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7514474 |
Prostaglandin analog compositions and methods to treat epithelial-related conditions
The present invention relates to the formulation and delivery of prostaglandin analogs to treat epithelial-related condition. In some embodiments, the compositions of the invention are used to...
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7476755 |
Therapeutic compounds
Therapeutic substituted cyclopentane compounds, and compositions, medicaments, and therapeutic methods related thereto are disclosed herein.
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7425651 |
Jasmonate derivative compounds, pharmaceuticals compounds and methods of use thereof
The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and...
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7396946 |
Compound for treatment of external secretion disorders
Disclosed is a method for treatment of external secretion disorders, which comprises administering a fatty 5 acid derivative to a subject in need of said treatment. The method of the present...
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7321057 |
Method for manufacturing prostaglandin analogue
The present invention provides a new method for manufacturing a prostaglandin analogue having one or more keto groups on the 5-membered ring and/or omega chain, which comprises the step of treating...
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7314890 |
Sulfonamides
The present invention provides
wherein R 1 is selected from the group consisting of C 1 -C 10 alkoxy, OH and NR 4 R 5 ;
R 2 is selected from the group consisting of C 1 -C 10 alkyl...
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7179937 |
Cyclopentenone derivatives for cancer therapy
The invention relates to the use of derivatives of cyclopentenone for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such...
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7173151 |
Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals
The invention relates to arylcycloalkyl-substituted derivatives and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the...
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7141606 |
Gabapentin analogues for sleep disorders
The invention provides a new use of compounds for formula 1 or 1A or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of insomnia and related disorders.
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7091231 |
12-Aryl prostaglandin analogs
Compounds comprising
are disclosed, wherein Y, A, X, R, D, and n are as described.
A compound comprising a prostaglandin EP 2 selective agonist wherein the ω-chain comprises a substituted...
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6956056 |
Method for providing a cathartic effect
The present invention relates to a novel method for providing a cathartic effect to a patient in need of cathartic induction, which comprises administering to the patient a cathartic-inducing...
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6909014 |
Intermediates for the synthesis of ether compounds
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias,...
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6878723 |
LTA4 hydrolase inhibitors
The invention concerns compounds inhibiting LTA 4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications.
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6864390 |
Method for the stereoselective synthesis of cyclic amino acids
The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks,...
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6680339 |
15-fluoro prostaglandins as ocular hypotensives
15-fluoro substituted analogs of PGF 2α and methods of their use in treating glaucoma and ocular hypertension are disclosed.
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6642274 |
Methods and compositions for preventing and treating prostate disorders
The present invention relates to methods, compositions, devices and kits for the prevention and treatment of prostate disorders in mammals, including, but not limited to, benign prostatic...
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6576786 |
Process for preparing substituted cyclopentane derivatives and novel crystalline structures thereof
The invention relates to a process for preparing substituted cyclopentane derivatives represented by the formula (I) wherein R 1 , R 2 , R 3 , R 4 , X and Y are as described in the...
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6576663 |
6-Keto prostaglandin F1α and analogs for treating dry eye
Compositions and methods for the treatment of dry eye and related diseases utilizing 6-keto-PGF 1α and its analogs are disclosed.
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6562861 |
Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
Compounds I-III wherein U is CH, O, or S; Z is mono- or di-substituted carbon; R is (CH2)nCO2H, (CH2)nSO3H, (CH2)nPO3H2, (CH2)nNO2, CH(SCH3)3, esters; R1 is H, hydroxyalkyl, aminoalkyl,...
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6528688 |
Prostacyclin derivatives
An improved method is described for making 9-deoxy-PGF 1 -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making...
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6512139 |
Oxidation inhibitors in prostane derivatives
The invention relates to the use of an oxidation inhibitor, i.e. active carbon, for ambient air in industrial manufacturing, especially in the processing of prostane derivatives, whereby the...
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6495725 |
Process for the preparation of optically active enones and intermediates thereof
The present invention provides a simplified and convenient process for the preparation of an optically active enone such as 7,7-dimethyl-6,8-dioxabicyclo-[3,3,0]oct-3-en-2-one. The invention...
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6455584 |
Prostaglandin E1 derivatives
To provide a prostaglandin derivative represented by the formula: wherein A is an ethylene group, a vinylene group, an ethynylene group, O(CH 2 ) q or S(O) r (CH 2 ) q , R 1 is a C 3-10 ...
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6444840 |
C11 oxymyl and hydroxylamino prostaglandins useful as FP agonists
The invention provides novel prostaglandin analogs. In particular, the present invention relates to compounds having a structure according to formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 ,...
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6433014 |
Compounds consisting in particular of effectors of the central nervous system receptors sensitive excitatory amino acids, preparation and biological applications
The invention concerns compounds of formula (I): in which: R 1 to R 4 , identical or different, represent hydrogen, alkyl or aryl, themselves substituted if required, R 1 and R 2 together...
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6410780 |
C11 oxymyl and hydroxylamino prostaglandins useful as medicaments
The invention provides novel prostaglandin analogs. In particular, the present invention relates to compounds having a structure according to formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 ,...
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6410591 |
3,7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure
The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma a therapeutically effective...
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6388128 |
Stannane synthesis of prostanoids
The present invention is directed to novel methods of prostanoid synthesis. Specifically, the invention is directed to the addition of alpha chains to prostanoids using cis-alkenylstannane...
