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7619116 |
Intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation
A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.
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7569729 |
Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability
Stable Atomoxetine hydrochloride, a process for the manufacture thereof, the use of stable Atomoxetine Hydrochloride for making a pharmaceutical formulation, a process for the preparation of any...
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7507861 |
Process for the preparation of atomoxetine hydrochloride
The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In...
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7439399 |
Processes for the preparation of atomoxetine hydrochloride
The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In...
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7439398 |
Enantiomerically pure atomoxetine and tomoxetine mandelate
The present invention provides enantiomerically pure (R)-(−)-tomoxetine (S)-(+)-mandelate and atomoxetine HCl. The present invention further provides enantiomerically pure (R)-(−)-tomoxetine...
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7342134 |
Method for the distillative recovery of toluylenediamine
The invention relates to a process for distillatively preparing TDA from a reactant stream comprising TDA, high boilers and low boilers in a dividing wall column in which a dividing wall is...
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7339079 |
Thyronamine derivatives and analogs and methods of use thereof
Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed.
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7307190 |
Process for the preparation of toluenediamine
Toluenediamine is produced and separated from by-products of the reaction by:
a) hydrogenating dinitrotoluene in the presence of a catalyst, b) separating the catalyst, water and optionally...
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7303792 |
Diaminobenzene derivative, polyimide precursor and polyimide obtained therefrom, and aligning agent for liquid crystal
The present invention provides a novel diamine which is especially useful as a material for a resin for a liquid crystal alignment film, a polyimide precursor and a polyimide synthesized by using...
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7226950 |
Sodium channel modulators
The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also...
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7217703 |
8-(2-hydroxyphenoxy)octyldiethanolamine and salts thereof for delivery of active agents
The present invention provides 8-(2-hydroxyphenoxy)octyldiethanolamine) and salts thereof, compositions containing the same and one or more active agents, and methods of administering active agents...
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6943193 |
Method for treating sexual dysfunction
Treatment of sexual dysfunction disorders comprising administering an effective amount of atomoxetine.
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6846957 |
Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor
The present invention concerns a method of synthesizing fluoxetine hydrochloride. The method includes the synthesis of 3-methylamino-1-phenyl-1-propanol by reduction of...
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6812244 |
Naphthyl compounds, intermediates, compositions, and methods of use
The instant invention provides novel substituted naphthyl compounds, intermediates, compositions, pharmaceutical formulations, and methods of use.
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6797344 |
Aromatic diamine derivatives, the preparation thereof and alignment film materials containing same for liquid crystal display cell
New aromatic diamine derivatives and the preparation thereof are disclosed. The diamine derivatives of the present invention can be added to conventional polymerization reactions of tetracarboxylic...
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6765022 |
Cyclohexylamine derivatives as subtype selective nmda receptor antagonists
Described are cyclobexylamine derivatives of Formula I, Formula II, or Formula III and their pharmaceutically acceptable salts thereof: The compounds are antagonists of NMDA receptor channel...
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6677485 |
Process for the preparation of fluoxetine hydrochloride
An improved and industrially advantageous process for the preparation of the antidepressant fluoxetine and its pharmaceutically acceptable salts, preferably hydrochloride.
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6610705 |
Process for the preparation of diaryl naphthyl methanes
The invention relates to novel diaryl naphthyl methane compounds having general formula I as shown herein below, and said compounds useful in the treatment of esterogen related disease or syndrome,...
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6599920 |
Naphthalene compounds, intermediates, formulations, and methods
This invention relates to the field of pharmaceutical and organic chemistry and provides naphthalene compounds, intermediates, formulations, and methods.
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6593497 |
β2-adrenergic receptor agonists
The present invention is directed to multibinding compounds which are β2 adrenergic receptor agonists and are therefore useful in the treatment and prevention of respiratory diseases such asthma,...
