Patents in Class 564/86

Matches 1 - 50 out of 677

Match	Document	Document Title
1	8183272	Indanyl compounds Compounds exhibiting calcium receptor antagonist activity that are safe and orally administrable having Formula (I) or pharmaceutically acceptable salts thereof:
2	RE43327	Hydrophobic polyamine analogs and methods for their use The disclosed invention provides new polyamine analogs and derivatives containing a hydrophobic region and a polyamine region as well as methods and compositions for their use.
3	8163735	Sulfonamide compounds as cysteine protease inhibitors The present invention is directed to compounds of formula (I) that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases...
4	8163956	Inhibitors of GLYT1 transporters A compound of the formula (I): wherein R1, R2, R3, R4, Ar, A, n and m are defined herein, is disclosed as a GlyT1 inhibitor; pharmaceutical compositions containing the compound of the formula (I)...
5	8158825	Modified malonate derivatives The present invention relates to a novel class of modified malonate derivatives. The modified malonate compounds can be used to treat cancer. The modified malonate compounds can also inhibit...
6	8143453	Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis α,β-Unsaturated sulfides, sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar1, Ar2, X, n, * and R are as defined herein, are prepared by dehydration of β-hydroxy sulfides, su...
7	8119685	Disubstituted aniline compounds The present invention relates to a novel class of disubstituted aniline compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal...
8	8101800	5,6-dihydro-1H-pyridin-2-one compounds The invention is directed to a 5,6-dihydro-1H-pyridin-2-one compound selected from:
9	8093424	Tetralin and indane derivatives and uses thereof Compounds of the formula I: or pharmaceutically acceptable salts thereof,wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and...
10	8063103	Polymorphs of acyl sulfonamides The application discloses novel polymorphic crystalline forms of 2-[4-Bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-( 2-chloro-4-propionylsulfamoyl-phenyl)-acetamide, sodium salt (Ib) with...
11	8044101	Nitrosation-inducible inhibitors biological macromolecules Biomacromolecules such as proteins are inactivated by hydrophobic ANSA derivatives of the formula: wherein R1 and R2 are hydrophobic or affinity groups and R3 is selected from the group consisting...
12	8017803	Process for the preparation of tamsulosin and intermediates thereof A process for producing tamsulosin of formula I and pharmaceutically acceptable addition salts, thereof comprises the steps of: a) Reacting compound...
13	7989497	Squaramide derivatives as CXCR2 antagonist The present invention relates to compounds of formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators....
14	7982067	Phenethanolamine derivatives for treatment of respiratory diseases Compounds of the formula (II) and (IV) are provided, which may be employed as intermediates for making compounds useful in treating respiratory diseases.
15	7973197	Colorant compound and blue resist composition for use in color filter containing the same The present invention provides (I) a method of manufacturing a triphenylmethane colorant that can suppress the sub-reactions in conversion to a sulfonamide and is industrially advantageous, (II) a...
16	7875746	Photosensitive composition, compound for use in the photosensitive composition and pattern forming method using the photosensitive composition A photosensitive composition comprising: (A) a compound capable of generating a compound having a specific structure upon irradiation with actinic rays or radiation, a pattern forming method using...
17	7842838	Pyrro[1,2-b]pyridazinone intermediates The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
18	7825278	Substituted enaminones, their derivatives and uses thereof The invention relates to substituted enaminones of Formula I and their derivatives and the discovery that these compounds modulate the effect of γ-aminobutyric acid (GABA) on the GABAA receptor ...
19	7776983	Fluorochemical polymeric surfactants Described are polymeric surfactants which include a fluorinated moiety and a non-fluorinated moiety where the fluorinated moiety contains two perfluoro-lower-alkyl sulfonamido segments in proximity...
20	7759518	Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK This invention concerns N-(2-arylamino)aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.
21	7608736	Process for preparing acylsulfamoylbenzamides The invention relates to a process for the preparation of a compound of formula (I): Which comprises reaction of a compound of formula (II) with a compound of the formula (III) in the presence of a...
22	7598418	Amide derivatives A medicament for enhancing an effect of a cancer therapy based on a mode of action of DNA injury, which comprises as an active ingredient a compound represented by the following general formula (I)...
23	7582673	Bissulfonamide compounds as agonists of GalR1, compositions, and methods of use Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are...
24	7572790	Biphenyl carboxylic amide p38 kinase inhibitors Compound of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
