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6737548 |
Process for preparing 1,5-diaminonaphthalene derivative
In a process where an ortho-alkylnitrobenzene derivative and a vinyl compound as starting materials are used to prepare a 1,5-diaminonaphthalene derivative via a 4-(2-nitrobenzene)propane...
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6723878 |
Method for preparing sertraline
(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-
1-naphthalenamine (sertraline) may be prepared by hydrogenating of N-[4-(3,4-dichlorophenyl)-3,...
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6696178 |
Cyclocondensed polycyclic hydrocarbon compound and light-emitting device using the same
An organic light-emitting device comprising a light-emitting layer or a plurality of organic compound thin layers including a light-emitting layer formed between a pair of electrodes, wherein at...
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6683220 |
Process for the preparation of optically pure or enriched racemic tetralone
A process for producing substantially optically pure sertraline utilizes chromatographic separation on a solid stationary chiral phase of spherical clay particles having an interlayer containing an...
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6600073 |
Methods for preparation of sertraline hydrochloride polymorphs
Novel methods for the preparation of sertraline hydrochloride Forms III, V, VI, VII, VII, IX and X are disclosed. According to the present invention, sertraline hydrochloride Form III may be...
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6593012 |
Organic electroluminescent deivce
An organic electroluminescent device of the type comprises an organic layer 5, 5 a or 5 b having a luminescent region and provided between an anode 2 and a cathode 3 . The organic layer...
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6593496 |
Process for preparing sertraline from chiral tetralone
This invention relates to a novel improved process for preparing the (+) enantiomer of N-[4(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene
]methanamine by reacting the (+) enantiomer of...
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6552088 |
Biphenyl derivatives
Biphenyl substituted amides with activity as antagonists of the neurokinin 1 (NK-1, substance P) receptor.
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6506940 |
Process for converting stereoisomers of sertraline into sertraline
A process for converting the cis (1R, 4R), trans (1S, 4R), and trans (1R, 4S) stereoisomers of sertraline into sertraline comprises, starting with an initial reaction mixture which contains at...
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6479702 |
3-amino-1-indanole, method of synthesizing the same and method of optical resolution
The present invention relates to a compound which is expected to be a synthetic intermediate for medicines and pesticides or a separating agent for chromatography or a enantiomerically resolving...
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6476265 |
Method for producing aryl oligoamines
In a process for preparing aryl oligoamines, an amine is reacted with an activated aromatic and a base in a temperature range from 0 to 150° C. in the presence of a palladium component and a...
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6455736 |
Process for preparation of pharmaceutically desired sertraline and sertraline analogs
Improved processes for preparation of sertraline or sertraline analogs in high enantiomeric purity centers on resolution using simulated moving bed chromatography of isomeric racemic sertraline or...
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6444860 |
Naphthopyrans and phenanthropyrans annelated in C5-C6 with a bicyclic group, and compositions and (co) polymer matrices containing them
The invention relates to novel naphthopyran- and phenanthropyran-type compounds having a carbobicycle annelated in 5,6- position. These compounds have formula (I) given below: These compounds...
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6426324 |
Lubricant composition
An antioxidant composition suitable for ester fluid lubricants is the reaction product of diphenylamine and N-aryl naphthylamine in the presence of an organic peroxide. The mole ratio of...
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6392097 |
Process for the preparation of derivatives of octafluoro-&lsqb 2,2&rsqb paracylophane
Processes for the preparation of parylene dimers, and more particularly to processes for the preparation of derivatives of octafluoro-[2,2]paracylophane, otherwise known as AF4.
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6355839 |
Alkylation of diphenylamine with polyisobutylene oligomers
A process for preparation of alkylated diphenylamine antioxidant which comprises alkylating diphenylamine with a polyisobutylene in the presence of a clay catalyst, wherein the polyisobutylene has...
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6350911 |
Method for producing amines
The invention relates to a process for the preparation of amines by hydrogenation of nitro compounds, which comprises carrying out the hydrogenation in a vertical reactor whose length is greater...
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6323368 |
Process
A process for preparing a substantially single enantiomer of tramadol, or a pharmaceutically-acceptable salt thereof, proceeds by means of a classical salt resolution using a substantially single...
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6297399 |
Indane compounds with smooth muscle relaxing and/or mast cell stabilizing and/or anti-inflammatory activity
Indane compounds of general formulas (7) and (8) and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or anti-inflammatory...
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6204391 |
Water soluble fullerenes with antiviral activity
A water soluble derivative of buckministerfullerene (C 60 ) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is...
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6169205 |
Process for the purification of (RR,SS)-2-(dimethylamino) methyl-1-(3-methoxyphenyl)-cyclohexanol from (RS,SR)-2-(dimethylamino)methyl-1-(3-methoxyphenyl) cyclohexanol
A process for the purification of (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)cyclohexa
nol, which comprises the selective precipitation of...
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6054614 |
Process for the preparation of tetralone imines for the preparation of active pharmaceutical compounds
4-(3,4-Dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-ylidene-m
ethylamine and related analogs are prepared from α-tetralone by a facile three-step process. This compound is the required intermediate...
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6034274 |
Process for preparing a naphtalenamine derivative
The present invention relates to a proccss for preparing cis-(1S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-
1-naphtalenami ne and its acid addition salts wherein...
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5997874 |
Dihydrophenanthrene
The present invention relates to a class of dihydrophenanthrene which are isolated from Calanthe discolor Lindl. and derivatives thereof.
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5936000 |
2-aminoindans as selective dopamine D3 ligands
Compounds and their pharmaceutically acceptable salts suitable for treating central nervous system disorders associated with the dopamine D3 receptor activity of Formula I: wherein R 1 and R 2 ...
