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7601876 |
Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the...
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7179926 |
Aryloxyalkylamine NK-1/SSRI inhibitors
The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts and solvates, their pharmaceutical compositions, and their use in treating disorders associated with an...
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7060851 |
Method of preparing retroviral protease inhibitor intermediates
Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral...
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7022882 |
NMDA receptor channel blocker with neuroprotective activity
Neuroprotectant agents are provided which do not contain peptides and axe protected from the degradation that limits the use of peptide-based drugs in systemic circulation. With great selectivity...
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7001925 |
Compounds and method for enhancing the efficacy of anti-cancer drugs
Polyamine compounds, method of synthesis and method of use for anti-cancer purposes, and for enhancing the activity of existing anti-cancer drugs are provided. This disclosure has identified...
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6872852 |
Polyamine analogues as cytotoxic agents
Cytotoxic polyamine analogues are provided that are useful for treating diseases where it is desired to inhibit cell growth and/or proliferation, for example cancer and post-angioplasty injury.
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6768024 |
Triamine derivative melanocortin receptor ligands and methods of using same
The invention provides triamine derivative melanocortin receptor ligands of the formula: wherein R 1 to R 8 and n have the meanings provided herein. The invention further provides methods of...
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RE38417 |
Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
The present invention relates to anti-neoplastic and anti-psoriasis pharmaceutical compositions and methods of treatment and to insecticidal compositions and methods of controlling the growth of...
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6649587 |
Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as...
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6514297 |
Detergents for use in preventing formation of iron complexes in hydrocarbon fuels
An improved detergent for use in hydrocarbon fuels comprising the composition produced by mixing (1) the Mannich reaction product of a polyisobutene-substituted phenol, (preferably, where the...
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6472426 |
Sterically hindered tetraamines and method for their production
Polyamines having the formula: wherein R 1 and R 2 are alkyl, aralkyl or aryl having up to 10 carbon atoms; and a and b may be the same or different and are integers from 1 to 8; or a salt...
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6455591 |
Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment
Anti-diarrheal, anti-secretory, nitric oxide agonist, nitric oxide synthase activating or gastrointestinal anti-spasmodic compounds of the formula: R 1 —N 1 H—(CH 2 ) 3 —N 2 H—(C 2 ) 3...
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6441238 |
N-(aminopropyl)-toluenediamines and their use as epoxy curing agents
The invention provides N-aminopropylated toluenediamines, processes for synthesizing them, compositions containing them and methods for using them to cure epoxy resins. In preferred embodiments,...
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6413987 |
Dermal anesthetic agents
The present invention relates to new aminoindane piperidine compounds, the method of using aminoindane compounds as local anesthetics, said compounds having particularly valuable properties as...
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6329523 |
Compounds having a plurality of nitrogenous substitutents
Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring...
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6270539 |
Mannich dispersants with enhanced lubricity
Reaction products of i) a compound containing at least one primary or secondary amine group and at least one hydroxyl group; ii) a polyamine containing at least two amine groups wherein at least...
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RE37087 |
Insecticidal triffluormethyl alkane derivatives
There are provided new alkane and alkoxyalkane derivatives of the general formula I ##STR1## in which R 1 , R 2 , R 3 , R 4 and A have the meanings given in the description, processes for their...
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6024768 |
Diaminoalkane and oxidation colorants
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6018069 |
2-isoxazoline derivative and process for producing the same and process for producing related derivatives from the same
A purified acid addition salt of a (2S, 3S, 5S)-2,5-diamino-1,6-diphenyl-3-hydroxyhexane, e.g., (2S, 3S, 5S)-2-tert-butoxycarbonylamino-3-hydroxy-5-amino-1,6-dipheny
lhexane, is obtained from its...
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5976202 |
Reaction products of polyolefins with vinyl esters and their use as fuel and lubricant additives
Reaction products of polyolefins having predominantly a terminal double bond and a number average molecular weight of from 250 to 10,000, which possess an aliphatic hydrocarbon skeleton which is...
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5973205 |
Process for the preparation of 1, 3-diaminopropane derivatives and intermediates useful in this process
A process for preparing a compound of formula (I) or an addition salt thereof and/or a solvate thereof: ##STR1## wherein R 1 , R 2 , R 4 and R 5 are each independently C 1 -4 alkoxy and R 3 is C...
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5922744 |
Ethane-1-2-diamine derivatives and tachykinin antagonists
The present invention provides a compound of formula: ##STR1## wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6a and R 6b are defined herein or a pharmaceutically acceptable salt thereof, a process...
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5874618 |
2-nitro-para-phenylenediamines substituted by sulphur in the 5-position, the process for their preparation, dyeing compositions in which they are present and their use in the dyeing of keratin fibers
Novel nitrobenzene compounds of the nitroparaphenylene-diamine type substituted by sulphur in the 5-position are disclosed. These compounds are intended especially for the dyeing of keratin fibers...
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5808003 |
Polyaminocarboxylate chelators
A compound according to the formula: ##STR1## and conjugates thereof.
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5756475 |
Isoprene derivatives
Isoprene derivatives of formula (I) ##STR1## wherein m is an integer of 0 to 3, n is an integer of 5 to 12, A is cyclo(C 3 -C 6 )alkylene, phenylene, fluorenylene, pyrrolidinylene,...
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5753714 |
Polyamine derivatives
This invention relates to certain polyamine derivatives, to the methods and intermediates useful for their preparation, and to their use in treating diseases caused by infestation with a variety of...
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5753715 |
2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents
The invention relates to cyclohexenyl antibacterial compounds of the formula I: ##STR1## and pharmaceutical compositions containing the compounds, methods for their production and use.