25	7550629	Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors A compound of Formula (I), or pharmaceutically acceptable salts and/or hydrates or prodrugs thereof, wherein Formula (I) has the structure: is provided, wherein R1-R7 are defined herein. These...
26	7547716	Sulfonamide derivatives A medicament for enhancing an effect of a cancer therapy based on a mode of action of DNA injury, which comprises as an active ingredient a compound represented by the general formula (I) or a...
27	7538246	Synthesis of optically pure(r)-5-(2-amynopropyl)-2-methoxybenzenesulphonamide The present invention relates to a new process for the preparation of optically pure(R)-5-(2-aminopropyl)-2-methoxybenzenesulphonamide, which is an intermediate in the synthesis of tamsulosin.
28	7511076	Nitrosation-inducible inhibitors biological macromolecules Biomacromolecules such as proteins are inactivated by hydrophobic ANSA derivatives of the formula: wherein R1 and R2 are hydrophobic or affinity groups and R3 is selected from the group consisting...
29	7511175	Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of...
30	7482487	Phenylaminoethanol derivatives as β2 receptor agonists The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The...
31	7476762	Methods for preparing sulfonamide compounds Methods for preparing substituted phenylsulfonamide compounds of the following structure are provided: or a pharmaceutically acceptable salt thereof, wherein, R1-R7 are defined herein. Also...
32	7459585	Benzene derivatives and pharmaceutical use thereof The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory...
33	7442719	Methods using phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their...
34	7439393	Phenethanolamine derivatives for treatment of respiratory diseases The invention relates to 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino ]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; and salts and solvates thereof, including those which are...
35	7402696	Benzene compounds The present invention provides novel benzene compounds presented by the following formulas, and analogs thereof, that exert an ACC activity-inhibiting effect that is effective in the treatment of...
36	7393873	Arylsulfonamide derivatives N-aryl arylsulfonamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin...
37	7378550	Process for preparing reverse transcriptase inhibitors The present invention is directed to processes for the synthesis of intermediates useful in the preparation of non-nucleoside reverse transcriptase inhibitors.
38	7375120	Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided.
39	7329780	Method of preparing optically pure phenethylamine derivatives Provided is a method of preparing an optically pure compound having formula 1 or its salts. The method includes: reacting (R)-2-(4-methoxy-3-aminosulfonyl-phenyl)-1 -methylethylamine or its salts...
40	7317023	Diaryl ether β2 adrenergic receptor agonists The invention provides novel β2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat ...
41	7312359	Tetralin and indane derivatives and uses thereof Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and...
42	7285565	Benzamides and related inhibitors of factor Xa Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or...
43	7271280	Process for preparing a biaryl compound A process for preparing an optically active biaryl compound the formula (4): which comprises reacting an aromatic sulfonic acid ester compound of the formula (1): with an organic boron compound of...
44	7256204	Amine compounds, their production and use A compound of the formula: wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or —SO2—, ...
45	7250447	Acylsulfamide inhibitors of factor VIIa Compounds having the general formula I are useful for inhibiting serine protease enzymes, such as Tissue Factor VIIa, factor Xa, thrombin and kallikrein and have improved permeability properties....
46	7244755	Hydroxypropylamines Disclosed are compounds of formula I: and the pharmaceutically acceptable salts thereof wherein the variables RN, R1, R2, R3, RP and RC are defined herein. These compounds are useful in treating...
47	7238839	Process for the resolution of racemic (R,S) -5-(2-(2-(2- ethoxyphenoxy) ethylamino)Propyl)-2-methoxybenzene sulfonamide (tamsulosin), its novel R and S isomers and their salts and processes for their preparation An improved process is described to resolve a racemic mixture in any proportion of 5-(2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2-methoxy benzene sulfonamide as a free base or some of its salts,...
48	7232923	Method of hydroaminating N-alkenoylcarbamates with primary aromatic amines The invention provides methods for hydroaminating N-alkenoyl carbamates with aromatic amines.
49	7232929	Amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid The invention relates to new 2,2,3,3-tetramethylcyclopropane carboxamide derivative compounds, pharmaceutical compositions thereof and uses thereof for treating psychotic disorders,...
50	RE39682	Farnesyl derivatives and pharmaceutical compositions containing them Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: wherein R1represents farnesyl,...

Matches 1 - 50 out of 677

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