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7262326 Process for the synthesis of indanylamine or aminotetralin derivatives and novel intermediates  
A process for preparing indanylamine and aminotetralin derivatives from indanone or tetralone oximes by acylating the oximes with an organic anhydride, followed by catalytic hydrogenation in the...
7157604 Selective estrogen receptor modulators  
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen...
6737547 Compositions containing and methods of using N-acyl-1H-aminoindenes  
The present invention provides novel aminoindenes having the structure: wherein n is 1 or 2, R 1 is hydrogen, linear or branched chain C 1 -C 8 alkyl or linear or branched chain C 1 -C 8 ...
6683220 Process for the preparation of optically pure or enriched racemic tetralone  
A process for producing substantially optically pure sertraline utilizes chromatographic separation on a solid stationary chiral phase of spherical clay particles having an interlayer containing an...
6649796 Process for the preparation of acetamide derivatives  
The invention provides a process for the preparation of diphenylmethylthioacetamide (I) as described in Scheme 4 comprising reacting of the isothiouronium salt or its corresponding base of the...
6635783 Bicyclic 1,3-aminoalcohols, d8-metal complexes and hydrogenation processes  
Bicyclic amino alcohols, whose amino group and hydroxy group are bonded in positions 1,3 adjacent to the bridge, for example are valuable ligands for metal complexes of the d-8 metals of the...
6602903 Substituted heterocyclic compounds  
The invention relates to compounds of formula (I): and medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.
6313175 Meta substituted arylalkylamines and therapeutic and diagnostic uses therefor  
Novel meta substituted arylalkylamine compounds are disclosed. These compounds can be administered as small molecule drugs to treat diseases or conditions associated with insufficient serotonin...
6297399 Indane compounds with smooth muscle relaxing and/or mast cell stabilizing and/or anti-inflammatory activity  
Indane compounds of general formulas (7) and (8) and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or anti-inflammatory...
6262308 Process for the preparation of racemic sertraline  
The invention relates to a process for preparing cis-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-nap hthylamine, or racemic sertraline, corresponding to formula (I) ##STR1## in salt...
6140372 Acyl derivatives of melatonin and of melatoninergic analogues and their use as medicinal products  
The invention relates to derivatives of general formula I ##STR1## as defined in the description. The invention also relates to a process for their preparation and to their therapeutic use, in...
6028112 Spirocyclopropyl fluorenes as melatonergic agents  
There is provided novel spirocyclopropyl fluorene derivatives having the general Formula I ##STR1## wherein R, R 1 and X are as defined herein which are useful as melatonergic agents.
5973204 Colchicine and thiocolchicine derivatives with antiinflammatory and muscle relaxant activities  
The present invention relates to 3-demethyl-thiocolchicine derivatives of general formula (I) ##STR1## in which R can be ##STR2## to a process for the preparation thereof, to pharmaceutical...
5849945 Aminotetralone derivatives and preparation process thereof  
The present invention pertains to a process for the preparation of Compound (4) through the below-described reaction route: ##STR1## wherein R 1 and R 2 each represents H, halogen, OH or C 1 -6...
5834521 Substituted dibenz (A F)azulenes and methods of preparation  
Tetracyclic compounds having the following structure are described: ##STR1## wherein R 1 -R 10 are as defined. The tetracyclic compounds are capable of potent effects on steroid sensitive tissues...
5817874 Process for alkylating and smiles rearrangement of hydroxy aromatics  
The present invention is a process of converting a hydroxy aromatic into a 2-hydroxy-N-arylacetamide, comprising: (1) treating a reaction mixture comprising a salt of a hydroxy aromatic with an...
5646188 Polyamine derivatives of 1-aminoindan  
A compound of general formula I ##STR1## wherein n is 1 or 2; R 1 and R 2 are each independently hydrogen, hydroxy, substituted or unsubstituted C 1 -4 alkyl, substituted or unsubstituted C 1 -4...
5599985 Optically pure 1-amido-2-indanols  
A two-step process for the conversion of a trans-1-amino-2-hydroxycycloalkane stereoselectively to a cis-1-amino-2-hydroxycycloalkane is disclosed. The novel step, a one-step hydrolysis with formal...
