|
Match
|
Document |
Document Title |
|
|
7635717 |
Process for the preparation of amino methyl cyclo alkane acetic acids
This invention relates to an improved process for the preparation of amino methyl cyclo alkane acetic acids. This invention particularly relates to an improved process for the preparation of...
|
|
|
7632864 |
Gabapentin analogues and process thereof
The present invention relates to compounds trans (E) and cis (Z) stereoisomers of 4-t-butyl gabapentin of formula (11) and (12) and a process for the preparation of the said stereoisomers.
|
|
|
7553987 |
Synthesis of 3-(5-nitrocyclohex-1-enyl) acrylic acid and esters thereof
This application discloses provides a process for the introduction of nitro-group functionality into a compound which contains also a site of unsaturation and/or oxygen functionality by direct (one...
|
|
|
7550628 |
Process for preparing phenolic acid salts of gabapentin
The present invention provides a novel process for preparation of the tannate salt of gabapentin for human and veterinary pharmaceutical use. Tannate salts of active pharmaceutical ingredients are...
|
|
|
7534915 |
Non-symmetrical gelling agent
The present invention relates to a novel trisubstituted cyclic thickener or gelator. The present invention further relates to a method for thickening or gelating a solution comprising the use of...
|
|
|
7514580 |
Process for the preparation of 4,5-diamino shikimic acid derivatives
The present invention relates to a process for the preparation of a 4,5-diamino shikimic acid derivative of formula
and pharmaceutically acceptable addition salts thereof
wherein
R 1 , R...
|
|
|
7488844 |
Therapeutic agents
The present invention provides a compound of formula I processes for preparing such compounds, their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or...
|
|
|
7459580 |
Process for trans-4-amino-1-cyclohexanecarboxilic acid derivatives
A process for the preparation of Compound (I) comprising reacting Compound (II) with a base in an aprotic solvent, which is represented by the following scheme:
wherein R 1 and R 2 are each...
|
|
|
7456312 |
Phenolic acid salts of gabapentin in solid dosage forms and methods of use
The present invention relates to pharmaceutical compositions of gabapentin tannate in solid dosage form, processes for production of those compositions and methods of use of those compositions....
|
|
|
7442834 |
Process suitable for industrial scale production of gabapentin
This invention relates to an improved process for the preparation of substantially pure, stable anhydrous gabapentin. Thus, cyclohexane 1,1-diacetic acid monoamide is first treated with NaOH/NaClO...
|
|
|
7439387 |
Process for the preparation of Gabapentin form-II
The present invention relates to a new industrial feasible process for the preparation of Gabapentin Form-II via a novel intermediate Gabapentin hemisulphate hemihydrate with out forming Gabapentin...
|
|
|
7419981 |
Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
The instant invention relates to a combination of an alpha-2-delta ligand and a PDEV inhibitor for use in therapy, particularly in the treatment of pain, particularly neuropathic pain. Particularly...
|
|
|
7417166 |
Process for the preparation of gabapentin
The present invention relates to a process for the preparation of gabapentin and, more particularly, it relates to a precipitation process of gabapentin by acidification of an aqueous solution...
|
|
|
7393975 |
Process for the purification of gabapentin
A process for the preparation of gabapentin which comprises the passage of a gabapentin inorganic salt through a strong cationic ionic exchange resin, the elution of gabapentin fixed on the column,...
|
|
|
7393974 |
Process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid
A conversion process of gabapentin hydrochloride into gabapentin comprising: a) dissolution of gabapentin hydrochloride in a solvent in which the gabapentin hydrochloride and the gabapentin are...
|
|
|
7390922 |
Phenolic acid salts of gabapentin in liquid and/or semi-solid dosage forms and methods of use
The present invention relates to pharmaceutical compositions of gabapentin tannate, processes for production of those compositions and methods of use of those compositions. The present invention...
|
|
|
7381823 |
Process for preparing cyclohexanediacetic acid monoamide
A new process is described for synthesising cyclohexanediacetic acid monoamide, a key compound in the synthesis of grabapentin precursors. The process of the invention is characterised by reacting...
|
|
|
7365226 |
Process for the purification of gabapentin
A process for the preparation of gabapentin comprising the passage of a salt of the same through a ionic exchange resin of strong cationic type, the elution of the gabapentin which has fixed onto...
|
|
|
7199266 |
Process for the preparation of gabapentin
A process for the purification of gabapentin by treatment of a crude aqueous gabapentin hydrochloride solution with a strong cationic ion exchange resin.
|
|
|
7196216 |
Process for preparation of Gabapentin
A process for producing gabapentin, (1-(aminomethyl)-1-cyclohexaneacetic acid) from gabapentin hydrochloride salt. In the disclosed process, the gabapentin hydrochloride is converted to gabapentin...
|
|
|
7173151 |
Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals
The invention relates to arylcycloalkyl-substituted derivatives and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the...
|
|
|
7151193 |
Process for the preparation of pure gabapentin “Form II”
Pure gabapentin form II can be directly obtained adding the solution of the corresponding hydrochloride in dry ethanol (from which the inorganic salts have been filtered off) with a tertiary amine...
|
|
|
7148377 |
4-Alkoxy cyclohexane-1-amino-carboxylic acid esters and method for the production thereof
The invention relates to novel 4-alkoxy-cyclohexane-1-amino-carboxylic esters of the formula (IV)
in which R 1 represents OR 3 , R 2 represents alkyl, and R 3 represents alkyl, to...
|
|
|
7141695 |
Methods for producing substituted acrylic acid esters and use of the latter for producing substituted γ-amino acids
The invention relates to methods for producing substituted acrylic acid esters and to the use of the latter for producing substituted γ-amino acids, such as gabapentin and pregabalin. The...
