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7612079 |
2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders
The present invention relates to compounds of formula I
or a pharmaceutically acceptable salt thereof wherein
R 2 is 2-hydroxymethylpyrrolidin-1-yl, or NHCH(R 4 )CH(R 3 )OH, wherein R 3 is...
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7601872 |
Transfection reagents
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure:
wherein
Q is selected from the group consisting...
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7598422 |
Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof
A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method...
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7582642 |
Purine derivatives
The present invention relates to compounds of formula 1
or pharmaceutically acceptable salts thereof, wherein
one of R 1 and R 2 is methyl, ethyl or isopropyl, and the other is H; R 3 and R...
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7566806 |
Alkylamino group-terminated fluoroether and process for producing the same
An alkylamino group-terminated fluoroether compound, represented by the following general formula:
RfO[CF(CF 3 )CF 2 O] m CF(CF 3 )(CH 2...
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7544689 |
Purine derivatives
The present invention relates to compounds of formula I
or pharmaceutically acceptable salts thereof, wherein
one of R 1 and R 2 is methyl, ethyl or isopropyl, and the other is H; R 3 and R...
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7531693 |
Lipids for transfection of nucleic acids
Cationic lipid compositions are provided that are useful for efficient delivery of macromolecules, such as nucleic acids, into a wide variety of eukaryotic cell types. Methods for using the...
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7524887 |
2-amino-1,3-propanediol compounds for the treatment of acute pain
The present invention relates to a method for the prophylaxis or treatment of pain using compounds of formula I,
in which R, R2, R3, R4 and R5 have the meanings indicated in the specification.
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7495131 |
Blowing catalyst compositions containing hydroxyl and surface active groups for the production of polyurethane foams
Tertiary amines useful as catalysts for preparing polyurethane foams are provided. Tertiary amines are employed to catalyze the trimerization reaction of isocyanates and the reaction between...
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7470817 |
Transfection reagents
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure:
wherein
Q is selected from the group consisting...
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7462746 |
Amino polyols and amino sugars
Synthetic methods provide for the simple, efficient preparation of amino polyols and derivatives. The methods include a three-component reaction of a carbohydrates with organoboron compounds and...
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7445771 |
Use of bis-amines to enhance the antimicrobial activity of aqueous compositions
The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous...
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7414154 |
Polyamine compounds and compositions for use in conjunction with cancer therapy
The invention provides novel polyamine compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered...
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7388033 |
Amine-functionalized polyisobutylenes for improved hydrophobizing microemulsions
In one embodiment, the present invention relates to amine-functionalized polyisobutylenes. Methods for preparing the amine-functionalized polyisobutylenes are also described. Furthermore, the...
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7387768 |
Method for purifying gases
The invention relates to the use of an absorption liquid for purifying gases from gaseous acidic contaminants, the absorption liquid comprising
A) 0.1 to 100% by weight of one or more amines of...
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7385076 |
Process for the preparation of phenylcarbamates
A process for the preparation of compound of formula (I); wherein R 1 is hydrogen, linear, branched or cyclic lower alkyl, cyclohexyl, allyl, propargyl or benzyl; R 2 is hydrogen, methyl, ethyl...
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7314959 |
Amino thiol compounds and compositions for use in conjunction with cancer therapy
The invention provides novel polyamine and amino thiol compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are...
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7307184 |
Processes for preparing oxazolidinone derivatives of β-hydroxyethlamine compounds and for preparing β-hydroxyethlamine compounds
The present invention provides a process of starting from N-alkoxycarbonyl-ethylamine compounds having a leaving group at the β-position to prepare oxazolidinone derivatives of...
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7217847 |
Method for the production of optically active 2-amino 2-chloro, 2 hydroxy or 2-alkoxy-1-alcohols
The invention relates to a process for preparing optically active 2-amino-, 2-chloro-, 2-hydroxy- or 2-alkoxy-1-alcohols by catalytically hydrogenating appropriate optically active 2-amino-,...
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7169818 |
Lysophosphatidic acid receptor agonists and antagonists
The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the...
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7164034 |
Alpha2delta ligands for fibromyalgia and other disorders
This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs...
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7157488 |
N-(2-Arylethyl) benzylamines as antagonists of the 5-HT6 receptor
The present invention provides compounds of formula I
pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are antagonists of the 5-HT 6 receptor. The...
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7145039 |
Transfection reagents
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure:
wherein
Q is selected from the group...
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7060731 |
Use of amines
This application relates to the use of certain amines of formula (I)
for combatting and preventing systemic and local complement activation, and in particular to the use of meglumine and...
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7049446 |
Process for chemical reaction of amino acids and amides yielding selective conversion products
The invention relates to processes for converting amino acids and amides to desirable conversion products including pyrrolidines, pyrrolidinones, and other N-substituted products. L-glutamic acid...
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7034176 |
Aminopropylphosphinic acids
Intermediates used in the preparation of compounds of formula I,
or a stereoisomer thereof, or a pharmaceutically acceptable form of either selected from the group consisting of a salt, a...
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7026515 |
Optically active amine derivatives and preparation process therefor
A readily available and inexpensive natural α-amino acid is converted into a compound represented by formula (1), which is then reacted with an organometallic reagent represented by formula (2) to...
