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5196590 Method of making 2,4,5-trihalobenzoic acid  
Disclosed is a method of making 2,4,5-trihalobenzoic acid by heating to a temperature of about 130° to about 190° C. a composition that comprises water, a mineral acid, and a compound having the...
5191095 Asymmetric hydrogenation of olefinic amides using organoruthenium catalyst  
A process for the asymmetric reduction of olefinic amides of the formula ##STR1## where R and R 1 are the same or different and are hydrogen, alkyl, cycloalkyl or haloalkyl and Ar is aryl or...
5190905 Asymmetric hydrogenation of aromatic-substituted olefins using metal or metal alloy catalysts  
A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R 1 are the same or different and are hydrogen, alkyl, cycloalkyl or...
5187281 Asymmetric hydrogenation of aromatic-substituted olefins using organoiridium catalyst  
A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R 1 are the same or different and are hydrogen, alkyl, cycloalkyl or...
5187136 Asymmetric hydrogenation of aromatic-substituted olefins using organorhenium catalyst  
A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R 1 are the same or different and are hydrogen, alkyl, cycloalkyl or...
5187135 Asymmetric hydrogenation of aromatic-substituted olefins using organo-cobalt catalyst  
A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R 1 are the same or different and are hydrogen, alkyl, cycloalkyl or...
5179230 Process for the preparation of 2,3,4,5-tetrafluorobenzoic acid  
A process for the preparation of 2,3,4,5,-tetrafluorobenzoic acid of the formula (1) ##STR1## by heating N'-substituted N-aminotetrafluorophthalimides of the formula (2) ##STR2## in which X is the...
5177231 Asymmetric hydrogenation of aromatic-substituted olefins using cationic ruthenium(III) complexes  
A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R 1 are the same or different and are hydrogen, alkyl, cycloalkyl or...
5162577 Process for lithiation of 1,3-bis(trifluoromethyl)benzene  
A novel process for the lithiation of 1,3-bis(trifluoro-methyl)benzene in a solvent is described, said process comprising carrying out the lithiation with the lithium salt of an amine of the...
5113013 Process for preparing fluorine-containing organic compounds  
A method for the preparation of a fluorine-containing organic compound which comprises reacting a sulphonyl halide of the formula: RfSO 2 X where Rf represents a fluorinated organic radical and...
5107053 Ruthenium phosphine complex  
A ruthenium phosphine complex having catalytic, hydrogenation activity is disclosed. The catalyst as the formula ##STR1## wherein R and R' are the same or different and are C 1 to C 6 linear or...
5093529 Process for the preparation of fluorinated benzoic acids  
In the process for the preparation of fluorinated benzoic acids of the formula I ##STR1## in which X and Y, for example, independently of one another denote chlorine or fluorine and X moreover...
5093515 Fluorinated benzoyl compounds  
A 2-chloro-4,5-difluorobenzoyl compound of the formula: ##STR1## wherein R 2 is a lower alkyl group, and R 7 is a 2,4-difluorophenyl group or a 4-fluorophenyl group.
5089661 New process for the preparation of 2-aryl-propionic acids  
A new process is described for the preparation of a 2-aryl-propionic acid, such as for instance 2-[4-(2-methyl-propyl)phenyl]propionic or 2-(6'-methoxy-2'-naphthyl)propionic acid, through...
5081252 Process for the preparation of aromatic carboxylic acids  
A process for the preparation of aromatic carboxylic acids or their salts comprises heating carboxyl-free aromatic compounds and aromatic carboxylic acid salts whose basic structures differ from...
5072038 2,3,4,5-tetrahalogenobenzene derivatives  
2,3,4,5-trihalogenobenzene derivatives of the formula ##STR1## in which R is --COOH, --COCl, --COF, --CN, --CONH 2 , --CH 2 OH, --CH 2 Cl, --CHCl 2 , --CCl 3 or --CHO, R 1 is H, Cl or F, and...
5047538 Quinolinecarboxylic acid antibacterial agents  
Novel 8-alkenyl, alkynyl, allenyl and cycloalkyl-quinolinecarboxylic acids are described as antibacterial agents as well as methods of manufacture including novel intermediates used in said...