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6380262 |
5-membered ring compounds
5-Membered ring compounds represented by general formula (I), optically active isomers thereof or salts of the same. These compounds have physiological activities including a carcinostatic effect....
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6353000 |
11-halo prostaglandins for the treatment of glaucoma or ocular hypertension
A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I:
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6326369 |
Bicyclic quinone compounds, their production and use
A compound of the formula: ##STR1## wherein R 1 and R 2 each represents a lower alkyl, or R 1 and R 2 may be bonded together to form a ring; X represents a spacer of which the number of atoms...
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6313341 |
Process for the preparation of prostaglandins
A hydroxy-1-alkyne is reacted with a tin hydride compound, and the obtained (E,Z)-hydroxyvinylstannanes are separated to give the (E)-substance which is further converted to a vinylcopper complex...
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6288119 |
11,15-O-dialkylprostaglandin E derivatives, process for producing the same, and drugs containing the same as the active ingredient
The present invention provides 11,15-O-dialkyl prostaglandin E derivatives of formula (I) ##STR1## (wherein all symbols are as described in Specification), or non-toxic salts thereof or...
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6265440 |
Prostaglandins E and anti ulcers containing same
The novel 13,14-dihydro-15-keto prostaglandins E of the invention have remarkable preventive effects against ulcers. Further, the novel 13,14-dihydro-15-keto-prostaglandins E of the invention have...
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6235780 |
ω-cycloalkyl-prostaglandin E1 derivatives
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6225347 |
9-halogen-(Z)-prostaglandin derivatives, process for their production and their use as pharmaceutical agents
The invention relates to 9-halogen-(Z) prostane derivatives of formula I ##STR1## in which ##STR2## Z represents the radicals Hal represents a chlorine or fluorine atom in the alpha or beta...
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6177592 |
Compounds
A compound represented by the following formula [I] or an optically active substance or a salt thereof. ##STR1## (In the formula, a bond shown by a dotted line in the five-membered ring means that...
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6160013 |
14-aza prostaglandins for the treatment of glaucoma and ocular hypertension
14-Aza analogs of PGF 2 α, PGD 2 , and PGE 2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.
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6114364 |
2,3-disubstituted cyclopentanone derivatives, process for producing the same, and medicinal use thereof
The present invention relates to a compound represented by the following general formula (1) ##STR1## (wherein X represents O, S, SO, SO 2 , or NH, Y is a substituted or unsubstituted hydrocarbon...
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6084125 |
Process for producing aliphatic acids using a reactor system having a shell and a tube reactor configuration to force circulation of reaction liquid
A shell and tube heat exchanger reactor with forced circulation is used to improve heat and mass transfer for exothermic liquid--liquid, gas-liquid and gas-liquid-solid reactions. Enhanced...
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6066751 |
Process for making epoxide intermediates
It has been surprisingly discovered that the disadvantages of the lengthy literature procedures to synthesize 13,14-dihydro prostaglandin A, E, and F derivatives can be overcome using a novel...
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6048895 |
Aromatic C16-C20 substituted tetrahydro prostaglandins useful as FP agonists
The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to the following formula: ##STR1## wherein R 1 , R 2 , R 3 , R 4 ,...
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6043275 |
3,7-dithiaprostanoic acid derivative
A 3,7-dithiaprostanoic acid derivative of the formula (I) ##STR1## (wherein, R 1 is OH, C1.about.6 alkyloxy, NR 6 R 7 (R 6 , R 7 are H, C1.about.6 alkyl.); R 2 is H, OH; R 3 is single bond,...
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5990346 |
Prostaglandins and processes for production thereof
A prostaglandin having formula (I), (II), or (III): ##STR1## a process of production thereof, and inhibitors of cell migration caused by chemokines containing (I) or (II) as an active ingredient.
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5990165 |
Pharmaceutical compounds
A pharmaceutical compound of the formula: ##STR1## in which n is 1 or 2, R 1 is --CO 2 H, R 2 is hydrogen or C 1 -4 alkyl and R 3 is hydrogen, C 1 -10 alkyl, C 2 -10 alkenyl, optionally...
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5985920 |
Difluoroprostaglandin derivatives and their use
A fluorine-containing prostaglandin derivative of the formula (1) (or a salt thereof) and a medicine containing it, particularly, a preventive or therapeutic medicine for an eye disease: ##STR1##...
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5962724 |
High enantio-selective process for producing pure enantiomeric cyclopentane and cyclopentene-(β)-amino acids
The present invention relates to a highly enantioselective process for the preparation of enantiomerically pure cyclopentane- and -pentene β-amino acids of the general formula (I) ##STR1## in...
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5945295 |
Method and compositions to detect autooxidation of lipids or fats ex vivo
This invention relates to a method to assess food spoilage ex vivo by quantification of prostanoid compounds and their metabolites produced by a noncyclooxygenase free radical catalyzed mechanism.
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5935939 |
Stabilized dispersions of misoprostol
The present invention provides for stabilization of misoprostol in solid dispersions using amorphous excipients or excipients which have been converted to an amorphous state such as hydroxypropyl...
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5932595 |
Matrix metalloprotease inhibitors
The present invention relates to compounds of Formula I: ##STR1## that are matrix metalloprotease inhibitors, pharmaceutical compositions containing them, methods for their use and methods of...
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