Patents in Class 564/304

Matches 1 - 50 out of 222

1 2 3 4 5 >

Match	Document	Document Title
1	7470816	Tramadol recovery process A process for the resolution of isomeric tramadol mixtures comprising: providing a purification stock comprising both cis and trans tramadol; contacting the purification stock with an acid under...
2	7414153	Process for preparation of optically active 1-erythro-2-amino-1-phenyl-1-propanol An efficient cost-effective process for preparation of 1-erythro-2-amino-1-phenyl-1-propanol from 1-1-phenyl-1-hydroxy-2-propanone, which comprises converting 1-1-phenyl-1-hydroxy-2-propanone to...
3	7368609	Optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy- substituted phenyl)alkylamine N-monoalkyl derivatives and process for producing same An optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative represented by the formula 4 is produced by a process including (a)...
4	7049469	Process for preparing (R)-salbutamol The present invention relates to an improved process for preparing levosalbutamol or the pharmacologically acceptable salts thereof on an industrial scale, using asymmetric hydrogenation as the key...
5	7030276	Process for preparing 2-[(dimethylamino)-methyl]-1-(3-methoxyphenyl)cyclohexanol A process for preparing 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol with high stereoselectivity and high yield by reacting 2-[(dimethylamino)methyl]-cyclohexanone in a Grignard...
6	6995286	Process for preparing isomers of salbutamol A process for making optically pure (R) and (S) salbutamol comprises obtaining the (R) or (S) isomer of either salbutamol or a salbutamol precursor in substantially optically pure form by resolving...
7	6989465	S-(−)-1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol, process for preparation thereof and process for preparation of S-(−)betaxolo The present invention relates to a novel compound S-(−)-1-{4-[2-(allyloxy)-ethyl] phenoxy}-3-isopropylamino propan-2-ol of formula 1 and to a process for the preparation thereof. More...
8	6982350	Process for the synthesis of (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.
9	6878848	Process for converting a cis-trans mixture of substituted benzylidene amines into the pure cis isomer A process for interconverting a mixture of cis-trans isomers of a compound of formula I into the substantially pure cis isomer. Cis isomers of formula I are useful intermediates in the...
10	6821998	Arylamines as inhibitors of chemokine binding to US28 Methods for treating CMV and CMV-related diseases are provided that use compounds having the formula: wherein the subscripts m and n are each independently integers from 1 to 2; and the R groups...
11	6809221	Process for preparing (&plus )-cis-sertraline The present invention is directed to (+)-cis-sertraline hydrochloride and methods of preparation. The present invention also includes processes for making sertraline having a cis/trans ratio...
12	6806386	Process for the preparation of ketimines The present invention relates to a process for the preparation of compounds of formula (1), in which R 1 , R 2 and R 3 independently of one another are hydrogen, halogen , trifluoromethyl of or C...
13	6570036	Co-crystallization process A process for isolating one or more enantiomer components from a mixture of enantiomers through co-crystallization is disclosed.
14	6506940	Process for converting stereoisomers of sertraline into sertraline A process for converting the cis (1R, 4R), trans (1S, 4R), and trans (1R, 4S) stereoisomers of sertraline into sertraline comprises, starting with an initial reaction mixture which contains at...
15	6469213	Tramadol, salts thereof and process for their preparation Cis-Tramadol hydrochloride is prepared by forming a Mannich hydrochloride, liberating the Mannich base, reacting the Mannich base with a Grignard reagent to form a base hydrate of cis-Tramadol...
16	6458955	Process for preparation of pharmaceutically desired enantiomers Improved processes for preparation of high enantiomeric purity compounds center on resolution using simulated moving bed chromatography of a racemic precursor early in the synthesis. Resolution is...
17	6455736	Process for preparation of pharmaceutically desired sertraline and sertraline analogs Improved processes for preparation of sertraline or sertraline analogs in high enantiomeric purity centers on resolution using simulated moving bed chromatography of isomeric racemic sertraline or...
18	6399829	Synthesis and purification of (r,r)-2-&lsqb (dimethylamino) methyl&rsqb -1-(3-methoxyphenyl) cyclohexanol hydrochloride (R,R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohe xanol (Tramadol) is synthesized in a Grignard reaction in the presence of an additive resulting in a higher trans:cis ratio of product...
19	6399826	Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain Methods of making and using racemic and optically pure metabolites of sibutramine, and pharmaceutically acceptable salts, solvates, and clathrates thereof, are disclosed. Pharmaceutical...
20	6323368	Process A process for preparing a substantially single enantiomer of tramadol, or a pharmaceutically-acceptable salt thereof, proceeds by means of a classical salt resolution using a substantially single...
21	6265614	Optically active intermediates for the preparation of optically active substituted oximes, hydrazones and olefins useful as neurokinin antagonists Intermediates having the formula ##STR1## wherein B I is --CH 2 OH or --CH 2 OR P , and R P is an alcohol protecting group; a is 1, 2, or 3; ##STR2## T I is --OH or Q I is phenyl,...
22	6225463	Synthesis of new β-lactams The object of the present invention is the development of new chiral auxiliaries for improved β-lactam formation that control both the diastereoselectivity of β-lactam formation and which can be...
23	6222072	Process for producing optically active amine A novel process for producing an optically active amine is provided. The optically active amine is adapted for use as an intermediate in synthesizing physiologically active compounds such as...
24	6218575	Process for preparing adrenaline An improved process for preparing adrenaline, or an addition salt thereof, on an industrial scale, with asymmetric hydrogenation as a key step and a special sequence of successive steps, using...
25	6184381	Process for preparing optically active compounds This document describes a novel and practically excellent process for the preparation of optically active compounds, such as optically active alcohols or amines which are useful for various...