5004832 Preparing alpha-arylalkanoic acids  
Compounds are described of formula ##STR1## in which: Ar represents an aryl, possibly substituted; R represents a C 1 -C 4 alkyl; R' represents a hydroxyl, an alkoxy, an amino group...
4999441 Tetrakis(dialkylamino)aromatics and their charge transfer complexes  
Tetrakis(dialkylamino)aromatics Ia to Ic ##STR1## where the radicals A may be identical or different and are n-C 1 -C 6 -alkyl and the radicals R may be identical or different and are hydrogen or...
4996355 Novel intermediates for the production of 2,4,5-trifluorobenzoyl fluoride  
The present invention comprises compounds of the formulas: ##STR1## wherein X is Cl or Br. These compounds are useful as intermediaries for the production of 2,4,5-trifluorobenzoic acid and...
4994610 Process for preparing fluorinated benzoyl compounds  
Fluorinated benzoyl compounds of the formula: ##STR1## wherein Q is a lower alkyl group, a halogen atom, --CH 2 CO 2 R 1 wherein R 1 is a lower alkyl group, or ##STR2## wherein each of R 2 and...
4990661 Process for the preparation of benzoic acid derivatives  
A process for the preparation of a compound of the formula ##STR1## in which X 1 and X 2 each independently is chlorine or fluorine, and Y is chlorine, bromine, fluorine or iodine, comprising...
4968830 Aromatization process  
Halogen substituted aromatic compounds of the formula ##STR1## wherein Y is selected from the group CO 2 H, COF, COCl, COBr, CF 3 , CN, NCO, or F, and X and X' are independently hydrogen or a...
4937379 Carboxylic acid synthesis process  
A process is described for preparing alpha-arylalkanoic acids, which comprises preparing and subsequently rearranging ketals of formula ##STR1## (in which Ar, R, R 1 , R 2 and R 4 have the...
4933367 Carboxylic acid derivatives, processes for the preparation thereof, the use thereof, and pharmaceutical compositions which contain these compounds  
This invention relates to carboxylic acid derivatives and their use thereof. The compounds are useful in treatment of various diseases such as diabetes, prediabetic conditions, adipositas ailments...
4929755 Process for making an optically active mixture of an N-acyl-amino acid or ester containing at least two chiral centers  
In the process of hydrocarboxylating an α-enamide with CO and H 2 O or an organic hydroxyl compound to produce an N-acyl-α-amino acid or ester, respectively, the improvement comprising using as...
4927967 Production of carboxylic acids from organic formate esters using rhodium complex catalysts  
A process for the production of organic carboxylic acids by the catalytic reaction of organic formate esters in contact with carbon monoxide and a homogeneous catalyst system of rhodium metal atom,...
4920120 Antibacterial agents  
Novel naphthyridine-, and quinolinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including...
4918226 Process for converting formate esters to carboxylic acids  
A process for converting formic acid esters or transesterification products thereof to carboxylic acids comprising contacting a formic acid ester of the formula (HCOO) n --R where R is aliphatic,...
4910321 Living catalysts, complexes and polymers therefrom  
This invention provides a novel catalyst composed of a complex of an organic acid or its ester and a Lewis acid, preferably boron trichloride that can add olefin monomers to increase the molecular...
4904646 Phosphorus-containing HMG-COA reductase inhibitors  
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## including salts thereof, wherein R is OH,...
4885386 Process for the synthesis of 3-chloro-2,4,5-trifluorobenzoic acid  
An improved process for the preparation of 3-chloro-2,4,5-trifluorobenzoic acid is described which involves reaction of a diester of 3,4,5,6-tetrafluoro-1,2-benzenedicarboxylic acid with a...
4885384 Process for the carbonylation of iodoaromatic compounds  
A process for the production of aromatic carboxylic acids which comprises carbonylating substituted iodoaromatic compounds in the presence of carbon monoxide, a catalytic amount of a transition...
