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7402698 Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use  
The present invention is directed to secondary amino- and cycloamino-cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment...
7214826 Amine compounds and inhibiting neurotransmitter reuptake  
The invention relates to amine compounds as well as methods and materials involved in modulating neurotransmitter reuptake. Specifically, the invention provides amine compounds, methods for...
7064236 Substituted 1-aryl-but-3-enylamine and 1-aryl-but-2-enylamine compounds  
The invention relates to substituted 1-aryl-but-3-enylamine and 1-aryl-but-2-enylamine compounds, to a method for the production thereof, to medicaments containing said compounds and to their use...
6995286 Process for preparing isomers of salbutamol  
A process for making optically pure (R) and (S) salbutamol comprises obtaining the (R) or (S) isomer of either salbutamol or a salbutamol precursor in substantially optically pure form by resolving...
6653508 3-amino-2-benzyl-1-phenylpropane derivatives  
Substituted 3-amino-2-benzyl-1-phenlypropane derivatives, methods for preparing them, pharmaceutical compositions containing them, and methods of using them to treat various medical conditions.
6586633 Amine derivatives  
The present invention relates to amine derivatives represented by formula (1) or salts thereof. R3 represents C1-C3 alkyl, hydroxylated C1-C5 alkyl, C1-C5 acyl; C2-C5 alkenyl, or a halogen atom;...
6545053 Tricyclic compounds and drug compositions containing same  
Compounds having a β-3 adrenaline receptor agonist and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc., represented by a general formula (I) and salts ...
6528686 Processes for producing optically active 2-amino-1-phenylethanol derivatives  
An (R)-2-amino-1-phenylethanol derivative shown by the general formula (IIa) wherein R1 and R5 represent a hydrogen atom, etc.; R2, R3 and R4 independently represent a halogen atom, etc., or a salt...
6495685 Process for preparing piperazine derivatives  
A process for preparing a piperazine derivative represented by the formula (V): comprising reacting 1-methyl-3-phenylpiperazine with 2-chloro-3-cyanopyridine in an aprotic polar organic solvent in...
6458817 Substituted arylsulfides, arylsulfoxides and arylsulfones as beta-3 adrenergic receptor agonists  
This invention provides compounds of Formula I having the structure wherein R1, R2, R3, R4, R5, R6, Y, Z, m, n, and are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which...
6420613 Process for preparing reductants of unsaturated organic compounds by the use of trichlorosilane and reducing agents  
A method of preparing a reduced product by efficiently reducing an unsaturated organic compound by using, as a reducing agent, a trichlorosilane which is industrially cheaply available and is easy...
6114582 Processes for producing optically active 2-amino-1-phenylethanol derivatives  
An (R)-2-amino-1-phenylethanol derivative shown by the general formula (IIa) ##STR1## wherein R1 and R5 represent a hydrogen atom, etc.; R2, R3 and R4 independently represent a halogen atom, etc.,...
6008412 Process to make chiral compounds  
The present invention relates to processes for resolving N-methyl-3(R,S)-hydroxy-3-phenylpropylamine and N,N-dimethyl-3 (R,S) -hydroxy-3-phenylpropylamine with the isomers of mandelic acid and the...
5545745 Enantioselective preparation of optically pure albuterol  
The invention relates to a method for producing albuterol by the resolution of a mixture of enantiomers of methyl 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-2-(phenylmet hoxy)benzoate or...
5527821 Pharmacologically active alpha-[tertiary-aminomethyl]-benzenemethanol derivatives  
RE35128 Method for the preparation of erythro vicinyl amino-alcohols  
The present invention is concerned with the preparation of erythro N-substituted vicinal aminoalcohol derivatives from hydroxyl-protected cyanohydrin derivatives by successive Grignard reaction,...
5442118 Asymmetric synthesis of (R)- and (S)-arylethanolamines from iminoketones  
A method for the enantioselective reduction of an α-iminoketone to an α-aminoalcohol is disclosed. The method utilizes a borane reducing agent as the reducing agent and a chiral 1,3,2-oxazaborole a...
