Patents in Class 562/21

Matches 1 - 50 out of 96

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Match	Document	Document Title
1	7560490	Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition and use thereof The present invention relates to a composition for prevention and/or treatment of metabolic diseases of bones comprising at least one bisphosphonate; viscosity agents comprising...
2	7288673	Salts of substituted methylene bisphosphonic acids A salt of substituted or unsubstituted methylene bisphosphonic acid of formula I wherein X 1 and X 2 are both chlorine or one of X 1 and X 2 is hydrogen and one is chlorine and the...
3	7109184	Phosphate transport inhibitors Disclosed is a phosphate transport inhibiting compound represented by Structural Formula (I): R1 and R2 are independently —H, an electron withdrawing group or a C 1 –C 10 alkyl group....
4	6909010	Facile synthesis of symmetric esters of alkylenebisphosphonic acids A facile synthesis of symmetric esters of C 1 -C 10 alkylenebisphopsphonic acids is disclosed in which a C 1 -C 10 alkylenebis(phosphonic dichloride) is reacted with an alcohol in the presence of...
5	6743784	Estrogen mimetics lacking reproductive tract effects A method for treating symptoms, diseases and conditions in extra-reproductive tract tissues that are responsive to treatment with estrogen, using triarylethanes of formula (I) wherein R 1 is...
6	6657076	Process for preparing methylene bisphosphonic and salts A process for the preparation of salts of substituted or unsubstituted methylene bisphosphonic acids by hydrolysing the corresponding acid ester with hydrochloric acid, removing water from the acid...
7	6242433	Geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions The present invention relates to novel geranylgeranyl derivatives and the pharmaceutically acceptable salts thereof having antiproliferative activity in eukaryotic cells with respect to the...
8	6121253	Prostaglandin conjugates for treating or preventing bone disease This invention relates to prostaglandin-bisphosphonate conjugates. These conjugates are effective for treating or preventing bone diseases such as osteoporosis. These conjugates simultaneously...
9	5824661	Sulfur-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism Compounds of the formula ##STR1## where m and n are integers 0 to 10 and m+n equals 0 to 10, (a) X is O or S (b) Z is a covalent bond; a monocyclic or polycyclic carbocycle ring moiety; or a...
10	5783728	Phosphinate compounds prepared from acetylenic compounds and inorganic phosphite salts and derivatives of these compounds An improved method is disclosed for the preparation of novel alkali metal diphosphinate salts by the reaction of an acetylenic compound with an alkali metal hypophosphite in the presence of a free...
11	5772893	Ether diphosphonate scale inhibitors The invention is a method for the prevention of scale formation on metal or other surfaces in contact with scale-forming industrial water with an effective scale-inhibiting amount of an ether...
12	5712396	α-phosphonosulfonate squalene synthetase inhibitors α-Phosphonosulfonate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These compounds have the formula ##STR1## wherein R 2 is OR...
13	5618804	Methanediphosphonic acid derivative, process for production thereof and use for pharmaceuticals A methane diphosphonic acid derivative represented by the general formula (I): ##STR1## wherein, X and Y are defined in the specification; m represents an integer of 0 to 3; n represents an integer...
14	5574025	Inhibitors of prenyl-protein transferases The compounds disclosed inhibit the prenylation of several proteins. These compounds are potent inhibitors of famesyl-protein transferase and geranylgeranyl-protein transferase. Further contained...
15	5428181	Bisphosphonate derivative A compound represented by the general formula: ##STR1## wherein A-O-denotes a residue of a compound having an estrogenic activity; R 1 denotes H or a C 1 -C 6 alkyl group; X denotes a single...
16	5374628	Aryl and heteroaryl(phosphinylmethyl)phosphonate squalene synthetase inhibitors and method Phosphonic acid squalene synthetase inhibitors are provided which are effective in lowering serum cholesterol and have the formula ##STR1## wherein m is 0 to 3, n is 1 to 5, Y 1 and Y 2 are H or...
17	5364846	N-cycloalkylaminoethane-1,1-bis (phosphonic acid) useful for the treatment of osteoporosis and degenerative joint disease Substituted aminoethane-1,1-bisphosphonic acids and aminoethane-1,1-alkylphosphinophosphonic acids, processes for their preparation and use thereof The invention relates to compounds of the formula...
