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7408079 Imaging agents and methods of imaging NAALADase or PSMA  
The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of...
7339077 Production process of dicreatine malate  
A process of producing dicreatine malate with high purity, includes the steps of providing a predetermined amount of malic acid, agitating a predetermined amount of anhydrous alcohol to the malic...
7314888 Compounds and medicinal use thereof  
A compound or a salt thereof having the atom corresponding to N 3 and the two or more atoms selected from N 1 , N 2 , N 4 and N 5 , said atoms constitute the pharmacophore represented by the...
7301051 Creatine salts and method of making same  
Disclosed are creatine salts having the general formula ##STR00001## wherein A is a member of a group consisting of an anion of ketoglutaric acid and succinic acid.
7129273 Dicreatine Malate  
This invention relates to a novel compound, dicreatine malate, comprising approximately two moles of creatine cations per one mole of malate anion. The creatine salt of this invention has been...
7128932 Formulations useful in the treatment of male and female impotence  
Disclosed are pharmaceutical compositions containing: extracts of Tribulus terrestris, Turnera diffusa and Cinnamon cassia in the weight ratio of 1.5–3.5:1–2:0.1–0.4 respectively; Ginkgo...
7109373 Creatine salts and method of making same  
Disclosed are creatine salts having the general formula wherein A represents an anion of a dicarboxylic acid, and a process of making such salts.
7026297 Neuroprotective agents  
Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); R a represents alkylene; R b and R c ...
6992067 Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use  
Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for...
6962905 Pharmaceutical formulation comprising a low molecular weight thrombin inhibitor and its prodrug  
A kit of parts containing (a) a pharmaceutical formulation including a low molecular weight thrombin inhibitor, or a pharmaceutically acceptable derivative thereof, in admixture with a...
6956131 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors  
The present invention is directed to a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R 2 is selected from the group consisting of H and methyl; and R 2 is...
6951889 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors  
The present invention relates to 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
6911470 Polyoxometalate compounds as antiviral agents  
Polyoxometalate compounds which exhibit anti-retroviral activity are disclosed. Compounds with anti-retroviral activity include those having the following general molecular formulas: ...
6828456 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors  
The present invention relates to 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
6797699 Neuroprotective agents  
Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); R a represents alkylene; R b and R c ...
6777391 Composition for an infant formula having a low threonine content  
A composition for an infant formula which comprises a low threonine content; a method of producing the composition; use of the composition in the manufacture of a medicament or nutritional product...
6759553 Process for the preparation of creatine or creatine monohydrate  
A process for the preparation of creatine or creatine monohydrate by reaction of sodium or potassium sarcosinate with cyanamide at a temperature from 20 to 150° C. and a pH from 7.0 to 14.0...
6756406 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors  
The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
6686345 DNA-cleaving antitumor agents  
A chemical composition and method of use of the composition is described. The chemical composition includes an aza-enediyne, aza-enyne allene, or an aza-diallene. These compound are preferably...
6653504 Non-hygroscopic salts of active ingredients having therapeutical and/or nutritional activities and orally administrable compositions containing same  
Derivatives of active ingredients with creatine and ornithine are disclosed having enhanced nutritional and/or therapeutic effects which favorably lend themselves to the preparation of orally...
6627769 RGD-analog non-peptidic molecules having anti-adhesive, anti-migration and anti-proliferative effects  
Novel molecules without intramolecular peptidic bonds, able to mimic the RGD peptide, containing ARG-GLY-ASP motif “arginine-glycine-aspartic acid” (that is a potent inhibitor, in vivo and in...
6586426 β-sheet mimetics and use thereof as protease inhibitors  
There are disclosed β-sheet mimetics and methods relating to the same for imparting or stabilizing the β-sheet structure of a peptide, protein or molecule. In one aspect, the β-sheet mimetics...
6524785 Perfusion and/or preservation and/or re-perfusion solution during organ transplant  
The invention concerns a perfusion and/or preservation and/or re-perfusion solution during organ transplant, in particular the cardiac organ, containing the following elements: K+ in the range of...
6514934 Imidazoline α-adrenergic receptor antagonist compounds in combination with nitric oxide donors, compositions and methods of use  
The present invention is directed to nitrosated or nitrosylated α-adrenergic receptor antagonists, compositions comprising α-adrenergic receptor antagonists that are optionally substituted with...
6509497 Process for preparing guanidine derivatives  
A process for preparing guanidine derivatives, in particular creatine, is described and entails continuously combining a cyanamide derivative and a primary or secondary amine in the presence of...
6465686 Halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors  
The present invention discloses halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
6465518 Halogenated 2-amino-4, 5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors  
The present invention contains halogenated 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
6399819 Process for purifying creatine  
A process for purifying creatine is described in which the creatine to be purified in the form free of water of crystallization is introduced into a saturated aqueous solution of creatine...
6329545 Aminoguanidine carboxylates for the treatment of non-insulin-dependent diabetes mellitus  
The present invention provides novel compounds of the formula I and II for the treatment of non-insulin dependent diabetes mellitius (NIDDM) and a new use of known compounds for this purpose.
