|
Match
|
Document |
Document Title |
|
|
7605180 |
Nateglinide-containing preparation
The present invention discloses, as a immediate-release preparation useful as an antidiabetic, a nateglinide-containing preparation comprising nateglinide as an active ingredient wherein the...
|
|
|
7601729 |
Matrix metalloproteinase inhibitors
Compounds of Formula (I):
wherein:
A represents bond, C 1-6 alkyl or CH═CH—C 1-4 alkyl; B represents bond, O, S, SO, SO 2 , CO, CR 7 R 8 , CO 2 R 14 , CONR 14 R 15 , N(COR 14 )(COR 15 ),...
|
|
|
7569723 |
Benzoic acid derivatives as non nucleoside reverse-transcriptase inhibitors
Compounds of formula (I):
wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein. The compounds are useful as reverse transcriptase inhibitors against HIV. In particular, the...
|
|
|
7553873 |
Glutamate aggrecanase inhibitors
The present invention relates to modulators of metalloproteinase activity.
|
|
|
7544834 |
Methods for producing nateglinide B-type crystals
A method for producing B-type crystals of nateglinide substantially free of H-type crystals is provided, which comprises drying solvated wet crystals of nateglinide at a low temperature until no...
|
|
|
7541485 |
Methods for preparing glutamic acid derivatives
The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.
|
|
|
7534914 |
Substituted methyl aryl or heteroaryl amide compounds
This invention provides a compound of the formula (I):
wherein
X represents a carbon atom or the like: Y represents imino, or the like: R 1 represents an alkyl group having from 1 to 6 carbon...
|
|
|
7534913 |
Crystalline form of nateglinide
Provided are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, O, P, Q, T, U, V, Y, α, β, γ, δ, ε, σ, θ and Ω, processes for their preparation and processes...
|
|
|
7517896 |
Aminodicarboxylic acid derivatives having pharmaceutical properties
The invention relates to compounds of formulae (II), (IV), and (VI) as shown below,
wherein the several variable groups are as defined in the specification and claims. Processes for making...
|
|
|
7498460 |
Isophthalic acid derivatives
The present invention relates to isophthalic acid derivatives, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in...
|
|
|
7495030 |
(5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid and salts thereof and compositions containing the same for delivering active agents
(5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid, salts thereof, and compositions containing the same for the delivery of active agents are provided. Methods of administration, treatment of disease...
|
|
|
7482483 |
Growth factor-binding compounds and methods of use
Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods...
|
|
|
7476759 |
Matrix metalloproteinase inhibitors
Compounds of Formula (I):
wherein: R 1 is optionally substituted —C 4-12 alkyl, —C 2-10 alkylcycloalkyl, —C 2-6 alkylheterocycloalkyl, —C 2-6 alkylaryl, optionally substituted 5-...
|
|
|
7476758 |
Process for preparing a phenylalanine derivative and intermediates thereof
The present invention provides a process for preparing a novel phenylalanine derivative of the formula (I): wherein X1 is a halogen atom, X2 is a halogen atom, Q is a group of the formula —CH2—...
|
|
|
7465825 |
Phenyl substituted carboxylic acids
Disclosed are compounds and pharmaceutically acceptable salts of formula (A):
which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or...
|
|
|
7462735 |
Amino acid diamides in non α position which are useful as adjuvants for administration of biological active agents
Amino acid diamides in non α position of formula (1), wherein R 1 is selected from amongst the group consisting of the functional groups alkyl, halogen, NO 2 , OH, OCH 3 alone or associated and...
|
|
|
7462644 |
Therapeutic agents
The present invention provides the S enantiomer of a compound of formula I
wherein R 1 represents chloro, trifluoromethyl or trifluoromethoxy, R 2 represents H or fluoro and R 3 represents a...
|
|
|
7459582 |
Methods for producing nateglinide crystals
There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture...
|
|
|
7456217 |
Inhibitors of alpha4 mediated cell adhesion
The present invention relates to a phenylalanine derivative of Formula (I) wherein X 1 is a halogen atom, X 2 is a halogen atom, Q is a CH 2 R— is a carboxyl group which may be esterified; or a...
|
|
|
7442830 |
Proteasome inhibitors
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of...
|
|
|
7439388 |
Process for converting primary amidoalcohols to amidocarboxylic acids in high yield using water as solvent
The invention relates to an improved process for oxidizing a primary amidoalcohol to the corresponding amidocarboxylic acid in high yield.
|
|
|
7427688 |
Production method of optically active diphenylalanine compounds
The present invention provides a production method including reacting a diphenylmethylene halide compound represented by the following formula (1) with a malonic acid diester compound represented...
|
|
|
7427600 |
Active agent delivery systems and methods for protecting and administering active agents
The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active...
|
|
|
7425648 |
Process for the preparation of nateglinide, preferably in B-form
The present invention relates to a process for the preparation of nateglinide, preferably in B-form, substantially free from the H-form, comprising three steps starting from D-phenylalanine methyl...
