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7405307 Biphenylcarboxamides useful as lipid lowering agents  
Biphenylcarboxamide compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for...
7385080 Method for producing optically active β-phenylalanine compounds  
Optically active β-phenylalanine compound may be prepared in an industrially advantageous manner by reacting an N-acyl-β-phenylalanine compound with a specific optically resolving agent to effect...
7384982 Disodium salts, monohydrates, and ethanol solvates for delivering active agents  
The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore,...
7378446 Compound having anti-HCV activity and process for producing the same  
The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its...
7371867 Non-racemic trifluoroleucine, and methods of making and using  
One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores...
7358390 Polymorphic forms of nateglinide  
Provides are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, O, P, Q, T, U, V, Y, α, β, γ, δ, ε, σ, θ and Ω, processes for their preparation and processes...
7355069 Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance  
The present invention provides a compound of formula (I), wherein n is 0, 1 or 2 and R 1 represents halo, a C 1-4 alkyl group which is optionally substituted by one or more fluoro, a C 1-4 alkoxy...
7351858 Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance  
The present invention provides a compound of formula (I), wherein n is 0, 1 or 2; R 1 represents halo, a C 1-4 alkyl group which is optionally substituted by one or more fluoro, a C 1-4 alkoxy...
7351855 Chemically defined non-polymeric valency platform molecules and conjugates thereof  
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide...
7351741 Compounds and compositions for delivering active agents  
Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provide as well.
7342126 Process for the preparation of 4-oxo-4-((4-(phenylamino)phenyl)amino)-2-butenoic acid  
A process for the preparation of 4-oxo-4-((4-(phenylamino)phenyl)amino)-2-butenoic acid includes reacting p-aminodiphenyl amine and maleic anhydride in a reaction first mixture containing a...
7321056 Selective peroxisome proliferator activated receptor modulators  
The present invention is directed to a novel compound, its composition and use of a compound having a structural formula (I), or a pharmaceutically acceptable salt, solvate, hydrate or...
7314955 Form of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine  
The present invention relates to a novel crystalline form of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and methods for preparing the same.
7312353 Cathespin cysteine protease inhibitors  
This invention relates to a novel class of compounds, represented by the formula below, wherein the meanings of G, E, E, n, R 1 , R 2 , R 3 et R 4 are indicated therein, which are cysteine...
7307187 Process for converting primary amidoalcohols to amidocarboxylic acids in high yield  
The invention relates to an improved process for oxidizing a primary amidoalcohol to the corresponding amidocarboxylic acid in high yield.
7304167 Biphenylcarboxamides useful as lipid lowering agents  
Biphenylcarboxamide compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for...
7273951 Polyhydroxy phenols and their use in binding p-selectin  
Polyhydroxy phenols, which are non-peptidic mimetics of galloyl peptides, and a process for the preparation of gallic acid derivatives using a gallic-acid providing moiety are provided as well as...
7259276 Polyenecarboxylic acid derivatives, processes for preparing them, and their use  
The present invention relates to novel compounds, termed serpentemycins, of the formula (I) in which Y, R, R 2 , R 3 , R 4 , X, X 2 , X 3 , n, m and o are as defined in the specification, which...
7250439 Matrix metalloproteinase inhibitors  
Compounds of formula (I): wherein: Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X represents O, S, NR 5 or CR 6 R 7 ; Y represents CHOH, CHSH, NOR 8...
7247746 Crystal forms of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine  
New crystal forms of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine, also known asnateglinide, may be produced by dissolving nateglinide in any of its forms, including solvates, in an...
7247736 Method of identifying inhibitors of DHODH  
The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting...
7238834 Piperidine derivatives and process for their production  
The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R 1 is hydrogen or hydroxy; R 2 is hydrogen; or R 1 and R 2 taken...
7227033 Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl) amino] butanoate  
The present invention relates to amorphous and polymorphic forms of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate and their use for facilitating the delivery of active agents, such as...
7214712 Isophthalic acid derivatives as matrix metalloproteinase inhibitors  
Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula wherein: R 1 , R 2 , and R 3 independently are hydrogen, halo, hydroxy, C 1 –C 6 alkyl, C 1 –C 6 ...
7208622 Methods for producing nateglinide crystals  
There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture...
7208178 Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl) amino] butanoate  
The present invention relates to amorphous and polymorphic forms of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate and their use for facilitating the delivery of active agents, such as...
7193108 Phenylpropionic acid derivatives  
Specified phenylpropionic acid derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents or preventive agents for various diseases...
7183317 Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality  
It has been discovered that certain selected ethers of probucol, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may...
