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7629367 |
N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment...
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7612236 |
Method for producing optically active bisamidoalcohol compound
It is provided that a method for producing an optically active bisamidoalcohol compound represented by the formula (3):
wherein R 1 represents a C1-6 alkyl group, an optionally substituted...
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7601876 |
Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the...
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7601872 |
Transfection reagents
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure:
wherein
Q is selected from the group consisting...
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7598412 |
Modulators of ATP-binding cassette transporters
The present invention provides compounds of Formula I useful as modulators of ABC transporter activity,
or a pharmaceutically acceptable salt thereof, wherein R B , n, B, R C , R D , R E , A,...
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7547731 |
Formamide derivatives for the treatment of diseases
The invention relates to compounds of formula (1)
and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
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7482487 |
Phenylaminoethanol derivatives as β2 receptor agonists
The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The...
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7479571 |
Generation of combinatorial synthetic libraries and screening for novel proadhesins and nonadhesins
One aspect of the present invention relates to compounds, comprising at least two moieties selected from the group consisting of aryl sulfonates and aryl sulfates. A second aspect of the present...
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7470817 |
Transfection reagents
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure:
wherein
Q is selected from the group consisting...
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7459585 |
Benzene derivatives and pharmaceutical use thereof
The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory...
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7449493 |
Diamines as modulators of chemokine receptor activity
The present application describes modulators of MCP-1 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis,...
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7358383 |
Polyphenol proteasome inhibitors, synthesis, and methods of use
The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present...
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7351862 |
Alpha, omega-difunctional aldaramides
Alpha, omega-difunctional aldaramides, in particular diaminoaldaramides, dihydroxyaldaramides, bis(alkoxycarbonylalkyl)aldaramides, and bis(carboxyalkyl)aldaramides, and processes for preparing the...
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7348451 |
Additives for inhibiting gas hydrate formation
The invention provides the use of compounds of the formula (1)
where
R 1 , R 2 are each independently C 1 - to C 22 -alkyl, C 2 - to C 22 -alkenyl, C 6 - to C 30 -aryl or C 7 - to C 30...
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7238834 |
Piperidine derivatives and process for their production
The present invention relates to substantially pure piperidine derivative compounds of the formulae:
wherein
R 1 is hydrogen or hydroxy; R 2 is hydrogen; or R 1 and R 2 taken...
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7205437 |
Selective androgen receptor modulators
The present invention relates to androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity, which are nonsteroidal ligands for the androgen receptor. The...
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7183431 |
Dihydroxy aromatic compounds and methods for preparation
A dihydroxy aromatic compound having a Formula (I),
wherein R 1 is a C 6 –C 60 aromatic divalent functionality, R 2 at each occurrence, can be the same or different and is independently at...
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7129377 |
Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
The present invention relates to an androgen receptor alkylating compound, wherein the compound may include, inter alia, an active functional group, which permits the alkylation of the androgen...
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7078565 |
Benzamide derivatives as antagonists of orexin receptors
Disclosed are phenyl-alkylene benzamides useful as orexin antagonists
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7053245 |
N-acylamino benzyl ether derivatives
This invention relates to N-acylamino aryl derivatives of the formula
where
R 1 , R 21 , R 22 , R 23 , R 24 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R, and n are as defined herein and where X is...
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7045660 |
Compounds as PDE IV and TNF-inhibitors
This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for...
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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7030201 |
Bottom antireflective coatings
The present invention relates to bottom antireflective coating compositions and polymers useful in making such compositions.
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6995285 |
ABCA-1 elevating compounds
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in...
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6982348 |
Aminoethanol derivatives
The present invention provides a pharmaceutical agent having cholesteryl ester transfer protein inhibitory action and useful as a blood lipid lowering agent and the like. The present invention...
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6930203 |
Gelling agents or thickeners
The present invention relates to a novel class of gelling agents or thickeners, to a process for preparing gelling agents or thickeners and to their use to prepare the gels. The present gelling...
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6924392 |
Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them
Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic active compounds, for...
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6914160 |
Oxytocin inhibitors
This invention relates to compounds of formula (I)
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6903092 |
Naphthamide neurokinin antagonists for use as medicaments
Compounds having the general formula
wherein R 1 , R 2 , R 3 , R 4 , R 5 , X 1 and X 2 are as defined in the specification, methods of using such compounds for the treatment of diseases and...
