Patents in Class 564/171

Matches 1 - 50 out of 303

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Match	Document	Document Title
1	7605288	Heat shock protein 90 inhibitors Novel compounds useful for inhibiting the 90 kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol.
2	RE40259	Alpha-aminoamide derivatives useful as analgesic agents The present invention relates to novel and known alpha-aminoamide compounds, to a process for their preparation, to pharmaceutical composition containing them and to their use as therapeutic...
3	7312368	Method for selective reduction of aromatic compounds A method for the selective reduction of an aromatic compound. The present invention provides a method for pre-venting the reduction of at least one halogen substituted aromatic ring of an aromatic...
4	7265245	Compounds useful for the treatment of diseases associated with the formation of amyloid fibrils The present invention provides new amyloidogenesis inhibiting compounds of formula (I): in which R 1 is a —NR a R b group, where R a and R b , independently, are a hydrogen atom or...
5	7253318	Benzyloxy derivatives as MAOB inhibitors The invention relates to compounds of the formula and their pharmaceutically acceptable salts wherein R 1 , R 2 , R 3 , R 4 , R 5 , n, m, and o are as defined in the specification. The...
6	7223888	Mu opioid receptor ligands: methods of use and synthesis Novel compounds and compositions including those compounds, as well as methods of using and making the compounds are herein described. The compounds are useful in therapeutic applications,...
7	7208630	Heat shock protein 90 inhibitors Novel compounds useful for inhibiting the 90 kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol.
8	7196119	Development of new selective estrogen receptor modulators The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen...
9	7138546	Compounds and compositions for delivering active agents Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
10	7053071	Induction of apoptosis in cancer cells The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical...
11	7045660	Compounds as PDE IV and TNF-inhibitors This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for...
12	6951884	Fluorobenzamides and uses thereof The invention relates to fluorobenzamide derivatives of the formula wherein R 1 , R 2 , R 3 R 4 , R 5 , R 6 and R 7 are as defined herein. =, The compounds of the invention are selective...
13	6900354	3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives The invention relates to 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives, for example, deriviatives of the formula wherein A is selected from R 1 , R 3 , R...
14	6777442	Diphenyl derivatives The present invention relates to compounds of the general formula (I) in which X represents O, S, SO, SO 2 , CH 2 , CHF, CF 2 or NR 8 , and Z represents a group of the formula in which A...
15	RE38506	Potent inducers of terminal differentiation and methods of use thereof The present invention provides the compound having the structure: wherein each of R 1 and R 2 are independently the same as or different from each other; when R 1 and R 2 are the same, each...
16	6703421	Methods of using phenylmethylbenzoquinone and hydroquinone compounds for treatment of myocarditis, dilated cardiomyopathy and heart failure A method for prevention or treating myocarditis, dilated cardiomyopathy and heart failure comprising administering to a patient in need of such treatment a NF-κB inhibitor in a therapeutically...
17	6693208	Compounds and compositions for delivering active agents Amino acid derivative as carrier compounds and compositions which are useful in the delivery of active agents are provided. The active agents can be a peptide, mucopolysaccharide, carbohydrate, or...
18	6610883	Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X...
19	6586475	β-amyloid protein production/secretion inhibitors A compound of the formula: wherein Ar is an aromatic group; X and Y are a bivalent group selected from —O—, —S—, —CO—, —SO 2 —, —NR 8 —, —CONR 8 —, SO 2 NR 8 and...
20	6576632	Biaryl compounds useful as anticancer agents The present invention relates to compounds of formula I and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 10 , R 11 , b, m, n, p...
21	6521663	Aminoguanidinyl- and Alkoxyguanidinyl-substituted phenyl acetamides as protease inhibitors Phenyl acetamide compounds are described, including compounds of Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R 3 -R 6 , R 11 , B, Y and W are set forth...
22	6403649	Non-acidic cyclopentane heptanoic acid,2-cycloalkyl or arylalkyl derivatives as therapeutic agents The present invention provides cydopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH...
23	6395787	Ocular hypotensive lipids Compounds of Formula 1, where the symbols are as defined in the specification, are useful as ocular hypotensive agents but do not exert their activity through the FP prostaglandin receptor. In...
24	6207852	Smooth muscle spasmolytic agents, compositions and methods of use thereof The present invention relates to smooth muscle spasmolytic agents, pharmaceutical compositions containing them and method of using said compounds and compositions for the treatment of urinary...
25	6121255	Phloroglucide derivatives and their pharmceutical use A phloroglucide derivative having the following formula: ##STR1## wherein Q is halogen; X is CH 2 or CO; Y is cephalosporin having a formula of ##STR2## wherein Ph is phenyl, Ac is acetoxy, or...
