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7572832 |
Non-hygroscopic L-carnitine salts
Stable and non-hygroscopic L-carnitine salts of organic acids are provided, each of which is present as a true complex salt, having the formula:
wherein Z is acetate, propionate, or butyrate....
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7563916 |
Process for producing an alcohol or a silyl ether thereof
A process for producing an alcohol or a silyl ether thereof of formula (4):
wherein R 1 represents a hydrocarbon, a heterocyclic, or an alkoxycarbonyl group; R 2 represents hydrogen or CO 2...
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7456216 |
Methods for the preparation and formulation of l-carnitine valproate salts
The present invention relates to methods for preparing an L-carnitine valproate salt and administering this compound to a subject in need of treatment with valproate. Pharmaceutical compositions...
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7420087 |
Method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof
The invention concerns a method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof of general formula (I), characterized in that it consists in reducing an...
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7371897 |
Preparation method for (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid
Provided is a novel preparation method of (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-hep
tenoic acid represented by the following formula (1), a key intermediate of cilastatin used as...
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7319164 |
5-azido-laevulinic acid, method for the production thereof and its use
The present invention relates to 5-azido levulinic acid, a process for its preparation, its use. Using 5-azido levulinic acid as starting material for the synthesis of 5-amino levulinic acid...
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7294742 |
Ring-opened azlactone initiators for atom transfer radical polymerization
Initiators for atom transfer radical polymerizations are described. The initiators have an azlactone or ring-opened azlactone moiety to provide telechelic (co)polymers.
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7268253 |
Process for preparing α, α-dialkyl-α-hydroxymethyl-carboxylic acid derivatives
The invention relates to a novel process for hydroxymethylating noncyclic α,α-dialkylcarboxylic acid derivatives with formaldehyde using amide bases at temperatures of from −40° C. up to the...
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7259273 |
Compositions containing lysophosphotidic acids which inhabit apoptosis and uses thereof
The invention provides anti-apoptotic compositions containing lysophosphatidic acids and methods for making and using the compositions. Such compositions may also contain LPA potentiating agents,...
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7205290 |
Diphenylazetidinone with improved physiological properties, process for its preparation, medicaments comprising this compound, and its use
The invention relates to the compound of the formula 1
and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.
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7186859 |
Uses for amino acid anticonvulsants
The present invention is directed to the use of compounds of the formula:
for treating pain, in particular neuropathic pain, bipolar disease and migraine headaches.
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7081535 |
Hydroxy-amino acids
Hydroxy-amino acids are provided and are prepared by contacting a substituted β-ketodiester having a ketone group and two ester functional groups with a ketoreductase under conditions permitting...
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7057066 |
Process for producing 3-amino-2-hydroxypropionic acid derivatives
The present invention provides a process for preparing 3-amino-2-hydroxypropionic acid derivatives (1) which does not use dangerous reagents, is economically advantageous, and is suitable for an...
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7002010 |
Process for the preparation of morpholinones as light stabilizers
The instant invention discloses a process for the preparation of compounds of the formula I:
wherein the general symbols are as defined in claim 1 , which process comprises reacting a...
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6949528 |
Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
The invention provides anti-apoptotic compositions lysophosphatidic acids and methods for making and using the compositions. Such compositions can also contain LPA potentiating agents, including...
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6822115 |
Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives are prepared using starting from aspartic acid with the same configuration as...
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6706923 |
Perfluoroalkyl-substituted amines, acids, amino acids and thioether acids
Perfluoroalkyl-substituted amines, acids, amino acids and thioether acid compounds containing a perfluoroalkyl-iodoalkyl or perfluoroalkyl-alkene group as well as derivatives thereof, are...
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6632921 |
Seryl-lysyl-based peptide and peptidomimetic inhibitors of N-myristoyl transferase as anti-infective agents
Seryl-lysyl-based peptide and peptidomimetic compounds are described as inhibitors of the enzyme N-myristoyl transferase to provide selective control of the fungal organism Candida albicans ....
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6627771 |
Gamma amino butyric and acid analogs
The instant invention is improved gamma amino butyric acid analogs, processes for their preparation, and methods of using them as agents for treating epilepsy and other neurodegenerative disorders,...