4883916 Polyprenyl Compounds  
A polyprenyl compound terminated with a group of ##STR1## is novel and useful as an antihypercholesterolemic agent and an antiarteriosclerotic agent, in which X is a group of the formula ##STR2##...
4876387 Process for preparing 2,4,5-trifluorobenzoic acid  
2,4,5-trifluorobenzoic acid is prepared by converting 4,5-di-fluoroanthranilic acid to the corresponding amine salt, converting the amine salt to the corresponding diazonium tetrafluoroborate and...
4874601 Radiolabelling kit  
A kit for the direct and rapid preparation of radiolabelled compounds is disclosed comprising a Resin-S-Hg-R component where R is an organic group together with MZ* where M is an alkali metal and...
4855517 Process for preparing aromatic bromine compounds  
Aromatic bromine compounds are prepared by reacting aromatic nitro compounds with elemental bromine in the gas phase at temperatures between about 310° to 550° C. In this reaction, the nitro...
4855292 1-cyclopropyl-6-fluoro-8-alkyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives  
Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R 2 is 1-pyrrolidinyl which may have 1 to 2 substituents selected from the group consisting of (i) C 1 -C 6 ...
4849530 Process for the preparation of crystalline salts or aryloxy-propanolamines  
The invention relates to novel crystalline salts of aryloxypropanolamines with diphenylacetic acid, a process for their preparation and the use of these salts for the preparation of chemically pure...
4836958 Fluorinated cationic compounds  
The instant invention relates to fluorinated cationic compounds of the formula ##STR1## wherein R f is a perfluoroalkyl or perfluoroalkoxy-perfluoroalkyl group; R 1 is alkylene optionally...
4833270 Process for preparing 2-chloro-4,5-difluorobenzoic acid  
This disclosure describes a novel process for preparing 2-chloro-4,5-difluorobenzoic acid which is useful in the preparation of...
4833247 Process for the production of 2-benzyl fatty acids  
A process for the production of 2-benzyl fatty acids and esters thereof corresponding to the following formula ##STR1## comprising reacting 2-fatty alkyl-4,4-dimethyl-2-oxazolines with...
4828765 Oxyalkylated quaternary ammonium compounds and their use as drag reducing agents  
Quaternary ammonium compounds of the formula ##STR1## in which R 1 denotes an alkyl or alkenyl radical with 12 to 22 carbon atoms; R 2 and R 3 are identical or different and denote an alkyl...
4826982 Quinolonecarboxylic acid derivatives  
Quinolonecarboxylic acid derivatives of the following formula, ##STR1## wherein R 1 , R 2 , R 3 and R 4 are each independently hydrogen atom or lower alkyl group; the hydrates or the...
4822913 Process for preparing carboxylic acids from esters of carboxylic acids  
Esters of carboxylic acids of the formula RCH 2 COOR"' and R'CH:C(R")COOR"' are reacted to form a carboxylic acid and an aliphatic alcohol R"'OH wherein R, R', and R" are individually selected...
4822912 Process for the preparation of 2,3,5,6-tetrafluorobenzoic acid  
2,3,5,6-Tetrafluorobenzoic acid is prepared by hydrogenolysis of pentafluorobenzoic acid (esters).
4814497 Dehalogenation process  
Particulate aluminum is intimately mixed with an aromatic material that contains at least one ar-halo substituent having an atomic number above 20 and at least one side-chain halo substituent...
4814108 Cationic surfactants based on quaternary ammonium compounds and use thereof in cleaning agents  
The invention relates to new cationic surfactants based on quaternary ammonium compounds which are characterized by the general formula ##STR1## wherein R 1 may be a linear or branched alkyl...
4804760 Process for the preparation of 4-hydroxy-quinoline-3-carboxylic acids  
A process for the preparation of a compound of the formula ##STR1## in which Y is a nitrile group, an ester group COOR 1 or an acid amide CONR 2 R 3 , R 1 , R 2 and R 3 each independently is...
4791225 Halogenobenzoic acid derivatives and their preparation  
The present invention is concerned with certain novel halogenobenzoic acid derivatives of the following formula, ##STR1## wherein R is a chlorine atom, amino group or hydroxy group, X is a chlorine...