Patents in Class 562/24

Matches 1 - 50 out of 95

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Match	Document	Document Title
1	7485745	Mixtures composed of monocarboxy-functionalized dialkylphosphinic esters and of further components The invention relates to mixtures composed of dialkylphosphinic esters and of further components, which comprise A) from 98 to 100% by weight of monocarboxy-functionalized dialkylphosphinic esters...
2	7294733	Method for preparing formylphosphonic acid An improved process for the manufacture of formylphosphonic acid derivatives is reported. An aminomethylphosphonic acid substrate is contacted with a reagent selected from the group consisting of...
3	7145034	Method for producing N-phosphonomethylglycine The invention relates to a process for preparing N-phosphono-methylglycine by reacting a hexahydrotriazine compound with a triacyl phosphite in an organic solvent, hydrolyzing the resulting...
4	7091376	Method for preparing formylphosphonic acid An improved process for the manufacture of formylphosphonic acid derivatives is reported. An aminomethylphosphonic acid substrate is contacted with a reagent selected from the group consisting of...
5	6943194	Synthesis of phenstatin and prodrugs thereof A newly discovered antineoplastic compound denominated “phenstatin” is herein described as are synthetic methods for producing phenstatin and the active prodrug thereof. Phenstatin was...
6	6924390	Surface coating agents Compounds useful as surface coating agents, including compounds of the formula: wherein X 1 comprises a first photoreactive species; X 2 comprises a second photoreactive species; Y comprises...
7	6919322	Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.
8	6486141	Phosphonic acid biaryl derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods...
9	6444837	Synthesis and antiviral activity of a series of pyrophosphate analogs Preparations of pyrophosphate analogues, including phosphonoformic acid, bisphosphonic acid, and phosphonoacetic acid derivatives, exhibiting antiviral activity. Such compounds, are used directly,...
10	6441214	Derivatives and analogs Preparation of phosphonoformic acid analogues containing one, two, three, or more sulfur atoms are described, with specific examples. Such compounds, not excluding cognates, derivatives, and...
11	6399814	Process for the preparation of 2-carboxyalkyl(aryl)phosphinic acid and corresponding anhydride(s) An improved hydrolysis process comprising a process for the preparation of 2-carboxyalkyl(aryl)phosphinic acid using a controlled addition of water to an acrylation reaction mixture, and control of...
12	6359162	Method for producing glufosinates and intermediate products for the same Glufosinate and the 2-methyl analog thereof can be prepared in a multi-step synthesis from methylphosphorus compounds (II) with unsaturated keto compounds (III) via adducts (IV), subsequent...
13	6355805	β3-adrenergic receptor agonists The present invention is directed to multibinding compounds which are β3 adrenergic receptor agonists and are therefore useful in the treatment and prevention of metabolic disorders such as...
14	6333426	Chiral adsorbents and preparation thereof as well as compounds on which the absorbents are based and preparation of the compounds Opticallly active adsorbents based on network polymerized derivative of dicarboxylic acids, diamines or diols which are chemically bonded to a carrier. The derivatives can be polymerized by radical...
15	6329547	Vinylbenzene derivatives The present invention provides compounds represented by the following general formula [I] and salts thereof, which are useful as therapeutic agents for glaucoma, ##STR1## wherein R 1 is H, lower...
16	6320071	Production of 2-carboxyalkyl (phenyl)phosphinic acid Processes for producing 2-carboxyalkyl(phenyl)phosphinic acid comprising hydrolyzing the reaction mixture produced from the reaction of dichloro(phenyl)phosphine with a carboxylic acid in the...
17	6274760	Preparation of formylphosphonic acid from tertiary aminomethylphosphonic acid N-oxides Formylphosphonic acid derivatives are prepared by the catalytic decomposition of a (phosphonomethyl)amine N-oxide compound to form the formylphosphonic acid derivative and a dephosphonomethylated...
18	6174874	Phosphonic acids derivatives as inhibitors of protein tyrosine phosphate 1B (PTP-1B) The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and...
19	6160166	Phosphonated agents and their antiangiogenic and antitumorigenic use Phosphonic acid agents are synthesized and characterized which are potent inhibitors of angiogenesis, tumorigenesis and metalloproteinase activity. Their method of use for the inhibition of...
20	6090976	Method for preparation 3-(hydroxyphenylphosphinyl)-propanoic acid Disclosed is a method for the preparation of 3-(hydroxyphenylphosphinyl)-propanoic acid which is commonly used as a flame retardant for polyester resins. The preparation of...
21	6071965	Phosphinic alkanoic acid derivatives The present invention relate to phosphinic alkanoic acid derivatives that inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the...
22	6028216	Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives The present invention relates to asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives.
23	6025344	Certain dioic acid derivatives useful as NAALADase inhibitors The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit...
24	5880309	Phenylphosphonic acid derivative and production process therefor A dialkyl dialkoxycarbonylphenylphosphonate which is useful as a resin modifier, a process for producing the same in high yield at a low cost, and a process for producing a...
25	5770587	Antifungal agents There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.
26	5739373	Optically active phosphono analogs of succinates and synthesis thereof The present invention relates to catalytic asymmetric hydrogenation of phosphorus analogs of itaconic acid to synthesize novel optically active phosphono succinates.
