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5196590 |
Method of making 2,4,5-trihalobenzoic acid
Disclosed is a method of making 2,4,5-trihalobenzoic acid by heating to a temperature of about 130° to about 190° C. a composition that comprises water, a mineral acid, and a compound having the...
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5191095 |
Asymmetric hydrogenation of olefinic amides using organoruthenium catalyst
A process for the asymmetric reduction of olefinic amides of the formula ##STR1## where R and R 1 are the same or different and are hydrogen, alkyl, cycloalkyl or haloalkyl and Ar is aryl or...
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5190905 |
Asymmetric hydrogenation of aromatic-substituted olefins using metal or metal alloy catalysts
A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R 1 are the same or different and are hydrogen, alkyl, cycloalkyl or...
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5187281 |
Asymmetric hydrogenation of aromatic-substituted olefins using organoiridium catalyst
A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R 1 are the same or different and are hydrogen, alkyl, cycloalkyl or...
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5187136 |
Asymmetric hydrogenation of aromatic-substituted olefins using organorhenium catalyst
A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R 1 are the same or different and are hydrogen, alkyl, cycloalkyl or...
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5187135 |
Asymmetric hydrogenation of aromatic-substituted olefins using organo-cobalt catalyst
A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R 1 are the same or different and are hydrogen, alkyl, cycloalkyl or...
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5179230 |
Process for the preparation of 2,3,4,5-tetrafluorobenzoic acid
A process for the preparation of 2,3,4,5,-tetrafluorobenzoic acid of the formula (1) ##STR1## by heating N'-substituted N-aminotetrafluorophthalimides of the formula (2) ##STR2## in which X is the...
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5177231 |
Asymmetric hydrogenation of aromatic-substituted olefins using cationic ruthenium(III) complexes
A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R 1 are the same or different and are hydrogen, alkyl, cycloalkyl or...
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5162577 |
Process for lithiation of 1,3-bis(trifluoromethyl)benzene
A novel process for the lithiation of 1,3-bis(trifluoro-methyl)benzene in a solvent is described, said process comprising carrying out the lithiation with the lithium salt of an amine of the...
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5113013 |
Process for preparing fluorine-containing organic compounds
A method for the preparation of a fluorine-containing organic compound which comprises reacting a sulphonyl halide of the formula: RfSO 2 X where Rf represents a fluorinated organic radical and...
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5107053 |
Ruthenium phosphine complex
A ruthenium phosphine complex having catalytic, hydrogenation activity is disclosed. The catalyst as the formula ##STR1## wherein R and R' are the same or different and are C 1 to C 6 linear or...
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5093529 |
Process for the preparation of fluorinated benzoic acids
In the process for the preparation of fluorinated benzoic acids of the formula I ##STR1## in which X and Y, for example, independently of one another denote chlorine or fluorine and X moreover...
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5093515 |
Fluorinated benzoyl compounds
A 2-chloro-4,5-difluorobenzoyl compound of the formula: ##STR1## wherein R 2 is a lower alkyl group, and R 7 is a 2,4-difluorophenyl group or a 4-fluorophenyl group.
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5089661 |
New process for the preparation of 2-aryl-propionic acids
A new process is described for the preparation of a 2-aryl-propionic acid, such as for instance 2-[4-(2-methyl-propyl)phenyl]propionic or 2-(6'-methoxy-2'-naphthyl)propionic acid, through...
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5081252 |
Process for the preparation of aromatic carboxylic acids
A process for the preparation of aromatic carboxylic acids or their salts comprises heating carboxyl-free aromatic compounds and aromatic carboxylic acid salts whose basic structures differ from...
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5072038 |
2,3,4,5-tetrahalogenobenzene derivatives
2,3,4,5-trihalogenobenzene derivatives of the formula ##STR1## in which R is --COOH, --COCl, --COF, --CN, --CONH 2 , --CH 2 OH, --CH 2 Cl, --CHCl 2 , --CCl 3 or --CHO, R 1 is H, Cl or F, and...
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5047538 |
Quinolinecarboxylic acid antibacterial agents
Novel 8-alkenyl, alkynyl, allenyl and cycloalkyl-quinolinecarboxylic acids are described as antibacterial agents as well as methods of manufacture including novel intermediates used in said...