|
|
|
7138542 |
Method of treating tinnitus
The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula
and pharmaceutically acceptable salts thereof, wherein...
|
|
|
7109383 |
Fluorine-containing allyl ether compounds, their copolymers, and resist compositions and anti-reflection film materials using such copolymers
The invention relates to a fluorine-containing allyl ether compound represented by the formula 1,
wherein R represents an organic group containing at least one fluorine atom and an alicyclic...
|
|
|
7098361 |
Rigid ring amino acids and polyamides there from
This invention is a family of α,ω amino acids based on 1,4 substituted rigid ring structures and the useful polyamides made from them.
|
|
|
7098362 |
Processes for the preparation of gabapentin
The present invention relates to new processes for the preparation of gabapentin by the desilylation of a silylated gabapentin or by the silylation-desilylation of an acid addition salt of...
|
|
|
7071356 |
Process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid
A method of producing gabapentin (1-amino-methyl)-1-cyclohexaneacetic acid) from its hydrochloric salt in an anhydrous medium, the method consisting of:
dissolving gabapentin hydrochloride...
|
|
|
7045655 |
Preparation and purification of hydroxylamine stabilizers
The invention relates to the preparation of ultra-high purity 1,2-diaminocyclohexane-tetraacetic acid being essentially free of unwanted metal and metal ion contaminants and its use as a stabilizer...
|
|
|
7030154 |
Stability of lipoic acid
A method of stabilizing R-α-lipoic acid includes combining R-α-lipoic acid with nicotinamide in a weight ratio between about 10:4 to about 10:8. A composition for treating oxidative stress...
|
|
|
7026505 |
Method of treating tinnitus
The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula
and pharmaceutically acceptable salts thereof, wherein...
|
|
|
7022678 |
Pregabalin lactose conjugates
In accordance with the present invention, there is provided pregabalin lactose conjugate compounds. Also provided as part of the present invention is a novel method of central nervous system...
|
|
|
6984496 |
Vitro assay for testing gabapentinoid activity
An assay and method for selecting analogs and derivatives of gabapentin based on the compounds inhibitory activity toward MAP kinase and MAP kinase mediated reporter gene expression. The method...
|
|
|
6909014 |
Intermediates for the synthesis of ether compounds
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias,...
|
|
|
6884821 |
Carboxylic acid derivatives and drugs containing the same
Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the...
|
|
|
6867327 |
Preparation and purification of hydroxylamine stabilizers
The invention relates to the preparation of ultra-high purity 1,2-diaminocyclohexanetetraacetic acid being essentially free of unwanted metal and metal ion contaminants and its use as a stabilizer...
|
|
|
6855832 |
O- or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
Compounds of the formula
where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
|
|
|
6846950 |
Process for synthesis of 1-(aminomethyl)cyclohexane acetic acid hydrochloride
A process for synthesis of 1-(aminomethyl)cyclohexane acetic acid hydrochloride (Gabapentin hydrochloride) comprising:
a) Reaction of a mixture of acetic anhydride/ammonium acetate with...
|
|
|
6809207 |
Amino acid derivatives
The present invention provides certain alpha-amino acids and derivatives thereof, such as, but not limited to, esters, amides and salts. These derivatives may comprise such representative side...
|
|
|
6794164 |
Process for the isolation of polyhydroxy cyclic carboxylic acids
This invention is directed to the use of crystallization acids, such as acetic, lactic and propionic acids, to obtain high purity polyhydroxyl cyclic carboxylic acids (PCCA) from low purity aqueous...
|
|
|
6790986 |
Process for the preparation of gabapentin free from inorganic acids anions
Gabapentin free from mineral acids anions is obtained by precipitating from a gabapentin aqueous solution a corresponding hydroxybenzoate, from which pure gabapentin is subsequently obtained by...
|
|
|
6777574 |
2-alkyl-5-halogen-pent-4-ene carboxylic acids and their production
Compounds of formula I in the form of their racemates or enantiomers, preferably compounds of formula Ia wherein R 4 is C 1 -C 6 alkyl, Z is chlorine, bromine or iodine, and X is —OH,...
|
|
|
6777573 |
Method for the synthesis of ceralure B1
A method has been developed for the preparation of ceralure B1, a potent attractant for the Mediterranean fruit fly. The method utilizes trans-siglure acid as starting material to produce...
|
|
|
6765114 |
Process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid
The invention relates to a new process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid of formula (I) via the new intermedier 1-(nitromethyl)cyclohexyl-acetic acid derivative of formula...
|
|
|
6730693 |
Double salts of fumaric acid with a carnitine and an amino acid and food supplements, dietary supplements and drugs containing same
Double fumarates of L-carnitine or isovaleryl L-carnitine and an amino acid having formula (I) are disclosed which are useful as active ingredients of food supplements, dietary supplements or...
|
|
|
6683112 |
Gabapentin prodrugs and formulations
The present invention relates to novel prodrugs of gabapentin and to pharmaceutical formulations and sustained release formulations containing the prodrugs.
|
|
|
6613782 |
Certain thiol inhibitors of endothelin-converting enzyme
Disclosed as endothelin converting enzyme inhibitors are the compounds of the formula wherein the variables have the meanings as defined hereinbefore.
|
|
|
6593314 |
Neuraminidase inhibitors
The present invention provides compounds of formula Ia and Ib or a pharmaceutically acceptable salt, prodrug, or ester thereof, useful in the inhibition of neuraminidase enzymes from...
|
|
|
6586471 |
Halogenated 2-amino-3, 4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
The present invention contains halogenated 2-amino-3,4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
|