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7321055 |
Production method of optically active dephenylalanine compounds
Optically active diphenylalanine compounds may be conveniently prepared in a good yield by reacting a diphenylalanine compound represented by formula (1) with an optically active amine compound...
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7214819 |
Fluorous triphasic reaction and separation processes for the generation of enantioenriched alcohols, amines, carboxylic acids and related compounds
A method of obtaining an enantioenriched organic compound comprising the steps of: 1) generating from a starting racemic, non-enantiopure or achiral compound a first mixture comprising at least one...
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7214820 |
Process for producing optically active flurbiprofen
The present invention provides a method for producing optically active flurbiprofen. The method of the present invention includes mixing racemic flurbiprofen and (S)- or...
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7034178 |
Process for the production of 3-phenylisoserine
This invention is drawn to a process for the production of (R,R)-phenylisoserine or a 1–4C-alkyl ester thereof.
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7019152 |
Process for the optical resolution of a precursor of sclareolide
The present invention relates to the field of organic synthesis and more particularly to a new process for the optical resolution of a precursor of sclareolide. This process includes the reaction...
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6559338 |
Method for racemate splitting of 2-hydroxypropionic acids
A process for racemate resolution of 2-hydroxypropionic acids by reacting the racemic acid with an optically active base and subsequently separating off a diastereomeric salt of acid and base...
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6462229 |
Process for the preparation of (-)-α-(difluoromethyl)ornithine-monohydrochloride monohydrate
(±)-α-(Difluoromethyl)-ornithine is separate into its isomers using (−)-O,O′-di-p-toluoyl-L-tartaric acid. (−)-α-(Difluoromethyl)-ornithine monohydrochloride monohydrate and in particular...
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6462221 |
Synthesis of nitroalcohol diastereomers
The present invention relates to a method of preparing a 1-nitro-3-substituted-3-amino-2-propanol diastereomer represented by Structural Formula I: In Structural Formula I, R is an amine...
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6458955 |
Process for preparation of pharmaceutically desired enantiomers
Improved processes for preparation of high enantiomeric purity compounds center on resolution using simulated moving bed chromatography of a racemic precursor early in the synthesis. Resolution is...
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6342629 |
Process for production of optically active n-protected-n-methyl-phenylalanine derivative
There is provided a process for industrially and efficiently producing an optically active N-protected-N-methyl-4-halogenophenylalanine at a high purity, which is useful as an intermediate for the...
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6207854 |
Preparation of 3-amino-3-cyclopropylpropanoate esters
Disclosed a process for preparing substantially enantiomerically pure 3-amino-3-cyclopropylpropanoate esters, i.e., esters of 3-amino-3-cyclopropylpropanoic acid (3-cyclopropylalanine esters or...
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6147254 |
Process for resolving mixtures of carbocyclic stereoisomers
A process for the preparation of carbocyclic stereoisomers of formulae (I), (I'), (IIA'), (IIB'), (VA') and (VB'), including enantiomerically pure (IIA'), (I) and (I') utilizing fractional...
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6093846 |
Process for preparing optically active 2-hydroxy-methyl-3-phenylpropionic acid
A process for preparing optically active 2-hydroxymethyl-3-phenylpropionic acid by resolving (RS)-2-hydroxymethyl-3-phenylpropionic acid via crystallization of an optically active amine salt, where...
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6090971 |
Resolution process for cyclohexylphenyl glycolic acid
A process for the preparation of optically active phenylcyclohexylglycolate esters is described. The process utilizes carboxylic acid activation to couple (R)-- or (S)-cyclohexylphenylglycolic acid...
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6087530 |
Process for preparing β-amino-α-hydroxy acid derivatives
An object of the present invention is to provide a process for producing a β-amino-α-hydroxy acid derivative via efficient and industrially utilizable steps. The present invention provides a...
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6008403 |
Method for producing optically active amino acid of derivative thereof having high optical purity
A method for producing an optically active amino acid or derivative thereof having a high optical purity from an optically active amino acid comprising optical isomers or derivative thereof, which...
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5994560 |
Resolution of racemic mixtures using polymers containing chiral units
Described herein is a novel process to resolve a racemic compound into its optically active isomers without need for chemical transformation such as salt formation. The process advantageously...
