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7619117 |
Rasagiline formulations and processes for their preparation
The subject invention provides a pharmaceutical composition comprising N-propargyl-1(R)-aminoindan mesylate; a pharmaceutically acceptable carrier; and greater than 0.7 ppm but less than 30 ppm in...
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7619004 |
Methods for concomitant administration of colchicine and macrolide antibiotics
Methods for concomitant administration of colchicine together with one or more macrolide antibiotics, e.g., clarithromycin or erythromycin, are disclosed. Such methods reduce the dangers commonly...
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7612114 |
Selective estrogen receptor modulator
The present invention provides a compound represented by the following formula (I);
[wherein T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like;
...
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7608680 |
Triarylamine polymer, process for producing the same, and use thereof
It is an object of the present invention to provide a novel triarylamine polymer which is excellent in solubility and film-forming property and has improved thermal stability; a simple process for...
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7601758 |
Methods for concomitant administration of colchicine and macrolide antibiotics in the treatment of gout flares
Methods for treating gout flares comprising concomitant administration of colchicine together with one or more macrolide antibiotics, e.g., clarithromycin or erythromycin, are disclosed. Such...
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7598667 |
Arylamine compound and organic electroluminescence device containing the same
Arylamine compounds having at least one spiro bond are provided to the layers of an electroluminescent device. The compounds act as hole transporting and luminescent host materials for both...
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7598420 |
Rasagiline formulations and processes for their preparation
The subject invention provides a pharmaceutical composition comprising N-propargyl-1(R)-aminoindan mesylate; a pharmaceutically acceptable carrier; and greater than 0.7 ppm but less than 30 ppm in...
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7589237 |
Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine
Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed....
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7586006 |
Aromatic amine derivative and organic electroluminescent element employing the same
The present invention relates to aromatic amine derivatives having a specific structure in which a substituted anthracene structure is bonded to an amine structure substituted with benzene rings...
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7572834 |
Rasagiline formulations and processes for their preparation
The subject invention provides a pharmaceutical composition comprising N-propargyl-1(R)-aminoindan mesylate; a pharmaceutically acceptable carrier; and greater than 0.7 ppm but less than 30 ppm in...
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7571894 |
Organic electroluminescence element
This organic electroluminescence element has an organic light-emitting layer between a positive electrode and a negative electrode, wherein the organic light-emitting layer contains a...
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7518019 |
Processes for preparing sertraline hydrochloride crystalline forms
The present invention discloses novel and improved processes for preparation of sertraline hydrochloride crystalline form II. Thus, for example, sertraline free base is dissolved in isoamyl alcohol...
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7518018 |
Processes for preparing sertraline
Provided are processes for the preparation of sertraline and sertraline hydrochloride.
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7491847 |
Methods for isolating propargylated aminoindans
A process for isolating from a reaction mixture a salt of a mono-propargylated aminoindan, a process for isolating from a reaction mixture a crystalline diastereomeric salt of a mono-propargylated...
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7482490 |
Amine compound having fluorene group as framework, process for producing the amine compound, and use of the amine compound
Novel amine compounds that can be utilized as hole transport materials, hole injection materials or the like of organic electroluminescence devices, electrophotographic receptors or the like, and...
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7442838 |
Polymorphic forms of sertraline hydrochloride
Sertraline hydrochloride polymorphic form II is conveniently prepared by adding hydrogen chloride to solution of sertraline free amine in a ketone. In preferred processes, the solution of...
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7423179 |
Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine
Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydro-1-napthalenamine is disclosed....
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7413682 |
Antioxidants and methods of making antioxidants
Antioxidants for industrial, automotive, and aviation lubricants and methods of making the same are provided. A process using alkylated diphenylamines; alkylated phenyl-α-naphthyl amines; and a...
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7375250 |
Aminoanthryl derivative substitution compound and organic electroluminescence device using the same
There is provided an aminoanthryl derivative substitution compound represented by the following general formula (1). The compound according to the present invention can provide an organic...
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7276629 |
Hydrogenation of imine intermediates of sertraline with catalysts
Provided are hydrogenation processes of sertraline imine intermediates with catalysts in various reactors.
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7262327 |
Recycling process for preparing sertraline
Provided is a recycling process for preparing sertraline, which may be carried out on an industrial scale.
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7259271 |
Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
Compounds of formula I:
where R 1 , R 2 and R 3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or...
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7253320 |
Process for preparing polymorphic form II of sertraline hydrochloride
The present invention relates to a new process for preparing sertraline hydrochloride form II.
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7250532 |
Method for producing aromatic amino compound
A method for producing aromatic amino compound (V):
by synthesizing intermediate compound (IV):
by the reaction of compound (I): H 2 N—R 1 with a mixture of halogenated aryl compounds...
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7235194 |
Two-photon or higher-order absorbing optical materials for generation of reactive species
Disclosed are highly efficient multiphoton absorbing compounds and methods of their use. The compounds generally include a bridge of pi-conjugated bonds connecting electron donating groups or...
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7196222 |
Sertraline hydrochloride form II and methods for the preparation thereof
The present invention is directed to Form II of sertraline hydrochloride and novel methods for its preparation. According to the present invention, sertraline hydrochloride Form II may be produced...
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7189876 |
Methods for preparing sertraline hydrochloride polymorphs
This invention relates to crystalline polymorphs of sertraline hydrocloride, i.e. (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-
1-naphtalenamine hydrochloride, denominated form I, II...