5283359 Process for preparing albuterol, acetal, hemi-acetal, and hydrates of arylglyoxal intermediates thereof  
The preparation of arylethanolamines, and in particular albuterol (salbutamol), together with their novel boron, acetal and hemi-acetal intermediates is described.
5283262 Phenethanolamine derivatives  
The invention provides compounds of the general formula (I) ##STR1## or a physiologically acceptable salt or solvate thereof, wherein Q represents a 1- or 2-naphthalenyl group.The compounds have a...
5235103 Process for the preparation of phenylethanolaminotetralins  
A process for the preparation of phenylethanolaminotetralins of formula ##STR1## wherein X is hydrogen, a halogen, a trifluoromethyl or a lower alkyl group and Ro is hydrogen or a methyl group...
5198587 Phenethylamine derivatives  
Phenethylamine derivatives shown by the general formula ##STR1## wherein Ro represents a lower alkyl group; R1 represents a lower alkyl group or a lower alkoxy group; R2 represents hydrogen atom or...
5189219 Method for the preparation of erythro vicinal amino-alcohols  
The present invention is concerned with the preparation of erythro N-substituted vicinal aminoalcohol derivatives from hydroxyl-protected cyanohydrin derivatives by successive Grignard reaction,...
5171753 Derivatives of 2-amino-1-phenylethanol having antiulcer activity  
Derivatives of 2-amino-1-phenylethanol were prepared from substituted amines and benzoin, stilbene oxide or styrene oxide to give compounds of Formula: ##STR1## where R is H or (un)substituted...
5130339 Phenylethanolaminomethyltetralins and pharmaceutical use  
New phenylethanolaminomethyltetralins of formula (I) ##STR1## wherein E represents hydrogen, (C1 -C4)alkyl, (C1 -C4)alkoxy, phenyl, nitro, halogen, or trifluoromethyl, L represents hydrogen, (C1...
5128479 Oxidized diphenylheteroalkanes  
Oxidized diphenylheteroalkanes of the formula I ##STR1## where R1 to R6 and A have the meanings specified in the description, and the preparation thereof are described. The substances are suitable...
5124334 Benzylalcohol phospholipase A2 inhibitors  
The invention relates to benylalcohol phospholipase A2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A2 -mediated conditions in mammals by...
5047433 N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline and pharmaceutical compositions having antihypertensive activity containing same  
N-alkyl derivatives of 2-amino-6,7-dimethoxy tetraline having general formula (I) ##STR1## wherein R is selected from hydrogen, ethyl, n-propyl and methyl cyclopropyl; R1 is selected from hydrogen,...
5017619 Phenethanolamine derivatives  
The invention is directed to phenethanolamine derivatives and their pharmaceutically compatible salts, having the formula ##STR1## wherein n is the number 1 or 2; L1 and L2 are hydrogen, C1-3...
4935409 Aminophenylethylamine yield promoters  
Animal growth promoters of the formula ##STR1## The intermediates of the formula ##STR2## are also new.
4918231 Process for the production of 1,2-amino alcohols  
A process for the production of 1,2-amino alcohols, in improved yields, comprising the steps of: (1) reacting a silylated cyanohydrin compound with a Grignard reagent; (2) treating the reaction...
4908386 Ethanolamine derivatives  
The present invention provides compounds of general formula (I) ##STR1## wherein Ar represents an unsubstituted or substituted phenyl gorup; R1 and R2 each represents a hydrogen atom or a C1-3...
4883804 Aromatic compounds  
There are described compounds of formula I, ##STR1## in which X represents a C2 to 8 alkylene chain optionally interrupted by a double bond or by S(O)n, wherein n is 0, 1 or 2; Y represents O or...
4880841 Process of producing phenethylamine derivatives  
Phenethylamine derivatives shown by the general formula ##STR1## wherein Ro represents a lower alkyl group; R1 represents a lower alkyl group or a lower alkoxy group; R2 represents hydrogen atom or...
4863959 Anthranilonitrile derivatives as useful agents for promoting growth, improving feed efficiency, and for increasing the lean meat to fat ratio of warm-blooded animals  
There are provided novel anthranilonitrile derivatives and related compounds which are useful for promoting growth, improving feed efficiency and for increasing the lean meat to fat ratio of...
