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5811576 |
Intermediates for anti-microbial quinolone carboxylic acids
Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R 1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1...
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5792892 |
Processes for preparing aromatic, bromine-containing compounds, novel bromine-containing compounds, and their use as intermediate products in the synthesis of active agents
The present invention relates to processes for the preparation of bromine-containing aromatic compounds, to novel bromine-containing compounds and to their use as intermediates in the synthesis of...
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5773651 |
Process for the preparation of fluorine-containing chemical compounds
Process for the preparation of fluorine-containing compounds by reduction in a container provided with a stirrer, the stirrer being constructed entirely or partly of a carbon material.
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5756849 |
Process for grafting a substituted difluoromethyl group onto a compound containing an electrophilic functional group
The invention relates to a process and a nucleophilic reagent which is useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function,...
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5756834 |
Process for preparing fluorinated aromatics
It is known to prepare fluorinated aromatic compounds of the formula I ##STR1## in which X, Y and Z can have the meaning specified in the description, by reacting aromatic compounds of the formula...
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5756804 |
Homogeneous process for carrying out cross-coupling reactions
A process for preparing polycyclic aromatic compounds, which comprises reacting a) an aromatic boron compound with b) an aromatic halogen compound or an aromatic perfluoroalkylsulfonate in...
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5736480 |
Supported phase chiral sulfonated BINAP catalyst solubilized in alcohol and method of asymmetric hydrogenation
Supported phase catalysts in which the support phase, is non-aqueous and highly polar, such as a primary alcohol, and most preferably ethylene glycol, are. disclosed. An organometallic compound,...
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5723658 |
Process for the preparation of salts of substituted or unsubstituted phthalic acids
The present invention relates to a process for the preparation of salts of substituted or unsubstituted phthalic acids, by reacting a compound of the formula ##STR1## in which R 1 , R 2 , R 3 and...
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5677469 |
Process for resolving chiral acids with 1-aminoindan-2-ols
A process for the full or partial resolution of a mixture of enantiomers of a genus of chiral carboxylic acids is disclosed. The process uses a pure enantiomer of 1-aminoindan-2-ol as the resolving...
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5543550 |
Process for the preparation of 5-fluoroanthranilic alkyl esters and/or 5-fluoroanthranilic acid
The present invention relates to a process for the preparation of 5-fluoroanthranilic alkyl esters and/or 5-fluoroanthranilic acid, which comprises dissolving a 3-fluorobenzoic alkyl ester in...
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5523476 |
Processes for producing tetrafluorophthalic anhydride and fluorobenzoic acids
A process for producing tetrafluorophthalic anhydride, which comprises chlorinating tetrachlorophthalic anhydride to obtain 3,3,4,5,6,7-hexachloro-1-[3H]-isobenzofuranone, then fluorinating it to...
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5523472 |
Process for the preparation of 5-fluoroanthranilic acid
The present invention relates to a process for the preparation of 5-fluoroanthranilic acid, which comprises reacting 5-fluoro-2-bromotoluene in the presence of a catalyst and of an acidic solvent,...
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5481032 |
Process for the preparation of halogenated benzoic acids
A process for the preparation of halogenated benzoic acids of formula (1): ##STR1## in which R 1 , R 2 , R 3 , R 4 and R 5 are hydrogen, fluorine, chlorine or bromine atoms or C 1 -C 6 -alkyl,...
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5478963 |
2,3-difluoro-6-nitrobenzonitrile and 2-chloro-5,6-difluorobenzonitrile-(2,3-difluoro-6-chlorobenzonitrile), process for their preparation and their use for the preparation of 2,3,6-trifluorobenzoic acid
The present invention describes the novel intermediates 2,3-difluoro-6-nitrobenzonitrile and 2-chloro-5,6-difluorobenzonitrile, a process for their preparation and their advantageous use for the...
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5473095 |
Process for the preparation of chlorinated 4,5-difluorobenzoic acids, -benzoic acid derivatives and -benzaldehydes
The present invention relates to a process for the preparation of compounds of the formula ##STR1## in which R 1 is --CN, --COOH, --COOR', R' being an organic radical having 1 to 6 carbon atoms,...
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5470998 |
Process for the preparation of esters of stilbenedicarboxylic acid
Disclosed is a process for the preparation of 4,4'-stilbenedicarboxylate esters by a 3-step process utilizing p-toluic acid, an alkyl p-formylbenzoate and a trialkyl phosphite. The steps comprise ...
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5430181 |
Process for improving a controlled oxidation reaction
Process for improving a controlled oxidation reaction between at least one reactant and oxygen, in which at least one reactant is reacted with oxygen or an oxygen containing gas, constituting a...