5530002 1-[2-(1H-inden-3-yl)ethyl]-4-(naphth-1-yl)piperazine derivatives, their preparation and their application in therapeutics  
Compounds of formula: ##STR1## in which X represents a hydrogen atom, a C 1 -C 3 alkoxy group or a cyclopropylmethoxy group and Y represents a hydrogen atom or a methoxy group, are useful in the...
5463126 Process for preparing sertraline  
The invention provides the substantially geometrically pure cis-stereoisomeric form of a compound of formula (I) and the substantially geometrically and optically pure cis-stereoisomeric form of a...
5442116 Process for preparing sertraline intermediates  
The invention provides the substantially geometrically and optically pure trans-stereoisomeric form of a compound of formula (I): ##STR1## wherein R 1 is H or C 1 -C 4 alkyl, together with...
5225595 Arylsulfonyl compounds with unsaturated radicals  
Sulfonyl compounds of the formula ##STR1## where Ar is the radical of a benzene or naphthalene ring, R 1 and R 2 are each hydrogen, substituted or unsubstituted C 1 -C 4 -alkyl, substituted...
5196454 Method of treating disorders of the dopaminergic systems using 2,5-diaminotetralines  
The invention relates to novel 2,5-diaminotetralines of the formula: ##STR1## wherein R1, R2, R3 and R4 are defined herein, processes for preparing them and their use in pharmaceutical...
5189065 Use of derivatives of 9,10-dihydrophenanthrene for the preparation of an anti-tumor medicament  
The use of products of formula (I) is described, wherein X and Y represent hydrogen, hydroxy or alkoxy; and R 1 and R 2 represent H, alkyl, alkenyl or alkynyl, arylalkyl, acyl or R 1 and R 2 ...
5153227 Phenylsulfonyl nitromethanes as aldose reductase inhibitors  
The invention concerns novel pharmaceutical compositions for use in the treatment of certain complications of diabetes and galactosemia and which contain a nitromethane derivative (or its non-toxic...
5128479 Oxidized diphenylheteroalkanes  
Oxidized diphenylheteroalkanes of the formula I ##STR1## where R 1 to R 6 and A have the meanings specified in the description, and the preparation thereof are described. The substances are...
5114975 Anilinophenyl carbodiimides compositions containing them, and the use thereof in pest control  
The invention relates to novel substituted aryloxyphenylthioureas, aryloxyphenylisothioureas and aryloxyphenylcarobodiimides of formula I ##STR1## wherein R 1 is C 1 -C 12 alkyl, unsubstituted...
5071875 Substituted 2-amidotetralins as melatonin agonists and antagonists  
The present invention relates generally to compounds having melatonin receptor activities and in particular to substituted 2-amidotetralin derivatives; to pharmaceutical preparations comprising...
5026730 Anilinophenylthioureas, compositions containing them, and the use thereof in pest control  
The invention relates to novel substituted anilinophenylthioureas, anilinophenylisothioureas and anilinophenylcarbodiimides of formula I ##STR1## wherein R 1 is C 1 -C 12 alkyl, unsubstituted or...
5021414 Phenol derivatives  
A phenol derivative of the formula NU--A--X--R 1 wherein NU is a defined bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl; hydroxyphenyl-hydroxyindanyl,...
4975461 P-aminophenols, derivatives thereof and method of use  
p-Aminophenols are provided having the structure ##STR1## wherein m is 0, 1 or 2; n is 0, 1, 2 or 3; R 1 and R 2 may be the same or different and are H, hydroxy or alkoxy; R 3 is H, lower alkyl,...
4922016 Process for the preparation of N-(sulfonylmethyl) formamide compounds  
N-(sulfonylmethyl)formamides are obtained by reacting a sulfinic acid, formaldehyde and formamide in the presence of a second acid and a controlled amount of water. The formamides can be converted...
4889924 Bisazo compounds  
A bisazo compound having good electrophotographic properties is disclosed, which is represented by formula (I) ##STR1## wherein X represents a hydrogen atom, a chlorine atom or a nitro group. A...
4885314 Novel HMG-CoA reductase inhibitors  
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I)...
4792628 Indane derivatives and salts thereof  
Indane derivatives and their salts represented by the general formula (1), ##STR1## wherein R 1 is an amino group which may have lower alkyl groups as the substituents, a hydroxylimino group, an...