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6836383 |
Diphenylsquarylium compound and filter for display containing the same
The object of the invention is to provide a diphenylsquarylium compound which has a sharp minimum value within the wavelength range of from 550 to 610 nm in the light transmittance curve and from...
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6828458 |
Topical antiandrogen for hair loss and other hyperandrogenic conditions
Compound (2-hydroxy-2-methyl-N-(4-X-3-(trifluoromethyl)phenyl)-3-(2,2
,2-perfluoroacylamino)propionamide) applied topically, specifically inhibits and/or eliminates cutaneous androgen receptors and...
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6821965 |
Amidobenzamide derivatives which are useful as cytokine inhibitors
The invention concerns amide derivatives of the Formula (I) wherein R 3 is (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy,...
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RE38551 |
Anticonvulsant enantiomeric amino acid derivatives
The present invention is directed to a compound in the R configuration about the asymmetric carbon in the following formula: pharmaceutical compositions containing same and the use thereof in...
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RE38506 |
Potent inducers of terminal differentiation and methods of use thereof
The present invention provides the compound having the structure: wherein each of R 1 and R 2 are independently the same as or different from each other; when R 1 and R 2 are the same, each...
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6696472 |
Substituted N-phenoxy-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6677359 |
N-substituted glycine derivatives
The present invention relates N-substituted glycine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising...
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6657083 |
5-acylamino-2-amino-4-substituted-phenol compounds and method of using them
Disclosed is a 2-amino-5-acylamino-4-substituted-phenol compound having the structural formula I: wherein Y is a substituent group, and R′ is a ballast group. Also disclosed is a simplified...
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6635786 |
Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use
Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as...
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6632836 |
Carbocyclic potassium channel inhibitors
The present invention relates to a class of carbocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like.
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6576642 |
Diamide compounds and compositions containing the same
Compounds having the formula (1): wherein A is a phenyl, naphthyl, dihydronaphthyindeny, pyridyl, indolyl,isoindolyl, quinolyl or isoquinolyl group which are optionally substituted; X is...
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6563002 |
Biscyclopropanecarboxamide compounds and pharmaceutical use thereof
The present invention discloses biscyclopropanecarboxamide compounds and pharmaceutically acceptable salts thereof; and also NF-kappa B activation inhibitors, Inflammatory cytokine production...
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6562963 |
Process for the preparation of macrocyclic metalloprotease inhibitors
The present invention is directed to a process for the preparation of a compound of formula (X-a) or a pharmaceutically acceptable salt form thereof, wherein: R 1 is selected from the group...
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6548703 |
Toning agent
A toning agent for an azo pigment, an azo pigment with a modified tone, and process for preparing the same are provide. 2-hydroxynaphthalene-3,6-dicarboxylic acid or a derivative thereof is admixed...
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6528655 |
Aromatic derivatives with HIV integrase inhibitory properties
A compound of formula I′ and pharmaceutically acceptable derivatives thereof including, for example, where applicable or appropriate pharmaceutically acceptable salts thereof. Ar and Ar′ are...
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6525219 |
4-amino-2-hydroxy-5-substituted-acylanilide compounds and method of using them
Disclosed is a 4-amino-2-hydroxy-5-substituted-acylanilide compound having the structural formula I: wherein R is hydrogen or an alkyl group, and Y is a substituent group linked to the rest of...
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6521607 |
(R)-chiral halogenated substituted N-phenoxy N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma...
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6492553 |
Methods for preparing N-&lsqb (aliphatic or aromatic)carbonyl)&rsqb -2-aminoaetamide compounds and for cyclizing such compounds
A method for preparing a N-[(aliphatic or aromatic)carbonyl)]-2-aminoacetamide compound, and for preparing a cyclized compound therefrom, as well as novel resin bound intermediate compounds that...
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6489364 |
Antiviral protease inhibitors
Compounds of formula (I), wherein A′ and A″ are independently the same or different group of formula (II) wherein: R′ is H, CH 3 , C(CH 3 ) 2 , —OR a , —N(R a ) 2 , —N(R a )OR a or...
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6444849 |
Amide derivatives
A compound represented by the following general formula (1); wherein X represents R 1 (R 2 )(R 3 )C— where R 1 represents a C 3 -C 8 cycloalkyl group, an optionally substituted C 6 -C 14 ...
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6420427 |
Aminobutyric acid derivatives
An aminobutyric acid derivative of the formula (I): (wherein all symbols are as defined in the specification) and salt thereof. salt thereof. The compounds of the formula (I) possess an...
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