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6916948 |
Bis(1,3-dihydroxy-prop-2-yl) amine and derivatives thereof in the manufacture of polymers
Derivatives of bis-(1,3-dihydroxy-prop-2-yl)amine are disclosed, together with the use of such derivatives and of bis(1,3-dihydroxy-prop-2-yl)amine itself in the preparation of polymers, in...
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6909018 |
Preparation of polyalkeneamines
Polyalkeneamines of the formula (I)
where R 1 , R 2 , R 3 , R 4 , R 5 and R 6 may have different meanings, are prepared by a process in which a polyalkene epoxide is reacted with an amine...
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6888030 |
Advances in amination
Inclusion of a branched alcohol in the catalytic hydrogenation reaction involving an aliphatic nitro compound dramatically increases the efficiency of the conversion of nitro groups into amino...
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6852892 |
Process for the synthesis of sphingosine
This invention relates to a method for the production of a sphingoid base according to formula
comprising the steps of
(1) dissolving a starting compound according to formula III or a salt...
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6784175 |
Use of substituted 1-amino-5-phenylpentane-3-ol and/or 1-amino-6-phenylhexane-3-ol compounds as medicaments
The use of at least one substituted 1-amino-5-phenylpentane-3-ol and/or 1-amino-6-phenylhexane-3-ol compound and/or one of the enantiomers thereof and/or one of the diastereomers thereof and/or one...
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6765116 |
Process of preparing a fluid rare earth alkoxylation catalyst
A process to prepare an improved fluid rare earth phosphate catalyst composition useful in preparing alkylene oxide adducts of organic compounds having active hydrogen atoms is provided. The...
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6762325 |
Method for production of alkoxylated compound
When the reaction solution formed during the addition of an alkylene oxide to an active hydrogen-containing compound has viscosity of not less than 10 mPa·s, this invention provides a method for...
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6747149 |
Glucamine salts for treating hepatitis virus infections
N-Substituted glucamine compounds of formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections the compounds of formular...
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6649780 |
Cationic lipids
Cationic lipids are provided which are useful in the preparation of liposomes and other lipid vesicle carriers. The lipids of the invention are particularly useful as carriers of nucleic acids and...
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6646150 |
Processes for producing (aminomethyl)trifluorocarbinol derivatives
The present invention provides a process for industrially producing (aminomethyl)trifluoromethylcarbinol derivatives, in particularly, optically active compounds thereof, which are useful as...
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6642398 |
Mono-and disubstituted 3-propyl gamma-aminobutyric acids
The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula I The compounds are useful as therapeutic agents in the treatment of epilepsy,...
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6583246 |
Modifiers for anionic polymerization
The invention provides modifiers for the anionic polymerization of conjugated dienes or of conjugated dienes with vinylaromatic compounds, wherein the modifiers are specific aminoethers.
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6583182 |
Compounds with chelation affinity and selectivity for first transition series elements: use in medical therapy and diagnosis
This invention involves synthesis and use of a class of compounds with chelation affinity and selectivity for first transition series elements. Administration of the free or conjugated compound, or...
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6552084 |
Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders are disclosed.
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6538032 |
Phytosphingosine derivatives with antitumor activity
The present invention relates to an antitumor agent containing a phytosphingosine derivative, and more specifically, to an antitumor agent containing a phytosphingosine derivative of formula I as...
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6525221 |
Fuel detergent composed of hydropoly(oxyalkylene) oxyalkyl amine compound
A fuel oil detergent which efficiently constricts precipitate formation and octane number requirement increase in a carburetor, injector, and inlet system of an internal combustion engine, i.e., a...
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6503945 |
Cationic amphiphiles containing N-hydroxyalkyl group for intracellular delivery of biologically active molecules
The present invention provides novel cationic amphiphiles containing novel N-hydroxyalkyl group and therapeutic formulations containing the said amphiphiles that are capable of facilitating...
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6492560 |
Discrete-length polyethylene glycols
The present invention provides discrete-length polyethylene glycol and polyethylene glycol containing compounds and methods for their preparation.
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6476004 |
Pharmaceutical composition
Medicinal compositions which can be processed into solutions and are useful in inhibiting rejection reactions against the transplantation of organs or bone marrow, in the maintenance immunotherapy...
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6458999 |
Ether diamines and derivatives
The present invention is related to a series of derivatives of novel ether diamine compounds prepared by the cyanobutylation reaction of an alcohol having 3 to 22 carbon atoms with 2-pentenenitrile...
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6458860 |
Advances in urethane foam catalysis
Provided herein are catalyst systems useful for providing polyurethane foam products which exhibit low fogging characteristics while possessing favorable overall physical properties when used as...
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6458837 |
Lipophilic diesters of chelating agents
The invention discloses stable diesters of chelating agents of divalent metal ions, processes for their preparation and pharmaceutical compositions thereof. Most preferred compounds according to...
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6444737 |
Water-dispersed polymer stabilizer
The invention provides stabilizer systems for scavenging acid, minimizing hydrolysis, or both in polymer systems. The invention comprises a combination selected from the group consisting of:...
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