|
Match
|
Document |
Document Title |
|
|
7619112 |
Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
The invention relates to pure (R)—CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically...
|
|
|
7592480 |
Process for producing optically active carboxylic acid
The invention provides a process for producing optically active 2,2-dimethylcyclopropanecarboxylic acid by reacting an optical isomer mixture of 2,2-dimethylcyclopropanecarboxylic acid with an...
|
|
|
7432394 |
Resolution of α-(phenoxy) phenylacetic acid derivatives with naphthyl-alkylamines
The present invention provides a methods and compounds for producing an enantiomerically enriched α-(phenoxy)phenylacetic acid compound of the formula:
from a mixture of its enantiomers, where...
|
|
|
7429675 |
Process for the preparation of racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid
The present invention provides a process for the preparation of substantially racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfon
yl)oxy]phenoxy}ethyl)phenyl]-propanoic acid which...
|
|
|
7417165 |
Crystalline forms of pregabalin
Crystalline form of Pregabalin characterized by X-ray powder diffraction peaks at about 5.8, 18.4, 19.2, 20.7, and 23.7° 2θ±0.2° 2θ, methods for its preparation, its pharmaceutical...
|
|
|
7388098 |
Dynamic resolution of isomers and resolved isomers
Provided is a dynamic resolution method of enriching a desired isomer of an alpha-substituted carboxylic acid relative to an undesired isomer, the method comprising: (a) in a solvent, contacting...
|
|
|
7388023 |
Amino acids with affinity for the α2δ-protein
Certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of...
|
|
|
7385080 |
Method for producing optically active β-phenylalanine compounds
Optically active β-phenylalanine compound may be prepared in an industrially advantageous manner by reacting an N-acyl-β-phenylalanine compound with a specific optically resolving agent to effect...
|
|
|
7381835 |
Resolution process for (R)-(-)-2-hydroxy-2-(2-chlorophenyl) acetic acid
The subject of the present invention is the preparation of the (R)-(−)-2-hydroxy-2-(2-chlorophenyl)acetic acid of the formula (I) by the resolution of the corresponding racemic compound by using...
|
|
|
7321055 |
Production method of optically active dephenylalanine compounds
Optically active diphenylalanine compounds may be conveniently prepared in a good yield by reacting a diphenylalanine compound represented by formula (1) with an optically active amine compound...
|
|
|
7271280 |
Process for preparing a biaryl compound
A process for preparing an optically active biaryl compound the formula (4):
which comprises reacting an aromatic sulfonic acid ester compound of the formula (1):
with an organic boron...
|
|
|
7199264 |
Method of resolving optical isomers of amino acid derivative
Provided is a separating method for an optical isomer mixture comprising the steps of mixing an amino acid derivative such as N-(tert-butoxycarbonyl)-DL-alanine in which optical isomers of a D type...
|
|
|
7105698 |
Process for the separation of R(-)-and S(+)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2- methoxybenzenesulfonamide
The process for separating the R(−)- and S(+)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy
benzene-sulfonamide enantiomers comprises (a) reacting a mixture of said enantiomers with an...
|
|
|
7034178 |
Process for the production of 3-phenylisoserine
This invention is drawn to a process for the production of (R,R)-phenylisoserine or a 1–4C-alkyl ester thereof.
|
|
|
6864389 |
Method for producing α-hydroxycarboxylic acid
The present invention relates to:
a method for producing α-hydroxycarboxylic acid, which comprises hydrolyzing cyanohydrin in the presence of a hydrocarbon solvent; a method for producing...
|
|
|
6794537 |
Manufacturing processes for Se-methyl-L-selenocysteine
Convenient processes are described for the synthesis of L-Se-methyselenocysteine from chloroalanine derivatives. The process is easily extendable to other selenium substituted amino acids....
|
|
|
6781012 |
Process for the preparation of optically and chemically highly pure (R)- or (S)-α-hydroxycarboxylic acids
Process for the preparation of optically highly pure (R)- and (S)-α-hydroxycarboxylic acids, in which either isolated, impure (R)- and (S)-α-hydroxycarboxylic acids prepared by acidic hydrolysis...
|
|
|
6750370 |
Process for racemizing optically active vinyl-substituted cyclopropanecarboxylic acid compound
There is disclosed a process for the racemization of a vinyl-substituted cyclopropanecarboxylic acid or a derivative thereof, which is characterized by reacting an optically active...