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5424278 |
Hydroxycornexistin
Hydroxycornexistin (1), the free dibasic acid thereof (2) ##STR1## agronomically acceptable bis-ester, monoester, monoamide, and monothioesters thereof, and agronomically acceptable salts thereof...
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5411933 |
Bromopropargyl quarternary ammonium compounds having antimicrobial activity
Antimicrobial compounds of the formula ##STR1## wherein R, R 1 and R 2 are selected according to the following: A. R is (C 11 -C 16 ) alkyl (straight or branched), and R 1 and R 2 are...
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5380927 |
Process for preparing optically active 2-aryl-alkanoic acids, in particular 2-aryl-propionic acids
A chemical process is disclosed for the preparation of a pharmaceutically active compound in stereospecific form selected from the group of compounds having the formula: ##STR1## and their...
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5362909 |
Process for the preparation of 3-chloro-2,4,5-trifluorobenzoyl chloride, 2,4,5-trifuluorobenzoyl fluoride, and 2,3,4,5-tetrahalogenobenzene derivatives
2,4,5-Trihalogenobenzene derivatives of the formula ##STR1## in which R is --COOH, --COCl, --COF, --CN, --CONH 2 , --CH 2 OH, --CH 2 Cl, --CHCl 2 , --CCl 3 or --CHO, R 1 is H, Cl or F, and ...
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5359122 |
Preparation of 3-arylacrylic acids and their derivatives
The preparation of 3-arylacrylic acids and their derivatives I ##STR1## where Ar is aryl which can additionally have substituents which do not react with ketene and are stable under the conditions...
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5352701 |
Leukotriene-B.sub.4 antagonist compounds and their use as pharmaceutical agents
1. Leukotriene-B 4 antagonists of formula I ##STR1## are described, in which X is a CH 2 group or an oxygen atom, Y is C 1 -C 4 -alkoxy or --S(O) p --C 1 -C 4 -alkyl, p is 0, 1 or 2 ...
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5347057 |
Method for oxidation of methane and other hydro-carbons
This invention teaches the oxidation of alkanes and cycloalkanes in the presence of air or oxygen and a ruthenium metal complex catalyst containing an end or bridged-oxo group with a liquid L and...
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5336806 |
Purification of 2,4,5-trifluorobenzoic acid
Disclosed is a process for isolating and purifying 2,4,5-trifluorobenzoic acid from a solution in a decarboxylating solvent such as NMP. The solution is neutralized with a hydroxide. This results...
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5331011 |
N-benzyl-n-phenoxyethylamines and agricultural and horticultural bactericides
Disclosed is an N-benzyl-N-phenoxyethylamine selected from the group consisting of the N-benzyl-N-phenoxyethylamine represented by the following formula (I): ##STR1## and an agriculturally...
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5321154 |
Optical resolution of (±)-2-(4-isobutylphenyl)-propionic acid
(±)-2-(4-Isobutylphenyl)-propionic acid can be resolved into optically active isomers easily and with high yields. The method is characterized by the use of the optically active amine of the...
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5302752 |
Acetic acid derivatives and their production
Compounds of formula ##STR1## where n is an integer from 1 to 12, R and R 1 are the same or different and are hydrogen or C 1 to C 6 linear or branched alkyl as well as their physiologically...
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5292928 |
Process for the reaction of a low-molecular hydroxyl compound with a carboxylic acid halide
In a process for reacting a low molecular weight hydroxy compound with a carboxylic acid halide, a small amount of the acid halide is introduced into the reaction vessel and the remainder of the...
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5274186 |
Intermediates and their use in the synthesis of organic compounds
Compounds of formula ##STR1## (wherein Ar, R, R 1 and X have the meaning reported in the description) are useful intermediates for the preparation of a variety of organic compounds, also optically...
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5264408 |
Ceramic materials, method of preparing the same and hydrogenation and oxidation processes using the same
The present invention relates to ceramic materials containing a homogeneous dispersion of metal particles, particularly sol-gel ceramic materials, a method of preparing the same, and processes for...
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5248817 |
Process for aromatic bromination
A novel procedure for bromination of aromatic moieties utilizes N-bromosuccinimide or dibromodimethylhydantoin in an aqueous alkali medium. The bromination procedure is employed for the preparation...
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5237092 |
Process for concurrently producing aryl formate and aromatic carboxylic acid
A process for efficiently producing aryl formate and aromatic carboxylic acid from aldehyde, which comprises oxidizing an aromatic aldehyde with an oxygen-containing gas in the presence of a...