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6585987 |
Complexes of hyaluronic acid/carnitines and pharmaceutical and cosmetic compositions
Complexes of hyaluronic acid and carnitine of its derivatives and the simple combinations of them are useful in therapeutics and cosmetics. They have pharmacological activity, that is protective...
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6583317 |
Synthesis of acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters
A process of preparing an acid addition salt of delta-aminolevulinc acid comprising: a) dissolving a lower alkyl 5-bromolevulinate and hexamethylenetetramine in a solvent selected from the group...
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6566552 |
Industrial process for the production of L-carnitine
The present invention describes a process for the industrial production of L-carnitine, comprising the enantioselective reduction of an alkyl 4-chloro-3-oxobutyrate or 4-chloro-3-oxobutyramide. The...
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6548693 |
Nitriloxy derivatives of (R) and (S)-carnitine
Carnitine derivatives of formula (I) are described in racemic and/or optically active form, as well as the process for their preparation and their use as pharmaceutical anti-angina active...
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6541654 |
Process for making optically active α-amino ketones and selected novel optically active α-amino ketones
The invention includes selected novel optically active α-amino ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as...
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6515020 |
Combination of carnitines and resveratrol for prevention or treatment of cerebral and ageing disorders
A pharmaceutical product which comprises admixed or separately packaged (A) L-Carnitine or an alkanoyl L-canitine and (B) a trihydroxy- or tetrahydroxystilbene such as resveratrol is useful for the...
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6465515 |
Solid compositions suitable for oral administration containing non-hydroscopic salts of L-carnitine and alkanoyl L-carnitines
Non-hygrocopic salts of L-carnitine and of the lower alkanoyl L-carnitines with pamoic acid are described, which are used to prepare solid compositions suitable for oral administration. Solid...
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6462173 |
Inhibitors of phosphoserine and phosphothreonine-proline-specific isomerases
Inhibitors of phosphoserine- or posphothreonine-specific peptidyl prolyl isomerases are described. Such inhibitors include molecules that mimic the structure and conformation of the pSer/pThr-Pro...
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6448228 |
Dipeptide compounds having a high fungicidal activity and their agronomic use
The invention relates to dipeptide compounds having formula (I): The compounds having formula (I) have a high antifungal activity and are used for the control of phytopathogens in the agronomic...
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6441035 |
Heteroatom-interrupted analogs of 15-hydroxyeicosatetraenoic acid and methods of use
Heteroatom-interrupted HETE derivatives and methods of their use for treating dry eye are disclosed.
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6433223 |
Silver halide photographic material and hydroxamic acid-based compounds used therefor
A silver halide photographic material is described, which contains the compound represented by the following formula (I): wherein R 1 represents a substituted or unsubstituted alkylene group...
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6423869 |
Polyol-amino acid compounds having anti-helicobacter pylori activity
A compound of the formula (I): wherein R 1 represents an amino group which may be substituted; R 2 represents a carboxy group which may be esterified or amidated; R 3 , R 4 , R 5 and R 6 ...
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6420599 |
Chemical process for the stereoselective synthesis of R-(-)-carnitine
A process is described for the stereoselective synthesis of R-(−)-carnitine in which the characterizing step is condensation of glycerol with an amine of (−)camphorsulfonic acid.
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6346547 |
N-substituted amino acids, antioxidant pharmaceutical compositions containing n-substituted amino acids and methods for preventing cardiovascular diseases and/or preventing and/or treating antioxidant responsive diseases therewith
Low-toxicity, highly-bioavailable, pharmaceutical antioxidant compositions for preferred oral administration to mammals are provided which have at least one amino acid-based compound of the general...
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6342034 |
Process for the preparation of L-carnitine
A process for the preparation of L-carnitine using (S)-3-activated hydroxybutyrolactone as a raw material, which is subject to a ring-opening reaction, expoxydation where the chiral center is...
