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7317127 |
Process for the optical resolution and recycling of tomoxetine
The present invention provides a process for the optical resolution of racemic tomoxetine under reaction conditions that improve reaction yields and optical purity. The invention also provides an...
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7262327 |
Recycling process for preparing sertraline
Provided is a recycling process for preparing sertraline, which may be carried out on an industrial scale.
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7122700 |
Arylamine processes
A method for bisformylation an arylamine compound by reacting an arylamine compound with an alkyleneamine in a reaction mixture while refluxing an acid in the reaction mixture.
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6965832 |
Investigating different physical and/or chemical forms of materials
Apparatus and a method are described for investigating polymorphs of a material, isomers of a material which allow different isomeric forms to be resolved, different hydrates/solvates and/or...
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6909017 |
Method for isolating and purifying (1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol
The invention relates to a method for isolating and purifying (1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cycl
ohexanol as a saccharinate from a mixture of the diastereomers...
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6586634 |
Process for the preparation on (1S,2R)-1-amino-2-indanol-(R,R)-tartrate methanol solvate
Process for the preparation of (1S,2R)-1-amino-2-indanol-(R,R)-tartrate methanol solvate, in which in a solvent a mixture of enantiomers of cis-1-amino-2-indanol reacts at an elevated temperature...
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6521792 |
Process for separating the diastereomeric bases of 2-&lsqb (dimethylamino)methyl&rsqb -1-(3-methoxyphenyl)-cylohexanol
A method for separating the diastereomer bases of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol in which the separation of the diastereomer bases takes place through formation of a...
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6469213 |
Tramadol, salts thereof and process for their preparation
Cis-Tramadol hydrochloride is prepared by forming a Mannich hydrochloride, liberating the Mannich base, reacting the Mannich base with a Grignard reagent to form a base hydrate of cis-Tramadol...
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6399829 |
Synthesis and purification of (r*,r*)-2-&lsqb (dimethylamino) methyl&rsqb -1-(3-methoxyphenyl) cyclohexanol hydrochloride
(R*,R*)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohe
xanol (Tramadol) is synthesized in a Grignard reaction in the presence of an additive resulting in a higher trans:cis ratio of product...
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6008412 |
Process to make chiral compounds
The present invention relates to processes for resolving N-methyl-3(R,S)-hydroxy-3-phenylpropylamine and N,N-dimethyl-3 (R,S) -hydroxy-3-phenylpropylamine with the isomers of mandelic acid and the...
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5952528 |
Process for enhancing the optical purity
A process for enhancing the purity of 2R- 1-hydroxy-1-trifluoromethyl-3-cyclopropylpropyn-2-yl!-4-chlo
roaniline comprising the formation of an acid addition salt which is capable of rejecting the...
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5919990 |
Reclamation of bisphenol tars as feedstock in the synthesis of aminophenylhydroxphenylalkanes
The disclosure is of a process for recovering valuable by-products of the condensation of phenol and a ketone from a mother liquor obtained for example upon crystallization of a 1:1 adduct of...
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5877351 |
Preparation and purification process for 2- (dimethylamino) methyl!-1-(3-methoxphenyl)-cyclohexanol and its salts
A process for the isolation and purification of (RR,SS)-2- (dimethylamino)methyl!-1-(3-methoxyphenyl)cyclohexanol and its salts from a Grignard reaction mixture which includes the (RR,SS) isomer,...
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5863952 |
Enantiomers of 1-(3,4-dichlorobenzyl)-2-methylaminoindane
The single enantiomers of formula (I) and salts thereof ##STR1## are calcium channel antagonists useful in the treatment of ischaemic conditions e.g., stroke.
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5856579 |
Adduct salts of novel substituted benzylamines and a process for optically resolving them
A process for optical resolution of a racemic substituted benzylamine is provided that involves reacting the racemic substituted benzylamine in a solvent with an optically active...
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5679857 |
Method of preparing D-amino acid-N-(S)-α-alkylbenzylamide
L-amino acid amides are converted to the corresponding D-amino acid amides. An amide formed from an L-amino acid and an optically active (S)-α-alkylbenzylamine is subjected to dehydration...
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5672755 |
Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts
The invention provides a process for the purification and isolation of (RR,SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexano
l from mixtures also containing the (RS,SR) isomer comprising...
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5629450 |
Addition salt of acyl-amino acid and α-aryl amine and process for optical resolution of α-arylamine
To produce optically active α-arylalkylamine from optically impure α-arylalkylamine. Optically impure α-arylalkylamine is mixed with optically active N-acyl-aspartic acid or glutamic acid in a...
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5414129 |
Process for the purification of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol and its salts
A process for the improved purification and separation of trans 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride from a reaction mixture containing the trans isomer, the cis...
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5306826 |
Process for preparation of an optically active amino acid amide
The present invention relates to a process for the preparation of optically active amino acid amide. L-amino and D-amino acid amides are mixed in the presence of 0.5-4 equivalents of an aldehyde,...
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5284975 |
Method of preparing α-d-phenylalkylbenzyl carbinol
A method of preparing an α-d-phenylalkylbenzyl carbinol by the reaction of a phenylbenzyl ketone with an alkali metal enolate of an amide to form an aldol adduct, which is reduced and purified to...
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5082970 |
Process for recycling amine isomer
A novel process for converting trans-isomeric N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphtha
leneamine to cis-isomeric...
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4652563 |
Vasodilators and β-adrenoceptor antagonists
This invention relates to dihydropyridazinone compounds having a cyclopropylmethoxyethyl group in the 6-substituent. These compounds are vasodilators and β-adrenoceptor antagonists. A particular...
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4489209 |
Separation of amines by preferential aqueous salt extraction
A process of separating amines having different basicity constants is disclosed. The more reactive amine is converted to a salt which is extracted with water in a multiple stage countercurrent...
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4224246 |
Process for the synthesis and separation of the threo and erythro isomers of 2-amino-1-phenyl-1-propanol
A process for the synthesis and separation of the threo and erythro isomers of 2-amino-1-phenyl-1-propanol comprising the steps of catalytically reducing 2-nitro-1-phenyl-1-propanol to form the...
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4174351 |
Separation of dissimilar amines
Amines which are dissimilar in nature by virtue of possessing different substituents, different structures or position isomers may be selectively separated by treatment with a reactive carbonyl...
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4150032 |
9-Oxobenzomorphan process and intermediates
Improved processes for preparing 2'-alkoxy-2,5-di-substituted-9-oxo-6,7-benzomorphans from benz[e]indolines and synthesis of the benz[e]indoline intermediates are described. A representative...
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3452096 |
PROCESS FOR THE SEPARATION OF ISOMERS OF DICHLOROANILINE
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2809884 |
Apparatus for separation by crystallization
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2798891 |
Separation of organic compounds by forming clathrates with werner complexes
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2790831 |
Improvements in nitrating 1-naphthylamine
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