18	5254544	Hydroxyphosphinyl phosphonate squalene synthetase inhibitors and method Hydroxyphosphinyl phosphonate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These compounds have the formula ##STR1## wherein R 2...
19	5212164	Phosphorus-containing squalene synthetase inhibitors Compounds which are inhibitors of cholesterol biosynthesis (by inhibiting de novo squalene biosynthesis), and thus are useful as hypocholesterolemic agents and antiatherosclerotic agents are...
20	5200554	Bisphosphonic acid derivatives and their use The invention relates to novel methylene bisphosphonic acid derivatives carrying a styrene group attached to the methylene carbon. The novel compounds are useful e.g. for functionalizing polymers...
21	5157027	Bisphosphonate squalene synthetase inhibitors and method Compounds which are inhibitors of cholesterol biosynthesis (by inhibiting de novo squalene biosynthesis), and thus are useful as hypocholesterolemic agents and antiatherosclerotic agents are...
22	5154843	Hydroxyalkane phosphonic acids and derivatives thereof and lubricants containing the same This invention relates to lubricating compositions containing hydroxyalkane phosphonic acids and derivatives thereof. More specifically, this invention relates to hydroxylakane phosphonic acids...
23	5153183	Methylenediphosphonic acid compounds and methods of use for the treatment of rheumatism and osteophorosis This invention relates to a methylenediphosphonic acid compound expressed by the formula (1). The compound has a marked effect as an anti-inflammatory agent or, more particularly, against...
24	5104863	Certain bicycloalkane and azabicycloalkane-1,1-diphosphonic acid derivatives useful for treating diseases associated with abnormal calcium and phosphate metabolism This invention relates to pyrindine-diphosphonic acid derivatives which are useful in treating or preventing diseases characterized by abnormal calcium and phosphate matabolism, in particular those...
25	5043330	Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them The invention relates to new gem-diphosphonates derivatives substituted by phenol groups of formula (I): ##STR1## as well as the process for their preparation and the pharmaceutical compositions...
26	5036058	N-substituted aminoalkanediphosphonic acids Compounds of the formula I ##STR1## in which R 1 is an aromatic radical, n is 0, 1, 2 or 3, X is an oxy group, a thio group which can be oxidized or an imino group which is unsubstituted or has...
27	5021324	Printing plate protectant A composition useful for the protection of actinic light-exposed presensitized lithographic printing plates. The composition contains an effective amount of the di-potassium salt of...
28	4962229	Olefinic diphosphonic acids, a process for their production, their use as thresholders, and complexing compositions containing them 3-R 1 -3-oxoprop-1-ene-1,1-diphosphonic acids corresponding to the following general formula ##STR1## in which R 1 is a tertiary substituted alkyl group, an optionally substituted cycloalkyl...
29	4960928	1-Hydroxy-omega-(alkyl- or arylphosphinico)alkane-1,1-diphosphonic acids, salts thereof, and processes for the preparation of these compounds The present invention relates to 1-hydroxy-ω-(alkyl- or arylphosphinico)alkane-1,1-diphosphonic acids of the general formula I ##STR1## and to the salts of these acids of the general formula II...
30	4939131	Certain cycloalkane-1,1-diphosphonic acids and derivatives thereof having the ability to treat diseases associated with abnormal calcium and phosphate metabolism Novel cyclic geminal-diphosphonic acid compounds, and pharmaceutical compositions containing these compounds, which are useful for treating diseases characterized by abnormal calcium and phosphate...
31	4892679	Oxa-alkane polyphosphonic acids, their use as thresholders, and complexing compositions containing these compounds Oxa-alkane polyphosphonic acids corresponding to general formula (I) ##STR1## in which R 1 is a C 1 -C 10 alkyl group, an optionally substituted C 6 -C 10 aryl group, a phenyl- or...
32	4876248	Anti-inflammatory products derived from methylene-diphosphonic acid, and process for their preparation The present invention relates to products of the formula ##STR1## where R 1 is H or alkyl, n is an integer from 0 to 10, and R 2 is chosen from amongst H, unsubstituted or substituted alkyl...
33	4818774	Organophosphorus compounds Polyvalent cations (e.g., U(IV), Fe(III) can be extracted from aqueous solution using novel organophosphorus compounds of the formulas: ##STR1## wherein R 1 and R 2 are the same or different and...
