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7632850 |
Arylalkylcarbamate derivatives and production thereof
The present invention provides a compound of the formula (I):
in which R 1 , R 2 , R 3 , A and n are described and set forth more fully herein. Also provided are their preparation and their...
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7605288 |
Heat shock protein 90 inhibitors
Novel compounds useful for inhibiting the 90 kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol.
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7476763 |
Oxo-substituted cyclohexyl-1,4-diamine compounds
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I:
methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
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7442830 |
Proteasome inhibitors
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of...
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7348322 |
Glucocorticoid receptor modulators as antiinflammatory agents
The present invention relates to compounds of formula I:
wherein A, X, R 1 , R 2 and R 3 are as defined herein and pharmaceutically acceptable salts thereof. The invention also relates to...
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7326813 |
Process for producing benzylamine derivative
Disclosed is a process for producing a benzylamine derivative represented by the general formula (3):
wherein X 1 , R 1 and R 2 are as defined below, which comprises reacting a benzyl...
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7300948 |
Alkynyl compounds as non nucleoside reverse transcriptase inhibitors
Inhibitors of HIV reverse transcriptase which are useful for the treatment of HIV infection. Exemplars of the invention are compounds of the formula
wherein the substituents are as defined in...
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7297818 |
Adamantane derivatives
The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions,...
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7291752 |
Production method of β-amino acid
A production method of an optically active β-amino acid represented by the formula (I)
wherein each symbol is as defined in the specification, which includes reacting a compound represented by...
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7273863 |
Benzophenones as inhibitors of reverse transcriptase
The present invention includes benzophenone compounds (I)
which are useful in the treatment of HIV infections.
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7256307 |
Substituted phenypropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor α(PPAR)
The present invention provides the S enantiomer of a compound of formula (I); wherein R 1 represents 2,4-difluorophenyl or cyclohexyl as well as pharmaceutically acceptable salts, solvates,...
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7235692 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Adamantane derivatives
The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions,...
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7208630 |
Heat shock protein 90 inhibitors
Novel compounds useful for inhibiting the 90 kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol.
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7179942 |
Halo-substituted active methylene compounds
In one aspect, the invention provides a process for the preparation of a compound of Formula I
wherein G is alkyl or aryl, by employing a novel halo-substituted active methylene compound of...
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7166744 |
Retinoid derivatives and methods for producing said compounds and anti-cancer pharmaceutical composition comprising said compounds
The present invention relates to a novel retinoid derivative compound represented by the formula I:
wherein X, R 1 , R 2 and R 3 are as defined herein or pharmaceutically acceptalbe salts...
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7135587 |
Urea and urethane derivatives as integrin inhibitors
Novel urea and urethane derivatives of general formula (I) in which R1, R2, R3, R5, R5′, X, Y, B, m, n and o are as defined in Patent Claim 1 , and physiologically acceptable salts or solvates...
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7087604 |
Cyclic derivatives as modulators of chemokine receptor activity
The present application describes modulators of MCP-1 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis,...
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7067543 |
Anthranilic acid amides and pharmaceutical use thereof
The invention relates to anthranilic acid amide derivatives of formula (I), wherein Ar is represented by the subformula (I a ), wherein R a represents H or lower alkyl, and R 1 represents H or...
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7049271 |
Phenyl-substituted 2-enamino-ketonitriles
The present invention relates to novel phenyl-substituted 2-enamino-ketonitriles of the formula (I):
in which
Ar, X, Z, Y and K are each as defined in the description,
to a plurality of...
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7045139 |
Process for manufacture of quaternary ammonium tosylate salts of cinnamidoalkylamines and/or benzamidoalkylamines
An efficient, simple, high yielding, eco-friendly process for the manufacture of tosylates quaternary ammonium salts of cinnamidoalkylamines and/or benzamidoalkylamines (Formula I) has been...
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6958417 |
Process for preparing zolpidem
A process for preparing a compound of formula (II)
wherein
R 1 denotes bromine,
wherein,
a compound of formula (IV)
is reacted with elemental bromine in a diluent.
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6919377 |
Cyclohexylamine derivative as subtype selective NMDA receptor antagonists
Described are compounds of Formula I and Formula II and their pharmaceutically acceptable salts. The compounds of Formulas I and II are antagonists of NMDA receptor channel complexes useful for...
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6867310 |
Arylation and vinylation of activated carbons
The present invention provides transition-metal-catalyst-based methods for the arylation and vinylation of activated methyl, methylene, and methine carbons with aryl halides, vinyl halides, and the...
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6849757 |
Antiangiogenic drug to treat cancer, arthritis and retinopathy
Compounds having Formula I
or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The...
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6831197 |
Methods for producing 2-(2-hydroxyphenyl)-2-(alkoxyimino)-N-methylacetamide derivatives
The present application relates to a plurality of novel processes for preparing 2-(2-hydroxyphenyl)-2-(alkoxyimino)-N-methylacetamide derivatives, to novel intermediates for their preparation, and...
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6777442 |
Diphenyl derivatives
The present invention relates to compounds of the general formula (I) in which X represents O, S, SO, SO 2 , CH 2 , CHF, CF 2 or NR 8 , and Z represents a group of the formula in which A...
