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7538127 |
Medicinal compounds
A compound of formula (I) or a salt, solvate, or physiologically functional derivative thereof, wherein: m is an integer of from 2 to 8; n is an integer of from 2 to 5; with the proviso that m+n is...
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7501542 |
Highly-packed polycationic ammonium, sulfonium and phosphonium lipids
The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds...
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6689911 |
Process
An integrated process for preparing α-(2,4-disulfophenyl)-N-tert-butylnitrone and its salts is disclosed in which N-tert-butylhydroxylamine acid addition salt is incompletely neutralised so as to...
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6512136 |
Substituted 2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them
New compounds of formula I are described The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders, where a...
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6417401 |
Ether diamines amine oxides
The present invention is related to a series of derivatives of novel ether diamine compounds prepared by the cyanobutylation reaction of an alcohol having 3 to 22 carbon atoms with 2-pentenenitrile...
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6291702 |
Azulenyl nitrone spin trapping agents, methods of making and using same
The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones...
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6002002 |
Anti-ischaemic hydroxylamine derivatives and pharmaceutical compositions
The present invention provides novel hydroxylamine derivatives represented by the general formula: wherein: X is O, --NH, or a group of formula NR', wherein R and R' are independently selected...
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5892117 |
Preparation and uses of N-methylnitrone
Oxidation of secondary amines with hydrogen peroxide and sodium tungstate is reported to give good yields of nitrones. However, when using dimethylamine in this manner, a considerable amount of...
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5837717 |
Hydroxamic acid anesthetic compounds
A compound of the following formula: ##STR1## and its pharmaceutically acceptable salt thereof, wherein R 1 and R 2 are independently hydrogen, C 1 -4 alkyl, C 3 -7 cycloalkyl, C 2 -4 alkenyl, C...
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5650425 |
Permanently ionic derivatives of steroid hormones and their antagonists
The present disclosure relates to compounds of the general formulae: ##STR1## wherein DRUG is a steroid agonist or antagonist, a mixed agonist-antagonist, or a partial agonist, and to the use of...
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5639880 |
Preparation of amine oxides
A process for preparing amine oxides of the general formula I ##STR1## where R 1 , R 2 and R 3 are each C 1 -C 30 -alkyl, C 3 -C 12 -cycloalkyl, C 1 -C 30 -hydroxyalkyl, C 1 -C 30 ...
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5498791 |
Nitrosamine and nitrite inhibition
A synergistic mixture of a carbonate and/or bicarbonate with a phosphonate, especially an organoamino methylene phosphonate or an N-oxide thereof, inhibits or reduces nitrosamine contamination...
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5461078 |
Anti-cancer compounds
Compounds of formula (I) ##STR1## in which R 1 is CHCHR, CHNNHR, CHN--A--N(O)R'R" or CH 2 --NH--A--N(O)R'R" and R 2 is separately selected from hydrogen, CHCHR, CHNNHR,...
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5223541 |
Tramadol N-oxide material, enantiomers and compositions thereof, and their use
This invention relates to a tramadol N-oxide material, enantiomers and compositions thereof and their use. The tramadol N-oxide material and compositions thereof are pharmacologically useful in...
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5164121 |
Pourable composition containing an amine oxide -polyethylene glycol mixture
A pourable amine oxide composition which is suitable for use in detergent compositions is obtained by reacting a tert-amine with aqueous hydrogen peroxide in a normally liquid polyethylene glycol...
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5087752 |
Synthesis of nitroxides using dioxiranes
The subject invention relates to a method of synthesizing nitroxides from secondary amines. This method uses a suitable dioxirane compound such as dimethyldioxirane (DMD), which is relatively...
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5082938 |
Organic materials containing poly(oxyalkylene) moieties having enhanced functionality and their preparation
Enhanced branched chain hydroxyl compounds are provided of formula Y--(Z) 1 -6 wherein Y is the residue of a nucleophile devoid of conjugated divalent linking moieties, and each Z is a...