|
|
|
6743944 |
Process for producing optically active aminoalcohol
An industrially advantageous process for producing optically active 4-amino-2-methylbutane-1-ol which is useful as an intermediate in synthesizing optically active medicines and pesticides. Racemic...
|
|
|
6683207 |
Production method of (R)-3 hydroxy-3-(2-phenylethyl) hexanoic acid and intermediate thereof
The present invention relates to a production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid which comprises optical resolution of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid with an...
|
|
|
6653501 |
Chiral resolution method for producing compounds useful in the synthesis of taxanes
A method is provided for processing a solution having optical isomers to obtain a (2R,3S) target isomer: wherein P 1 is H or a hydroxyl protecting group, R 1 is H, an alkyl group, an olefinic...
|
|
|
6608221 |
Process for the preparation of (2R)-2-propyloctanoic acid
A process for the preparation of (2R)-2-propyloctanoic acid which is characterized by subjecting (2S)-2-(2-propynyl)octanoic acid or (2S)-2-(2-propenyl)octanoic acid to reduction using platinum on...
|
|
|
6559338 |
Method for racemate splitting of 2-hydroxypropionic acids
A process for racemate resolution of 2-hydroxypropionic acids by reacting the racemic acid with an optically active base and subsequently separating off a diastereomeric salt of acid and base...
|
|
|
6525214 |
Therapeutic agent
The use of S(−)sodium 2-(4-isobutylphenyl)-propionate (the sodium salt of S(+)-ibuprofen) in pharmaceutical compositions for the treatment of inflammation, pain and pyrexia is described....
|
|
|
6495729 |
(&plus )- and (−)-2-cyclododecylpropanol and (&plus )- and (−)-2-cyclododecylpropionic acid and the preparation and use thereof
The compounds are (+)- and (−)-2-cyclododecylpropanol and (+)- and (−)-2-cyclododecylpropionic acid, and salts thereof. (−)-2-cyclododecylpropanol is suitable as a fragrance while the...
|
|
|
6458955 |
Process for preparation of pharmaceutically desired enantiomers
Improved processes for preparation of high enantiomeric purity compounds center on resolution using simulated moving bed chromatography of a racemic precursor early in the synthesis. Resolution is...
|
|
|
6437175 |
Process for racemization of n-acylamino acids by means of transition metal catalysts
The present invention relates to a process for the racemization of N-acylamino acids of the formula (I) R—CH(NR 1 COR 2 )CO 2 H (I) in which, in a solvent, an enantiomerically enriched...
|
|
|
6407284 |
Method of resolving 2-oxobicyclo &lsqb 3.1.0&rsqb hexane-6-carboxylic acid derivatives
There is disclosed a method of resolving 2-oxobicyclo[3.1.0]hexane-6-carboxylates having the following relative configuration of formula (1): wherein X 1 , X 2 , R 1 , R 2 and R 3 have the...
|
|
|
6407282 |
Process for producing monoester from dicarboxylic acid fluoride
Monoester monoacid fluoride of dicarboxylic acid is produced by allowing dicaroxylic acid fluoride represented by the following general formula: FOCCF(CF 3 )OCF 2 (A)p(CF 2 )qCOF where A is a...
|
|
|
6372936 |
Optical resolution of aminoisobobutyric acid
A process for resolving amino protected racemic 3-amino-2-methylpropionic acid which comprises the steps of: (1) reacting said amino protected acid with a protected amino group with an enantiomer...
|
|
|
6342629 |
Process for production of optically active n-protected-n-methyl-phenylalanine derivative
There is provided a process for industrially and efficiently producing an optically active N-protected-N-methyl-4-halogenophenylalanine at a high purity, which is useful as an intermediate for the...
|
|
|
6340762 |
Method for optical resolution of piperidine carboxylic acid derivative
A method for producing an optically active piperidine carboxylic acid derivative, which comprises subjecting a piperidine carboxylic acid derivative of the formula (1): wherein Z is a protecting...
|
|
|
6320069 |
Production of optically active ketone
Process for producing an optically active ester by reaction of a racemic alcohol with an optically active amino or tartaric acid derivative, a process for producing an optically active alcohol by...
|
|
|
6268525 |
Process for producing optically active chrysanthemic acid
The present invention provides an advantageous method for producing an optically active chrysanthemic acid. Disclosed is a method for producing an optically active chrysanthemic acid whose trans...
