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7544831 |
Green catalytic process for the synthesis of acetyl salicylic acid
The present invention provides a green catalytic process for the synthesis of acetyl salicylic acid using solid acid catalysts at atmospheric pressure. The invention involve the solid acid catalyst...
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7507817 |
Prostaglandin prodrugs
Novel compounds, and therapeutic methods, compositions and medicament related thereto are disclosed herein.
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7439372 |
Therapeutic compounds
A compound having a structure
is disclosed herein. Compositions, medicaments, and therapeutic methods related thereto are also disclosed.
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7365225 |
Aryl dicarboxamides
The present invention is related to aryl dicarboxamides of formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or...
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7176240 |
Pentanoic acid derivatives
The compound of the formula (I):
wherein R 1 is alkyl substituted by fluorine(s);
R 2 is hydroxy, alkoxy, alkoxy substituted by phenyl, NR 3 R 4 ,
in which R 3 , R 4 is (i) hydrogen, (ii)...
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7109238 |
Calcilytic compounds
Novel calcilytic compounds and methods of using them are provided.
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7057067 |
Process for the preparation of 2-halobenzoic acids
The present invention provides a process for producing 2-halobenzoic acids of the general formula (I), characterized by reacting a benzoic acid of formula (II) with a halogenating agent in the...
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7057055 |
Process for preparing a deuterated or tritiated compound
A process for labeling organic compounds with deuterium and tritium is described using specific catalysts.
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7057038 |
Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids
One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic...
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7015349 |
Reduction of hair growth
Compositions including a conjugate of α-difluoromethylornithine can be applied topically to reduce hair growth.
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6989462 |
Synthesis of 2-chloromethyl-6-methylbenzoic ester
A process is described for preparing compounds of formula (I)
where R is H, optionally halogen-substituted alkyl, cycloalkyl, aryl, alkyl-aryl or heteroaryl, and, in alkyl and cycloalkyl, one...
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6943257 |
Process for preparation of aromatic halides from aromatic amines
The present invention provides a process for preparing an aromatic bromide or aromatic iodide from an aromatic amine derivative using nitrite anion and halodimethylsulfonium halide generated in...
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6936636 |
5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity
Compounds of the formula:
where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side...
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6727098 |
Biaryl-type compounds, CD color fixing agent and method for determination of absolute configuration
A novel achiral biaryl-type compound and a circular dichroism (CD) color fixing agent are provided. Furthermore, a method for determining an absolute configuration of a chiral compound is carried...
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6689891 |
2-bromomethyl-6-methyl-benzoic acid and a process for the preparation thereof
A process for the preparation of 2-bromomethyl-6-methyl-benzoic acid (I) and derivatives thereof by selective bromination of 2,6-dimethylbenzoic acid (II) with sodium bromate and hydrobromic acid...
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6586625 |
Synthesis of 2-halobenzyl alkanoic acid
A method for synthesizing compounds of Formula I in which R is alkyl or aryl and X is any halogen is described.
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6555078 |
Method of preparing lithium salts
The present invention provides an inexpensive process for the preparation of lithium salts of formula LiX having a desired or required level of purity using lithium chloride and lithium sulfate. In...
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6489507 |
Process for the synthesis of 3,5-bis(trifluoromethyl)benzoic acid
The present invention is concerned with a novel process for the preparation of 3,5-bis(trifluoromethyl)benzoic acid (CAS 725-89-3). This compound is useful as an intermediate in the synthesis of...
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6462227 |
Stabilized o-iodoxybenzoic acid compositions and process for the preparation thereof
Compositions that comprise, for one mole of o-iodoxybenzoic acid, from 0.5 to 4 moles of an aliphatic acid of formula CH 3 (CH 2 ) n COOH, in which n is from 8 to 20, of a benzenecarboxylic acid...
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6455725 |
Substituted cinnamic acids and cinnamic acid esters
The invention relates to substituted cinnamic acids and cinnamic acid esters of formula (I), wherein X represents F, Cl or J and R 1 and R 2 are the same or different and represent hydrogen, an...
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6420601 |
Process for the preparation of 3,5-bis(trifluoro-methyl)-benzoyl chlorides and novel 3,5-bis(tri-halogenomethyl)-and 3,5-dimethylbenzoyl halides
3,5-Bis(trifluoromethyl)benzoyl chlorides optionally substituted with fluorine or chlorine are advantageously prepared by converting 3,5-dimethylbenzoic acids optionally substituted with fluorine...
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6414186 |
Process for producing chloromethylphenylacetic acid
A method for preparing chloromethylphenylacetic acids represented by formula (II): wherein a methylphenylacetic acid represented by formula (I): is reacted with a chlorine gas, in an inert...
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6410783 |
Method of producing carboxylic acid salts
The present invention is a method of producing dry, alkali metal or ammonium carboxylic acid salt particles. In accordance with the invention, a molten carboxylic acid is mixed with a solution of...
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6392084 |
Method for production of organic fluorine compound
A method for the production of an aromatic fluorine compound is provided which is capable of preventing the occurrence of benzoic acid fluorides during the course of a halogenation exchange...
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6391823 |
Separation process
A process for separating a compound from a mixture of different compounds is disclosed for compounds comprising at least two negatively charged groups connected by a linker group. The process...
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RE37670 |
Antiproliferative and neurotrophic molecules
Neurotrophic and antiproliferative compounds related to the antiepileptic drug valproate are provided. These compounds are useful for promoting neuronal function as in neurodegenerative disorders...
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6362365 |
Preparation of trifluorobenzoic acids
The present invention relates to a process for preparing trifluorobenzoic acids of the formula in which R is a straight-chain or branched alkyl radical having 1 to 6 C-atoms, an unsubstituted...