4845127 Phenethanolamines, compositions containing the same and method for effecting weight control  
Optically active N-3-(4-substituted phenyl)propyl-β-phenethanolamines are provided as well as pharmaceutical compositions containing such compounds. A method for effecting weight control in obese ...
4835179 Antiulcer dihydrodibenzocycloheptyliden-ethylamine derivatives and process for the preparation of these compounds  
Dihydrodibenzocycloheptyliden-ethylene derivatives of the general formula: ##STR1## in which, R1 represents an alkyl group having from 1 to 4 carbon atoms; R2 represents a hydrogen atom or an alkyl...
4835315 Fluorophenacyl-amine derivatives and application thereof in therapeutics  
The present invention relates to new compounds belonging to the family of fluorophenacyl-amine derivates of formula: ##STR1## [wherein A is CO or CHOH and R is CH(CH3)2 or C(CH3)3 ] and selected...
4820717 Antimicrobial aromatic derivatives substituted by an (omega amino) alkanol group and compositions containing them  
The present invention relates to new aromatic derivatives of formula: ##STR1## wherein: Alk is an alkylene group with 1 to 10 carbon atoms, R1 is hydrogen or an alkyl with 1 to 6 carbon atoms, R2...
4806667 Promoting production of useful livestock with silylated aminophenylethylamine derivatives  
A method for promoting production of useful livestock comprising administering to such livestock an amount effective therefor of a monosilylated aminopheylethylamine derivative of the formula...
4754047 Phenylethanolamine derivatives and acid addition salts thereof for enhancing the growth rate of meat-producing animals and/or improving the efficiency of feed utilization thereby  
There is provided a method for enhancing the growth rate of meat-producing animals and/or improving the efficiency of feed utilization thereby, which involves, orally or parenterally, administering...
4695589 Alpha-(aminoalkyl-4-hydroxy-3-(alkylthio)benzenemethanols  
Alpha-(aminoalkyl)-4-hydroxy-3-(alkylthio)benzenemethanols useful as intermediates and as antihypertensive agents are prepared by reduction of the corresponding aminoalkyl...
4652679 Aziridine and phenethanolamine derivatives having antiobesity and anti-hyperglycaemic acitivity  
Aziridine and phenethanolamine derivatives of formulae I and II-1 ##STR1## wherein R1 and R2 are hydrogen or lower-alkyl; Z1 is phenyl or a phenyl group substituted in a defined manner; Z2 and Z21...
4622342 Secondary amines  
Compounds of formula (II): ##STR1## or salt thereof; wherein R1 is hydrogen or methyl, R2 is hydrogen or methyl, R3 is hydrogen, C1-12 straight or branched alkyl, C3-10 cycloalkyl,...
4602044 β-phenethanolamine antiobesity agents  
β-Phenethanolamines are useful as antiobesity agents.
4588749 Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions  
Compounds of formula (II): ##STR1## or a pharmaceutically acceptable salt thereof, in which X is an oxygen atom or a bond, R1 is a hydrogen, fluorine, chlorine or bromine atom or a trifluoromethyl...
4587248 4-alkyl-thiophenyl-ethanolamines, having an activity the cerebral circulation, the blood platelet-aggregation and the lipenia  
4-alkyl-thiophenyl-ethanolamines are disclosed, which are compounds having a therapeutical activity against blood-platelet aggregation, and against lipemia and improving the cerebral circulation,...
4490392 Benzylalcohol derivative and process for preparing  
A benzylalcohol derivative of the formula: ##STR1## wherein R is hydroxy, benzyloxy, halogen or alkoxy having one to four carbon atoms, and Ring A is monomethoxyphenyl, dimethoxyphenyl,...
4486602 Valienamine derivatives, their production and use  
A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an...
4414210 2-Hydroxyarylethyltriazole fungicides  
This invention relates to 2-hydroxyarylethyl-1,2,4-triazoles, their acid addition salts and metal salt complexes. This invention also relates to the method of preparation and use of these...
T103206 Production of urea phosphate  
A two-stage continuous crystallization process for production of urea phosphate by reaction of impure wet-process orthophosphoric acid (about 54 percent P2 O5) and urea with simultaneous addition...
Matches 1 - 50 out of 139 1 2 3 >