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7629492 |
Halo active aromatic sulfonamide organic compounds and odor control uses therefor
Aromatic N-halosulfonamide organic compounds have been known for over one hundred years. The ability of these compounds to release active halogen ions has been utilized in a range of biocidal and...
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7582772 |
Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as CPLA2 inhibitors
The present invention provides method for making a compound of formula 1:
comprising the steps of reacting compounds of formulas 2 and 3:
to produce a compound of formula 4:
wherein R 1...
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7566739 |
Substituted N-sulfonylaminophenylethyl-2-phenoxyacetamide compounds as VR1 receptor antagonists
This invention provides compounds of the formula (I) useful for the treatment of disease conditions caused by over activation of Vr1 receptors such as pain or the like in mammals as well as...
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7560592 |
Active aromatic sulfonamide organic compounds and biocidal uses thereof
A biocidal solution comprising aromatic N-halosulfonamide organic compounds and methods of using the biocidal solution are disclosed. The solution may further comprise a wetting agent, a low...
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7544717 |
2-amino- and 2-thio- substituted 1,3-diaminopropanes
Disclosed are compounds of the formula:
where variables Q, Z, X, R 15 , R 2 , R 3 , and R c are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are...
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7465829 |
Halo active aromatic sulfonamide organic compounds and uses therefor
Halo active aromatic sulfonamide organic compounds have been known for over one hundred years. The ability of these compounds to releaser active halogen ions has been utilized in a range of...
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7453010 |
Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof
The invention relates to compounds of general formula (I):
where R 1 represents H or a (C 1 -C 4 )alkyl, —CO(C 1 -C 4 )alkyl, (C 1 -C 4 )alkylphenyl or —CO-phenyl group, said phenyl...
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7417169 |
Amino alcohol derivatives, medicinal composition containing the same, and use of these
The present invention provides compounds represented by general formula (I):
a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein R 1 is hydrogen or lower alkyl; each of R2...
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7375136 |
pH-dependent NMDA receptor antagonists
NMDA receptor blockers, including pH-sensitive NMDA receptor blockers, are provided as neuroprotective drugs that are useful in stroke, traumatic brain injury, epilepsy, and other neurologic events...
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7365196 |
Sulphonamido-substituted bridged bicycloalkyl derivatives
A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of...
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7321001 |
Asthma and allergic inflammation modulators
Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides...
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7291620 |
N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease
The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and which are useful in the treatment or prevention of diseases in which the beta-secretase enzyme...
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7247748 |
Amide compounds and methods of using the same
Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as...
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7232930 |
Compounds and methods for preparing methanesulfonamides
A process for preparing (S)-(−)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hy
droxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting...
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7217492 |
Onium salt compound and radiation-sensitive resin composition
An onium salt compound having a cation moiety of the following formula (1) is disclosed.
wherein A represents I or S, m is 1 or 2, n is 0 or 1, x is 1–10, and Ar1 and Ar2 are (substituted)...
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7169952 |
Process to prepare sulfonamides
A process for the preparation of a sulfonamide of formula (II), comprising reacting at elevated temperature an aniline of formula (I), with a sulfonating agent A of the formula R 1 —SO 2 -Z in...
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7141609 |
α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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7115780 |
Propanolaminomethyltetralines, their preparation and pharmaceutical composition comprising same
The invention concerns compounds of formula (I), wherein A is a group of formula (a) or (b), wherein: R represents a hydrogen or halogen atom, a —S(O) z (C 1 –C 4 )Alk wherein z is 0, 1 or 2, a...
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7034045 |
Monofluoroalkyl derivatives
The present invention provides certain monofluoroalkyl derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions,...
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7030160 |
Propanolaminotetralines, preparation thereof and compositions containing same
The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that...
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6998423 |
Prevention of loss and restoration of bone mass by certain prostaglandin agonists
Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The...
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6958416 |
Valproyltaurinamide derivatives as anticonvulsant amd CNS active agents
The invention relates to derivatives of valproyltaurinamide of formula (I) in which R 1 and R 2 are independently hydrogen, a C 1 -C 6 -alkyl group, an arylalkyl group or an aryl group. The...
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6919369 |
Serine protease inhibitors
Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of...
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6911476 |
Sulfonamide derivatives
The present invention provides certain sulfonamide derivatives useful for potentiating glutamate receptor function in a patient and therefore, useful for treating a wide variety of conditions, such...
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6908947 |
Sulfonamide-substituted fused 7-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them
The present invention relates to compounds of formula I,
in which X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4) and R(5) have the meanings mentioned in the specification, their preparation and...
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6900353 |
Cyclopentyl sulfonamide derivatives
The present invention provides compounds of formula (I): useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as...
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6890942 |
Acyl sulfonamides as inhibitors of HIV integrase
The present invention relates a series of compounds of Formula I
wherein R 1 , R 2 , R 3 , and B are as defined in the specification. The compounds are useful for the inhibition of HIV...