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RE38506 |
Potent inducers of terminal differentiation and methods of use thereof
The present invention provides the compound having the structure: wherein each of R 1 and R 2 are independently the same as or different from each other; when R 1 and R 2 are the same, each...
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6710056 |
Amidinophenylpyruvic acid derivatives
An amidinophenylpyruvic acid derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an excellent antagonistic effect against activated blood...
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6703421 |
Methods of using phenylmethylbenzoquinone and hydroquinone compounds for treatment of myocarditis, dilated cardiomyopathy and heart failure
A method for prevention or treating myocarditis, dilated cardiomyopathy and heart failure comprising administering to a patient in need of such treatment a NF-κB inhibitor in a therapeutically...
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6699463 |
Photostable cationic organic sunscreen compounds with antioxidant properties and compositions obtained therefrom
Compounds of Formula I Each R is independently linear or branched C 1 to C 8 alkyl, or linear or branched C 1 to C 8 alkoxy or one R is H and the other R is linear or branched C 1 to C 8 ...
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6696605 |
Process for preparing α-hydroxyamides and α-ketoamides on a solid phase support
The present invention relates to a process for preparing a α-hydroxyamide or α-ketoamide, said process comprising the steps of: a) reacting a resin which comprises a polymer-supported isocyanide...
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6686503 |
Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries
The invention relates to methods of synthesizing libraries of diverse and complex highly substituted 2,4-dioxopiperidine compounds of the general formula: wherein R 1 , R 2 and R 3 are as...
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6653309 |
Inhibitors of IMPDH enzyme technical field of the invention
The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions...
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6653321 |
Naphthylsulfonic acids and related compounds as glucose uptake agonists
Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or...
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6642417 |
Photocleavable and acid cleavable linkers for combinatorial chemistry
A substrate for solid phase synthesis comprising a solid phase-linker combination of the formula I is disclosed. Also disclosed are processes for preparing the substrate and chemical intermediates...
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6624184 |
Amide and diamide inhibitors of IMPDH enzyme for use in treating IMPDH-associated disorders
The present invention discloses the identification of the inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful...
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6613340 |
Substantive hydrophobic cationic UV-absorbing compounds
Substantive UV absorbing organic-soluble quaternary salts of cinnamidoalkylamine are described. Hair, skin and fabric care compositions containing the compounds of formula I. wherein R 1 is a...
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6576664 |
Inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis
This invention relates to molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of...
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6566394 |
Salicylamide derivatives
Salicylamide derivatives represented by formulae ( 1 a ) and ( 1 b ); intermediates in the production thereof; a process for producing the same; and drugs containing the same as the active...
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6472435 |
Anti-tumor agents
The invention concerns anti-tumor agents of formula (I), wherein each of R 1 , R 2 and R 3 has the meanings defined in the specification including hydrogen, (1-4C)alkyl, (3-4C)alkynyl and...
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6441233 |
Process for the preparation of aromatic carboxylic acid amides
A process for the preparation of primary aromatic carboxamides by the carbonylation of an aromatic compound, which contains at least one leaving group, with carbon monoxide, in the presence of a...
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6407288 |
Naphthylsalicylanilides as antimicrobial and antiinflammatory agents
The present invention discloses novel naphthylsalicylanilides of the general formula wherein W is a substituted or unsubstituted naphthyl ring. The substitution on W includes replacing one or...
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6391175 |
Carbonate ionophore with improved selectivity
The invention pertains to a novel ionophore having the general structure: wherein R 1 , R 2 , R 3 and R 4 are independently straight or branched chain alkyl having 4 to 12 carbon atoms or the...
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6369226 |
Substituted benzamide inhibitors of rhinovirus 3C protease
Nonpeptide benzamide-containing inhibitors of human rhinovirus (HRV) 3C protease are described.
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6339082 |
Tricyclic compounds, preparation method and said method intermediates, application as medicines and pharmaceutical compositions containing same
A compound selected from the group consisting of a compound of the formula wherein the substituents are defined as set forth in the specification and its salts with non-toxic pharmaceutically...
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6310245 |
3-aminocarbonyl/3-aminothiocarbonyl-substituted 2-benzoyl-cyclohexan-1,3-diones with herbicidal effect
The invention relates to 2-benzoylcyclohexane-1,3-diones of the formula I ##STR1## where R 1 , R 2 are hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl,...
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6303350 |
Physiologically active substances TKR2449, process for producing the same, and microorganism
The present invention has for its object to provide novel biologically active substances which is of value as a therapeutic agent for fungal infections and immune disorders. This invention is...
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6288265 |
Phloroglucidic acid and derivatives as antibacterial agents
A series of phloroglucide derivatives are synthesized, which possess potent antibacterial activities. They include unsymmetrical phloroglucide analogs, phloroglucides attached to cephalosporins at...
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6251917 |
Benzamidoaldehydes and their use as cysteine protease inhibitors
Compounds of the formula ##STR1## where R 1 , R 2 , R 3 , X and n are as defined in the description, are inhibitors of cysteine protease.
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6239179 |
N-aminoalkyl-2-anthracenecarboxamides; new dopamine receptor subtype specific ligands
Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are the same or...
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