|
Match
|
Document |
Document Title |
|
|
7632850 |
Arylalkylcarbamate derivatives and production thereof
The present invention provides a compound of the formula (I):
in which R 1 , R 2 , R 3 , A and n are described and set forth more fully herein. Also provided are their preparation and their...
|
|
|
7629493 |
Process for the crystallisation of guandinium salts
The invention relates to a process for the crystallization of the compounds of the formula (I) or acid-addition salts thereof, in which R 1 , R 2 and R 3 have the meaning indicated in Claim 1 .
|
|
|
7598419 |
Compounds for modulating cell proliferation
Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.
|
|
|
7592485 |
Process for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane hydrochloride
The present invention provides a process for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropan
e or hydrochloride thereof, which comprises a step of reacting...
|
|
|
7553969 |
Substituted phenethylamine derivatives
Substituted phenethylamine compounds of Formula (1) that function as motilin receptor antagonists: Formula (1).
|
|
|
7449315 |
Bifunctional energy-reversible acyl-compositions
Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include:
|
|
|
7423154 |
Asymmetric process for the preparation of diarylethylpiperazines derivatives and novel asymmetric diarylmethylamines as intermediates
An asymmetric synthesis of diarylmethylpiperazines is described. The synthetic route enables preparation of a variety of enatiomerically pure amines with different N-alkyl groups. The invention...
|
|
|
7390923 |
Propionamide derivatives useful as androgen receptor modulators
Compounds of formula (I)
wherein R1 to R4, X and A are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess...
|
|
|
7390925 |
Oxime-containing acyl guanidines as beta-secretase inhibitors
There is provided a series of substituted oxime-containing acyl guanidines of Formula (I)
or a stereoisomer; or a nontoxic pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R...
|
|
|
RE40259 |
Alpha-aminoamide derivatives useful as analgesic agents
The present invention relates to novel and known alpha-aminoamide compounds, to a process for their preparation, to pharmaceutical composition containing them and to their use as therapeutic...
|
|
|
7282608 |
Inhibitors of histone deacetylase
The invention provides compoods and methods for treating cell proliferative-diseases. The invention provides new inhibitors of histone deacetylase enzymatic activity, compositions of the compounds...
|
|
|
7268147 |
Compounds useful for the treatment of diseases
The invention relates to compounds of formula (1)
and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
|
|
|
7265220 |
Amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative
Compound of formula (I):
wherein:
R 1 represents aryl, heteroaryl or alkyl which is optionally substituted, or a group of formula —(CO)—CR 6 R 7 NR 8 R 9 wherein R 6 , R 7 , R 8 and R 9...
|
|
|
7247748 |
Amide compounds and methods of using the same
Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as...
|
|
|
7244866 |
Carboxamido opioid compounds
This invention is directed to carboxamido opioid compounds pharmaceutically useful as agents for treating or modulating a central nervous system disorder and methods for treating or modulating a...
|
|
|
7227038 |
Adamantane derivatives, processes for their preparation and pharmaceutical composition containing them
The invention provides compounds of formula
in which m, n, R 1 , R 2 , R 3 , R 4 , and R 5 , have the meanings defined in the specification; processes for their preparation; pharmaceutical...
|
|
|
7151195 |
Phthalamide derivative, agricultural or horticultural insecticide, and method of use thereof
The present invention relates to a phthalamide derivative represented by the general formula (I):
wherein R 1 , R 2 , R 3 , X, Y, m, and n are as defined in the disclosure, which can be used as...
|
|
|
7144881 |
Arylcyclopropylcarboxylic amides as potassium channel openers
The present invention provides novel arylcyclopropylcarboxylic amides and related derivatives having the general Formula I
wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined...
|
|
|
7132457 |
Adamantane derivatives
The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions,...
|
|
|
7132455 |
Phthalamide derivatives
This invention relates to novel phthalamide derivatives of formula (I)
wherein R 1 , R 2 , R 3 , R 4 , and R 5 have the meanings given in the disclosure, to processes for their...
|
|
|
7053211 |
Process for the preparation of α-aminosubstituted carboxylic acid amides
The invention relates to a process for the preparation of α-aminosubstituted carboxylic acid amide compounds and/or their salts comprising reacting a carboxylic acid amide of a primary amine with...
|
|
|
7049271 |
Phenyl-substituted 2-enamino-ketonitriles
The present invention relates to novel phenyl-substituted 2-enamino-ketonitriles of the formula (I):
in which
Ar, X, Z, Y and K are each as defined in the description,
to a plurality of...
|
|
|
7041844 |
Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
The present invention relates to an antiandrogen compound and a method of treating prostate cancer in a patient utilizing the compound. The present invention also relates to a pharmaceutical...
|
|
|
7005546 |
Acetamidobenzamide compounds for neurodegenerative disorders
A group of benzamide compounds are disclosed which are useful for treating neurodegenerative disorders. Methods for making these compounds are provided. These materials are formed into...
|
|
|
6995269 |
Guanidinobenzamides
Compounds of formula IIA and IIB are novel guanidine compounds
where the variables R 1 through R 10 have the values set forth herein. Such compounds have use in treating diseases such as...
|
|
|
6995284 |
Synthesis of selective androgen receptor modulators
The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a...
