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7626054 |
Biaromatic compounds which activate PPARγ-type receptors and cosmetic/pharmaceutical compositions comprised thereof
Novel biaromatic compounds having the following structural formula (I):
are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine, in particular...
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7572933 |
Skin and hair restoration by natural amino acid peptide complexes
This invention relates to certain skin and hair care agents of formula (I), derived from natural amino acids and peptides. These agents provide multi-functional treatment of enzyme-related topical...
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7557143 |
Thyroid receptor ligands
Thyroid receptor ligands are provided which have the general formula I
wherein:
R1 is
R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 4...
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7495126 |
Process of preparation of substituted tetrafluorobenzylaniline compound and its pharmaceutically approved salts
This invention relates to a method for preparing tetrafluorobenzyl-5-aminosalicylic acid derivative and its pharmaceutically acceptable salt compounds. In particular, this invention relates to a...
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7485742 |
Non-glycosidic and non-peptidic inhibitors of selectin, and the use thereof
A new class of non-glycosidic and non-peptidic inhibitors of selectins with low molecular weight according to the general formula 1
is described, as well as methods for their production. These...
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7482484 |
Carboxylic acids and derivatives for the treatment of and preventing diabetes and dyslipidaemia
Disclosed are Compounds of formula I
And methods of use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes.
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7459585 |
Benzene derivatives and pharmaceutical use thereof
The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory...
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7439396 |
Pharmaceutical/cosmetic compositions comprising novel ligands that activate RAR receptors
Novel ligand compounds that activate RAR receptors have the following structural formula (I):
and are suited for formulation into pharmaceutical compositions useful in human or veterinary...
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7439383 |
Sodium channel blockers
The present invention is directed to novel phenytoin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be...
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7427496 |
Anti-cancer compounds
The invention provides bradykinin antagonists and pharmaceutically acceptable salts thereof having anti-cancer activity. These anti-cancer compounds are particularly useful for inhibiting the...
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7423172 |
Tyrosine derivatives as PPAR-γ-modulators
Compounds of general formula I, and the salts and solvates thereof, wherein R1 represents the radical 2-benzoylphenylamino; R2 represents —(CH 2 ) s —N(COR 3 )-A-J-T or —(CH 2 ) s —N(R 4...
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7417060 |
Aminoalcohol derivatives
The present invention relates to a compound formula[I]:
wherein
X is bond, —CH 2 —, —O— or —NH—, R 1 and R 12 are each independently hydrogen, halogen, lower alkyl, etc., R 2 ...
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7411031 |
Synthesis of polyanhydrides
The present invention provides a method for forming compounds of Formula
HO—C(═O)R 1 —X—R 2 —X—R 1...
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7408078 |
Anthranilic acid derivatives useful in treating infection with hepatitis C virus
The present invention provides pharmaceutical compositions useful in treating hepatitis C infection. The present invention also provides methods of treating hepatitis C infection by administering...
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7384789 |
Divalent metal ion sensors and binders
Diamino polyacetate benzene compounds are used as a selective fluorescence probe, sensor, or binders for divalent metal ions. The compounds provide for uses as divalent metal ion sensors in...
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7371867 |
Non-racemic trifluoroleucine, and methods of making and using
One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores...
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7361686 |
Compounds for the treatment of metabolic disorders
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and...
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7351849 |
Process for producing optically active β-amino acid derivatives
The present invention is to provide a method for producing the desired optically active β-amino acid derivatives of high optical purities in high yields, without requiring a step of deprotection....
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7319164 |
5-azido-laevulinic acid, method for the production thereof and its use
The present invention relates to 5-azido levulinic acid, a process for its preparation, its use. Using 5-azido levulinic acid as starting material for the synthesis of 5-amino levulinic acid...
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7312361 |
Inhibitors of transthyretin amyloid fibril formation
Bisaryloxime ethers and bisarylhydroazones are shown to be effective for inhibiting formation of amyloid fibrils of transthyretin.
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7300948 |
Alkynyl compounds as non nucleoside reverse transcriptase inhibitors
Inhibitors of HIV reverse transcriptase which are useful for the treatment of HIV infection. Exemplars of the invention are compounds of the formula
wherein the substituents are as defined in...
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7220876 |
Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals
Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl derivatives having branched side...
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7166641 |
Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same
The present invention provides pharmaceutically acceptable salts having local anesthetic and anti-inflammatory activities. The preferred pharmaceutically acceptable salt is a diclofenac salt of...
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7164034 |
Alpha2delta ligands for fibromyalgia and other disorders
This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs...
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7157596 |
Inhibitors of serine protease activity of matriptase or MTSP1
The present invention provides compounds which inhibit serine protease activity of matriptase or MTSP1. Also provided are pharmaceutical compositions comprising those compounds and methods of using...
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7135587 |
Urea and urethane derivatives as integrin inhibitors
Novel urea and urethane derivatives of general formula (I) in which R1, R2, R3, R5, R5′, X, Y, B, m, n and o are as defined in Patent Claim 1 , and physiologically acceptable salts or solvates...
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7132559 |
Non-racemic hexafluoroleucine, and methods of making and using it
One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores...
