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7355077 |
Process for preparing tolterodine
A process for preparing tolterodine with high purity.
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6875775 |
Triphenylalkene derivatives and their use as selective estrogen receptor modulators
The invention provides novel selective estrogen receptor modulator compounds of the general formula:
wherein R1 and R2, which are the same or different are
a) H, halogen, OCH 3 , OH; or...
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6451817 |
Alpha-substituted-1-benzyl-napthyls
This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are α-substituted with ether, thioether, amino, hydrazino, cyano or halo...
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6391892 |
Naphthyl pharmaceutical compounds
The present invention provides a compound of formula I wherein R 1 is H, OH, halo, OCO(C 1 -C 6 alkyl), OCO(aryl), OSO 2 (C 4 -C 6 alkyl), OCOO(C 1 -C 6 alkyl), OCOO(aryl), OCONH(C 1 -C 6 ...
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6384053 |
α-substituted-1-benzyl-napthyls
This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are α-substituted with ether, thioether amino, cyano or halo that are...
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6204067 |
Methods of identifying modulators of the estrogen receptor
The present invention discloses the mechanism of tamoxifen mediated inhibition of acidification. This mechanism information is then used to design methods of identifying compounds that will have...
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6096301 |
Combined interferon/antiestrogen therapy for treatment of breast cancer
Proliferation of breast cancer is treated by a combined type I interferon/non-steroidal antiestrogen therapy. Preferably antiestrogen treatment is sequential to treatment with interferon.
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5773469 |
Diaryl antimicrobial agents
The invention relates to diaryl antimicrobial compounds of the general formula: ##STR1## where G, E L, J, q, m, X, Ar, W, p, n and A are as described herein, pharmaceutical compositions containing...
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5693863 |
Method for the production of E-1- 4'- (2- Dimethylaminoethoxy) - Phenyl!-1-(3-Hydroxyphenyl) -2-Phenyl-1-Butene
The present invention relates to methods for the production of E-1- 4'-(2-dimethylaminoethoxy)-phenyl!-1-(3'-hydroxyphenyl)-2-ph
enyl-1-bu tene of formula (I) which comprises heating the compound...
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5637771 |
Compound useful for lowering cholesterol
A method of lowering cholesterol which comprises administering to a host requiring such treatment an effective amount of a compound of the formula ##STR1## wherein one of R 1 and R 2 is C 1 -7...
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5589500 |
Substituted 1,1,2-triphenylbutenes and their use in the treatment of cancer
Compounds of the general formula (2) ##STR1## wherein n is an integer of from 3 to 10, the iodo substituent is in the 3- or 4-position and R 1 and R 2 , which may be the same or different,...
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5565611 |
Process for preparing acid addition salt of Z-isomer of triphenylethylene compound
The present invention provides a process for preparing an acid addition salt of the Z-isomer of a compound of the formula ##STR1## wherein R 1 and R 2 represent a lower alkyl group, or taken...
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5525633 |
Triaryl-ethylene derivatives
The present invention relates to novel triaryl-ethylene derivatives that are useful as anti-neoplastic agents, antiatherosclerotic agents, and hypocholesterolemic agents.
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5495048 |
Amino alkenyloxybenzene derivatives
A method of lowering cholesterol which comprises administering to a host requiring such treatment an effective amount of a compound of the formula ##STR1## wherein one of R 1 and R 2 is C 1 -7...
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5491173 |
Tri-phenyl alkene derivatives and their preparation and use
The invention provides novel compounds of the formula: ##STR1## wherein R 1 and R 2 , which can be the same or different are H or OH, R 3 is ##STR2## wherein R 4 and R 5 , which can be the same...
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5464836 |
Benzophenones having an antifungal activity
A description follows of benzophenones having an antifungal activity and responding to the general formula (I): ##STR1## wherein: R 1 and R 2 , the same or different, represent C 1 -C 6 alkyl...
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5219548 |
High affinity halogenated-tamoxifen derivatives and uses thereof
Applicants describe the synthesis of fluorotamoxifen and iodotamoxifen analogs with the halogen atom positioned on the aliphatic chain of the tamoxifen molecule. The halogenated-tamoxifen...
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5214046 |
Substituted aminoalkoxybenzene anti-fungicidal compositions and use
The compound of the formula ##STR1## wherein each of R 1 and R 2 individually is hydrogen, lower alkyl or lower alkenyl or together signify straight-chain alkylene with 2 to 4 carbon atoms, R 3 ...