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7186863 |
Sertraline compositions
An acid salt of sertraline, wherein the acid is citric acid, fumaric acid, malic acid, maleic acid, malonic acid, phosphoric acid, succinic acid, sulfuric acid, L-tartaric acid, HBr, acetic acid,...
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7173153 |
Sertraline hydrochloride form II and methods for the preparation thereof
This invention relates to a method for the preparation of sertraline hydrochloride, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-
1-naphtalenamine hydrochloride, in its crystalline...
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7157604 |
Selective estrogen receptor modulators
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen...
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7154007 |
Luminous compounds and labeling reagents using the same
This invention provides: a compound represented by formula (I):
R—Y—(—X-Phe-COCH 2 COC n F 2n+1 ) m (I)
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7132571 |
Self-assembled calixarene-based guest-host assemblies for guest storage by van der Waals confinement
A guest-host assembly having a generally spheroidal host assembly formed of trimers of calixarene molecules in a hexagonal close-packed assembly and its preparation. The calixarene trimers are...
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7115780 |
Propanolaminomethyltetralines, their preparation and pharmaceutical composition comprising same
The invention concerns compounds of formula (I), wherein A is a group of formula (a) or (b), wherein: R represents a hydrogen or halogen atom, a —S(O) z (C 1 –C 4 )Alk wherein z is 0, 1 or 2, a...
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7105699 |
Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine and its formamide
Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed....
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7094930 |
Pharmaceutically acceptable salts of sertraline and pharmaceutical compositions thereof
The present invention is directed to certain pharmaceutically acceptable salts of the therapeutically potent selective serotonin reuptake inhibitor, sertraline:
and pharmaceutical compositions...
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7081550 |
Arylamine compound and organic electroluminescence device
A novel arylamine compound represented by the following general formula (1): wherein R 1 and R 2 each independently represent an alkyl group, an alkoxyl group, an aryl group, an arylalkyl group...
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7067700 |
Process for preparing sertraline hydrochloride polymorphic form II
Sertraline hydrochloride, (1Scis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1
-naphtalenaminehydrochloride, polymorph II is prepared by extracting or dissolving the sertraline base into...
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7067555 |
Sertraline oral concentrate
The present invention provides an essentially nonaqueous, liquid pharmaceutical concentrate composition for oral administration containing sertraline or a pharmaceutically acceptable salt thereof...
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7057071 |
Process for producing 5-nitro-3,4-dihydro-1(2H)-naphthalinone, 1-5-naphthalenediamine and 1,5-naphthalene diisocyanate
The present invention relates to a process for producing 5-nitro-3,4-dihydro-1(2H)-naphthalinone, 1,5-naphthalenediamine and 1,5-naphthalene diisocyanate, in which 4-(2-nitrophenyl)-n-butyronitrile...
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7022881 |
Sertraline hydrochloride polymorphs
The present invention is directed to forms II, III, V, VI, VII, VIII, IX and X of sertraline hydrochloride and novel methods for their preparation. According to the present invention, sertraline...
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6979566 |
Method of treatment of viral infection including HIV using water soluble fullerenes—III
A water soluble derivative of buckministerfullerene (C 50 ) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is...
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6946462 |
N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents
New compounds represented by the formula
or pharmaceutically acceptable salts or prodrugs thereof,
wherein
X 1 and X 2 are each independently selected from a CH group or a nitrogen atom;...
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6900355 |
Process for the cis-selective catalytic hydrogenation of cyclohexylidenamines
The invention relates to a process for the cis-selective preparation of cyclic amines of the sertralin type by reductive alkylation of cyclic imines or their precursors and catalytic hydrogenation...
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6861560 |
Bis-o-aminophenols and processes for producing bis-o-aminophenols
A bis-o-aminophenol has a formula I
These bis-o-aminophenols permit the preparation of polybenzoxazoles stabilized at high temperatures. The bis-o-aminophenols are preferably prepared from the...
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6858652 |
Sertraline hydrochloride polymorphs, processes for preparing them, compositions containing them and methods of using them
The present invention is directed to novel polymorphic Forms XI, XII, XIII, XIV, XV and XVI of sertraline hydrochloride, to processes for preparing them, methods of using them to treat disease,...
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6830834 |
Organic light emitting devices with host-guest bonding
A compound having a host moiety chemically bonded to at least one guest moiety according to the following general molecular structure: H o —(L—G) n. H o represents a host moiety that receives...
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6828461 |
Process for producing 1,5-diaminonaphthalene
A process for producing 1,5-diaminonaphthalene without formation of 1,8-diaminonaphthalene and not through an unstable nitro imine and nitro enamine as intermediates, the process including the...
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6809221 |
Process for preparing (&plus )-cis-sertraline
The present invention is directed to (+)-cis-sertraline hydrochloride and methods of preparation. The present invention also includes processes for making sertraline having a cis/trans ratio...
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6806386 |
Process for the preparation of ketimines
The present invention relates to a process for the preparation of compounds of formula (1), in which R 1 , R 2 and R 3 independently of one another are hydrogen, halogen , trifluoromethyl of or C...
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6749644 |
2-hydroxy-5-amino-biphenyl-derivatives and oxidative hair coloring agents containing said compounds
The object of the present invention are colorants for oxidative dyeing of keratin fibers, particularly hair, based on a developer-coupler combination containing as the developer at least one...
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