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7452921 |
Piperazine-based sensitisers
Compounds of formula (I) where: {R 1 is methyl, ethyl, cycloalkyl or optionally substituted aryl; Z is arylene or a group of formula —(CHR 4 )n-, where R 4 is hydrogen, hydroxy or alkyl, and n...
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7408084 |
Process for producing optically active β-amino alcohol
A process for easily producing an optically active β-amino alcohol useful as a pharmaceutical intermediate from an inexpensive, readily available starting material is provided. A readily available...
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6846957 |
Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor
The present invention concerns a method of synthesizing fluoxetine hydrochloride. The method includes the synthesis of 3-methylamino-1-phenyl-1-propanol by reduction of...
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6538160 |
Process for producing α-aminohalomethyl ketone derivatives
Herein is disclosed a process for producing an α-aminohalomethyl ketone derivative which comprises subjecting to catalytic reduction the corresponding α-aminodihalomethyl ketone derivative, and...
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6482987 |
Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
Novel, stable formulations of bupropion hydrochloride are provided which will maintain at least 80% of initial bupropion hydrochloride potency after one year. Methods of inhibiting degradation of...
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6462237 |
Cyclodextrin stabilized pharmaceutical compositions of bupropion hydrochloride
An inclusion complex of bupropion hydrochloride with beta cyclodextrin that stabilizes the bupropion hydrochloride against degradation. A method of preparing an inclusion complex of bupropion...
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6420606 |
Method for producing alkoxy arylamine compounds
Disclosed are methods of producing of alkoxy arylamine compounds which find particular use in the syntheses of pharmaceutical drug. The alkoxy arylamine compounds generally have the formula: H 2...
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6281393 |
Polyols useful for preparing water blown rigid polyurethane foam
Mannich polyols having a viscosity of from 300 to 3,500 cps (0.3 to 3.5 Pa*s) at 25° C. are prepared by admixing a phenol, an alkanolamines, and formaldehyde mixed in molar ratios of from 1:1:1 to...
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6191182 |
Phenyl alkyl ketone substituted by cyclic amine and a process for the preparation thereof
A novel process for the preparation of compounds of formula I ##STR1## by aminolysis of a p-halophenyl alkyl ketone of formula II ##STR2## with a cyclic amine of formula III ##STR3## in water at a...
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5962743 |
Process for preparing acylaromatic compounds
This invention provides a process for preparing acylaromatics comprising reacting an aromatic compound with a carboxylic acid in the presence of a reaction medium comprising polyphosphoric acid and...
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5932766 |
Process for the preparation of substituted keto-enamines
The present invention discloses a process for the preparation of a compound having formula 4: ##STR1## The process comprises the step of reacting an enolate having the formula: ##STR2## with a...
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5688985 |
Process for producing keto nitrile derivative
A process for producing a (4S)-4-(N,N-dibenzyl)amino-5-phenyl-3-oxo-pentanenitrile derivative which comprises reacting a (2S)-2-(N,N-dibenzyl)aminophenylalanine ester derivative with acetonitrile...
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5631405 |
Method of forming amino acid-derived diaminopropanols useful as chemical intermediates for protease-inhibitors
The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs,...
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5618966 |
Method forming protease inhibitor synthetic intermediates
The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs,...
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5565432 |
Smooth muscle cell proliferation inhibitors
This invention comprises polyanionic benzylglycosides of benzene triacid amides of the general formula I ##STR1## wherein each of R 1 , R 2 , R 3 , and R 4 are, independently, H, SO 3 M, or...
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5561135 |
N,N,N',N'-tetrasubstituted-1,2-ethanediamine derivative compounds
The invention relates to new N,N,N'N'-tetra-substituted-1,2-ethanediamine compounds of the general formula (I): ##STR1## wherein X is a carbonyl (CO), hydroxymethylen (CHOH) or...
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5510538 |
Process for the oxidation of primary and secondary alcohols to aldehydes and ketones and for the oxidation of 1,2-diols to α-ketols and α-diketones
A process for the selective oxidation of a primary or secondary alcohol to an aldehyde or ketone and for the oxidation of a 1,2-diol to an α-ketol or α-diketone, which comprises contacting the...