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5192799 |
Coumaran group containing amine compounds and their acid addition salts and quaternary ammonium salts and the use thereof as anti arrhythmic agents and as psychotropic agents
Amine represented by the following formula (1), or their acid addition salts or their quaternary ammonium salts. ##STR1## The amines of formula (1) or their pharmaceutically acceptable acid...
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5091574 |
Polyoxyethylene diamine derivatives of diglycidyl ethers
Tetrafunctional amine derivatives of digyclidyl ethers of Bisphenol A that are liquid at ambient temperatures and that are useful as curing agents for epoxy resins are disclosed together with the...
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5089529 |
Butanol derivatives
4-mono- and di-isobutylamino butanols of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof wherein R 1 and R 2 are the same or different and each is selected from the group...
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5047431 |
1,1,2-triphenylbut-1-ene derivatives
Novel (E)-1-[4'-(2-alkylaminoethoxy)phenyl]-1- (3'-hydroxyphenyl)-2-phenylbut-1-enes of the general formula ##STR1## wherein R 1 and R 2 may be the same or different, provided that, when R 1 and...
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4996225 |
Tri-phenyl alkane derivatives and their oestrogenic, anti-oestrogenic and progestanic uses
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4973755 |
Stable solvent adducts of Z-1-(p-β-dimethylaminoethoxy-phenyl)-1-(p-hydroxyphenyl)-2-phenyl-b ut-1-ene
This invention relates to new stereochemically pure and stable adducts of Z-1-(p-β-dimethylaminoethoxyphenyl)-1-(p-hydroxyphenyl)-2-p
henyl-but- 1-ene and certain solvents which by virtue of their...
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4960937 |
Process for the preparation of trans-1,1,2-triphenyl-but-1-ene derivatives
The invention concerns the direct preparation of trans-1,1,2-triphenyl-but-1-ene derivatives having the general formula 1 by dehydration of carbinols having the general formula 2 by heating in a...
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4839155 |
Iodotamoxifen derivatives and use for estrogen receptor-positive breast cancer detection and therapy
Iodotamoxifen derivatives which are compounds of formula (3) ##STR1## wherein X represents 3- or 4- iodo and R 1 and R 2 , which may be the same or different, represent C 1 -3 alkyl, especially...
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4826672 |
Astatinated organic compounds
Methods and kits for incorporating a radioactive astatine isotope (particularly 211 At) into an organic compound by electrophilic astatodestannylation of organostannanes.
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4806685 |
1,1,2-triphenylpropane and -propene derivatives
A novel 1,1,2-triphenylpropene derivative, namely: ##STR1## acts on the endocrine system of rats. It exerts oestrogenic or antioestrogenic effects of varying strength in rats, and furthermore...
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4696949 |
Novel tri-phenyl alkane and alkene derivatives and their preparation and use
The invention provides novel compounds of the formula: ##STR1## wherein n is 0 to 4, R 1 and R 2 , which can be the same or different are H, OH, alkoxy of 1 to 4 carbon atoms, benzyloxy or...
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4659741 |
β-[2-(halogenobenzyl)-phenoxy]-ethylamine derivatives
This invention is concerned with new β-[2-(halogenobenzyl)-phenoxy]-ylamine derivatives of the general formula ##STR1## wherein R represents a C 1 -C 8 -alkyl group having a linear or branched...
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4645779 |
Dialkylaminoalkoxybenzylalcohol derivatives, process for their preparation and pharmaceutical compositions containing them
The invention relates to new dialkylaminoalkoxybenzylalcohol derivatives of the formula (I) ##STR1## wherein R 1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or...
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4645774 |
Aminoethoxybenzylalcohol derivatives, process for their preparation and pharmaceutical compositions containing them
The invention relates to new aminoethoxybenzylalcohol derivatives of the formula (I) ##STR1## wherein R 1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy...
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4623660 |
Triphenylalkene derivatives
The disclosure relates to 1-p-aminoalkoxy phenyl-1-p-hydroxyphenyl-2-phenylalk-1-ene derivatives, processes for their manufacture and pharmaceutical compositions containing them. The compounds...
