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7601874 |
Indene derivatives as pharmaceutical agents
Compounds of formula (Ia):
wherein R 1 , R 2 , R 3 , R 4a , R 4b , R 5 and R 6 are defined herein, as well as other indene derivatives are disclosed herein. Pharmaceutical compositions...
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7456222 |
Anti tubercular drug: compositions and methods
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the...
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7456318 |
Process for preparing benzylated amines
This present invention relates to a process for preparing benzylated amines by the reaction of an amine selected from methamphetamine and propylhexedrine with benzyl halide. Numerous improvements...
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7388112 |
Immunomodulation with novel pharmaceutical compositions
The synthesis and use of a novel class of tumor necrosis factor (TNFα) inhibitors and immunomodulators are provided. Examples are those having the structures:
wherein a, b and c are integers...
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7235695 |
Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds...
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7214828 |
Durable coating compositions containing novel aspartic amine compounds
A coating composition comprising a binder of
a. polyisocyanate crosslinking agent; b. an isocyanate-reactive component having at least one compound having the following formula:
...
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7196226 |
Fluoraminoolefins and fluorination reagents which can be prepared therefrom
The present invention relates to fluorination reagents comprising 1-fluoro-1-aminoolefins and also processes for preparing fluorination reagents comprising 1-fluoro-1-aminoolefins.
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7164034 |
Alpha2delta ligands for fibromyalgia and other disorders
This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs...
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7026514 |
Compounds used to treat alcoholism
N,N′-bis(3-aminopropyl)cyclohexane-1,4-diamine, of formula (I), is a new compound that is prepared by hydrogenation with Raney nickel catalyst of N,N′-bis(2-cyanoethyl)-cyclohexane-1,4-diamine,...
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7018978 |
Fragrance pro-accords and aldehyde and ketone fragrance libraries
The present invention relates to novel heterocyclic pro-fragrances, preferably oxazolidines, tertahydro-1,3-oxazines, thiazolidines, or tetrahydro-1,3-thiazines, more preferably oxazolidines, or...
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7019149 |
Thromboxane ligands without blood clotting side effects
A method of treating ocular hypotension, hypertension, hemorrhage, myocardial ischemia, angina pectoris, coronary contraction, cerebrovascular contraction after subarachnoidal hemorrhage, cerebral...
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6943272 |
Norbornane and norbornene derivatives, use thereof and perfumed products containing same
The invention concerns a novel compounds of formula (I), wherein the dotted line bond is present or not, and wherein R 1 represents: when the dotted line bond is present —CHCH 3 OH or —CHCH 3...
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6861402 |
Pro-fragrances
The present invention relates to fragrance delivery systems which comprise: A) from about 0.01% by weight of a pro-fragrance component which comprises pro-fragrances or pro-accords selected from at...
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6828318 |
2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission
Compounds of formula (1): wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are independently selected from hydrogen, alkyl, aryl and non-aromatic heterocyclic groups, or each of one or more pair(s)...
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6828462 |
Unsaturated 1-amino-alkylcyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists
Unsaturated 1-Amino-alkylcyclohexane compounds which are systemically-active as NMDA, 5HT 3 , and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of...
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6747149 |
Glucamine salts for treating hepatitis virus infections
N-Substituted glucamine compounds of formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections the compounds of formular...
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6642398 |
Mono-and disubstituted 3-propyl gamma-aminobutyric acids
The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula I The compounds are useful as therapeutic agents in the treatment of epilepsy,...
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6583246 |
Modifiers for anionic polymerization
The invention provides modifiers for the anionic polymerization of conjugated dienes or of conjugated dienes with vinylaromatic compounds, wherein the modifiers are specific aminoethers.
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6329523 |
Compounds having a plurality of nitrogenous substitutents
Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring...
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6214859 |
Ethylamine derivatives
Ethylamine derivatives of the formula (I): ##STR1## (wherein R 1 is hydrogen, hydroxyl, lower alkoxy or halogen; R 2 is alkyl having 2 to 5 carbon atoms; R 3 is hydrogen, alkyl having 2 to 5...
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6166234 |
Tripodal cyclopentadiene derivatives and their use
Novel tripodal cyclopentadiene derivatives have the formula (I) ##STR1## where E are identical or different and are --N(R)(R), --P(R)(R), --As(R)(R), --Sb(R)(R), --OR, --SR, --SeR, --TeR, where R...
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6137019 |
Process for converting a geminally substituted cyclopentadiene
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6028225 |
Method of making hydroxy-substituted hydroxylamines and color developers containing same
Hydroxy-substituted hydroxylamine antioxidants can be prepared by reacting hydroxylamine or a mono-substituted hydroxylamine, in free base form, with an epoxide. The antioxidant reaction product...
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5952316 |
2-amino-1,3-propanediol compound and immunosuppressant
2-Amino-1,3-propanediol compounds of the formula (I) ##STR1## wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted...
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5849802 |
Fungicidal spirocyclic amines
New antimicrobial spirocarbocyclic compounds are described, having the general formula I, ##STR1## or an acid-addition salt thereof, in which R 1 represents an optionally substituted alkyl,...
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5817698 |
Substituted cycloalkylamine derivatives and their use as calcium channel antagonists
A method of treatment of a condition or disease related to the accumulation of calcium in the brain cells of a mammal which comprises administering to a subject in need thereof an effective amount...
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5739397 |
Process for the production of secondary amines and the amines produced by the process
Secondary amines having a hydrocarbon backbone, a functionality of at least 1 and a molecular weight of at least 74 are produced by reacting a hydrocarbon containing a leaving group with a primary...
