Patents in Class 564/189

Matches 1 - 50 out of 258

1 2 3 4 5 6 >

Match	Document	Document Title
1	8163956	Inhibitors of GLYT1 transporters A compound of the formula (I): wherein R1, R2, R3, R4, Ar, A, n and m are defined herein, is disclosed as a GlyT1 inhibitor; pharmaceutical compositions containing the compound of the formula (I)...
2	8115031	Anti-inflammatory quinic acid derivatives for oral administration Disclosed are compounds comprising analogs of quinic acids or shikimic acids having anti-inflammatory properties. The compounds are suitable for oral administration, stable, and demonstrate...
3	7989439	Substituted pyrazoles, compositions containing these, method of production and use The disclosure relates to a compound of formula (I): and salts thereof; wherein Ar, L, A, X, R1, R2, R3, R4a, R4b, and R5 are as defined in the disclosure; compositions comprising said compounds,...
4	7947852	Naphthalene compounds, a process for their preparation and pharmaceutical compositions containing them Compounds of formula (I): wherein: R1 represents alkyl, alkenyl, haloalkyl, polyhaloalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl,X represents a group N—OR2 w...
5	7728171	Process for the production of acid chlorides A process for the preparation of acid halides of formula I which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
6	7632972	Compounds and methods for treatment of cancer and modulation of programmed cell death for melanoma and other cancer cells Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. The generation of...
7	7601870	Substituted aniline derivatives The present invention relates to aniline derivatives of the general formula I or salts thereof, described therein, and their use.
8	7592365	Substituted pyrroles, compositions containing same, method for making same and use thereof The disclosure concerns substituted pyrroles of formula (I): wherein A, L, Ar, R1, R2, R5, and Ra are as defined in the disclosure, compositions containing the same, methods for making the same and...
9	7560591	Benzamidine derivatives having anti-inflammatory and immunosuppressive activity Compounds which can be represented by the general formula (I) indicated below: and in which: A is selected independently from the carboxamide group, the thiocarboxamide group, and the carbonyl...
10	7511175	Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of...
11	7476755	Therapeutic compounds Therapeutic substituted cyclopentane compounds, and compositions, medicaments, and therapeutic methods related thereto are disclosed herein.
12	7435849	Process for the production of acid chlorides A process for the preparation of acid halides of formula I which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
13	7435851	Puleganic amides The present invention provides substituted puleganic amides and compositions thereof, which are both useful as a topical treatment for skin, such as a repellant for insects and arthropods.
14	7414152	N-substituted p-menthane carboxamides Cooling compounds are provided having the formula: wherein, m is 0 or 1, Y and Z are selected independently from the group consisting of H, OH, C1-C4 straight or branched alkyl, and a C1-C4...
15	7381827	Processes and intermediates The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing...
16	7220814	Hydrophilicized blocked polyisocyanates The present invention relates to new hydrophilicized blocked polyisocyanates, a process for preparing them and their use.
17	7161016	Cannabimimetic lipid amides as useful medications Novel analogs of arachidonylethanolamide are presented which have higher affinities for the cannabinoid CB1 and/or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic...
18	7091231	12-Aryl prostaglandin analogs Compounds comprising are disclosed, wherein Y, A, X, R, D, and n are as described. A compound comprising a prostaglandin EP2 selective agonist wherein the ω-chain comprises a substituted phenyl, ...
19	7071359	Neuropathy improvers containing nitrogenous compounds as the active ingredient A compound represented by the Formula below, and an agent for the remedy of neural damage having the said compound as the active ingredient. [Here, G represents G1 shown below R4 represents,...
20	7049317	CCR-3 receptor antagonists The invention provides compounds of Formula (I): wherein R1–R4 have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions containing t...
21	7015349	Reduction of hair growth Compositions including a conjugate of α-difluoromethylornithine can be applied topically to reduce hair growth.
22	6683212	Fungicidally active carboxylic acid amides Compounds of Formula (I) are disclosed which are useful as fungicides wherein R1 is hydrogen; halogen; C1-C2 alkoxy; C1-C2 haloalkoxy, cyano; or C1-C2 alkyl optionally substituted with halogen,...
23	6667406	Methods for the synthesis of complex reduced isoindole, isooxyindole and isooxyquinoline libraries Disclosed are methods of synthesizing libraries of diverse complex hexahydroisoindole, hexahydroisooxyindole and octahydroisooxyquinoline compounds through the use of a facile intramolecular Diels...
24	6593312	Cyclic α-amino-&ggr -hydroxyamide compounds A compound of formula (I): wherein: represents an optionally substituted saturated carbon ring having from 4 to 8 ring members,R1 and R4, which may be identical or different, each represents...
25	6576792	2-halo-1-cycloalkenecarboxamides and their preparation The invention relates to a 2-halo-1-cycloalkenecarboxamides represented by Formula I: whereinn is 1 or 2;R is hydrogen or an alkyl group; andX is a halogen.