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5004832 |
Preparing alpha-arylalkanoic acids
Compounds are described of formula ##STR1## in which: Ar represents an aryl, possibly substituted; R represents a C 1 -C 4 alkyl; R' represents a hydroxyl, an alkoxy, an amino group...
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4999441 |
Tetrakis(dialkylamino)aromatics and their charge transfer complexes
Tetrakis(dialkylamino)aromatics Ia to Ic ##STR1## where the radicals A may be identical or different and are n-C 1 -C 6 -alkyl and the radicals R may be identical or different and are hydrogen or...
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4996355 |
Novel intermediates for the production of 2,4,5-trifluorobenzoyl fluoride
The present invention comprises compounds of the formulas: ##STR1## wherein X is Cl or Br. These compounds are useful as intermediaries for the production of 2,4,5-trifluorobenzoic acid and...
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4994610 |
Process for preparing fluorinated benzoyl compounds
Fluorinated benzoyl compounds of the formula: ##STR1## wherein Q is a lower alkyl group, a halogen atom, --CH 2 CO 2 R 1 wherein R 1 is a lower alkyl group, or ##STR2## wherein each of R 2 and...
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4990661 |
Process for the preparation of benzoic acid derivatives
A process for the preparation of a compound of the formula ##STR1## in which X 1 and X 2 each independently is chlorine or fluorine, and Y is chlorine, bromine, fluorine or iodine, comprising...
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4968830 |
Aromatization process
Halogen substituted aromatic compounds of the formula ##STR1## wherein Y is selected from the group CO 2 H, COF, COCl, COBr, CF 3 , CN, NCO, or F, and X and X' are independently hydrogen or a...
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4937379 |
Carboxylic acid synthesis process
A process is described for preparing alpha-arylalkanoic acids, which comprises preparing and subsequently rearranging ketals of formula ##STR1## (in which Ar, R, R 1 , R 2 and R 4 have the...
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4933367 |
Carboxylic acid derivatives, processes for the preparation thereof, the use thereof, and pharmaceutical compositions which contain these compounds
This invention relates to carboxylic acid derivatives and their use thereof. The compounds are useful in treatment of various diseases such as diabetes, prediabetic conditions, adipositas ailments...
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4929755 |
Process for making an optically active mixture of an N-acyl-amino acid or ester containing at least two chiral centers
In the process of hydrocarboxylating an α-enamide with CO and H 2 O or an organic hydroxyl compound to produce an N-acyl-α-amino acid or ester, respectively, the improvement comprising using as...
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4927967 |
Production of carboxylic acids from organic formate esters using rhodium complex catalysts
A process for the production of organic carboxylic acids by the catalytic reaction of organic formate esters in contact with carbon monoxide and a homogeneous catalyst system of rhodium metal atom,...
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4920120 |
Antibacterial agents
Novel naphthyridine-, and quinolinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including...
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4918226 |
Process for converting formate esters to carboxylic acids
A process for converting formic acid esters or transesterification products thereof to carboxylic acids comprising contacting a formic acid ester of the formula (HCOO) n --R where R is aliphatic,...
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4910321 |
Living catalysts, complexes and polymers therefrom
This invention provides a novel catalyst composed of a complex of an organic acid or its ester and a Lewis acid, preferably boron trichloride that can add olefin monomers to increase the molecular...
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4904646 |
Phosphorus-containing HMG-COA reductase inhibitors
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## including salts thereof, wherein R is OH,...
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4885386 |
Process for the synthesis of 3-chloro-2,4,5-trifluorobenzoic acid
An improved process for the preparation of 3-chloro-2,4,5-trifluorobenzoic acid is described which involves reaction of a diester of 3,4,5,6-tetrafluoro-1,2-benzenedicarboxylic acid with a...
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4885384 |
Process for the carbonylation of iodoaromatic compounds
A process for the production of aromatic carboxylic acids which comprises carbonylating substituted iodoaromatic compounds in the presence of carbon monoxide, a catalytic amount of a transition...