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6555287 |
Non-subliming, difunctionalized ultraviolet dyes for use in anti-reflective coatings
An improved light attenuating compound for use in the production of microdevices is provided. Broadly, the light attenuating compound is difunctional and can be directly incorporated (either...
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6541668 |
Methods for preparing 3-arloxy-3-arylpropylamines and intermediates thereof
The present invention provides processes for the preparation of 3-aryloxy-3-arylpropylamines and intermediates thereof using an nucleophilic aromatic displacement in 1,3-dimethyl-2-imidazolidinone...
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6538158 |
Process for preparing 1,4-diaminonaphthalene and/or 1,5-diaminoNaphthalene
1,4-diaminonaphthalene and/or 1,5-diaminonaphthalene are produced by (a) reacting naphthalene with a halogen, (b) optionally, separating 1,4-dihalogen naphthalene or 1,5-dihalogen naphthalene from...
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6525222 |
Process for preparing amines
Amines are prepared by reacting aldehydes or ketones at elevated temperature under elevated pressure with nitrogen compounds selected from the group of ammonia, primary and secondary amines, and...
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6492556 |
Form A of fluoxetine hydrochloride
The present invention relates to novel polymorphic Form A of fluoxetine hydrochloride.
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6458955 |
Process for preparation of pharmaceutically desired enantiomers
Improved processes for preparation of high enantiomeric purity compounds center on resolution using simulated moving bed chromatography of a racemic precursor early in the synthesis. Resolution is...
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6441237 |
Substituted 3-phenoxy- and 3-phenylalkyloxy-2-phenyl-propylamines
The present patent application relates to new substituted 3-phenoxy- or 3-phenylalkyloxy-2-phenyl-propylamines of general formula 1, processes for preparing them and their use as pharmaceutical...
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6350913 |
3-alkoxybenzylamine derivatives and their use as medicines for treating schizophrenia
The present invention relates to novel 3-alkoxybenzylamine derivatives of general formula (1): which are useful as medicinal products and in particular as antipsychotic agents.
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6329399 |
Antifungal amine derivatives and processing for producing the same
Novel amine derivatives having an excellent antimycotic effect represented by general formula (1) below and salts thereof are provided. ##STR1## [in the formula (1, R 1 represents a C 1 -5 alkyl...
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6255528 |
Process for preparing phenethylamines and novel chemical compounds
Fluorine-containing phenethylamines are obtained in an advantageous manner by reacting fluorine-containing bromobenzenes with acrylamide in the presence of a palladium catalyst, hydrogenating the...
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6232348 |
Hydroxymethyl derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene as cardiovascular agent
Compounds of formula (I) ##STR1## wherein R, R', R", R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X, Y, m, n, and p have the meanings reported in the description; and their pharmaceutically acceptable salts...
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6162949 |
Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers
Improved processes for preparation of the (S)-oxetines in high enantiomeric purity centers on resolution using simulated moving bed chromatography of a racemic precursor early in the oxetine...
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6136863 |
Antifungal agents
This invention relates to compounds represented by the following formula (1): ##STR1## wherein R 1 represents a substituted or unsubstituted phenyl group, R 2 represents a substituted or...
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6133479 |
Phenylethylamine derivatives, processes for preparing them and their use as pharmaceutical compositions
The present invention relates to new phenylethylamine derivatives, processes for preparing them and their use as pharmaceutical compositions. The phenylethylamines according to the invention...
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6063145 |
Fuel compositions containing etheramine alkoxylates
This invention concerns a fuel additive comprising an etheramine alkoxylate, and fuel compositions and additive concentrates made therefrom. The etheramine alkoxylate may be of formula: ##STR1##...
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6057442 |
Preparation of amines
Amines are prepared from primary or secondary alcohols and nitrogen compounds selected from the group of ammonia, primary and secondary amines, at from 80 to 250° C. under pressures from 0.1 to 40...