27	5731299	Phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism The present invention relates to phosphonsulfonates and the pharmaceutically-acceptable salts and esters thereof, having the following structure according to formula (I): ##STR1## The present...
28	5719182	Endothelin receptor anatagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists.
29	5710308	Process for producing ogranophosphorus ester compound and reactive flame retardant 1 A process for producing a purified organophosphorus alkyl ester compound in which the reaction mixture obtained by reacting a dichlorophosphine derivative with (meth)acrylic acid is esterified...
30	5683994	Phosphosuccinic acid derivatives, processes for the production thereof and pharmaceutical agents containing these compounds Compounds of formula I are disclosed, ##STR1## as well as processes for their production and pharmaceutical agents containing these compounds suitable for treating disorders of calcium metabolism.
31	5639909	Production of 2-phosphonobutane-1,2,4-tricarboxylic acid and the alkali metal salts thereof This invention relates to an improved process for the production of 2-phosphono-butane-1,2,4-tricarboxylic acid (PBTC) and the alkali metal salts thereof, in which process dialkyl phosphite,...
32	5635449	Arylthioalkyl- and arylthioalkenylphosphonic acids and derivatives thereof useful as herbicidal agents The present invention provides arylthioalkyl- and arylthioalkenylphosphonic acids and derivatives thereof having the structural formula I ##STR1## Further provided are compositions and methods...
33	5635608	α-carboxy caged compounds The invention relates to caged compounds for the study of biological processes, where the caged compound has a photoremoveable α-carboxy-substituted o-nitrobenzyl group. Covalent attachment of the...
34	5627173	Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders Compounds of the formula I ##STR1## are suitable for producing pharmaceuticals for the treatment and...
35	5591889	Method for the synthesis of trisodium phosphonoformate hexahydrate The present invention relates to a method for the synthesis of foscarnet, i.e. trisodium phosphonoformate hexahydrate, comprising the steps of adding sodium hydroxide to water, heating the aqueous...
36	5407969	Acyl-(2'-hydroxybiphenyl-2-yl)-phosphinic acid salts, their preparation and use The invention relates to acyl-(2'-hydroxydiphenyl-2-yl)-phosphinic acid salts of formula (I) ##STR1## in which each of the radicals R 1 , R 2 and R 3 may be included singly or multiply and in...
37	5362906	Farnesyl pyrophosphate analogs The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further...
38	5349069	Process for the preparation of 4-phosphinyl-3-keto-carboxylate and 4-phosphonyl-3-keto-carboxylate intermediates useful in the preparation of phosphorus containing HMG-COA reductase inhibitors A process for the preparation of compounds of formula ##STR1## or salt thereof where R 1 is --X--Z and X is --C.tbd.C--, R 2 and R 2 ' are independently hydrogen, alkyl or trialkylsilyl; R...
39	5334760	Method of producing a phosphinyl-carboxylic acid derivative A phosphine derivative of the following general formula ( I ): ##STR1## (wherein R 1 is an alkyl group having 1 to 18 carbon atoms or an aryl group having 6 to 18 carbon atoms, and the aryl group...
40	5312814	α-phosphonocarboxylate squalene synthetase inhibitors α- Phosphonocarboxylate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These compounds have the formula ##STR1## wherein R 1 is...
41	5294371	Corrosion and/or scale inhibition A corrosion- and/or scale inhibitor composition comprising: A) a corrosion- and/or scale inhibitor; and B) a compound having the formula (I): ##STR1## or a water-soluble salt thereof in which R 1 ...
42	5208224	Phosphorus containing compounds as antihypercholesterolemic and antiatherosclerotic agents Novel phosphorus containing compounds are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of...
43	5091562	Process for eliminating 1-carboxy-1-phosphonocyclopentan-3-one from, or reducing its content in, technical 2-phosphonobutane-1,2,4-tricarboxylic acid using bleaching liquor The present invention relates to a process for eliminating 1-phosphono-1-carboxycyclopentan-3-one (ketone) from, or reducing its content in, an aqueous solution of...
44	4988681	Phosphinic acid derivatives A phosphinic acid derivative represented by the general formula [I], or a pharmaceutically acceptable salt thereof, ##STR1## wherein R 1 represents an alkyl, cycloalkyl or aralkyl group which may...
45	4966991	Process for the preparation of alkali metal phosphonoformates A process for the production of alkali-phosphonoformates which comprises bringing together in a first stage a trialkyl ester of phosphonoformic acid and an aqueous solution of an alkali hydroxide...
46	4931586	Process for the continuous production of 2-phosphone-butane-1,2,4-tricarboxylic acid and alkali metal salts thereof This invention relates to an improved process for the continuous production of 2-phosphonobutane-1,2,4-tricarboxylic acid (PBTC) and alkali metal salts thereof, in which dialkylphosphite, and...
47	4900860	Process for preparing phosphonyloxyacyl amino acids A process is provided for preparing phosphonyloxyacylamino acids and derivatives thereof having the structure ##STR1## wherein X is ##STR2## which includes the steps of treating a phosphonic acid...
48	4847017	Hydroxyphosphonocarboxylic acids New compounds have the formula I: ##STR1## wherein R is a C 1 -C 12 straight or branched chain alkyl residue, a C 2 -C 12 straight or branched chain alkenyl residue, a C 5 -C 12 cycloalkyl...
49	4769182	Process for production of 3-(hydroxyphenylphosphinyl)-propanoic acid 3-(Hydroxyphenylphosphinyl)-propanoic acid is produced by reacting phenylphosphonous dichloride with a 0 to 20 percent molar excess of acrylic acid at a temperature of 60° to 150° C., heating the...
50	4753757	Process for preparing solid acetyl phosphate salt A salt of monoacetyl phosphate which is useful in the field of enzymatic reactions can be obtained as a precipitate by using a specified amount of lithium ion as a precipitating agent in the...

Matches 1 - 50 out of 95

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