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5892112 |
Process for preparing synthetic matrix metalloprotease inhibitors
Synthetic mammalian matrix metalloprotease inhibitors are disclosed that are useful for treating or preventing diseases wherein said diseases are caused by unwanted mammalian matrix metalloprotease...
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5840964 |
Process for the preparation of the enantiomers of 2-(2-fluoro-4-biphenyl)propionic acid
A process for the preparation of 2-(2-fluoro-4-biphenyl)propianic acid enantiomers comprising a II order resolution of ketals of formula ##STR1## wherein R 1 ad R 2 have the meanings reported in...
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5763647 |
Preparation of optically active 1,4-bridged-cyclohexane carboxylic acid derivatives
A process for preparing an optically active 1,4-bridged-cyclohexane carboxylic acid derivatives which are clinically important thromboxane A 2 thromboxane of formula (IV): ##STR1## wherein, R is...
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5510520 |
Optical resolution method
The present invention provides three optical resolution methods. The first aspect comprises the steps of adding an optically active bifunctional resolving reagent to a bifunctional compound to form...
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5449728 |
Optically active acetylene polymer, membrane thereof and optical resolution method using the same
An optically active acetylene polymer which is obtained by polymerizing an optically active form of 1-[dimethyl(10-pinanyl)silyl]-1-propyne which is represented by the following formula (I) and has...
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5426215 |
Process for converting [R(-)-2(3-benzoylphenyl)-propionic acid to the S(+) isomer]
Process for transforming (benzoyl-3-phenyl)-2-propionic-R(-) acid into an S(+) isomer through the action of a base either in situ during the splitting of racemic ketoprofen or on the...
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5391634 |
Optically-active, amphiphilic, water-soluble free-radical addition copolymers and their use in the resolution of racemic mixtures
Optically-active, amphiphilic, free-radical addition copolymers having an optically-active hydrophobic portion and an ionic hydrophilic portion are effective resolving agents. This utility is based...
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5321154 |
Optical resolution of (±)-2-(4-isobutylphenyl)-propionic acid
(±)-2-(4-Isobutylphenyl)-propionic acid can be resolved into optically active isomers easily and with high yields. The method is characterized by the use of the optically active amine of the...
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5306826 |
Process for preparation of an optically active amino acid amide
The present invention relates to a process for the preparation of optically active amino acid amide. L-amino and D-amino acid amides are mixed in the presence of 0.5-4 equivalents of an aldehyde,...
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5302751 |
Profen resolution
A process is disclosed that is useful for separating the enantiomers of a racemic mixture of an aliphatic carboxylic acid having the formula ##STR1## where R 1 is hydrogen or alkyl, R 2 , R 3 and...
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5302741 |
Optical resolution of threo-2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)-propionic acid
D(+)-threo-2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxypheny
l)propionic acid, an important intermediate in the synthesis of diltiazem hydrochloride, is obtained in better yields and high optical...
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5231181 |
Process for the preparation of (8As,12AS,13AS)-decahydroisoquino ((2,1-G) (1,6)-naphthyridin-8-one derivatives
The invention provides a process for preparing single enantiomers of compounds represented by the formula: ##STR1## and chiral acid addition salts thereof; wherein: X and Y are independently...
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5200555 |
Process for the preparation of S(+)-6-methoxy-α-methyl-2-naphthalene-acetic acid
The invention relates to a process for the preparation of S(+)-6-methoxy-α-methyl-2-naphthalene-acetic acid by resolution of R,S-6-methoxy-α-methyl-2-naphthalene-acetic acid. According to the...
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5198557 |
Process for the resolution of 3-(4-substituted-phenyl)-glycidic acid derivatives
A process for the kinetic resolution of cis or trans enantiomeric mixtures of the compounds of formula ##STR1## wherein R 3 and X have the meanings reported in the specification and the asterisks...
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5196575 |
Supercritical separation of isomers of functional organic compounds at moderate conditions
A method of separating isomers of functionalized aromatic compounds using solvent-modified supercritical carbon dioxide is disclosed and claimed. In one embodiment, isomers of hydroxynaphthoic acid...
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5191112 |
Process for optical resolution of (±)-2-(3-benzoyl)-phenylpropionic acid
Optical resolution of (±)-2-(3-benzoyl)-phenylpropionic acid is attained effeciently in high yield by the use of a specific optically active amine which is represented by the general formula [I]:...