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7129366 |
Group of a novel anti-cancer compounds with specific structure
Compounds containing a specific saturated or unsaturated branched chain terminal group; a polar leading group; and a long-chain aliphatic, non-cyclic, saturated or unsaturated, substituted or...
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7115766 |
Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
Radiolabeled fluorinated compounds useful for imaging in the diagnosis of Parkinson's Disease are disclosed. Methods and kits for their synthesis are also disclosed.
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7109364 |
Group of anti-cancer compounds with specific structure and their production method
Compounds containing a specific branched chain end terminal group, which is isopropyl, sec.-butyl, or tert.-butyl; a polar leading group; and long-chain aliphatic, non-cyclic, saturated or...
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7109343 |
Metal catalysts and methods for making and using same
Compounds having the formula:
are disclosed. M 1 and M 2 are the same or different and are transition metal atoms or ions; Z 2 and Z 3 , independently, are the atoms necessary to complete a...
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7078564 |
Process for the preparation of ωbenzyl esters of amino diacids and of alkanesulphonates of these esters, and these alkanesulphonates
The invention relates to a process for the preparation of an ω-benzyl ester of an amino diacid, characterized in that the amino diacid is reacted with a benzyl alcohol derivative of formula (I)
...
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7071168 |
Anti-cancer compounds and methods related thereto
The present invention provides compounds useful to inhibit tumor growth and to induce apoptosis. In general, the anti-cancer agents (ACA) are described by the formula:
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7067694 |
Halogen-substituted amino dicarboxylic acid derivatives as medicaments for treating cardiovascular diseases
Compounds of the general formula (I)
wherein R 1 represents halogen, R 2 and R 3 represent H or halogen, and R 4 represents C 3-8 -cycloalkyl or optionally substituted phenyl,...
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7067530 |
Compounds, their preparation and use
Novel compounds of general formula (I), the use of these compounds as medicaments, pharmaceuticaly compositions comprising the compounds and methods of treatment employing these compounds and...
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7057066 |
Process for producing 3-amino-2-hydroxypropionic acid derivatives
The present invention provides a process for preparing 3-amino-2-hydroxypropionic acid derivatives (1) which does not use dangerous reagents, is economically advantageous, and is suitable for an...
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7053122 |
Therapeutic use of aryl amino acid derivatives
The compounds of formula (I)
are useful in the treatment of faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, neuropathic pain,...
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7034055 |
2-aminoindane analogs
The present invention relates to therapeutically active 2-aminoindane analogs of formula (I):
Also provided is a method of preparing compounds of formula (I), and pharmaceutical compositions...
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7030267 |
Cycloproply β-amino acid derivatives
This invention relates to novel cyclopropyl β-amino acids derivatives of the formula
wherein R 1 through R 4 are defined as in the specification, pharmaceutical compositions containing them...
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7030262 |
3-Amino-2-hydroxyalkanoic acids and their prodrugs
Compounds having the formula
are useful for treating conditions which arise from or are exacerbated by angiogenesis. Also disclosed are pharmaceutical compositions comprising the compounds,...
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7022875 |
Thiobutacin and antifungal and antioomycete composition for controlling plant diseases using the same
A novel antibiotic thiobutacin, obtainable from Lechevalieria aerocolonigenes strain VK-A9, and antifungal and antioomycete compositions comprising thiobutacin as an active ingredient for control...
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7019161 |
Processes for the preparation of 3-aminocarboxylic acids and their esters
The present invention relates to novel processes for the preparation of optically active 3-aminocarboxylic acids and their esters, in particular processes for the preparation of optically active...
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7019033 |
2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives
Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula
where R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are hydrogen or substituent groups such as alkyl, and...
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7015352 |
Pro drugs for selective drug delivery
Prodrug compounds capable of permeating a desired biological compartment and releasing a biologically active molecule in active form to effect a therapeutic functional change in the compartment to...
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7015349 |
Reduction of hair growth
Compositions including a conjugate of α-difluoromethylornithine can be applied topically to reduce hair growth.
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7015345 |
Propionic acid derivatives
A compound represented by the following formula (1) or a salt thereof:
wherein R 1 represents a C 1-12 alkyl group, phenyl group, 1-naphthyl group and the like, R 2 represents a C 2-12 ...
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7012151 |
Method for nitrating aniline derivatives
The present invention relates to a process for the highly regioselective aromatic nitration of alkyl 4-alkanoylamino-3-alkyl-benzoates in the 5-position in a mixture containing nitric acid and the...
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6974796 |
Therapeutic compositions for treatment of a damaged tissue
The present invention relates to a therapeutic composition and uses thereof for treatment of damaged tissue, wherein the composition comprises at least one extracellular matrix compound, at least...
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6939990 |
Derivatives of dicarboxylic acid having pharmaceutical properties
The invention relates to compounds of the general formula (I)
wherein R 1 represents H, halogen, or OCF 3 ; R 2 and R 3 each represents H or halogen; R 4 represents C 1-6 -alkyl, C 3-8...
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6939989 |
Side-chain halogenated amino dicarboxylic acid derivatives as medicaments for treating cardiovascular diseases
Compounds of the general formula (I)
wherein R 1 represents halogen, R 2 represent H or halogen, and R 3 represents C 3-8 -cycloalkyl, C 3-8 -cycloalkenyl, or optionally substituted phenyl,...
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