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5214193 |
Production of bisphenol monoester
A bisphenol monoester represented by the formula (I): ##STR1## wherein R 1 is hydrogen or alkyl, R 2 and R 3 are each alkyl, and R 4 is alkyl, alkenyl or phenyl, is produced by continuous two...
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5208366 |
High yield method for preparation of dialkyl esters of polyhaloaromatic acids
An improved process is provided for the preparation of esters of polyhalophthalic acids, polyhalobenzoic acids, and polyhalophthalic anhydride useful as flame retardants for thermoplastic and...
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5202472 |
Asymmetric hydrogenation of aromatic-substituted olefins using organonickel catalyst
A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R 1 are the same or different and are hydrogen, alkyl, cycloalkyl or...
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5198576 |
Bicyclooctyl phosphines and catalysts thereof
Bicyclooctyl phosphines are disclosed having the formula: ##STR1## where R is C 1 to C 6 linear or branched alkyl, phenyl, substituted phenyl, halo, or C 1 or C 6 alkoxy; Ar is phenyl,...
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5196590 |
Method of making 2,4,5-trihalobenzoic acid
Disclosed is a method of making 2,4,5-trihalobenzoic acid by heating to a temperature of about 130° to about 190° C. a composition that comprises water, a mineral acid, and a compound having the...
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5191095 |
Asymmetric hydrogenation of olefinic amides using organoruthenium catalyst
A process for the asymmetric reduction of olefinic amides of the formula ##STR1## where R and R 1 are the same or different and are hydrogen, alkyl, cycloalkyl or haloalkyl and Ar is aryl or...
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5190905 |
Asymmetric hydrogenation of aromatic-substituted olefins using metal or metal alloy catalysts
A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R 1 are the same or different and are hydrogen, alkyl, cycloalkyl or...
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5179230 |
Process for the preparation of 2,3,4,5-tetrafluorobenzoic acid
A process for the preparation of 2,3,4,5,-tetrafluorobenzoic acid of the formula (1) ##STR1## by heating N'-substituted N-aminotetrafluorophthalimides of the formula (2) ##STR2## in which X is the...
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5162577 |
Process for lithiation of 1,3-bis(trifluoromethyl)benzene
A novel process for the lithiation of 1,3-bis(trifluoro-methyl)benzene in a solvent is described, said process comprising carrying out the lithiation with the lithium salt of an amine of the...
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5113013 |
Process for preparing fluorine-containing organic compounds
A method for the preparation of a fluorine-containing organic compound which comprises reacting a sulphonyl halide of the formula: RfSO 2 X where Rf represents a fluorinated organic radical and...
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5093529 |
Process for the preparation of fluorinated benzoic acids
In the process for the preparation of fluorinated benzoic acids of the formula I ##STR1## in which X and Y, for example, independently of one another denote chlorine or fluorine and X moreover...
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5093515 |
Fluorinated benzoyl compounds
A 2-chloro-4,5-difluorobenzoyl compound of the formula: ##STR1## wherein R 2 is a lower alkyl group, and R 7 is a 2,4-difluorophenyl group or a 4-fluorophenyl group.
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5089661 |
New process for the preparation of 2-aryl-propionic acids
A new process is described for the preparation of a 2-aryl-propionic acid, such as for instance 2-[4-(2-methyl-propyl)phenyl]propionic or 2-(6'-methoxy-2'-naphthyl)propionic acid, through...
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5081252 |
Process for the preparation of aromatic carboxylic acids
A process for the preparation of aromatic carboxylic acids or their salts comprises heating carboxyl-free aromatic compounds and aromatic carboxylic acid salts whose basic structures differ from...
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5072038 |
2,3,4,5-tetrahalogenobenzene derivatives
2,3,4,5-trihalogenobenzene derivatives of the formula ##STR1## in which R is --COOH, --COCl, --COF, --CN, --CONH 2 , --CH 2 OH, --CH 2 Cl, --CHCl 2 , --CCl 3 or --CHO, R 1 is H, Cl or F, and...
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5004832 |
Preparing alpha-arylalkanoic acids
Compounds are described of formula ##STR1## in which: Ar represents an aryl, possibly substituted; R represents a C 1 -C 4 alkyl; R' represents a hydroxyl, an alkoxy, an amino group...
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4999441 |
Tetrakis(dialkylamino)aromatics and their charge transfer complexes
Tetrakis(dialkylamino)aromatics Ia to Ic ##STR1## where the radicals A may be identical or different and are n-C 1 -C 6 -alkyl and the radicals R may be identical or different and are hydrogen or...
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