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5189208 |
Ibuprofen resolution
A process for obtaining a substantially pure enantiomer of ibuprofen is described. The process utilizes first an enantiomerically enriched mixture of ibuprofen obtained from kinetic resolution,...
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5183922 |
Process for the optical resolution of threo-2-hydroxy-3-(2'-aminophenylthio)-3-(4"-methoxyphenyl)-propionic acid
The present invention relates to a process for the separation of the enantiomers of threo-2-hydroxy-3-(2'- aminophenylthio)-3-(4"-methoxyphenyl)-propionic acid, which is an important intermediate...
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5177257 |
Benzocycloalkenecarboxylic acid and process for its preparation
The novel (S)-4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxyl
ic i.e. the compound of the formula ##STR1## in free form or in salt form, can be used as active ingredient in pharmaceutical...
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5136050 |
Process for resolving amino acids using substituted lactones
Novel substituted lactones of amino acids in all their possible stereoisomeric forms or mixtures thereof of the formula ##STR1## wherein A is a hydrocarbon chain of 1 to 10 chain members containing...
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5097059 |
Resolution process of intermediates useful for the preparation of diltiazem
A process of spontaneous resolution of compounds of formula ##STR1## wherein R has the meanings reported in the description, is described. The compounds of formula III are intermediates useful for...
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5013834 |
Process for the preparation of an optically active benzothiazepinone
A process for the optical resolution of 2-hydroxy-3-(4-methoxyphenyl)-3-(2-acetylaminophenylthio)-pr
opionic acid sodium salt by seeding of a supersaturated solution of said salt with one of the...
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5003076 |
Benzotriazole derivatives and chiral derivatization reagents for carboxylic acids thereof
Novel fluorescent chiral derivatization reagent containing a compound of the formula: ##STR1## being useful for the determination of carboxylic acid enantiomers with high sensitivity, which are...
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4994604 |
Formation and resolution of ibuprofen lysinate
A process is disclosed for the formation and resolution of (S)-ibuprofen-(S)-lysine. The process employs preferential crystallization to separate a pair of diasteromeric salts,...
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4983765 |
Process to separate mixtures of enantiomeric arylpropionic acids
A process is described in which a mixture of enantiomeric arylpropionic acid is split and one of enantiomeric forms of the acid is recovered. The mixture is transformed into a diastereoisomeric...
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4933490 |
Process for the preparation of L(-)carnitine hydrochloride and of L(-)carnitine inner salt
The invention refers to a process for the preparation of L(-)carnitine by using dibenzoyl-D(31 )tartaric acid and crystallizating the relative salt at low temperature.
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4931587 |
Process for the optical resolution of a racemic acid
A process for the optical resolution of 2-hydroxy-3-(4-methoxyphenyl)-3-(2-acetylaminophenylthio)-pr
opionic acid sodium salt by seeding of a supersaturated solution of said salt with one of the...
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4910309 |
Enrichment of optical of 2-(4-aryloxyphenoxy)-propionic acids by crystallization as hydrates
The optical purity of an optically active 2-(4-aryloxyphenoxy)propionic acid is enriched by formation of the hydrate of the enantiomer in excess and its removal from solution.
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4874473 |
Separation of diastereomers by extractive distillation
Diastereomers can be separated with good industrial success with the aid of extractive distillation. The separation process is characterized in that an auxiliary which changes the partial pressure...
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4865770 |
Process for the optical resolution of 2-(6-methoxy-2-naphthyl)propionic acid
A process for the optical resolution of 2-(6-methoxy-2-naphthyl)propionic acid by seeding a supersaturated solution of the ethylamine salt of said acid.
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4864031 |
Process for the resolution of D,L-racemic mixtures
The invention relates to a process for the kinetic resolution of D,L-racemic mixtures of racemates crystallizing as conglomerates. Resolution is effected from supersaturated solutions of these...
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4855446 |
Process for the resolution of racemates using lactone esters
Racemic carboxylic acids are resolved into their enantiomers using optically active enantiomers of four lactones as resolving agents. The four lactones are 2,3-isopropylidene-ribonic...
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4847409 |
Recovery of L-amino acid isomers from their racemic mixtures
A method for the isolation of a substantially pure L-isomer of an amino acid from its D,L racemic mixture does not require the use of a resolving agent, the formation of a derivative of the amino...
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