26	6083987	Phenylenediamine derivative, radical scavenger, brain-infarction depressant, and brain-edema depressant A phenylenediamine derivative or a salt thereof in accordance with the present invention is expressed by the following formula 1: ##STR1## wherein A represents a group expressed by --CO--, --CH 2 ...
27	6057342	Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof,...
28	6013827	Compounds This invention relates to componds of formula I ##STR1## which are useful as PDE IV inhibitors and for treating diseases related thereto.
29	5948418	Sulfur-based amides and bis-amides useful against skin disorders Novel sulfhydryl group-containing amides and disulfide group-containing bis-amides useful for treating or preventing an abnormal biological condition or a disease, and/or improving the texture or...
30	5945557	Benzyloxy substituted aromatics and their use as fungicides and insecticides Compounds with fungicidal and insecticidal properties having formula ##STR1## wherein A is N or CH; V is O or NH; m and n are the integers 0 and 1, provided that m+n is 0 or 1; X is independently...
31	5945454	2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives Novel 2(4-substituted)-benzylamino-2-methyl-propanamides compounds, having CNS activity, of general formula (I) wherein: n is zero, 1, 2 or 3; X is --O--, --S--, --CH 2 -- or --NH--; each of R and...
32	5935978	Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also...
33	5925646	Heterocyclic aryl-, alkyl- and cycloalkylacetamides The heterocyclic aryl-, alkyl- and cycloalkylacetamides are prepared by reacting the appropriately substituted acetic acids with amines, if appropriate in complexed form. The heterocyclic aryl-,...
34	5916922	Phenyl glyoxamides as SPLA2 inhibitors A class of novel phenyl glyoxamides is disclosed together with the use of such compounds for inhibiting sPLA 2 mediated release of fatty acids for treatment of conditions such as septic shock.
35	5900432	Therapeutic N-(4-benzoyl-2-methyl-phenyl)-3,3,3-trifluoro-2-hydroxy-2-methyl-propana mides Compounds of formula I: ##STR1## wherein, ring C, A--B, R 1 , n, R 2 , and R 3 have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful in the...
36	5880156	Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical or diagnostic, and pharmaceutical containing them Benzoylguanidines of the formula I ##STR1## are...
37	5827891	HIV protease inhibtors HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These...
38	5783602	Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents The invention relates to leukotriene-B 4 derivatives of general formula I, ##STR1## in which R 1 represents CH 2 OH, CH 3 , CF 3 COOR 4 CONR 5 R 6 , and R 3 symbolizes H; C 1 -C 14 ...
39	5763610	Composition and processes for treating subterranean formations A composition comprising a nitrogen-containing olefinic compound and a process for using the nitrogen-containing olefinic compound to produce a water-soluble polymer which has applications in a...
40	5753715	2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents The invention relates to cyclohexenyl antibacterial compounds of the formula I: ##STR1## and pharmaceutical compositions containing the compounds, methods for their production and use.
41	5750784	Method for effecting vasodilation with (1,5-inter) aryl prostaglandin derivatives The present invention provides a method of effecting vasodilation, comprising: administering to a warm blooded animal in need of such treatment, an effective amount of a (1,5-inter) aryl...
42	5747539	Fluorine-containing benzoylguanidines Fluorine-containing benzoylguanidines of the formula I ##STR1## in which R 1 , R 2 and R 3 have the meanings indicated, and their physiologically acceptable salts, have antiarrhythmic properties...
43	5728737	N-alkoxy-amidine derivatives The present invention relates to novel N-alkoxy-arnidine derivatives of the formula (I), to a process for their preparation and to their use as pesticides. In addition, the invention also relates...
44	5721276	Arylalkyl(thio)carboxamides The invention relates to a compound selected from those of formula (I): ##STR1## in which A, B, X and R 1 are as defined in the description, and medicinal product containing the same useful for...
45	5693611	Cyclic peptide antifungal agents Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I ##STR1## wherein: R', R", R'", R x1 , R x2 , R y1 , R y2 , R y3 , R...
46	5677303	Enolethers and their use as a fungicide Enolethers and thioenolethers of formula I ##STR1## are disclosed. The compounds are useful for combatting phytopathogenic fungi.
47	5559134	Leukotriene-B.sub.4 antagonists, process for their production and their use as pharmaceutical agents The invention relates to leukotriene-B 4 antagonists of formula I ##STR1## in which n represents a whole number from 2 to 5, X represents a direct bond, 1 to 6 methylene units, an ortho-, meta-...
48	5514719	Fungicidal phenylbenzamides The invention provides agriculturally useful fungicidal phenylbenzamides of the formula ##STR1## wherein R 1 and R 2 , which are identical or different, are each a hydrogen or halogen atom or an...
49	5498795	Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity Compounds of the formula ##STR1## wherein R 1 -R 3 and R 5 independently are hydrogen, lower alkyl of 1 to 6 carbons, branched chain alkyl or cycloalkyl of 3 to 15 carbons, lower alkyl...
50	5498792	Process of producing N-alkylacetamides There is disclosed a process of producing an N-alkylacetamide of the general formula (III): ##STR1## wherein X 1 , X 2 and X 3 are the same or different and are independently hydrogen, lower...

Matches 1 - 50 out of 303

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