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6887903 |
N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them
The compounds of formula 1
wherein R and R 2 are as defined in the disclosure, are useful in the prevention and treatment of tissue damage due to exacerbated recruitment of polymorphonuclear...
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6878721 |
Beta2-adrenoceptor agonists
Compounds of formula
in free or salt or solvate form, where
Ar is a group of formula
Y is carbon or nitrogen and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , X, n,...
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6864392 |
α-Sulfin and α-Sulfonamino amide derivatives
The invention relates to novel pesticidally active α-sulfin- and α-sulfonamino acid amides of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein n...
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6836383 |
Diphenylsquarylium compound and filter for display containing the same
The object of the invention is to provide a diphenylsquarylium compound which has a sharp minimum value within the wavelength range of from 550 to 610 nm in the light transmittance curve and from...
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6818777 |
Intermediates for synthesis of vinblastine compound and method for synthesizing the intermediate
Intermediates A, which are important in the whole synthesis of vindoline; and a method of synthesizing intermediates respectively represented by the general formulae B and C. By the method, the...
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6803484 |
Sulfonamide derivatives
The present invention relates to a compound of formula (Ia) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction,...
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6790991 |
Process for the preparation of diphenyl ether compounds
A process for producing fomesafen from acifluorfen comprises the steps of (a) converting acifluorfen to its acid chloride, (b) coupling the acid chloride so formed with methanesulphonamide to form...
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6743929 |
Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
Sulfonamide-containing hydroxyethylamine compounds are effecive as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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6720357 |
Sulfonamide derivatives
The present invention relates to a compound of formula (Ia) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction,...
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6713516 |
Sulphonamide derivatives
The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their...
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6703525 |
Sulfonamide intermediates and methods of producing same
Disclosed are intermediates of the formula (A) and methods of making same. The intermediate compounds are useful in the synthesis of heteroaryl/aryl urea compounds,
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6660772 |
Use of 2-amino-1-(4-hydroxy-2-methanesulfonamidophenyl)ethanol for treating urinary incontinence
A method of treating urinary incontinence in a patient in need thereof, the method comprising administering to the patient an effective amount of...
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6632826 |
Carbocyclic HIV protease inhibitors
The present invention is concerned with novel HIV protease Inhibitors of formula I as individual isomers, racemates, non-racemic mixtures or mixtures of diastereoisomers; wherein n, R 1 and R 4...
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6620858 |
Colorants containing copolymerizable vinyl groups and sulfonamide linkages
Disclosed are thermally-stable, colored, photopolymerizable compounds containing a vinyl group which are capable of being copolymerized with reactive vinyl monomers to produce colored compositions...
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6620933 |
Azomethine yellow dye compound
A azomethine yellow dye compound of general formula (I): General formula (I) wherein R 1 and R 2 each independently represent a hydrogen atom or a substituent; R 3 represents a substituent; m...
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6610747 |
Phenoxybenzylamine derivatives as SSRIs
A compound of general formula (I) wherein R 1 and R 2 are H, C 1 -C 6 alkyl or (CH 2 ) d (C 3 -C 6 cycloalkyl) wherein d=0, 1, 2 or 3; or R 1 and R 2 together with the nitrogen to which they...
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6583318 |
Method for synthesis of α-sulfonamido amide, carboxylic acid and hydroxamic acid derivatives
A method of synthesizing α-sulfonamido amide, carboxylic acid or hydroxamic acid derivatives comprising providing a set of polymer-bound reactant(s) (sulfonamide, aldehyde or ketone, isocyanide or...
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6573278 |
Aryl sulfonamides and analogues thereof and their use in the treatment of neurodegenerative diseases
The present invention relates to new aryl ether sulphonamides and analogues, processes for their preparation and their use for the treatment of neurodegenerative disorders, in particular for the...
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RE38103 |
5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
The Compound of Formula I and pharmaceutically acceptable sales thereof in the treatment of cyclooxygenase-2 mediated diseases are disclosed.
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6545053 |
Tricyclic compounds and drug compositions containing same
Compounds having a β-3 adrenaline receptor agonist and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc., represented by a general formula (I) and salts...
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6538159 |
α-sulfin-and α-sulfonamino acid amides
The invention relates to α-sulfin- and α-sulfonamino acid amides of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one;...
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6509499 |
Nitromethylthiobenzene derivatives as inhibitors of aldose reductase
The invention concerns novel compound of general formula (1) in which: P, T 1 , T 2 , X and n are as defined in claim 1, their tautomeric forms, and their additive salts with pharmaceutically...
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6503282 |
Means and method for dying keratinic fibers
Composition for coloring keratin fibers based on a developer-coupler combination characterized in that it contains as the coupler 3-(2,4-diaminophenoxy)-1-propanol and as the developer a...
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