34	4814326	Pharmaceutical compositions based on diphosphonates for the treatment of arthrosis and osteoarthritis This invention relates to pharmaceutical compositions for the treatment of arthrosis by intraarticular administration of the compositions diluted in a suitable aqueous or lyophilized carrier,...
35	4810486	Bone-seeking complexes of technetium-99m A composition for use in the preparation of a bone-scanning agent comprises a mixture of a bis-phosphonic acid of formula (I), wherein R 1 and R 3 may be the same or different group selected from...
36	4732998	Bisphosphonic acids and esters The present invention relates to hitherto unknown compounds of the formula I ##STR1## in which R 1 is a straight or branched, saturated or unsaturated aliphatic or alicyclic C 1 -C 10 ...
37	4687768	Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism Novel cyclic geminal-diphosphonic acid compounds, and pharmaceutical compositions containing these compounds, which are useful for treating diseases characterized by abnormal calcium and phosphate...
38	4572807	Oligophosphonic acids, oligophosphinic acids, and process of preparation This invention relates to a process for preparing oligophosphonic or oligophosphinic acids or esters or salts thereof which comprises reacting an alkali metal ester of phosphorous acid or an alkali...
39	4536348	Dihydroxyalkane diphosphonic acids α,ω-dihydroxyalkane-α,α-diphosphonic acids of the formula R--CH(OH)--(CH 2 ) n --C(OH) (PO 3 H 2 ) 2 (I) wherein R represents a phenyl radical, a substituted phenyl radical, or a hydrogen...
40	4515766	Labeled phosphonic acid compositions for investigations of in vivo deposits of calcium The composition and methodology associated with the formulation of a halogenated phosphonic acid labeled in the ring moiety are disclosed having the formula: ##STR1## wherein R 1 is aryl and is...
41	4478763	Process for preparing alpha-fluorinated alkanediphosphonates A method for the production of alpha-fluorinated methane diphosphonates consists of the reaction of diphosphonate esters with a strong base, preferably potassium t-butoxide, and perchloryl fluoride...
42	4416877	Anti-atherosclerotic pharmaceutical compositions containing diphosphonate compounds The present invention relates to a pharmaceutical composition for increasing the relative quantity of circulating high density lipoproteins favorable augmentating the alpha/beta lipoprotein...
43	4399817	Boron containing polyphosphonates for the treatment of calcific tumors Boron containing polyphosphonates of the formula ##STR1## wherein Z is a boron-containing radical; R 2 is an alkyl group containing from 1 to about 10 carbon atoms; R 3 is a geminal diphosphonate...
44	4330486	Bis(phosphonic acid) difluoromethane Fluorine-containing phosphonates and phosphonic acids are described. The method of preparation is a reaction of trialkylphosphites with dihalodifluoromethanes or a reaction of the salts of...
45	4309364	Diphosphonates This invention relates to new diphosphonate compounds of formula (I) ##STR1## where X is H, OH, ##STR2## or NH 2 ; R and R' identical or different are H, CH 3 or C 2 H 5 ; m is zero or 1; and A...
46	4234562	Radiographic scanning A composition and method for the preparation of a technetium-99 m based scintigraphic scanning agent are disclosed. The agent is prepared by the addition of a pertechnetate-99 m solution to an...
47	4172787	Reaction of α-phosphorus containing carboxylic acids with phosphorous acid to prepare scale and corrosion inhibitors Novel compounds and the use of these compounds in inhibiting corrosion and scale in open cooling systems containing ferrous materials which are: ##STR1## These compounds are prepared by a...
48	4120890	Diphosphonoalkane carboxylic acids, process of preparation and methods of use Diphosphonoalkane carboxylic acids having the formula ##STR1## wherein R is H or --CH 2 --CH 2 --COOH; as well as their water-soluble salts. The compounds are excellent sequestering agents,...
49	4062828	Flame resistant polyamide moulding compositions The present invention relates to novel agents for the flame-proofing of polymers, especially transparent polyamides. These agents, phosphinylphosphinic acids, are used in quantities of 3 to 40...
50	3962318	Substituted ethane diphosphonic acids and salts and esters thereof New and useful substituted ethane diphosphonic acids and salts and esters thereof as exemplified by the ester compound having the formula ##EQU1## tetraethyl, 1,2 dihydroxy ethane-1,1-diphosphonate...

Matches 1 - 50 out of 96

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