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6028224 |
Fluoxetine process from benzoylpropionic acid
A synthesis of fluoxetine is disclosed. The process begins with a lower alkyl ester of 3-benzoylpropionic acid, which is reduced in the presence of a chiral ligand to produce the corresponding...
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6018079 |
Process for removing N-nitroso compounds from organo-amine compositions including dinitroaniline herbicides
A simple and inexpensive process is described for reducing the concentration of N-nitroso-containing compounds in compositions comprising N-nitroso-containing compounds and other desired compounds...
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5994370 |
Indene compounds having activity as SERMS
The present invention provides a class of substituted indene compounds and their pharmaceutically acceptable salts which possess selective estrogen receptor modulator (SERM) activity and are thus...
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5977410 |
N-[(fluoroalkoxy) phenoxyalkyl]benzamide compounds, intermediates thereof, process for producing the same, and agricultural and horticultural pesticides
Disclosed are A N-[(fluoroalkoxy)phenoxyalkyl]benzamide compound represented by the formula (1): ##STR1## wherein R 1 and R 3 may be the same or different and represent a hydrogen atom, a halogen...
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5952350 |
Naphthyl compounds and compositions, as estrogen receptor binding agents
The invention provides a compound of formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical compositions containing a compound of formula I, and methods of...
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5942547 |
2-Deoxystreptamine derivatives, pharmaceutical compositions thereof and therapeutic methods using same
This invention provides a compound having the formula: ##STR1## wherein R 1 and R 3 independently are hydrogen, --CHO, --COCH 3 , --COR 7 , --A--Ar--(Q) z , etc.; wherein D is a C 1 -6 linear, C...
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5917091 |
Preparation and use of 2-methyl-5-phenylisoxazolidine
(a) An alkali metal base (hydroxide, oxide, carbonate, bicarbonate or sesquicarbonate), an acid addition salt of N-methylhydroxylamine, and (iii) water are mixed together to form a reaction mixture...
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5892117 |
Preparation and uses of N-methylnitrone
Oxidation of secondary amines with hydrogen peroxide and sodium tungstate is reported to give good yields of nitrones. However, when using dimethylamine in this manner, a considerable amount of...
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5849048 |
Substituted biphenyl poly (oxyalkylene) ethers and fuel compositions containing the same
Substituted biphenyl poly(oxyalkylene) ethers having the formula: ##STR1## wherein R 1 is hydrogen or hydroxyl; R 2 is hydroxyl, cyano, nitro, amino, aminomethyl, N-alkylamino or...
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5847214 |
Process for preparing N-methyl-3-(P-trifluoromethylphenoxy)-3-phenyl-propylamine and salts thereof in a highly pure form
The present invention relates to a process for preparing N-methyl-3-(p-trifluoromethylphenoxy)-3-phenyl-propylamine and pharmaceutically acceptable acid addition salts thereof. The process in...
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5691353 |
Method of inhibiting aortal smooth muscle cell proliferation using naphthyl compounds
The present invention provides a compound of formula I ##STR1## wherein R 1 is H, OH, halo, OCO(C 1 -C 6 alkyl), OCO(aryl), OSO 2 (C 4 -C 6 alkyl), OCOO(C 1 -C 6 alkyl), OCOO(aryl), OCONH...
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5650541 |
Ethacrynic acid-like compounds and use thereof to treat glaucoma
Compounds structurally related to ethacrynic acid are described. The compounds are useful for controlling intraocular pressure. Unlike ethacrynic acid, the compounds of the present invention are...
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5618968 |
N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and the procedure for their preparation
The invention provides the preparation procedure for N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3 -phenylpropylamine having the general formula (I), where R is hydrogen and...
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5556864 |
α-ω-diarylalkane compounds serotonin-2 receptor agonists
Compounds of formula (I): ##STR1## [wherein: R 1 is aryl; R 2 is hydrogen, alkyl, alkoxy, halogen or cyano; R 3 is a group of formula --B--NR 4 R 5 , where R 4 and R 5 are independently...
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