6326513 Process for producing creatine or creatine-monohydrate  
The present invention relates to a process for producing creatine or creatine-monohydrate, comprising the step of reacting N-methylglycine, sodium N-methylglycinate and/or potassium...
6326403 Diacylhydrazine derivatives as integrin inhibitors  
Compounds of the formula I ##STR1## wherein X, Y, Z, R 1 and R 2 are as defined in claim 1, and their salts and solvates, can be used as integrin inhibitors in particular for the prophylaxis and...
6306840 Cell adhesion inhibitors  
The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical...
6274557 Inhibition of nitric oxide synthase by amino acids and dipeptides  
Methods and compositions for inhibiting at least one isoform of nitric oxide synthase are provided. Pharmaceutical compositions include derivatives of arginine as well as dipeptides and dipeptide...
6251869 Enhancement of oxazolidinone antibacterial agents activity by using arginine derivatives  
The present invention provides methods and compositions for enhancing the effectiveness of oxazolidinone antibacterial agents against gram-negative organisms infection by using an arginine derivative.
6211407 Dicreatine citrate and tricreatine citrate and method of making same  
A dicreatine citrate or tricreatine citrate, comprising two and three creatine cations per citrate anion, respectively. The dicreatine citrate has a melting point of about 146° F., and the...
6172111 Creatine pyruvates and a method of producing them  
Creatine pyruvates are described which have the general formula (I) (creatine) x (pyruvate) y (H 2 O) n (I) where x=1 to 100 y=1 to 10 and n=0 to 10 These creatine pyruvates, which...
6166249 Creatine pyruvates  
Creatine pyruvates are described which have the general formula (I) (creatine) x (pyruvate) y (H 2 O) n (I) where x=1 to 100 y=1 to 10 and n=0 to 10 These creatine pyruvates,...
6147258 Preparation of substituted guanidine derivatives  
Substituted guanidine derivatives of the formula I ##STR1## are prepared by reacting calcium cyanamide with a primary or secondary amino carboxylic acid or a primary or secondary amino sulfonic...
6143929 Process for preparing guanidine derivatives  
A process for preparing guanidine derivatives, in particular creatine, is described and entails an O-alkylisourea salt and a primary or secondary amine being reacted in the presence of crystals of...
6130315 Peptidase inhibitors  
This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone...
6127420 L-N.sup.5 -(1-imino-3-alkenyl) ornithine and related compounds and use thereof  
Selective and irreversible inhibitors of neuronal isoform of nitric oxide synthase catalyzed production of nitric oxide are L-ornithine or L-lysine derivatives having the formula ##STR1## wherein Q...
6126939 Anti-inflammatory dipeptide and pharmaceutical composition thereof  
The present invention is directed to peptides of the formulas (i) Xaa-Yaa-Arg, wherein either Xaa is any amino acid residue and Yaa is Glu or Xaa is absent and Yaa is any amino acid residue with...
6117842 Fibrinogen receptor antagonists  
Compounds of this invention have the formula: X--(CH 2 ) n --C(O)NH--A--C(COOR 5 )R 3 R 4 or a pharmaceutically acceptable salt thereof, e.g. ##STR1## which are useful for inhibiting fibrinogen...
6093848 Preparation of substituted guanidine derivatives  
Substituted guanidine derivatives of the formula I ##STR1## are prepared by a) converting urea into an alkylated isourea of the formula II ##STR2## and b) reacting the alkylated isourea with a...
6090785 Substituted N-carboxyalkylpeptidyl derivatives as antidegenerative agents  
Novel N-carboxyalkylpeptidyl compounds represented by the formula ##STR1## which are found to be useful inhibitors of matrix metalloendoproteinases which degrade major components of articular...
6069172 (R)-2-(3-benzoylphenyl) propionic acid salts and pharmaceutical preparations containing them  
A new use of the enantiomer (R)-ketoprofen and of its salts with suitable organic and inorganic bases in the therapy of neutrophil-dependent diseases and phlogistic processes is described as well...
6049003 Azoamidine compound  
Azoamidine compounds shown by the general formula [1] ##STR1## wherein R 1 and R 2 are independently a lower alkyl group, R 3 and R 4 are independently a hydrogen atom or a lower alkyl group,...
6034067 Serine protease inhibitors  
The invention relates to a compound having formula (I), wherein A, B, X, N, Z and Q are defined as described in the description. The compounds of the invention have anticoagulant activity and can...
6017888 Stimulation of hair growth by peptide copper complexes  
Peptide-copper complexes are disclosed which stimulate the growth of hair on warm-blooded animals. In one aspect of this invention, the peptide-copper complexes are dipeptides or tripeptides...
5994582 Preparation of substituted guanidine derivative  
Substituted guanidine derivatives of the formula I, ##STR1## are prepared by reacting haloformamidinium salts of the formula II, ##STR2## where Hal can be Cl, F, Br and I, with primary or secondary...
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