|
|
|
7419970 |
Cosmetic compositions comprising N-acylamino amides
The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing,...
|
|
|
7385080 |
Method for producing optically active β-phenylalanine compounds
Optically active β-phenylalanine compound may be prepared in an industrially advantageous manner by reacting an N-acyl-β-phenylalanine compound with a specific optically resolving agent to effect...
|
|
|
7384982 |
Disodium salts, monohydrates, and ethanol solvates for delivering active agents
The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore,...
|
|
|
7378446 |
Compound having anti-HCV activity and process for producing the same
The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its...
|
|
|
7371867 |
Non-racemic trifluoroleucine, and methods of making and using
One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores...
|
|
|
7358390 |
Polymorphic forms of nateglinide
Provides are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, O, P, Q, T, U, V, Y, α, β, γ, δ, ε, σ, θ and Ω, processes for their preparation and processes...
|
|
|
7355069 |
Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance
The present invention provides a compound of formula (I), wherein n is 0, 1 or 2 and R 1 represents halo, a C 1-4 alkyl group which is optionally substituted by one or more fluoro, a C 1-4 alkoxy...
|
|
|
7351855 |
Chemically defined non-polymeric valency platform molecules and conjugates thereof
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide...
|
|
|
7351741 |
Compounds and compositions for delivering active agents
Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provide as well.
|
|
|
7342126 |
Process for the preparation of 4-oxo-4-((4-(phenylamino)phenyl)amino)-2-butenoic acid
A process for the preparation of 4-oxo-4-((4-(phenylamino)phenyl)amino)-2-butenoic acid includes reacting p-aminodiphenyl amine and maleic anhydride in a reaction first mixture containing a...
|
|
|
7321056 |
Selective peroxisome proliferator activated receptor modulators
The present invention is directed to a novel compound, its composition and use of a compound having a structural formula (I), or a pharmaceutically acceptable salt, solvate, hydrate or...
|
|
|
7314955 |
Form of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine
The present invention relates to a novel crystalline form of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and methods for preparing the same.
|
|
|
7312353 |
Cathespin cysteine protease inhibitors
This invention relates to a novel class of compounds, represented by the formula below, wherein the meanings of G, E, E, n, R 1 , R 2 , R 3 et R 4 are indicated therein, which are cysteine...
|
|
|
7273951 |
Polyhydroxy phenols and their use in binding p-selectin
Polyhydroxy phenols, which are non-peptidic mimetics of galloyl peptides, and a process for the preparation of gallic acid derivatives using a gallic-acid providing moiety are provided as well as...
|
|
|
7259276 |
Polyenecarboxylic acid derivatives, processes for preparing them, and their use
The present invention relates to novel compounds, termed serpentemycins, of the formula (I)
in which Y, R, R 2 , R 3 , R 4 , X, X 2 , X 3 , n, m and o are as defined in the specification, which...
|
|
|
7250439 |
Matrix metalloproteinase inhibitors
Compounds of formula (I):
wherein:
Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X represents O, S, NR 5 or CR 6 R 7 ; Y represents CHOH, CHSH, NOR 8...
|
|
|
7247746 |
Crystal forms of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine
New crystal forms of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine, also known asnateglinide, may be produced by dissolving nateglinide in any of its forms, including solvates, in an...
|
|
|
7247736 |
Method of identifying inhibitors of DHODH
The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting...
|
|
|
7238834 |
Piperidine derivatives and process for their production
The present invention relates to substantially pure piperidine derivative compounds of the formulae:
wherein
R 1 is hydrogen or hydroxy; R 2 is hydrogen; or R 1 and R 2 taken...
|
|
|
7227033 |
Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl) amino] butanoate
The present invention relates to amorphous and polymorphic forms of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate and their use for facilitating the delivery of active agents, such as...
|
|
|
7214712 |
Isophthalic acid derivatives as matrix metalloproteinase inhibitors
Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula
wherein:
R 1 , R 2 , and R 3 independently are hydrogen, halo, hydroxy, C 1 –C 6 alkyl, C 1 –C 6 ...
|
|
|
7193108 |
Phenylpropionic acid derivatives
Specified phenylpropionic acid derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents or preventive agents for various diseases...
|
|
|
7183317 |
Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality
It has been discovered that certain selected ethers of probucol, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may...
|
|
|
7084176 |
N-arylphenylacetamide derivatives and medicinal compositions containing the same
N-Arylphenylacetamide derivatives represented by the following formula [I]:
(wherein R 1 is C 1-6 alkoxy, etc.; R 2 is hydrogen, —(CH 2 ) m —N(R 6 )(R 7 ) (m is an integer of from 1 to...
|
|
|
7064229 |
Succinic acid derivatives
The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of...
|
|
|
7056707 |
Bioactive compound and its isolation and method of treatment for lipoxygenase inhibition and as free radical scavenging agent
The present invention relates to a novel compound having a molecular formula C 13 H 15 NO 5 having molecular structure of Formula I and a process for the isolation of said compound. The present...
|