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4618611 |
1-(aminoalkoxyphenyl)-1-phenyl-propanols, process for their preparation and pharmaceutical compositions containing them
The invention relates to new aminopropanol derivatives of the formula (I) ##STR1## wherein R 1 is halogen, trihalomethyl, alkoxy having from one to 3 carbon atoms or alkyl having from one to 3...
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4605672 |
Diethylaminoalkoxybenzhydrol derivatives, process for their preparation and pharmaceutical compositions containing them
The invention relates to the preparation of new diethylaminoalkoxybenzhydrol derivatives of the formula (I) ##STR1## wherein R 1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4...
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4536516 |
Alkene derivatives
Triphenylalkene derivatives, in particular 1-(p-β-dimethylaminoethyoxyphenyl)-1,2-diphenylbut-1-ene, which possess utility as anti-oestrogens.
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4376788 |
Basic ethers of 4-hydroxy-benzophenones acting as beta-blocking agents
Basic ethers of 4-hydroxy-benzophenones acting as beta-blocking agents, sting from 4-hydroxy-benzophenones and, by reacting them with epichlorohydrin, transforming them into the corresponding...
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4371546 |
Benzophenone derivatives
Described are compounds of the formula ##STR1## wherein R is hydrogen, loweralkyl, aminomethyl or halo, R 1 is hydroxy or NHX where X is H, loweralkyl, phenyl, substituted phenyl, acetyl, benzyl...
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4360649 |
Curable composition
A curable resin composition comprising an epoxy resin, a hardener and an epoxy compound-dialkylamine adduct as a latent hardener. The composition is excellent in storage stability at ambient...
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4323707 |
Antifertility compounds
Derivatives of 3-phenyl-4-aroyl-1,2-dihydronaphthalenes and 1-aroyl-2-phenylnaphthalenes are useful as antifertility agents.
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4206234 |
Triphenylbut-1-ene derivatives and pharmaceutical compositions and uses thereof
The disclosure relates to the compound 1-(p-β-dimethylaminoethoxyphenyl)-cis-1-(p-hydroxyphenyl)-2
-phenylbut -1-ene, to pharmaceutical compositions containing it and to the use of the compound to...
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4201790 |
Benzophenone derivatives
Benzophenone derivatives of the formula: ##STR1## wherein R 1 is isopropyl, t-butyl or 2-phenylethyl, R 2 is methyl or chlorine, n is 1 or 2 and m is 0, 1 or 2, are new compounds possessing...
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4100299 |
Pharmaceutically active 2-omega-aminoalkoxydiphenylmethylmethanes
2-Omega-aminoalkoxydiphenylmethylmethanes have been found useful for palliating conditions of depression in warm blooded animals.
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4094908 |
Alpha-substituted benzhydrol derivatives
The invention relates to new α-substituted benzhydrols and pharmaceutically acceptable acid addition salts or quaternary ammonium salts thereof with enzyme promoting or inhibiting effects;
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4091114 |
Pharmaceutically active 2-omega-aminoalkoxydiphenylmethanes
2-Omega-aminoalkoxydiphenylmethanes are prepared and shown to be useful antidepressants.
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4075223 |
Novel antifertility agents
Derivatives of 2-aroyl-3-phenylindenes, 3-aroyl-4-phenyl-1,2-dihydronaphthalenes, and 1-phenyl-2-aroyl-naphthalenes are useful as antifertility agents.
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4060641 |
Pharmaceutically active 2-(3-alkylaminopropoxy)diphenylmethanes
2-(3-Alkylaminopropoxy) diphenylmethanes have been produced and have been found to possess antidepressant activity.
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4053514 |
2-[Dialkylaminoalkoxyphenyl]-methylene-2,3-dihydro-1H-inden-1-ones and the salts thereof
Compounds of the formula ##STR1## wherein X, n and B are as defined herein are useful as intermediates in preparing compounds which exhibit antidepressant activity.
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4051166 |
Araliphatic diisocyanates
Novel araliphatic diisocyanates having the formula OCN(CH 2 ) 3 OArX(CH 2 ) 3 NCO are disclosed wherein X is oxygen or a single bond and Ar is an arylene radical. The araliphatic diisocyanates...
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4038319 |
Substituted phenoxyalkylamines, process for their preparation and applications thereof
This invention relates to phenoxyalkylamines having the formula ##STR1## in which R 1 is hydrogen, halogens or methyl, A is cyclohexylmethyl, propenyl, butenyl, cyclohexenylmethyl or a group...
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