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5082940 |
Process for the production of oxides of aromatic tertiary amines
Aromatic tertiary amines are oxidized by means of hydrogen peroxide in an inert solvent medium in the presence of a catalyst selected from metal selenium and compounds of selenium. The process is...
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5021429 |
Pharmacologically active aminoalkylphenyl compounds and their use
Compounds of the general formula: ##STR1## and physiologically acceptable salts, and hydrates, N-oxides and bioprecursors of such compounds and such salts in which R 1 and R 2 , which may be...
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4992589 |
Substituted phenyl hydroxyethyl sulfones, and process for their preparation
Compounds of the formula (1) ##STR1## in which X denotes a sulfur atom or the group ##STR2## in which R denotes a hydrogen atom, an alkylene-C 1 -C 4 -alkoxy-C 1 -C 6 - or alkyl-C 1 -C 6 -...
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4960934 |
Amine oxide process
The reaction of aqueous hydrogen peroxide with tert-amines to yield tert-amine oxides is catalyzed by the addition of a promoter amount of ammonium carbonate, ammonium bicarbonate or ammonium...
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4942260 |
Amine oxide process with CO.sub.2 and aluminum
Amine oxides which have low levels of nitrosamines or are substantially-free of nitrosamines are made by reacting tert-amines with hydrogen peroxide in the presence of carbon dioxide and aluminum...
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4696949 |
Novel tri-phenyl alkane and alkene derivatives and their preparation and use
The invention provides novel compounds of the formula: ##STR1## wherein n is 0 to 4, R 1 and R 2 , which can be the same or different are H, OH, alkoxy of 1 to 4 carbon atoms, benzyloxy or...
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4677049 |
Spin castable photobleachable layer forming compositions
Spin castable mixtures having aryl nitrones are provided which are useful in making photobleachable layers for use in contrast enhanced photolithography.
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4661433 |
Storage stable aryl nitrone compositions
Aryl nitrones, of the type used in contrast enhancement photolithography techniques, are stabilized by adding thereto a drying agent such as molecular sieve, silica gel or an alkylalkoxysilane. The...
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4399077 |
Certain polyoxy perfluorinated surface active oligomers
Perfluorinated surface-active block or random oligomers of the formula ##STR1## where R denotes a C 2 -C 18 -hydrocarbon or- hydrofluorocarbon radical, Y denotes a C 6 -C 13 -fluorocarbon...
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4347381 |
Method of treating long chain alkyl amines or products derived therefrom
The pink color content often produced in products such as amine salts, amine oxides, betaines, quaternary ammonium compounds or other compounds derived from long chain alkyl amines is eliminated by...
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4275236 |
Tertiary di-(β-hydroxy organo) amine oxides and their preparation
Disclosed are tertiary amine oxides which comprise an amine oxide nucleus substituted with an organic group and with two hydroxy groups which have carbon atoms in at least the α, β and γ...
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4264776 |
Production of secondary amines
Tertiary amines such as alkyl or benzyl amines are catalytically oxidized by oxygen over an activated carbon catalyst to selectively produce secondary amines.
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4172093 |
Pharmacodynamically active indan derivatives
The present invention relates to new pharmacodynamically active compounds of the general structure ##STR1## as well as the corresponding amine oxides, quarternary ammonium compounds and salts with...
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4153629 |
9,10-Dihydro-9,10-methanoanthracene N-oxide
9,10-Dihydro-9,10-methanoanthracene N-oxide derivatives represented by the formula: ##STR1## wherein A represents a straight or branched C 1 -C 6 alkylene; R 1 and R 2 each represents C 1 -C 4...
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3957872 |
Benzobicycloalkane amine N-oxides and the salts thereof
Benzobicycloalkane amines, their pharmacologically acceptable addition salts, intermediates therefore the processes for their preparation and use. The compounds of the invention exert analgesic and...