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6337349 |
Solid compositions suitable for oral administration comprising an alkanoyl-l-carnitine magnesium citrate
Solid and non hygroscopic salts consisting of lower alkanoyl L-carnitine magnesium citrates are disclosed which are suitable for preparing solid composition useful as dietary/nutritional...
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6335465 |
Sterilized 5-aminolevulinic acid
Colored 5-aminolevulinic acid crystals useful for photodynamic therapy Eire disclosed. Preferably the colored 5-aminolevulinic acid crystals have the color imparted by irradiation of the crystals,...
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6316667 |
Process for the preparation of R-(-)-carnitine
R-(-)-carnitine is prepared by (a) conversion of (S)-3-hydroxy-4-butyrolactone [1] to alkyl (S)-4-halogen-3-hydroxy-butyrate [2] by reaction with a linear or branched C 1 -C 7 alcohol (b),...
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6294692 |
Process for producing N-formylleucine of high purity
A process for producing N-formylleucine includes reacting leucine with formamide, precipitating the N-formylleucine, once the reaction is complete, at a temperature of approximately 0° to 40° C.,...
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6281379 |
Process for producing norstatin derivatives
This invention to provide a process for producing an optically active threo-phenylnorstatin derivative which does not require a toxic cyanating agent or a costly reagent, or a complicated...
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6271258 |
Process for the preparation of stable, non-hygroscopic salts of L(-)carnitine
An improved process for producing stable, non-hygroscopic salts of l(-)carnitine is disclosed, which comprises preparing at room temperature a pasty/semiliquid slurry of L(-)carnitine inner salt...
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6218536 |
1,2-bis-adducts of stable nitroxides with substituted ethylenes and stabilized compositions
1,2-Bis-adducts of stable hindered nitroxide compounds with substituted ethylenes are prepared by reacting two equivalents of nitroxyl compound with an ethylenically unsaturated compound such as...
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6211197 |
Prostaglandin receptor ligands
Compounds and methods for treating prostaglandin mediated diseases, and certain pharmaceutical compositions thereof are disclosed. The compounds are represented by formula II: Ar 1 --W--Ar 2 ...
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6207828 |
Process for making 2-(trihaloacetyl)-3-(substituted amino)-2-propenoates
This invention provides a convenient, new, one step process for the preparation of 2-(trihaloacetyl)-3-(substituted amino)-2-propenoates and related derivatives thereof by reaction of carbonyl...
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6130249 |
Solid compositions suitable for oral administration comprising L-carnitine and alkanoyl-L-carnitine magnesium tartrate
Stable and nonhygroscopic salts consisting of L-carnitine magnesium tartrate or lower alkanoyl-L-carnitine magnesium tartrate are disclosed that are suitable for preparing solid compositions useful...
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6071510 |
Modified amino acids and compositions comprising the same for delivering active agents
The present invention provides modified amino acids for delivering active agents, and particularly biologically or chemically active agents. The preferred modified amino acids of the present...
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6063955 |
Method for producing optically active erythro-3-amino-2-hydroxybutyric esters and acids thereof
A method for producing an optically active erythro-3-amino-2-hydroxybutyric ester as an important intermediate of pharmaceutical agents, specifically HIV protease inhibitor, in high purity and in...
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6020489 |
Cytoprotective fatty moiety compounds
Water or lipid soluble, pharmacologically active, antioxidant, anti-phospholipase compounds that are chemically defined. The compounds protect mammalian cells by inhibiting PLA 2 and preventing...
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6018050 |
Method of preparing optically active α-amino acids and α-amino acid derivatives
The invention relates to a new process for the preparation of optically active amino acids and amino acid derivatives of the general formula (I), wherein *, X and R 1 to R 4 have the meaning...
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6017426 |
Process for the preparation of ceramide-type compounds
A process for the preparation of ceramide-type compounds by reacting, an amino alcohol with a carboxylic acid of defined structures, where the reaction is conducted with irradiation with microwaves...
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6008188 |
Cytokine potentiator and pharmaceutical formulation for cytokine administration
A cytokine activity enhancer comprising an ethanolamine derivative of the following general formula (I) or a salt thereof, or comprising it along with cytokine or a cytokine production promoter;...
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