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5912386 |
Bridged anthraquinones
The present invention relates to compounds of the formula (I) R 1 --NH--B--NH--R 2 (I), wherein R 1 and R 2 independently of one another denote an...
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5872296 |
Synthesis of optically active aminoindanol
A process for preparing enantiomerically pure cis-1-amino-2-hydroxyindane, which comprises a) converting racemic trans-1-aminoindan-2-ol with acids or acid derivatives of the general formula...
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5843606 |
Phenanthrylenediamine derivative
In accordance with the present invention, there is provided a phenanthrylenediamine derivative represented by the general formula (1). The derivative is excellent in the electric charge...
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5840980 |
Diamine compounds and electrophotographic photoreceptor
A diamine compound of the following formula (1): ##STR1## wherein R 1 is a hydrogen atom, a lower alkyl group or a lower alkoxy group, each of A 1 , A 2 and A 3 which are independent of one...
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5821386 |
Compounds for treating cocaine abuse
Disclosed are novel compounds which are dopamine reuptake blockers for treating cocaine abuse. The compounds are represented by the following structural formula: ##STR1## R2 is n-propyl,...
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5773469 |
Diaryl antimicrobial agents
The invention relates to diaryl antimicrobial compounds of the general formula: ##STR1## where G, E L, J, q, m, X, Ar, W, p, n and A are as described herein, pharmaceutical compositions containing...
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5767315 |
Naphthylenediamine derivative
The present invention provides a novel naphthylenediamine derivative which is superior in electric charge transferring capability, compatibility with binding resin and stability. The above...
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5763719 |
Thermally stable fullerene derivatives and process for producing the same
A fullerene derivative of the formula I ##STR1## where the symbols and indices have the following meanings: F is a fullerene radical of the formula (C 20 +2m), where m is a number from 1 to 50 R...
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5734083 |
Sertraline polymorph
A novel polymorph of sertraline hydrochloride, i.e. (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-
1-naphthalenam ine hydrochloride, is disclosed, having improved water solubility...
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5708018 |
2-aminoindans as selective dopamine D3 ligands
Compounds and their pharmaceutically acceptable salts suitable for treating central nervous system disorders associated with the dopamine D3 receptor activity of Formula I: ##STR1## wherein R 1 ...
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5705686 |
Inhibition of farnesyl transferase
A compound of the formula C 1 R where C 1 is 3-mercapto-2-amino-propylamino and R is an aryl group. The compounds are useful for inhibiting p21ras farnesyltransferase.
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5698740 |
Hole-transport material
A hole-transport material having excellent hole-transport capability and durability, suitable for use in an organic EL device and as an organic photoconductive material, has the formula (1).
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5690906 |
Dopamine D-3 and serotonin (5-HT.sub.1A) receptor ligands and imaging agents
Tetralin derivatives, such as 7-hydroxy-2-(N-n-propyl-N-3 '-iodo-2'-propenyl)-amino!tetralin and 8-hydroxy-2-(N-n-propyl-N-3 '-iodo-2'-propenyl)amino-tetralin, are disclosed which have affinity and...
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5672728 |
Method for preparing the pyrenylamine derivatives
An electrophotographic photoconductor comprises an electroconductive substrate and a photoconductive layer formed thereon comprising as an effective component at least one pyrenylamine derivative...
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5670666 |
Process for preparing intermediates for the synthesis of D1 antagonists
Disclosed are a process and intermediates of the formulae ##STR1## wherein X - is halide, BF 4 - , R 3 SO 3 - , wherein R 3 is C 1 -C 6 alkyl, CF 3 , C 1 -C 6 alkylphenyl or phenyl, and Q...
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5654481 |
Amine compound
There is provided an amine compound represented by formula (1): ##STR1## wherein Ar 1 represents a substituted or unsubstituted aryl group; Ar 2 represents a substituted or unsubstituted...
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5639913 |
Method for preparing optically active 1-aminoindan derivatives
Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of...
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5631404 |
Diamine compounds for use in electrophotographic photoconductors
An electrophotographic photoconductor includes an electroconductive support and a photoconductive layer formed thereon containing a diamine compound represented by formula (I): ##STR1## wherein R 1...
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5616805 |
Methods for preparing pyrenylamine derivatives and intermediates
A pyrenylamine derivative having an unsaturated bond formula (I), which can be employed as an organic photoconductive material for use in electrophotography: ##STR1## wherein R 1 , R 2 , R 3 , R 4...
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5610183 |
Phenylglycine derivatives pharmaceutical compositions containing them and their use in therapy
Compounds of Formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein Q is optionally substituted phenyl or naphthyl; X and Y are each H, C 1 -6 alkyl, C 2 -6 alkenyl or X and...
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5599991 |
Esylate and sulfate salts of R(+)-N-propargyl-1-aminoindan
The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also...
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5576353 |
Method of treating memory disorders using R-enantiomers of N-propargyl-aminoindan compounds
R(+)-N-propargyl-1-aminoindan, its preparation and use and pharmaceutical compositions containing it. The novel compound was found to be useful for the treatment of human patients for Parkinson's...
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5569669 |
Alkylaminoindane compounds
The invention relates to a compound selected from those of formula (I): ##STR1## in which R 1 , R 2 , R 2 ', R 2 ", R 2 '", R 3 and n are as defined in the description, an optical isomer, and an...
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5545755 |
Therapeutically useful 2-aminotetralin derivatives
This invention is therapeutically useful 2-aminotetralins and pharmaceutically acceptable acid addition salts thereof of the formula ##STR1## R, R 1 to R 5 and p are as defined in the...
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5482942 |
(3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants
This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to...
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