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5399763 |
Process for preparing optically active 2-aminopropanal
A process for preparing an optically active 2-aminopropanal through oxidative cleavage of the corresponding optically active 3-amino-1,2-butanediol of the following formula (2): ##STR1## wherein R1...
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5382684 |
Nitrogenous 1,3-substituted adamantanes
The invention is directed to nitrogenous 1,3-substituted adamantanes, their preparation and use in synthesis of inorganic porous solids. The nitrogenous 1,3-substituted adamantanes are compounds...
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5342981 |
Substantially isomerically pure hexane or hexene compounds
The present invention relates to intermediates useful in a process for the preparation of a compound of the formula: ##STR1## wherein R 2a is hydrogen or loweralkyl, R 2b is hydrogen, loweralkyl,...
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5296632 |
Continuous reduction of a hindered nitro moiety in aliphatic nitro polyamines
Nitro polyamines, and especially dinitro polyamines, can be readily reduced by a catalyst of zerovalent nickel on silica where the silica contains not more than 10% alumina and where the nickel...
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5288911 |
Preparation of α,ω-aminoalcohols
Preparation of α,ω-aminoalcohols of the general formula I HO--CH 2 --X--CH 2 --NH 2 (I), in which x denotes a C 1 -C 20 -alkylene chain optionally substituted by inert...
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5254707 |
Preparation of cyclopentadiene derivatives
The process for preparing a compound of the formula: Cp'YNHR wherein: Cp' is a cyclopentadienyl or a substituted cyclopentadienyl group, Y is a covalent bridging group which contains one or more...
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5239120 |
Preparation of 2-(3-aminopropyl)-cycloalkylamines
A process for the preparation of a 2-(3-aminopropyl)-cycloalkylamine of the general formula I ##STR1## in which the subscript n is an integer from 1 to 4, from a 2-(2-cyanoethyl)-cycloalkanone of...
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5232836 |
Vitamin D derivatives: therapeutic applications and applications to assays of metabolites of vitamin D
Vitamin D derivatives corresponding to the following formula I ##STR1## in which R 1 denotes a substituted alkyl group having 1 to 15 carbon atoms, in particular the side chains of vitamin D 2 (C...
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5162353 |
Carbacyclins, processes for their preparation, and their use as medicinal agents
The invention relates to carbacyclin derivatives with general formula I: ##STR1## in which Y 1 stands for the radical --CH 2 --X--(CH 2 ) n --R 1 or the radical ##STR2## n, 1 or 3, R 1 , the...
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5084592 |
Azulenesquaric acid dyes, azulene intermediates therefor, and optical recording medium
Azulenesquaric acid dyes of the formula ##STR1## where R 1 , R 2 , R 3 , R 4 and R 5 each have specified meanings are prepared from azulene derivatives of the formula ##STR2## where R 1 , R 2 , R...
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4835224 |
Process for the preparation of polyamines and their use for the production of polyurethanes
Polyamines are produced by hydrolyzing an isocyanate compound in the presence of at least one of a selected group of catalysts and a water miscible polar organic solvent in substantially...
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4804659 |
Decahydronaphth-2-yl-alkylamines
Novel fungicidally active decahydronaphth-2-yl-alkylamines of the formula ##STR1## in which A represents optionally substituted decahydronaphth-2-yl and R 1 and R 2 are identical or different...
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4716248 |
Aminocyclohexyl-substituted, branch alkylamines
New compounds having the formula: X--(YQNH 2 ) p I wherein p is 1 or 2 and the residues QNH 2 are the same or different and each is a residue of formula:...
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4714777 |
Cyclopropanone hydrate derivatives
The subject invention relates to novel cyclopropanone hydrate derivatives of the structural formula ##STR1## wherein R 1 and R 2 are selected from the group consisting of --H, --(CH 2 ) n --...
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4705897 |
Process for producing bicyclic diamines
Bicyclic diamines are prepared by a process comprising reacting 5-vinyl-2-norbornene or norbornadiene, synthesis gas and an amine from the group consisting of primary amines and secondary amines in...
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4695631 |
Process for the preparation of enamines or imines
A process for the preparation of enamines or imines by isomerization of allylamine derivatives is described. Allylamine derivatives represented by formula (I): ##STR1## are isomerized using as a...
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4683330 |
Interphenylene carbacyclin derivatives
A compound of the formula ##STR1## and intermediates useful in preparing same.
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4673759 |
Process for the preparation of 2-alkyl cyclopent-2-enones
A process for the preparation of 2-alkyl cyclopent-2-enones having the formula: ##STR1## wherein R is as defined hereinafter. An α-olefin having the formula CH 2 CH--CH 2 R is oxidized to the...
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4628110 |
Novel 9-substituted carbacyclin analogs
Novel compounds of the following general formula: ##STR1##
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4605768 |
1-cycloalkylamino-3-t-butylamino-2-propanols, a method of preparing the same, and a method of use thereof
A compound having the formula: ##STR1## wherein n is an integer between 6 and 11, inclusive; or the pharmaceutically-acceptable salts thereof. The compounds of the present invention and...
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4575516 |
Cyclopropylmethyl(ene) ethers and arthropocidal use thereof
Substituted cyclopropylmethyl(ene) ethers of the formula ##STR1## in which X 1 and X 2 are identical or different and represent halogen, R 1 represents hydrogen or alkyl, R 2 and R 3 are...
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4575517 |
Microbicidal agent for preserving industrial materials
Cyclopropylmethyl(ene) ethers have an outstanding action in microbicidal agents for preserving industrial materials from damage or destruction by microorganisms.
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4556515 |
Manufacturing process of β-acylenamine
A method for preparing β-acylenamine by condensing an oxime sulfonate with silyl enol ether in the presence of reagent, particularly the oxime sulfonate being represented by the following general...
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