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4883916 |
Polyprenyl Compounds
A polyprenyl compound terminated with a group of ##STR1## is novel and useful as an antihypercholesterolemic agent and an antiarteriosclerotic agent, in which X is a group of the formula ##STR2##...
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4876387 |
Process for preparing 2,4,5-trifluorobenzoic acid
2,4,5-trifluorobenzoic acid is prepared by converting 4,5-di-fluoroanthranilic acid to the corresponding amine salt, converting the amine salt to the corresponding diazonium tetrafluoroborate and...
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4874601 |
Radiolabelling kit
A kit for the direct and rapid preparation of radiolabelled compounds is disclosed comprising a Resin-S-Hg-R component where R is an organic group together with MZ* where M is an alkali metal and...
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4855517 |
Process for preparing aromatic bromine compounds
Aromatic bromine compounds are prepared by reacting aromatic nitro compounds with elemental bromine in the gas phase at temperatures between about 310° to 550° C. In this reaction, the nitro...
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4855292 |
1-cyclopropyl-6-fluoro-8-alkyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives
Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R 2 is 1-pyrrolidinyl which may have 1 to 2 substituents selected from the group consisting of (i) C 1 -C 6 ...
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4849530 |
Process for the preparation of crystalline salts or aryloxy-propanolamines
The invention relates to novel crystalline salts of aryloxypropanolamines with diphenylacetic acid, a process for their preparation and the use of these salts for the preparation of chemically pure...
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4836958 |
Fluorinated cationic compounds
The instant invention relates to fluorinated cationic compounds of the formula ##STR1## wherein R f is a perfluoroalkyl or perfluoroalkoxy-perfluoroalkyl group; R 1 is alkylene optionally...
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4833270 |
Process for preparing 2-chloro-4,5-difluorobenzoic acid
This disclosure describes a novel process for preparing 2-chloro-4,5-difluorobenzoic acid which is useful in the preparation of...
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4833247 |
Process for the production of 2-benzyl fatty acids
A process for the production of 2-benzyl fatty acids and esters thereof corresponding to the following formula ##STR1## comprising reacting 2-fatty alkyl-4,4-dimethyl-2-oxazolines with...
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4828765 |
Oxyalkylated quaternary ammonium compounds and their use as drag reducing agents
Quaternary ammonium compounds of the formula ##STR1## in which R 1 denotes an alkyl or alkenyl radical with 12 to 22 carbon atoms; R 2 and R 3 are identical or different and denote an alkyl...
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4826982 |
Quinolonecarboxylic acid derivatives
Quinolonecarboxylic acid derivatives of the following formula, ##STR1## wherein R 1 , R 2 , R 3 and R 4 are each independently hydrogen atom or lower alkyl group; the hydrates or the...
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4822913 |
Process for preparing carboxylic acids from esters of carboxylic acids
Esters of carboxylic acids of the formula RCH 2 COOR"' and R'CH:C(R")COOR"' are reacted to form a carboxylic acid and an aliphatic alcohol R"'OH wherein R, R', and R" are individually selected...
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4822912 |
Process for the preparation of 2,3,5,6-tetrafluorobenzoic acid
2,3,5,6-Tetrafluorobenzoic acid is prepared by hydrogenolysis of pentafluorobenzoic acid (esters).
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4814497 |
Dehalogenation process
Particulate aluminum is intimately mixed with an aromatic material that contains at least one ar-halo substituent having an atomic number above 20 and at least one side-chain halo substituent...
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4814108 |
Cationic surfactants based on quaternary ammonium compounds and use thereof in cleaning agents
The invention relates to new cationic surfactants based on quaternary ammonium compounds which are characterized by the general formula ##STR1## wherein R 1 may be a linear or branched alkyl...
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4804760 |
Process for the preparation of 4-hydroxy-quinoline-3-carboxylic acids
A process for the preparation of a compound of the formula ##STR1## in which Y is a nitrile group, an ester group COOR 1 or an acid amide CONR 2 R 3 , R 1 , R 2 and R 3 each independently is...
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4791225 |
Halogenobenzoic acid derivatives and their preparation
The present invention is concerned with certain novel halogenobenzoic acid derivatives of the following formula, ##STR1## wherein R is a chlorine atom, amino group or hydroxy group, X is a chlorine...
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