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7504435 |
Method for stimulating weight loss and/or for lowering triglycerides in patients
Administration of a therapeutically effective amount of 3,5-diiodothyropropionic acid stimulates weight loss in patients, lowers triglyceride levels and reduces risk of death or progression of...
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7357835 |
Production of crystalline materials by using high intensity ultrasound
A crystalline material sufficiently pure for use in pharmaceuticals may be made by forming a saturated solution of the material, changing the temperature of the solution so it becomes...
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7163918 |
Iodothyronine compositions
The present invention relates to compositions comprising thyroxine (T4) and triiodothyronine (T3). More specifically, the invention relates to thyroxine (T4) and triiodothyronine (T3) compositions...
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7153997 |
Benzamide derivatives as thyroid receptor ligands
This invention relates to novel compounds, which are thyroid receptor ligands, and to methods of preparing such compounds. In addition, a method is provided for preventing, inhibiting or treating...
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7145040 |
Process for the preparation of amino acids useful in the preparation of peptide receptor modulators
The present invention provides process useful for the preparation of intermediates which are useful in the preparation of amino acids useful in preparing peptide receptor modulators, for example...
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6716877 |
Method to treat chronic heart failure and/or elevated cholesterol levels
A method for treating a patient having congestive heart failure by administering a therapeutically effective amount of 3′,3,5-triiodothyropropionic acid (TRIPROP) or...
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6337064 |
Manganese chelates with high relaxivity in serum
Compounds of formula (I) both in the racemic and optically active forms, are used in MRI diagnostic imaging.
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6229011 |
N-aroylphenylalanine derivative VCAM-1 inhibitors
Compounds of the formula: ##STR1## are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose...
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5958979 |
Stabilized medicaments containing thyroid hormones
The present invention relates to stabilized medicaments containing thyroid hormone the stabilizing component of which is sodium thiosulfate in a mass ratio of thyroid hormone to sodium thiosulfate...
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5917087 |
Process for producing sodium 1-thyroxine comprising the oxidative coupling of a diido-1-tyrosine catalysed by a manganese salt in the presence of an amine
Improvements to a six stage process for production of sodium l-thyroxine from l-tyrosine described in U.S. Pat. No. 2,889,363 and U.S. Pat. No. 2,889,364 (Baxter)! are described, the improvements...
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5219764 |
Hapten-biotin conjugates and their use
Hapten-biotin conjugates in which the hapten is linked with biotin via a spacer, which has 26 to 40 atoms in its chain and contains at least 5 heteroatoms, are novel and are suitable, in particular...
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5169984 |
Synthesis and characterization of N-bromoacetyl-3,3'5-triiodo-L-thyronine using high speed countercurrent chromatography
A method for synthesizing N-bromoacetyl-3,3',5-triiodo-L-thyronine which involves subjecting 3,3', 5-triiodo-L-thyronine to a one-step bromacetylation reaction wherein 3,3', 5-triiodo-L-thyronine...
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4820860 |
Novel thyronine derivatives
The invention relates to novel thyronine derivatives of the formula ##STR1## in which n is 10-400, R denotes H, alkyl or N-carbonylthyronine, R 1 and R 2 are identical or different and denote...
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4801742 |
N-formylation of amino carboxylates with alkyl formates
Formylating the amino nitrogen of an alkali metal salt of an amino carboxylic acid, by reacting the salt with an alkyl formate in an alkanol solvent. In one embodiment, the alkyl formate is added...
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4741897 |
Thyroxine analogs and reagents for thyroid hormone assays
The present invention relates to new compounds of the general formula: ##STR1## where X is iodine or hydrogen; A is a linking portion; and R is an iodinatable aryl or heteroaryl group having...
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4675439 |
Preparation process of N-acylphenylalanines
A process for preparing an N-acylphenylalanine represented by the formula (II): ##STR1## wherein R 3 and R 4 mean individually a hydrogen atom or an alkyl, alkoxy, phenoxy, hydroxy or...
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4613691 |
Preparation of amino acids from unsaturated hydantoins
Amino acids can be easily prepared by reducing unsaturated hydantoins to the corresponding saturated hydantoins by hydrogenating the unsaturated hydantoin using either Raney Nickel catalyst in the...
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4612388 |
Process for producing N-acylphenylalanines
Disclosed herein is a process for producing an N-acyl-substituted or unsubstituted phenylalanine comprising hydrolyzing a 2-substituted-4-substituted or unsubstituted benzylidene-5-oxazolone with...