7148376 Polymorphic forms of nateglinide  
Provides are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, O, P, Q, T, U, V, Y, α, β, γ, δ, ε, σ, θ and Ω, processes for their preparation and processes...
7084176 N-arylphenylacetamide derivatives and medicinal compositions containing the same  
N-Arylphenylacetamide derivatives represented by the following formula [I]: (wherein R 1 is C 1-6 alkoxy, etc.; R 2 is hydrogen, —(CH 2 ) m —N(R 6 )(R 7 ) (m is an integer of from 1 to...
7064229 Succinic acid derivatives  
The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of...
7056707 Bioactive compound and its isolation and method of treatment for lipoxygenase inhibition and as free radical scavenging agent  
The present invention relates to a novel compound having a molecular formula C 13 H 15 NO 5 having molecular structure of Formula I and a process for the isolation of said compound. The present...
7049342 Substituted phenylpropionic acid derivatives  
The invention provides novel substituted phenylpropionic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor α (PPARα) to activate and...
7045653 Pharmaceuticals  
The invention relates to NEP inhibitors for treating cardiovascular disorders. Preferred NEP inhibitors are compounds of formula (I) wherein R 1 is C 1 –C 6 alkyl, C 1 –C 6 alkoxyC 1 –C 3...
7030268 Methods for producing acylphenylalanine  
There is provided a method for producing easily highly-purified acylphenylalanine that is useful as a raw material of pharmaceutical products and the like, which comprises the step of reacting an...
7026501 Inhibitors of α4 mediated cell adhesion  
The present invention relates to a phenylalanine derivative of Formula (I) wherein X 1 is a halogen atom, X 2 is a halogen atom, Q is a CH 2 R— is a carboxyl group which may be esterified; or a...
6992207 Melphalan derivatives and their use as cancer chemotherapeutic drugs  
The invention refers to new alkylating di- and tripeptides based on a melphalan unit, and one or two additional amino acids or amino acid derivatives, which can be used in the treatment of...
6962899 Method for reducing the inflammation and inducing an analgesic effect and compounds thereof  
Pharmaceutically acceptable compounds for administering to a subject, comprising the general structure II: wherein R 1 is an L-amino acid or salt or ester thereof, or an L-amino acid...
6939889 Quarternary ammonium compounds  
Novel compounds and pharmaceutical compositions containing such compounds and possessing anti-tussive activity, and a method of administering the same to warm-blooded animals, including humans.
6936597 Prodrugs of anticancer agents employing substituted aromatic acids  
Polymeric prodrugs of the formula: wherein B is selected from the group consisting of OH, leaving groups, residues of amine-containing moieties and a residues of hydroxyl-containing...
6930106 Inhibitors of HCV NS5B polymerase  
The present invention provides compounds of Formula I, compositions and methods that are useful for treating viral infections and associated diseases, particularly HCV infections and associated...
6903232 Process for the preparation of a highly pure pharmaceutical intermediate, 4-(cyclopropylcarbonyl)-α, α-dimethylphenylacetic acid  
This invention relates to a novel process to obtain highly pure 4-(cyclopropylcarbonyl)-α,α-dimethylphenylacetic acid of Formula I through crystallization from a mixture of para and meta...
6900344 Method of preparing alkylated salicylamides via a dicarboxylate intermediate  
The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention...
6887877 Compounds and methods for the treatment or prevention of Flavivirus infections  
The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating Flaviviridae viral infection.
6861553 Process for preparing nateglinide and intermediates thereof  
Provided is a process for preparation of an intermediate in the synthesis of nateglinide. Trans-4-isopropylcyclohexane acid chloride is formed by reacting 4-isopropylcyclohexanecarboxyl acid with...
6849649 N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase  
The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R 1 is optionally substituted C 1-6 alkyl, optionally substituted carbocyclyl, optionally...
6849648 Phenylene alkyne matrix metalloproteinase inhibitors  
A compound of Formula I or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G 1 , G 2 , and B are as defined in the application, are selective inhibitors of...
6831193 Trisubstituted-N-&lsqb (1S)-1,2,3,4-Tetrahydro-1-naphthalenyl&rsqb benzamides which inhibit P2X3 and P2X2/3 containing receptors  
Compounds of formula (I) are novel P2X 3 and P2X 2 /P2X 3 antagonists which are useful in treating pain, urinary incontinence and bladder overactivity.
6803383 Inhibition of angiogenesis and tumor growth  
Compounds which inhibit tumor growth and angiogenesis, of general formula (II) are provided. These compounds include glycyl lysine derivatives bound to a central aromatic linking core.
6770778 N-(4-substituted phenyl)-anthranilic acid hydroxamate esters  
The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions, and methods of use thereof.
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