Patents in Class 562/450

Matches 1 - 50 out of 376

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Match	Document	Document Title
1	8076374	Glucagon receptor antagonists, preparation and therapeutic uses The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods...
2	8026392	Crystalline forms of the di-sodium salt of N-(5-Chlorosalicyloyl)-8-aminocaprylic acid The present invention relates to crystalline polymorphic forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of...
3	8013184	Manufacture process of organic compounds The present invention relates to a method of preparing N-substituted salicylamides or derivatives thereof and their derivatives, e.g. their salts. In particular, the present invention relates to a...
4	8003819	Proteasome inhibitors The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of...
5	8003697	Disodium salts, monohydrates, and ethanol solvates for delivering active agents The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore,...
6	7998933	Process for treating the skin comprising applying to the skin at least one composition comprising at least one N-aminoacylamide The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing,...
7	7977506	Compounds and compositions for delivering active agents Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
8	7939666	Enzyme inhibitors Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers.
9	7915314	*WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST* Disodium salts, monohydrates, and ethanol solvates for delivering active agents The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore,...
10	7893297	Amorphous sodium 4-[4-chloro-2-hydroxybenzoyl)amino]butanoate The present invention relates to amorphous and polymorphic forms of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate and their use for facilitating the delivery of active agents, such as...
11	7863329	Glucagon receptor antagonists, preparation and therapeutic uses The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods...
12	7858665	Drugs for chronic pain The present invention relates to nitrooxyderivatives or salts thereof having the following general formula (I): R—NR1c—(K)k0—(B)b0—(C)c0—NO2 (I) wherein c0, b0 and k0 are 0 or 1; R is the radical o...
13	7816557	Glucagon receptor antagonists, preparation and therapeutic uses The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods...
14	7790770	Heterocyclic CETP inhibitors Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.
15	7781470	Aminodicarboxylic acid derivatives having pharmaceutical properties The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, wherein the several variable groups are as defined in the specification and claims. Processes for making these...
16	7767847	Process for the preparation of chirally pure N-(trans-4-is) The invention relates to N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine (nateglinide) in the novel crystalline form “G” and a process for the preparation thereof. A process for the pre...
17	7754897	Synthetic processes for the preparation of aminocyclohexyl ether compounds This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate,...
18	7750181	Antiproliferative agents This invention relates to certain dioxodihydropyridine derivatives and certain methacrylic acid and furan derivative precursors thereof, processes for their preparation, pharmaceutical compositions...
19	7745489	Compositions and methods for inhibition of phospholipase A2 mediated inflammation Specific, highly potent 2-oxo-amide based inhibitors of phospholipase A2 (PLA2) activity are provided. A role for PLA2 activity in spinally mediated inflammatory processes is established, and a...
20	7732492	Nateglinide-containing preparation The present invention provides a small-sized preparation that is easy to take, containing 26% or more of nateglinide and 28% or more of at least one disintegrant selected from the group consisting...
21	7696248	Glucagon receptor antagonists, preparation and therapeutic uses The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods...
22	7671090	Inhibitors of α4 mediated cell adhesion The present invention relates to a phenylalanine derivative of Formula (I) wherein X1 is a halogen atom, X2 is a halogen atom, Q is a CH2R— is a carboxyl group which may be esterified; or a p...
23	7662994	Method for the preparation of crystalline dexloxiglumide and products obtained The present invention describes a novel method for the purification of dexloxiglumide by crystallization from isopropyl ether which permits the production, in a reproducible manner, of a product...
24	7642289	Drugs for chronic pain The present invention relates to nitrooxyderivatives or salts thereof having the following general formula (I): R—NR1c—(K)k0—(B)b0—(C)c0—NO2 (I) wherein c0, b0 and k0 are 0 or 1;R is the radical o...
25	7605180	Nateglinide-containing preparation The present invention discloses, as a immediate-release preparation useful as an antidiabetic, a nateglinide-containing preparation comprising nateglinide as an active ingredient wherein the...
26	7569723	Benzoic acid derivatives as non nucleoside reverse-transcriptase inhibitors Compounds of formula (I): wherein R1, R2, R3, R4, R5 and R6 are as defined herein. The compounds are useful as reverse transcriptase inhibitors against HIV. In particular, the compounds are active...