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6348624 |
Process for making certain benzoic acid compounds
The subject invention involves processes for making 2,4-difluoro-3-Q1-benzoic acid, wherein Q1 is derived from an electrophilic reagent, comprising the steps of: (a) treating...
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6333431 |
Processes for the preparation of fluorinated benzoic acids
An object of the present invention is to provide a commercially advantageous process for preparing a fluoro benzoic acid. The process according to the present invention comprises either alkylating...
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6307091 |
Trifluoro-substituted benzoic acid, esters thereof and processes for preparing the same
The present invention is to provided a trifluoro-substituted benzoic acid, an ester thereof, particularly 2,3,4-trifluoro-5-iodobenzonic acid, 2,3,4-trifluoro-5-trifluoromethylbenzonic acid, esters...
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6303812 |
Isolation of products from selective dehalogenation of haloaromatics
Disclosed is a method of isolating the aromatic product formed when a substrate having the general formula ##STR1## is dehalogenated, forming a product mixture of copper salts and aromatic product,...
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6288271 |
Process for the preparation of (2,2,2-trifluoroethoxy)benzoic acids
A process for producing trifluoroethoxybenzoic acids or salts thereof by reaction of halobenzoic acids or salts thereof with 2,2,2-trifluoroethanol in the presence of a strong base and copper...
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6268527 |
Method for producing benzoic acid derivatives
The invention relates to a method for producing a benzoic acid derivative represented by the general formula (1). The method includes the step of reacting an aromatic compound represented by the...
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6268513 |
Phosphine ligands metal complexes and compositions thereof for cross-coupling reactions
The present invention discloses new efficient processes for various bond forming reactions, including Suzuki reactions and aryl aminations. Organic compounds (e.g., ligands), their metal complexes...
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6265601 |
Methods for using phosphine ligands in compositions for suzuki cross-coupling reactions
The present invention discloses new efficient processes for various bond forming reactions, including Suzuki reactions. Organic compounds (e.g., ligands), their metal complexes and compositions...
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6235949 |
Process for the preparation of halogenated derivatives and Lewis acid base catalysts thereof
A process for the preparation of halide compounds, preferably aryl halides, by contacting a gaseous mixture of hydrohalic acid and a compound selected from an aryl halogen formate, an aryl...
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6191307 |
Process for making benzoic acids
A process of producing benzoic acids from phthalimides is described. The ability to dramatically reduce the reaction time in comparison to currently practiced processes by the addition of readily...
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6168913 |
Coding combinatorial libraries with fluorine tags
The present invention relates to coding combinatorial chemical libraries synthesized on a plurality of solid supports by attaching "tags" that comprise fluorine containing compounds in combinations...
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6166273 |
Processes for fluorinating aromatic ring compounds
A process is provided for increasing the fluorine content of benzene or pyridine rings which are optionally substituted with from 1 to 3 inert substituents. The process involves (a) contacting the...
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6162943 |
Method for producing α-alkoxy-α-trifluoromethyl-aryl acetic esters and -aryl acetic acids
Process for the preparation of α-alkoxy-α-trifluoromethyl-arylacetic esters of the formula (I) ##STR1## wherein R is a component selected from the group consisting of C 1 -C 6 -alkyl, C 2 -C 6...
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6127573 |
Oxidaton of primary alcohols to carboxylic acids with a TEMPO catalyst using NaClO.sub.2 and NaClO
The present invention relates to a TEMPO-catalyzed oxidation of primary alcohols, RCH 2 OH to corresponding carboxylic acids, RCOOH in the presence of catalytic in the presence of catalytic amount...
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6127191 |
Aminobenzenedicarboxylic acid-based combinatorial libraries
The present invention provides a library of compounds, each comprised of a common aminobenzenedicarboxylic acid core structure (scaffold) that serves as a template for synthesizing approximately 10...
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6124476 |
Catalyst ligands, catalyst compositions, catalyst metal complexes and processes for cross-coupling aromatic boron compounds with aromatic halogens or perfluoroalkylsulfonates
The present invention discloses new organic compounds (e.g., ligands), their metal complexes and compositions using those compounds. The invention also relates to the field of catalysis. In...
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6054605 |
2, 3-dihalogeno-6-trifluoromethylbenzene derivatives and process for producing the same
The present invention is to provide 2,3-dihalogeno-6-trifluoromethylbenzene derivatives represented by a general formula [I]; ##STR1## wherein X 1 and X 2 are the same or different and each...
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6001877 |
Phenylalkan(en)oic acid
The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, posses an antagonistic activity on leukotriene B 4 .
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5886218 |
Process for preparing 4, 5-dichloro-2-methylbenzoic acid
The present invention relates to a process for preparing 4,5-dichloro-2-methylbenzoic acid and also its salts in high yields and in high purities by reacting 3,4-dichlorotoluene with acetyl...
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5886210 |
Method for preparing aromatic compounds
A method for synthesizing aromatic compounds by selectively dehalogenating aromatic starting materials is provided. Compounds may be prepared which are substituted with fluoro, chloro or bromo. The...
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5872289 |
Hydrolysis of carboxylic acid alkyl esters in the liquid phase
A liquid-phase process for hydrolyzing a carboxylic acid alkyl ester having 2 to 18 carbon atoms to provide a product mixture comprising a carboxylic acid and an alcohol comprising contacting a...
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5843863 |
Process for improving flow characteristics of crystalline ibuprofen
A process for producing crystalline ibuprofen having a crystal habit characterized by a particle length larger than 75 microns average and a length to width aspect ratio of greater than about 4 to...
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5841001 |
Process for the preparation of optically active 2-halo-1-(substituted phenyl) ethanol
The present invention provides an industrially advantageous process for the preparation of an optically active 2-halo-1-(substituted phenyl)ethanol useful as medicines, agricultural chemicals or as...
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