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4540792 |
Process for the preparation of a free L α-amino acid
This invention relates to a process for the preparation of free L α-amino acids by the complete conversion of their D antipodes taken individually or possibly in racemic mixtures. The process...
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4510251 |
Fluorescent polarization assay for ligands using aminomethylfluorescein derivatives as tracers
This disclosure relates to a method for determining ligands in biological fluids such as serum, plasma, spinal fluid, amnionic fluid and urine, wherein a novel class of aminomethylfluorescein...
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4452783 |
Derivatives of substituted phenylacetic acids and compositions containing them
Aminoacid and peptide derivatives of the formula: A--NH--R 1 --CO] x [NH--R 2 --CO] y NH--R 4 --COOH in which A, R 1 , R 2 , x and y have the meanings specified in claim 1 for formula I, and...
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4423227 |
Process for the preparation of reactive, couplable derivatives of the thyroid hormones
Process for the preparation of reactive, couplable derivatives of the thyroid hormones 3,3',5-triiodothyronine (T 3 ) and 3,3',5,5'-tetraiodothyronine (T 4 ) by reaction with reactive carboxylic...
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4399121 |
Iodothyronine immunogens and antibodies
Immunogen conjugates comprising N-aminoalkyl derivatives of iodothyronines, e.g., thyroxine and its lower alkyl esters, coupled to an immunogenic carrier material, and antibodies raised against...
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4358604 |
N-Aminoalkyl iodothyronine derivatives
N-Aminoalkyl derivatives of iodothyronines, e.g., thyroxine and its lower alkyl esters, immunogen conjugates comprising the derivatives coupled to an immunogenic carrier material, and antibodies...
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4311853 |
Selenium derivatives of thyroxine and tri-iodothyronine
Novel Selenium derivatives of thyroxine and tri-iodothyronine have the formula: ##STR1## wherein M is I or H and either (a) R 1 is OH or a carboxyl protecting group and R 2 contains at least one...
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4133753 |
Method of ion exchange chromatography
The separation of constituents is carried out in such a way that a mixed amino acid sample is supplied to a separation column packed with a cation exchange resin and that, during the analysis of...
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3776698 |
TEST FOR THYROID HORMONE
Method for separating thyroid hormone from blood serum, which is particularly suitable for use in an improved T-4 test procedure. The improved T-4 test procedure includes an extraction step whereby...
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3753655 |
PROCESS FOR ISOLATION AND SEPARATION OF THYROID HORMONES
A process for isolating and separating the thyroid hormones triiodothyronine and thyroxine from blood serum which comprises first isolating the hormones from the serum by means of a mixed...
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3536726 |
PREPARATION OF ALPHA-AMINO-CARBOXYLIC ACIDS
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3477954 |
PHOSPHONIUM IODIDE COMPLEXES OF THYROXINE,METHODS OF PREPARING SAME,AND METHODS OF PREPARING 3,5,3'-L-TRIIODOTHYRONINE THEREFROM
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3471553 |
METHOD FOR DETERMINATION OF PROTEINBOUND IODINATED COMPONENTS
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3410891 |
Novel thyronine derivatives
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3374269 |
Process of producing 3, 5-diiodothyronines
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3352879 |
Metal chelates of hydantoins and their use in making 5-substituted hydantoins
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3287396 |
Phenyldesoxythyronines
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3149153 |
3'-substituted-3, 5-diiodothyronine and salts thereof
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3109024 |
Method of preparing thyroxine and its analogs
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3102136 |
Process of preparing diiodinated analogs of thyronine
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3085111 |
Process for preparing 3-nitrobenzaldehyde ethers
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3067247 |
Process for preparing l(+)-3, 5-diiodothyronine
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3046306 |
Process of preparing triiodinated analogs of thyronine
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3045041 |
Naphthoxy substituted phenylalanine derivatives
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3023235 |
New amino acids and derivatives thereof
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3017428 |
Antihypercholesterolemic thyronine derivatives
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3010993 |
Thyromimetic amino acids
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2993928 |
Preparation of triiodothyronine
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2970165 |
Sulfate compounds
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2950315 |
Production of 3, 5-diiodothyronine
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2895927 |
Synthesis of thyronine compounds
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2894977 |
Process of preparing phenoxycinnamic acid derivatives
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