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5475138 |
Method preparing amino acid-derived diaminopropanols
The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs,...
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5466873 |
Process for preparing arylketoamines
Arylketoamines are prepared by reacting arylisonitrosoalkanones with hydrogen in the presence of a transition metal catalyst and a liquid carboxylic acid at a temperature of less than about 600° C.
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5410066 |
Process for the preparation of substituted pyrazolines
A new process for the preparation of pyrazolines of formula ##STR1## is provided, in which R 1 and R 3 are identical or different and each represent optionally substituted aryl or optionally...
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5399763 |
Process for preparing optically active 2-aminopropanal
A process for preparing an optically active 2-aminopropanal through oxidative cleavage of the corresponding optically active 3-amino-1,2-butanediol of the following formula (2): ##STR1## wherein R1...
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5395971 |
Molybdenum-catalyzed amination of olefins
A process for making unsaturated α-amines from olefins wherein the process includes adding an aminating agent, an olefin and a molybdenum based catalyst to a reaction vessel having a nitrogen...
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5322964 |
Process for the preparation of alpha-aminoketone salts
There is disclosed a process for the preparation of an alpha-aminoketone salt of formula I ##STR1## which comprises reacting a nitrosated keto ester of formula II ##STR2## with a carboxylic...
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5322963 |
Method for preparing α-amino-β, δ-diol derivatives
Intermediate compounds (formula [III]and [IV]) useful as starting materials for the synthesis of amino acid derivatives which have renin inhibitory activity and which are useful as remedies for...
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5284962 |
Multistage process for making methyl carbamates
A continuous process employing at least two reaction stages for manufacturing pesticides from methyl isocyanate and oxime or phenol reactants in water.
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5276191 |
Process for the preparation of ketones
According to the invention, there is provided a process for the preparation of an aminoalkyl p-hydroxyphenyl ketone comprising reacting phenol with a nitrile, in the presence of a Lewis acid...
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5198585 |
Method for the preparation of arylketoamines
Acid addition salts of arylketoamines are prepared by reacting arylisonitrosoalkanones with hydrogen in the presence of a transition metal catalyst and strong acid in a dipolar aprotic solvent.
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5182401 |
Preparation of 3-amino-2-(het)aroyl-acrylic acid derivatives
A process for the preparation of a 3-amino-2-(het)aroyl-acrylic acid derivative fo the formula ##STR1## in which Y represents a nitrile, or an ester group, --COOR 1 , or an acetyl group, where R...
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5132457 |
Stereospecific synthesis of 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP)
In a method for producing 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP), a chiral ester of the formula ##STR1## wherein R is an alkyl of from 1 to about 5 carbon atoms, is provided. The...
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4980377 |
1-(aminophenyl)-2-aminopropanone derivatives
The present invention relates to the preparation of new 1-(aminophenyl)-2-aminopropanone derivatives of the general formula: ##STR1## in which X is NH 2 , Y is H or a halogen atom, Z is H or a...
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4978773 |
Process for the preparation of 2,6-dichlorodiphenylaminoacetic acid derivatives
A new process for the preparation of 2,6-dichlorodiphenylamine derivatives is described, which process provides the desired active compound in a high yield and with a very high degree of purity by...
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4973756 |
Hydroxylated ene ketones, acetylenic grignards and hydroxylated yne ketones therefrom
An alpha-hydroxyl-alpha,alpha-di(inert-substituted)-gamma',delt
a'-yne ketone can be prepared by a procedure comprising contacting an acetylenic Grignard reagent with an...
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4906781 |
Method for the preparation of 4'-(substituted)-amino-2-(substituted) amino-3',5'-dichloroacetophenone and salts thereof
A method for the preparation of 4'-(substituted)-amino-2-(substituted)amino-3',5'-dichloroac
etophenone and salts thereof. The method involves the chlorination of the corresponding...
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4886914 |
Process for synthesis of alpha aklyl amino aldehydes
The present invention relates to a process for the preparation of alpha alkyl amino aldehydes of formula ##STR1## in which R is alkyl or aralkyl possibly substituted, characterized in that...