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3928427 |
N,N'-bridged-bis[2-alkyl-2-hydroxyethylamine]salts
N,N'-Bridged-Bis[2-alkyl-2-Hydroxyethylamine]salts of the formula ##EQU1## are prepared by condensing an epoxide of the formula ##EQU2## and a diamine of the formula R'NH--X--NHR'. The products and...
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3892776 |
N-oxides of bis-basic tricyclic ethers
Novel N-oxide derivatives of bis-basic tricyclic ethers, their preparation and use for the prevention and inhibition of virus infections.
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3890328 |
N,N-dioxides of bis-basic cyclic ketones
Novel N,N-dioxide derivatives of bis-basic cyclic ketones, their preparation and use for the prevention and inhibition of virus infections.
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3875234 |
N-(lower alkyl)-hydroxy-benzyl-N-lower alkyl-aniline-N-oxides
N-benzyl-N-loweralkyl-aniline-N-oxides are disclosed having utility in retarding the formation of popcorn polymers. Representative compounds are N-methyl-N-(2-hydroxy-3-t-butyl-5-methyl...
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3859355 |
1-P-(ω)-AMINOALKOXY)PHENYL-3,5-DIARYL-CYCLOHEPTANES
Disclosed are 1-p-(ω-aminoalkoxy)phenyl-3,5-diaryl-cycloheptanes useful as hypolipidemic agents, and intermediates useful in the preparation of said compounds including the corresponding...
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3856863 |
4-P-(ω-AMINOALKOXY)PHENYL-1,2-DIARYL-CYCLOPENTANES AND CYCLOPENTENES
Disclosed are 4-p-(ω-aminoalkoxy)phenyl-1,2-diaryl-cyclopentanes useful as hypolipidemic agents, and intermediates useful in the preparation of said compounds including the corresponding...
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3856795 |
PROCESS FOR PREPARATION OF SECONDARY AMINES FROM TERTIARY AMINES
A process of converting tertiary amines to secondary amines is described comprising reacting the tertiary amine with a peracid to form the N-oxide which is converted to the secondary amine in the...
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3855296 |
CYCLO-SUBSTITUTED-1-p(ω-AMINOALKOXY) PHENYL CYCLOHEXANES
This invention relates to cyclo-substituted-1-p-(ω-aminoalkoxy) phenyl cyclohexanes useful as hypolipidemics and to preparation thereof, e.g., by hydrogenation of corresponding substituted...
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3627751 |
BASIC AZO DYESTUFFS CONTAINING ETHERIFIED HYDROXYLAMINE GROUPS
Basic dyestuffs that are free from acidic groups imparting solubility in water which contain at least one etherified hydroxylamino residue which is linked through the nitrogen atom to a carbon atom...
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3607861 |
PROCESS FOR THE PREPARATION OF WATER-INSOLUBLE AZO-DYESTUFFS
Process for the preparation of a water-insoluble azo-dyestuff having partlarly good qualities for printing by adding in the coupling process an auxiliary comprising a mixture consisting essentially...
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3504092 |
1,2-DIARYL-6-TERTIARY AMINO LOWER ALKOXY-3,4-DIHYDRO NAPHTHALENES AS HYPOCHOLESTEREMIC AGENTS
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3494962 |
ARYL-SUBSTITUTED ALIPHATIC AMINE OXIDES
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3483209 |
ARALKYLAMINES
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3481941 |
BASICALLY ETHERFIED BISPHENOLS
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3476767 |
1,2-DIARYL - 6 - TERTIARY AMINO LOWER-ALKOXY-3,4-DIHYDRO NAPHTHALENES
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3422114 |
BASIC ETHERS OF DIHYDRONAPHTHYL-PHENOLS
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3396169 |
Substituted 2-phenyl-1-(tertiary-aminoalkoxy) phenyl-3, 4-dihydronaphthalenes
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3356727 |
Alkyl-and alkaryl-oxyalkyl-nu-hydroxyalkyl amine oxides
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