fluids. The aim of the invention...
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6865407 |
Calibration technique for non-invasive medical devices
There is a need for a non-invasive method of calibrating medical devices at the point of care, where the calibration is performed without the removal of blood or bodily fluids. The invention is...
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6852500 |
Method for determining the concentration of glucose in a body fluid with glucose-containing perfusate
The invention concerns a method and an arrangement for determining the concentration of glucose in a body fluid. In the microdialysis technology used for this purpose, perfusate containing glucose...
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6849249 |
Ocular diagnosis of Alzheimer's Disease
The invention features a method of diagnosing or providing a prognosis regarding the state of Alzheimer's Disease in a mammal by contacting an ocular tissue with a detectably-labeled compound,...
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6825928 |
Depth-resolved fluorescence instrument
A fluorescence instrument illuminates the surface of tissue with light of a selected wavelength and light emanating from the tissue due to fluorescence is collected. The size of the effective...
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6806089 |
Low frequency modulation sensors using nanosecond fluorophores
Described is a new approach to fluorescence sensing based on a mixture of fluorophores, one of which is sensitive to the desired analyte. If a long lifetime analyte-insensitive fluorophore is mixed...
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6804544 |
Detection of biological molecules using chemical amplification and optical sensors
Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an...
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6766183 |
Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
Fluorescent biosensor molecules, fluorescent biosensors and systems, as well as methods of making and using these biosensor molecules and systems are described. Embodiments of these biosensor...
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6757554 |
Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution
A system for evaluating the cardiovascular system parameters using indicator dilution and non-invasive or minimally invasive detection methods is disclosed. Intravascular indicators are stimulated,...
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6747281 |
Flourescent—light image display method and apparatus therefor
According to a method of and apparatus for displaying as an autofluorescent-light image emitted from a target subject upon the irradiation thereof by a excitation light, even for cases in which a...
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6728560 |
Non-invasive tissue glucose level monitoring
Instruments and methods for performing non-invasive measurements of analyte concentrations and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.
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6721582 |
Non-invasive tissue glucose level monitoring
Instruments and methods are described for performing non-invasive measurements of analyte levels and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.
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6701168 |
Apparatus for measuring an oxygen concentration gradient and method of use thereof
The invention provides an improved, reliable and efficient way of measuring the oxygen concentration gradient in a sample by a novel apparatus and accompanying method of calculating linear oxygen...
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6694158 |
System using a portable detection device for detection of an analyte through body tissue
A portable optical system includes interrogation of an implanted sensor located in a body tissue. The sensor contains a labeled analogue and a reference, which emit light at different wavelengths....
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6693287 |
Laser imaging apparatus using biomedical markers that bind to cancer cells
A method for collecting data for use in image reconstruction of a tissue being scanned containing cancer cells comprises the steps of providing a source of laser beam; providing a biochemical...
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6687534 |
Fluorescent-light image display apparatus
A fluorescent-light image display apparatus for displaying on a monitor a fluorescent-light image emitted from a target area irradiated by a excitation light. A photo-detector inputs the output...
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