|
|
|
6245938 |
4-pentenoyl groups for derivatization and protection of amino acids
A method of separating a racemic mixture of amino acid enantiomers, which entails reacting the mixture with a 4-pentenoyl compound, thereby derivatizing the enantiomers to form two diastereomers,...
|
|
|
6239252 |
Single step process for the preparation of poly (oxyalkylene)-alpha, omega-dicarboxylic acid
The invention relates to single step process for the preparation of poly (oxyalkylene)-alpha, omega-dicarboxylic acids of the formula HO 2 CCH 2 O(CH 2 CHRO) n CH 2 CO 2 H, wherein R is...
|
|
|
6207854 |
Preparation of 3-amino-3-cyclopropylpropanoate esters
Disclosed a process for preparing substantially enantiomerically pure 3-amino-3-cyclopropylpropanoate esters, i.e., esters of 3-amino-3-cyclopropylpropanoic acid (3-cyclopropylalanine esters or...
|
|
|
6207853 |
Homogeneous asymmetric hydrogenation using phosphine ligands of transition metals
A process for the preparation of an enantiomerically enriched 2-substituted succinic acid derivative of formula 2, which comprises asymmetric hydrogenation of the dehydro precursor of formula 7 or...
|
|
|
6177591 |
Optically active phosphine oxide carboxylic acid and method of producing the same
An optically active 1-phenylethylamine is reacted to a phosphine oxide carboxylic acid of a racemic modification shown by the following general formula (2): ##STR1## and a produced diastereomeric...
|
|
|
6172259 |
Production of enantiomer-free biarylketocarboxylic acids
The invention relates to a continuous process for the preparation of enantiomerically pure biarylketocarboxylic acids, S-phenylethylamine being employed as an auxiliary base in the resolution....
|
|
|
6166260 |
Tandem reduction and host-guest complexation
The present invention relates to a tandem process of reduction and host-guest complexation using metal-hydride complexes to reduce chemical entities bearing carbonyl groups or their equivalents,...
|
|
|
6160134 |
Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines
A process is provided for preparing chiral cyclopropane carboxylic acids, preferably of the structure ##STR1## which are intermediates used in preparing acyl guanidine sodium/proton exchange (NHE)...
|
|
|
6156900 |
Racemization of precursors to levobupivacaine and analogues thereof
A process for the preparation of optically-enriched pipecolic acid as a salt with an optically-active acid, comprises asymmetric transformation of pipecolic acid, as a racemic mixture of a mixture...
|
|
|
6147254 |
Process for resolving mixtures of carbocyclic stereoisomers
A process for the preparation of carbocyclic stereoisomers of formulae (I), (I'), (IIA'), (IIB'), (VA') and (VB'), including enantiomerically pure (IIA'), (I) and (I') utilizing fractional...
|
|
|
6130353 |
Chiral separations of amino acids
An enantiomeric mixture of a chiral amino acid is separated into its respective enantiomers through chromatography on a chiral polysaccharide stationary phase eluting with a mobile phase comprising...
|
|
|
6130352 |
Method for producing (+) (2S,3S)-3-(2-aminophenylthio)-2-hydroxy-3(4'-methoxyphenyl)-propionic acid
A process for the preparation of (+) (2S, 3S)-3-(2-aminophenylthio)-2-hydroxy-3-(4'-methoxyphenyl)-pro
pionic acid which comprises treating the (±) compound of (2RS, 3RS)...
|
|
|
6114523 |
Process for the recycle of a waste product of diltiazem synthesis
A process which allows the re-use of compounds of formula ##STR1## in diltiazem synthesis through a process of conversion to a mixture of enantiomers III-(2R,3R) and III-(2S,3S) is described.
|
|
|
6093846 |
Process for preparing optically active 2-hydroxy-methyl-3-phenylpropionic acid
A process for preparing optically active 2-hydroxymethyl-3-phenylpropionic acid by resolving (RS)-2-hydroxymethyl-3-phenylpropionic acid via crystallization of an optically active amine salt, where...
|
|
|
6093830 |
Enantioselective resolution process for arylpropionic acid drugs from the racemic mixture
The invention relates to a novel non-catalytic enantioselective resolution process for the separation of enantiomer of arylpropionic acid drugs from the racemic mixture, which comprises dissolving...
|
|
|
6080887 |
Process for racemization of N-acetyl-(D)L-α-amino carboxylic acids
With known methods of racemizing N-acetyl-D(L)-α-amino carboxylic acids in the non-aqueous state by heating them to temperatures above room temperatures, significant quantities of by-products are...
|