4755511 Tricyclic pyridazinone compounds  
This invention relates to tricyclic pyridazinone compounds, pharmaceutical compositions containing the compounds, and a method of stimulating cardiac activity in a mammal by administering an...
4754066 Age protection agents, the production thereof and the polymers which contain them  
Compounds corresponding to the formula ##STR1## wherein R 1 and R 2 represent H or C 1 -C 4 -alkyl, R 3 represents H or CH 3 , R 4 represents C 7 -C 20 -aralkyl, n represents 1 or...
4692463 Antiinflammatory 2,3-didemethylcolchicine and additional derivatives  
The present invention describes the finding of potent antiinflammatory properties in 2,3-didemethylcolchicine and its analogs.
4692447 Tricyclic dihydropyridazinones and pharmaceutical compositions containing them  
The tricyclic dihydropyridazinone derivatives having formula I ##STR1## are endowed with interesting hypotensive, vasodilating, antiaggregant, antithrombotic and cytoprotective properties and are...
4642373 Substituted dodecahydrotripheylenes, and decahydropyrrolo[1,2-f]phenanthridines as CNS agents  
1,2,3,4,4a,4b,5,6,7,8,8a,12b-Dodecahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy or alkoxyalkyl)triphenylenes, 2,3,3a,3b,4,5,6,7,7a,11b-decahydro-6-(oxo, hydroxy or...
4602032 Dibenz[cd,f]indole derivatives, their preparation and pharmaceutical compositions containing them  
A 2-alkyl-9,10-dioxy-4,5,5a,6-tetrahydro-dibenz[cd,f]indole or an acid addition salt thereof is a useful anti-parkinson agent.
4540806 Benzocycloalkane amines  
Benzocycloalkane amine derivatives and their non-toxic acid addition salts as novel analgesic agents.
4473704 Substituted dodecahydrotriphenylenes, decahydro-1H-cyclopenta[1]phenanthrenes, decahydro-1H-pyrido[1,2-f]phenanthridines and decahydropyrrolo[1,2-f]phenanthridines as CNS agents  
1,2,3,4,4a,4b,5,6,7,8,8a,12b-Dodecahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy or alkoxyalkyl)triphenylenes, 2,3,3a,3b,4,5,6,7,7a,11b-decahydro-6-(oxo, hydroxy or...
4473586 Aminoalkyl dihydronaphthalenes  
Disclosed herein are 1-aminoalkyl-3,4-dihydronaphthalenes represented by the formula ##STR1## wherein n is 1 or 2; R, R 1 , and R 2 are independently selected from hydrogen, hydroxy, loweralkoxy...
4442126 1,2,3,4-Tetrahydronaphthalene derivatives  
New compounds of the formula: ##STR1## wherein R 1 represents a hydrogen atom or an alkanoyl group containing from 1 to 4 carbon atoms, R 2 and R 3 each represent a hydrogen atom or a C 1 -C 4 ...
4435426 Ethers of phenol active on the cardiovascular system, process for preparing same and use thereof in drugs  
The present invention relates to novel products, responding to general formula: ##STR1## in which R 1 and R 2 taken together represent an atom of oxygen O or R 1 represents hydrogen and R 2 ...
4394314 Process of preparing aromatic aldehydes by reacting selected aromatic compounds with formamidine acetate and an organic acid anhydride  
A process of reacting a ring carbon atom of an aromatic compound Ar with a compound of the formula H 2 NCHNH 2 + CH 3 CO 2 - , and an anhydride which has the ##STR1## at from 10° to 200° C....
4320148 2-Aminotetralin compounds, pharmaceutical compositions and method of producing central alpha.sub.1 agonist activity  
2-Aminotetralin compounds having 5- and 8- substituents are centrally acting alpha 1 agonists.
4310693 o-Aminophenol compounds  
o-Aminophenol derivatives are described represented by the formula (I) ##STR1## wherein R represents --NH 2 or --NH--CO--R 6 ; R 1 and R 2 which may be the same or different, each can represent...
4299984 Benzo-bicyclononene-derivatives  
The present invention relates to novel biologically active tricyclic compounds of the general formula: ##STR1## and salts thereof, in which R 1 and R 2 stand for hydrogen, alkyl or alkenyl, an...
Matches 1 - 50 out of 133 1 2 3 >