27	7553873	Glutamate aggrecanase inhibitors The present invention relates to modulators of metalloproteinase activity.
28	7544834	Methods for producing nateglinide B-type crystals A method for producing B-type crystals of nateglinide substantially free of H-type crystals is provided, which comprises drying solvated wet crystals of nateglinide at a low temperature until no...
29	7541485	Methods for preparing glutamic acid derivatives The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.
30	7534913	Crystalline form of nateglinide Provided are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, O, P, Q, T, U, V, Y, α, β, γ, δ, ε, σ, θ and Ω, processes for their preparation and processes for pre...
31	7534914	Substituted methyl aryl or heteroaryl amide compounds This invention provides a compound of the formula (I): wherein X represents a carbon atom or the like: Y represents imino, or the like: R1 represents an alkyl group having from 1 to 6 carbon atoms...
32	7517896	Aminodicarboxylic acid derivatives having pharmaceutical properties The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, wherein the several variable groups are as defined in the specification and claims. Processes for making these...
33	7498460	Isophthalic acid derivatives The present invention relates to isophthalic acid derivatives, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in...
34	7495030	(5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid and salts thereof and compositions containing the same for delivering active agents (5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid, salts thereof, and compositions containing the same for the delivery of active agents are provided. Methods of administration, treatment of disease...
35	7482483	Growth factor-binding compounds and methods of use Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods...
36	7476759	Matrix metalloproteinase inhibitors Compounds of Formula (I): wherein:R1 is optionally substituted —C4-12 alkyl, —C2-10alkylcycloalkyl, —C2-6alkylheterocycloalkyl, —C2-6alkylaryl, optionally substituted 5- or 6-membered aryl or hete...
37	7476758	Process for preparing a phenylalanine derivative and intermediates thereof The present invention provides a process for preparing a novel phenylalanine derivative of the formula (I): wherein X1 is a halogen atom, X2 is a halogen atom, Q is a group of the formula —CH2— or ...
38	7465825	Phenyl substituted carboxylic acids Disclosed are compounds and pharmaceutically acceptable salts of formula (A): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or...
39	7462735	Amino acid diamides in non α position which are useful as adjuvants for administration of biological active agents Amino acid diamides in non α position of formula (1), wherein R1 is selected from amongst the group consisting of the functional groups alkyl, halogen, NO2, OH, OCH3 alone or associated and R2 is ...
40	7462644	Therapeutic agents The present invention provides the S enantiomer of a compound of formula I wherein R1 represents chloro, trifluoromethyl or trifluoromethoxy, R2 represents H or fluoro and R3 represents a C2-4alkyl...
41	7459582	Methods for producing nateglinide crystals There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture...
42	7456217	Inhibitors of alpha4 mediated cell adhesion The present invention relates to a phenylalanine derivative of Formula (I) wherein X1 is a halogen atom, X2 is a halogen atom, Q is a CH2R— is a carboxyl group which may be esterified; or a p...
43	7442830	Proteasome inhibitors The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of...
44	7439388	Process for converting primary amidoalcohols to amidocarboxylic acids in high yield using water as solvent The invention relates to an improved process for oxidizing a primary amidoalcohol to the corresponding amidocarboxylic acid in high yield.
45	7427688	Production method of optically active diphenylalanine compounds The present invention provides a production method including reacting a diphenylmethylene halide compound represented by the following formula (1) with a malonic acid diester compound represented...
46	7427600	Active agent delivery systems and methods for protecting and administering active agents The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active...
47	7425648	Process for the preparation of nateglinide, preferably in B-form The present invention relates to a process for the preparation of nateglinide, preferably in B-form, substantially free from the H-form, comprising three steps starting from D-phenylalanine methyl...
48	7419970	Cosmetic compositions comprising N-acylamino amides The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing,...
49	7384982	Disodium salts, monohydrates, and ethanol solvates for delivering active agents The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore,...
50	7385080	Method for producing optically active β-phenylalanine compounds Optically active β-phenylalanine compound may be prepared in an industrially advantageous manner by reacting an N-acyl-β-phenylalanine compound with a specific optically resolving agent to effect a...

Matches 1 - 50 out of 376

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