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5686609 |
Aromatic amine compounds, Their method of preparation and pharmaceutical compositions in which they are present
The invention relates to compounds of the formula ##STR1## in which: m is 2 or 3; Ar and Ar' independently are a thienyl group; a substituted or unsubstituted phenyl group; or an imidazolyl...
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5633407 |
Process for preparing substituted aromatic amines
A process for preparing substituted aromatic azo compounds is provided which comprises contacting a nucleophilic compound and an azo containing compound in the presence of a suitable solvent...
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5578685 |
Curing component for epoxy resins comprising Mannich base from alkylated polyhydroxy aromatic
Curing components containing amino groups for curing epoxy resins are obtained by the reaction of alkylated polyhydroxy aromatics (A) with polyamines (B) and aldehydes (C) by the mechanism of the...
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5576108 |
Curing component for epoxy resins
Curing components containing amino groups for curing epoxy resins are obtained by the reaction of alkylated polyhydroxy aromatics (A) with polyamines (B) and aldehydes (C) by the mechanism of the...
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5554793 |
Catalytic reforming of alkyleneamines
A process of reforming an alkyleneamine feedstock or a mixture of such feedstocks to an alkyleneamine or a mixture of alkyleneamines which is different from the feedstock or feedstock mixture. The...
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5554656 |
Disinfectant concentrates and disinfectants on amine and alcohol base and their use
The invention relates to a disinfectant concentrate which contains amine and alcohol wherein the alcohol component includes at least one glycol ether of limited miscibility with water and the amine...
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5521220 |
Acyclic ethylenediamine derivatives
The present invention relates to novel acyclic ethylenediamine derivatives of nitrogen containing heterocyclic compounds, and specifically, to compounds of the formula ##STR1## wherein R 1 , R 2 ,...
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5488168 |
Tertiary amino alcohol and method of producing the same
A tertiary amino alcohol, being useful as an emulsifier, is defined by the formula (1) or (2): ##STR1## where R is a C 2 to C 24 straight-chain or branched alkylene group, an alicyclic alkylene...
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5433875 |
Ashless mannich despersants, their preparation, and their use
Ashless dispersants are formed using polymers of propylene characterized in that they are liquid substantially linear polymers, they have stereo-irregularity in the polymer chain, at least 60 mol...
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5391808 |
Substituted 1,4-diamino-2-butene stabilizers
N,N,N',N'-Tetrasubstituted 1,4-diamino-2-butenes where the substituents are alkyl, cycloalkyl, aralkyl, aryl or mixtures thereof provide effective antioxidant protection to lubricants and/or...
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5362747 |
2-nitroaryl and 2-cyanoaryl compounds as regulators of nitric oxide synthase
2-Nitroaryl or 2-cyanoaryl compounds of the formula ##STR1## pharmaceutical compositions thereof, intermediates useful in the preparation of these compounds, and methods for treating disorders of...
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5354782 |
Polyamine phenols as radioprotective agents
The present invention relates to certain polyamine phenols which are useful as radioprotective agents.
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5308840 |
Substituted or unsubstituted benzhydryl heteroalkyl-substituted aminophenol compounds and pharmaceutical compositions thereof
Aminophenol derivatives of the following formula (I) ##STR1## wherein X is hydrogen atom, lower alkyl or a protecting group for phenolic hydroxy, Y is hydrogen atom or lower alkyl, Z is hydrogen...
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5302370 |
Chelating agents for forming complexes with radioactive isotopes, metal complexes thereof and use thereof in diagnosis and therapy
The invention relates to compounds having the general formula I ##STR1## where A if required can contain a functional and/or activated group C for coupling to selectively concentrating compounds or...
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5294638 |
Phenyalkylaminoalkyl compounds and pharmaceutical compositions containing them
Pharmacologically active compounds corresponding to the general formula I: ##STR1## wherein m represents 1-4, n represents 2-5, R 1 is hydrogen or lower alkyl, R 2 is hydrogen, lower...
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5252737 |
Process for preparing N-aliphatic substituted p-phenylenediamines
A process for preparing N-aliphatic substituted p-phenylenediamine intermediates is provided which comprises contacting an aliphatic amine or substituted aliphatic amine derivative and nitrobenzene...
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5243074 |
Immunoreagents
An immunofluorescent assay method, characterized in using an immunodetective reagent, which is an antigen-like substance comprising a fluorescent substance and an antigen chemically bonded thereto...
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5217964 |
Polyamine thiols as radioprotective agents
The present invention relates to certain polyamine thiols which are useful as radioprotective agents.
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5210307 |
Catalytic reforming of alkyleneamines to linearly-extended polyalkylenepolyamines
A process for reforming alkyleneamines to predominantly linearly-extended polyalkylenepolyamines comprising contacting an alkyleneamine or mixture thereof with a catalyst under conditions such that...
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5210306 |
Promoted amines catalysis
This invention relates to a process for making amines by condensing an amino compound in the presence of a condensation catalyst and a condensation catalyst promoter, wherein said condensation...
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5183940 |
Poly-(n-[2-hydroxybenzyl])-1,2-diaminoethanes
Gallium is efficiently extracted from strongly basic solutions containing aluminates by extractants having the tris- and/or tetrakis (2-hydroxybenzyl)-1,2-diaminoethane chemical moiety. The...
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5166439 |
Composition containing a mannich base of a partially sulfurized hindered phenol mixture
A sulfurized, phenolic antioxidant having a low chlorine content and good copper corrosion properties is prepared by reacting a partially sulfurized mixture of reactive, hindered phenols with...
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5132458 |
Curable compounds
A curable compound carrying groups containing basic nitrogen, essentially comprising structural units derived from A) a compound which contains, on average, at least one preferably terminal...
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