26	6441232	Selective nitrogen functionalization of organic compounds There is provided a method of selectively replacing a carbon-hydrogen bond at an unactivated saturated sp3 hybridised carbon atom in an organic compound by a carbon-nitrogen bond, the method...
27	6437183	Method for making amides The invention relates to the manufacture of amide compounds provided through the reaction of nitrile compounds and a sulfate compound to form the related amide compound. In a preferred embodiment a...
28	6423748	Amido polybiguanides and the use thereof as antimicrobial agents Amido polybiguanides and their use as antimicrobial agents in pharmaceutical compositions are disclosed. A method of synthesis of amido polybiguanides is also disclosed. The amido polybiguanides...
29	6403649	Non-acidic cyclopentane heptanoic acid,2-cycloalkyl or arylalkyl derivatives as therapeutic agents The present invention provides cydopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH...
30	6395787	Ocular hypotensive lipids Compounds of Formula 1, where the symbols are as defined in the specification, are useful as ocular hypotensive agents but do not exert their activity through the FP prostaglandin receptor. In...
31	6316669	Bis-amido polybiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions Bis-amido polybiguanides and their use as antimicrobial agents in pharmaceutical compositions are disclosed. A method of synthesis of bis-amido polybiguanides is also disclosed. The bis-amido...
32	6303658	Cyclopentane heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxy-cyclopentyl(enyl)] heptanoic or heptenoic acids and derivatives of said acids,...
33	6235789	Benzocycloalkene compounds, their production and use A compound of the formula ##STR1##wherein R1 and R2 are H, a hydrocarbon group or a heterocyclic group, or R1 and R2 are combinedly a spiro ring; R3 is a hydrocarbon group, a substituted amino...
34	6235780	ω-cycloalkyl-prostaglandin E1 derivatives
35	6194611	N-sulphonyl and N-sulphinyl amino acid derivatives as microbicides α-Amino acid amides of formula (I) wherein the substituents are defined as follows: n is the number zero or one; R1 to R7 are as herein defined; R8 is C1 -C6 alkyl, C3 -C6 alkenyl or C3 -C6 ...
36	6162923	Process for the preparation of imidazolones The present invention relates to a process for the preparation of a compound of general formula (I), ##STR1## wherein R1 represents a hydrogen atom or an alkyl group of 1-6 carbon atoms, and their...
37	6124277	Antithrombotic agents This invention relates to peptide derivatives, pharmaceutical formulations containing those compound and methods of their use as thrombin inhibitors.
38	6037361	Fluorinated butyric acids and their derivatives as inhibitors of matrix metalloproteinases Fluorinated butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix...
39	6028112	Spirocyclopropyl fluorenes as melatonergic agents There is provided novel spirocyclopropyl fluorene derivatives having the general Formula I ##STR1## wherein R, R1 and X are as defined herein which are useful as melatonergic agents.
40	5994562	Preparation of N-alkenylcarboxamides In a process for preparing N-alkenylcarboxamides by dehydration of N-(2-hydroxyalkyl)carboxamides and/or diethers thereof in the presence of a catalyst, molecular sieves, in particular zeolites,...
41	5959023	Moisture-crosslinking PU hot-melt adhesives Moisture-crosslinking PU hot-melt adhesives produced by reacting an --NCO containing prepolymer and a sterically hindered polyamine which have a very high initial strength.
42	5939554	Diarylaminopropanediol and diarylmethyl-oxazolidinone compounds A method for preparing a diarylalanine compound is provided. The method includes reacting a diarylaminopropanediol with a reducing agent to form a diarylaminopropanol compound and/or contacting a...
43	5935988	Tolerability of pharmaceutically active β-amino acids The present invention relates to mixtures of α-amino acids and/or derivatives thereof and cyclopentane-β-amino acids and/or derivatives thereof, dipeptides of the abovementioned α-amino acids an...
44	5925770	Certain fused pyrrolecarboxanilides; a new class of gaba brain receptor ligands The present invention encompasses structures of the formula: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## wherein: W represents substituted or unsubstituted...
45	5925674	Cycloalkylcarboxanilides This invention relates to cycloalkylcarboxanilides of the formula ##STR1## which are used to combat pests.
46	5889031	N-acyl-2-aryl cyclopropylmethylamine derivatives as melatonergics Certain N-acyl 2-aryl cyclopropylmethylamine derivatives are useful as melatonergic agents.
47	5886223	Process for the preparation of substituted β-ketoanilide compounds There is provided a process for the preparation of substituted β-ketoanilide compounds having the structural formula I ##STR1## The substituted β-ketoanilide compounds are useful for the control o...
48	5783712	Vinyl ether compounds having additional functional groups other than vinyl ether groups and the use thereof in the formulation of curable compositions The invention relates to compounds having at least one vinyl ether group which also contain in the molecule at least one further functional group selected from acrylate, methacrylate, epoxy,...
49	5780512	Alkylated (hetero) cyclic compounds The invention relates to a compounds selected from these of formula (I): ##STR1## in which: R1, R2, R3 and A are as defined in the description, and a medicinal product containing the same useful...
50	5777138	Ring-opening amidation process A process for amidating a 2-azabicyclo 2.2.1!heptan-3-one or a 2-azabicyclo 2.2.1!hept-5-en-3-one by reaction with an amine, to form the corresponding ring-opened amide, is modified by the addition...

Matches 1 - 50 out of 258

1 2 3 4 5 6 >