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7786325 |
Process for producing O-methyl-N-nitroisourea
Disclosed is an industrially advantageous process for producing O-methyl-N-nitroisourea. Disclosed is a process for obtaining O-methyl-N-nitroisourea represented by the following chemical formula...
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7560593 |
Process for producing nitroisourea derivatives
Disclosed is an improved process for producing nitroisourea derivatives which is necessary for producing nitroguanidine derivatives having an insecticidal activity. Specifically disclosed is a...
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7371807 |
Blocked biuretized isocyanates
The present invention is directed to blocked biuret group-containing polyisocyanate compositions, wherein the blocking agent is of the formula: wherein R1, R2, R3 and R4 may be the same or...
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6096923 |
Process for the preparation of nitrosourea compounds
A process for the preparation of a nitrosourea derivative, in particular 1,2-bis(2-chloroethyl)-1-nitrosourea, comprises reacting a non-nitrosated urea derivative with a metal nitrite in a...
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5001158 |
Nitrosoureas compounds preparation thereof and utilization thereof in anticancerous
Compounds having the general formula (I), ##STR1## wherein X and Y represent individually H or --NO, at least one of them being a group-NO, n is 0, 1 or 2, R represents hydrogen, an aliphatic,...
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4613695 |
N-nitroso compounds and compositions containing such compounds
The invention concerns N-nitroso compounds having the general formula: ##STR1## wherein A is lower alkyl or halolower alkyl; B is hydrogen; lower alkenyl; lower alkynyl; 3-6 C cycloalkyl; --RSO2...
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4568694 |
Growth-enhancing cystamine derivatives
Cystamine derivatives of the formula: ##STR1## [wherein n represents 2 or 3, R1 and R2 each represents a hydrogen atom, or an alkyl group optionally substituted by a hydroxy, amino, alkylamino or...
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4558129 |
Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade
Novel compounds of the general formula: ##STR1## and the pharmaceutically acceptable esters and acid addition salts thereof, wherein: R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each independently...
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4513148 |
Method for the preparation of methylnitramine
The invention is an improved process for the production of methylnitramine y nitrating dimethylurea with a mixture of sulfuric acid and nitric acid with subsequent separation of...
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4476322 |
Synthesis of dimethylmethylene dinitramine
A process for preparing 2,4-dinitro-2,4-diazapentane by (1) nitrating dimethylurea to form dimethyldinitrourea; (2) hydrolyzing the dimethyldinitrourea to form methylnitramine; (3) reacting one...
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4430347 |
Cystamine derivatives suitable for use as medicaments
The invention relates to new chemical compounds.The compounds according to the invention are compounds of the following formula ##STR1## in which one of the substituents A and B is hydrogen and the...
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4423076 |
1-Branched-alkyl-3-(2-haloethyl)-3-nitrosoureas as novel antitumor agents
1-Branched-alkyl-3-(2-haloethyl)-3-nitrosoureas which exhibit antitumor activity. Pharamaceutical compositions containing these novel compounds and methods of using them are also disclosed.
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4377687 |
Analogs of 1-(2-chloroethyl)-1-nitroso-3-(cycloheyl)-urea substituted by heterocyclic rings or alkyl radicals
This invention relates to compounds having the formula: ##STR1## wherein R1 and R2 are selected from the group consisting of hydrogen, acyl, trifluoroacetyl, straight chained and branched alkyl...
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4367239 |
Nitrosourea derivatives, pharmaceutical compositions thereof and method of preparation
The present invention relates to novel aminoalkyl substituted nitrosourea derivatives as well as their acid addition salts with pharmaceutically acceptable acids showing pronounced antineoplastic...
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4335247 |
Novel nitrosourea derivatives and process for their production
The specification describes a nitrosourea derivative having the general formula: Cl--(CH2)2 --N(NO)CO--NHR, wherein --NHR represents a 2-(1,3,4-thiadiazolyl)amino group, an amino residue of a...
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4237273 |
Bis(nitrosoureido)-polyol derivatives
The invention relates to bis(nitrosoureido)-polyol derivatives of general formula I B1 --A--B2 (I)wherein A stands for an open chain polyol comprising 4 to 6 carbon atoms or a six-membered cyclic...
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4150146 |
Process for the preparation of unsymmetrically 1,3-disubstituted nitroso ureas
The invention relates to the preparation of unsymmetrically 1,3-disubstituted nitroso ureas from the corresponding N-substituted alkyl-N-nitrosocarbamoyl azide which is reacted with an amine, a...
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4148921 |
Antitumor agents
Novel inosadiamine derivatives of the formula ##STR1## exhibit high effectiveness against various mammalian tumor systems.
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4039578 |
1-Tetrahydroxycyclopentyl-3-nitroso-3-(2-chloroethyl)-urea antitumor agents
Novel water-soluble nitrosourea derivatives of the formula ##STR1## WHEREIN R represents a 2', 3', 4', 5'-tetrahydroxycyclopentyl group exhibit high effectiveness in various animal tumor systems.
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4028410 |
Process of preparing 1,3-bis(2-chloroethyl)-1-nitrosourea
A method of producing 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) by nitrosation of 1,3-bis(2-chloroethyl)-urea utilizing as a nitrosating agent dinitrogen trioxide (N2 O3) in molar excess of...
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3925446 |
1-Aryloxy-2-hydroxy-3-alkynylamino-propanes
Racemic and optically active compounds of the formula ##EQU1## wherein R1, R2, R3, R4 and R5 are hydrogen or various substituents, and their physiologically compatible acid addition salts, as well...
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3888898 |
N,N'-bis-(3-phenoxy-2-hydroxy-propyl)-alkenediamines and salts thereof
Compounds of the formula ##SPC1## Wherein R1 is --OH; --COOH; --CONH2 ; --NO2 ; --CF3 ; halogen; alkyl of 4 to 5 carbon atoms; alkoxy of 4 to 5 carbon atoms; alkenyl of 3 to 5 carbon atoms; alkynyl...
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3859277 |
D-1-1-(β-CHLOROETHYL)-3-(2-OXO-3-HEXAHYDROAZEPINYL)-1-NITROSOUREA
Novel nitrosourea derivatives represented by the formula ##SPC1## Wherein R1 is a hydrogen atom or a nitroso group, R2 and R3, which may be the same or different, each represents a hydrogen atom, a...
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3849450 |
BIS(TRIFLUOROMETHYL)EPOXIDES
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3375259 |
Difluoramino compounds
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3309373 |
N-nitroso derivatives of aromatic amines and a method for their preparation
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3303214 |
Nitrososemicarbazides
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3296307 |
Production of monoalkylhydrazines
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3267138 |
Nu-nitroso-nu-(2-hydroxyethyl) urea
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3258478 |
Hydrazine salts of nitramines and method for preparing same
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3251737 |
Methods for inhibiting gastric secretions with substituted biurets
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3215701 |
Process for the preparation of 3-amino-2-oxazolidone hydrochloride
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3119865 |
Arylene-bis nitroso ureas
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3113152 |
Preparation of methylhydrazine
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3098872 |
Production of nitrourea
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3071617 |
Nitro plastic propellants
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3017391 |
Preparation of polycaprolactam using n-acyl activators
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3000939 |
N-nitro,n,n'-bis(trinitroalkyl)-urea
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2997501 |
1, 3-dinitro-1, 3-dimethyl urea
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2880206 |
Mecurated biuret derivatives
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