26	6162949	Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers Improved processes for preparation of the (S)-oxetines in high enantiomeric purity centers on resolution using simulated moving bed chromatography of a racemic precursor early in the oxetine...
27	6118025	Method for preparing optically active α-substituted benzyl alcohols The invention concerns a method for preparing an optically active alcohol of formula (I) in which the carbon atom indicated by the symbol * can have the configuration (R) or (S) and X represents a...
28	6040479	Racemic separation of ketamine
29	6034278	Method for producing optically active 1-phenylethylamines The invention concerns a new method for producing optically active 1-phenylethylamines, wherein (a) racemic 1-phenylethylamines are reacted with (S)-(-)-N-phenylcarbamate lactic acid in the...
30	5962737	2-amino-1-phenylpropanols, stereospecific synthesis thereof, and method of optically resolving the same Stereospecific synthesis of the racemic threo isomers of 2-nitro-1-phenylpropanols by reacting a benzaldehyde derivative with nitroalkane in the presence of a tertiary amine and reducing...
31	5885787	Process for preparing optically active amines In accordance with a novel process, (R)-amines of the formula ##STR1## in which R 1 , R 2 and n have the meanings given in the description, can be prepared by reacting reating N-acyl-amines of the...
32	5874620	Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride The invention provides a process for the separation of (RR,SS) 2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol hydrochloride (RR,SS)-Tramadol!, from a mixture consisting of (RR,SS) Tramadol...
33	5863952	Enantiomers of 1-(3,4-dichlorobenzyl)-2-methylaminoindane The single enantiomers of formula (I) and salts thereof ##STR1## are calcium channel antagonists useful in the treatment of ischaemic conditions e.g., stroke.
34	5856579	Adduct salts of novel substituted benzylamines and a process for optically resolving them A process for optical resolution of a racemic substituted benzylamine is provided that involves reacting the racemic substituted benzylamine in a solvent with an optically active...
35	5808156	Process for the production of the isomers (R) and (S)-α-methyl-3(trifluoromethyl)benzeneethanamine Process for the production of the isomers (R) and (S)-α-methyl-3-(trifluoromethyl)benzeneethanamine, the second being useful as intermediate in the synthesis of the anorexic drug dexfenfluramine...
36	5728885	Method of preparing the enantiomers of O-dimethyltramadol A method of preparing the enantiomers of O-demethyltramadol and the use of the enantiomers as pain-killing drugs are described.
37	5723668	Method of separating the racemate of tramadol A method of separating the racemate of tramadol is disclosed.
38	5679857	Method of preparing D-amino acid-N-(S)-α-alkylbenzylamide L-amino acid amides are converted to the corresponding D-amino acid amides. An amide formed from an L-amino acid and an optically active (S)-α-alkylbenzylamine is subjected to dehydration...
39	5639913	Method for preparing optically active 1-aminoindan derivatives Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of...
40	5545745	Enantioselective preparation of optically pure albuterol The invention relates to a method for producing albuterol by the resolution of a mixture of enantiomers of methyl 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-2-(phenylmet hoxy)benzoate or...
41	5510519	Optically active secondary amine compound, process for producing optically active secondary amine compound and process for producing optically active carboxylic acid by using said compound Disclosed are optically active secondary amine compounds and salts thereof having the general formula (I): ##STR1## a process for the preparation of the optically active secondary amine compounds...
42	5476964	Continuous racemization of benzylic alcohols, ethers, and esters by solid acid catalyst Benzyl alcohols having a chiral center at the benzylic carbon can be conveniently racemized by treatment with solid acids which are strongly acidic cation exchange materials. Racemization may be...
43	5461175	Method for separating enantiomers of aryloxipropanolamine derivatives, and chiral solid-phase chromatography material for use in the method A method for separating enantiomers of a derivative of an aryloxipropanolamine is disclosed, characterized in that the derivative is contacted with a chiral solid-phase chromatography material...
44	5449694	(-)-ritodrine, therapeutic compositions and use, and method of preparation (-)-Ritodrine, that is (-)-erythro-1-(p-hydroxyphenyl)-2-[2-(p-hydroxyphenyl)ethyla mino]-1-propan ol or a salt thereof substantially free from the (+)-isomer is disclosed. The compound has a...
45	5442117	Enantiomeric resolution A process for obtaining a substantially pure enantiomer of an hydrocarbyl amine is described. The process utilizes first an enantiomerically enriched mixture the of hydrocarbyl amine obtained from...
46	5391735	Process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane The present invention relates to a new process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane in the form of single diastereoisomers, to certain of these...
47	5321154	Optical resolution of (±)-2-(4-isobutylphenyl)-propionic acid (±)-2-(4-Isobutylphenyl)-propionic acid can be resolved into optically active isomers easily and with high yields. The method is characterized by the use of the optically active amine of the...
48	5292933	Process for the resolution of threo-3-[(2-aminophenyl)-thio]-2-hydroxy-3-(4-methoxy-phenyl)propionic acid The invention relates to a novel process for the resolution of an acid mixture (hereinafter: threo acid mixture) containing...
49	5292893	Catalytic asymmetric and non-asymmetric reduction of times and oximes using metal catalysts A process is provided for catalytically reducing imines, oximes, hydrazones and related compounds. Moreover, there is provided a process for the catalytic asymmetric reduction of imines, oximes,...
50	5284966	Intermediates for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers Intermediates for transforming (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R)-enantiomers are described. The final compounds are useful intermediates for the synthesis of antibiotics...

Matches 1 - 50 out of 222

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