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4861854 |
Photosensitive polyimide precursor
A photosensitive polyimide precursor composed of the structural units (A) represented by the following general formula (I) and the structural units (B) represented by the following general formula...
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4816489 |
1-(aminophenyl)-2-aminoethanone derivatives
The present invention relates to the preparation of new derivatives selected from the group consisting of: (i) 1-(aminophenyl)-2-(alkylamino)ethanones of the formula: ##STR1## in which R is...
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4730075 |
Chemical process involving ethers and amines
A process for the production of (1) an ether or (2) a second amine comprises reacting an activated olefin with respectively an alcohol or first amine in the presence of a catalyst which is either...
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4695652 |
Process for the preparation of β-aminoethyl ketones
β-Aminoethyl ketones are obtained in a low-polluting manner by Mannich condensation of an aryl ketone having an acidic H with an aldehyde and ammonia or an amine by carrying out the reaction in...
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4670535 |
Photosensitive polyimide precursor and process for producing the same
The photosensitive polyimide precursor of the invention has a recurring unit represented by the following general formula [I]: ##STR1## (R 1 represents a tetravalent aromatic hydrocarbon residue;...
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4603019 |
N-(methoxyphenacyl)-amine derivatives
This invention relates to new N-(methoxyphenacyl)-amine derivatives selected from the group consisting of (i) the N-(methoxyphenacyl)-alkylamines of the general formula ##STR1## wherein A is OCH...
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4587248 |
4-alkyl-thiophenyl-ethanolamines, having an activity the cerebral circulation, the blood platelet-aggregation and the lipenia
4-alkyl-thiophenyl-ethanolamines are disclosed, which are compounds having a therapeutical activity against blood-platelet aggregation, and against lipemia and improving the cerebral circulation,...
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4408074 |
Process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-methylamino) ethanol hydrochloride
A process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-methylamino) ethanol hydrochloride is described by reacting 2,6-dimethoxyphenol with anhydrous chloral in the presence of a catalyst,...
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4326077 |
N-Haloacetylphenylamino carbonyl cyclic intermediates
Novel N-haloacetylphenylamino carbonyl oximes represented by the formula ##STR1## wherein Ar is phenyl or substituted phenyl; R 1 is halomethyl; R 2 and R 3 are each independently hydrogen,...
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4322530 |
Alkylation of polyamines
A process for alkylating a polyamine by contacting, in a liquid media, a polyamine, an olefinic compound, carbon monoxide, and a hydrogen source in the presence of a catalytic amount of a rhodium...
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4317932 |
Preparation of secondary amines
A process for forming amines by contacting, in a liquid media, an olefinic compound, carbon monoxide, water, and ammonia in the presence of a rhodium atom containing compound selected from metallic...
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4314081 |
Arloxyphenylpropylamines
3-Aryloxy-3-phenylpropylamines and acid additions salts thereof, useful as psychotropic agents, particularly as anti-depressants.
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4313005 |
Inhibiting amidine formation during hydrogenation of organo nitriles
This invention relates to a process for reducing amidine formation during reduction of organonitriles. The process comprises including a boron compound in the reaction medium in sufficient amount...
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4288624 |
Acylation or sulfenylation process
A process or acylating or sulfenylating 1-amino-2-phenyl-1-butene-3-ones to prepare the corresponding 4-acyl or 4-substituted-thio compounds provides intermediates useful for preparing herbicides.
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4282251 |
Trans-n-cinnamyl-n-methyl-(1-naphthylmethyl)amine
Cinnamylalkyl-1-naphthylmethylamines, useful as antimycotic agents, and processes for their production.
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4209621 |
(Substituted-phenyl)-1,2,4-triazolo[4,3-a]-pyrimidines and (substituted-phenyl)-1,2,4-triazolo[1,5-a]pyrimidines
This disclosure describes substituted 1,2,4-triazolo[1,5-a]pyrimidines and substituted 1,2,4-triazolo[4,3-a]pyrimidines which possess anxiolytic activity.
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