|
|
|
6949658 |
Process for producing optically active α-amino acid and optically active α-amino acid amide
The present invention provides a process for efficiently producing an optically active α-amino acid and an optically active α-amino acid amide. After contacting with cells or processed cells...
|
|
|
6946489 |
Substituted biphenyl derivatives
The invention relates to compounds of the formula I
in which R 1 , R 2 , R 3 , R 4 and X have the meaning indicated in the text. The compounds act as inhibitors of factors Xa and VIIa and can...
|
|
|
6924391 |
Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors
Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general...
|
|
|
6921774 |
Compounds and their use as glycine transport inhibitors
The invention provides novel compounds of the formula I below:
wherein the meaning of each substituent is defined in the application. The compounds are useful as inhibitors of the glycine...
|
|
|
6846955 |
Process for racemising an enantiomer-enriched schiff base of an amino acid amide
The invention relates to a process for racemising an enantiomer-enriched Schiff base of a primary amino acid amide with a strong base that is chemically reactive towards water. The reaction is...
|
|
|
6831197 |
Methods for producing 2-(2-hydroxyphenyl)-2-(alkoxyimino)-N-methylacetamide derivatives
The present application relates to a plurality of novel processes for preparing 2-(2-hydroxyphenyl)-2-(alkoxyimino)-N-methylacetamide derivatives, to novel intermediates for their preparation, and...
|
|
|
6803378 |
HIV integrase inhibitors
Novel diketoacid compounds of Formula I are provided which are useful as HIV integrase inhibitors and for the treatment of AIDS or ARC.
|
|
|
6794542 |
Method for the preparation of enantiomerically enriched compounds
Process for the preparation of a diasteromerically enriched phenylglycine amide derivative in which an enantiomerically enriched phenylglycine amide is converted into the corresponding Schiff base...
|
|
|
6787670 |
Glyoxyl acid amides, method for producing them and their use for controlling harmful organisms
The invention relates to novel gloyoxylic acid amides, to a process for their preparation and to their use for controlling harmful organisms.
|
|
|
6780995 |
Activated iododerivatives for the treatment of cancer and aids
A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an...
|
|
|
6774116 |
Prodrugs via acylation with cinnamate
A prodrug composition containing a cinnamate moiety and a biologically active molecule moiety which can be released by hydrolysis or activated by light is disclosed. The cinnamate moiety can have...
|
|
|
6770778 |
N-(4-substituted phenyl)-anthranilic acid hydroxamate esters
The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions, and methods of use thereof.
|
|
|
6730705 |
Alkoximino acetic acid amides
The invention relates to new alkoximinoacetic acid amides, a process for their preparation and their use as agents for combating pests.
|
|
|
6706765 |
Aminoguanidines and alkoxyguanidines as protease inhibitors
Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR 9 and R 1 -R 4 , R 6 -R 9 , R 11 , R 12 , R a , R b , R c , Y, Z, n and m are set forth in...
|
|
|
6699463 |
Photostable cationic organic sunscreen compounds with antioxidant properties and compositions obtained therefrom
Compounds of Formula I Each R is independently linear or branched C 1 to C 8 alkyl, or linear or branched C 1 to C 8 alkoxy or one R is H and the other R is linear or branched C 1 to C 8 ...
|
|
|
6673794 |
Substituted aminomethyl-phenyl-cyclohexane derivatives
A substituted aminomethyl-phenyl-cyclohexane derivative of formula I or Ia, and their a diastereomer, enantiomer, or of a salt formed with a physiologically tolerated acid. Also disclosed are...
|
|
|
6646151 |
Process for the preparation of pesticides
The invention relates to a process for the preparation of compounds of the formula or, if appropriate, a tautomer thereof, in each case in the free form or in salt form, in which A, X, Y, Z, R 2...
|
|
|
6638980 |
Inhibitors of factor Xa
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating...
|
|
|
6620933 |
Azomethine yellow dye compound
A azomethine yellow dye compound of general formula (I): General formula (I) wherein R 1 and R 2 each independently represent a hydrogen atom or a substituent; R 3 represents a substituent; m...
|
|
|
6620960 |
Process for the preparation of substituted phenylacetonitriles
Disclosed is a process for the preparation of a compound of the formula (1) wherein R 1 is unsubstituted or substituted sing reacting a compound of the formula (2) with a compound of the formula...
|
|
|
6610886 |
Intermediate for preparing midodrine
The invention provides a process for the preparation of 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide of the formula 1 by hydrogenolysis of substituted...
|
|
|
6603043 |
Process for the preparation of (schiff bases of) α-alkyl-α-amino acid amides
Process for the preparation of a Schiff base of an α-alkyl-α-amino acid amide and an aldehyde, wherein the corresponding α-aminonitrile is contacted with a base and the aldehyde and wherein it...
|
|
|
6600072 |
Substituted 1-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic , and medicament containing them
Substituted 1-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them. Substituted 1-naphthoylguanidines of the formula I in...
|
|
|
6593312 |
Cyclic α-amino-&ggr -hydroxyamide compounds
A compound of formula (I): wherein: represents an optionally substituted saturated carbon ring having from 4 to 8 ring members, R 1 and R 4 , which may be identical or different, each...
|