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8097752 Antiprotozoal ring-substituted phospholipids  
Disclosed are novel ring containing phospholipids represented by the structural formula A-X—PO3—W and physiologically acceptable salts thereof and a process for the preparation of these com...
7833993 Immunomodulatory compounds and methods of use thereof  
The present invention is directed to methods of treating diseases and disorders related to immune responses by administering one or more immunomodulatory compounds. In particular, the invention is...
7767846 Fluorescent dyes for use in glucose sensing  
A novel class of compounds that includes HPTS-Cys-MA, and methods of making them are disclosed herein. The class of compounds including HPTS-Cys-MA are useful as fluorescent dyes for analyte...
7329778 Process and catalyst for dehydrogenating primary alcohols to make carboxylic acid salts  
This invention is directed to a process for making a salt of a carboxylic acid. The process comprises contacting a catalyst with an alkaline mixture comprising a primary alcohol. In one embodiment,...
7157092 Acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same  
Compounds of the formula wherein the substitutents are defined as in the specification useful for modulating immune responses in warm-blooded animals.
7087781 Polyaminomethylenephos phonate derivatives  
In one embodiment, a scale inhibitor comprising at least one polymethylenephosphonate derivative having the following formula: wherein n is a number, wherein M is hydrogen or a cation, wherein R1,...
7084298 Method for producing n-phosphonomethyl iminodiacetic acid  
The present invention relates to a process for the preparation of N-phosphonomethyliminodiacetic acid by reacting an alkali metal salt of iminodiacetic acid with phosphorus trichloride in aqueous...
7064234 Enantioselective cation-exchange materials  
The present invention relates to an enantioselective cation-exchange material, comprising a chiral selector (1), composed of a chiral component (2) and at least one cation-exchange group (X), a...
6759549 Method of preparing amino carboxylic acids  
Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl )urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that ca...
6692764 Wet granulation formulation for bisphosphonic acids  
Pharmaceutical compositions of bisphosphonic acids, and salts thereof, are prepared by wet granulation tablet formulation. These pharmaceutical compositions are useful in the treatment of...
6590118 Aromatic compounds  
Disclosed are compounds of formula I wherein A, R1, R2, R3, R4 and R5 are described in the specification, pharmaceutical formulations comprising these compounds, the use of these compounds are...
6576766 Signal transduction inhibitors, compositions containing them  
This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediate by one or more molecular interactions involving a...
6509324 Chelating compounds, their complexes with paramagnetic metals  
Compounds able to chelate bi- and trivalent paramagnetic metal ions, their chelated complexes with these metal ions and physiologically compatible salts thereof and therein magnetic resonance imaging.
6265605 Method of preparing amino carboxylic acids  
Novel compounds, N,N'-bis(phosphonomethyl)-N,N'-bis(hydroxycarbonylmethyl)ure a and N,N,N',N'-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that...
6153775 Polydentate imines and their metal complexes  
Tripodal chelating agents incorporating imine CN bonds are disclosed for the formation of lanthanide and other metal complexes which are relatively stable in the presence of water at neutral pH.
6143776 Tosylproline analogs as thymidylate synthase inhibitors  
Tosylproline analogs of formula I, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are thymidylate synthase inhibitors; and are useful...
5990098 Therapeutic use of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid and its salts  
Use of 1-amino-3-N,N-dimethylamino)-propyliden-1,1-bisphosphonic acid of the structural formula: ##STR1## or of its monosodium or other pharmaceutically acceptable salt, as a biological carrier for...
5670493 Aminophenylphosphonic acid compounds  
A compound of formula (I): ##STR1## in which: R1, R2, which may be identical or different, represent hydrogen or halogen, or alkyl, alkoxy, nitro or trihalomethyl, X represents CO, SO2 or CH2, A1...
5606106 Hexamethlene phosphonate concentrate  
Concentrated aqueous hexamethylene phonic acid solutions are described containing, in addition to high levels e.g. 40%-50% of phosphonic acid a narrowly defined level of non-oxidizing mineral acid,...
5495042 Non-alkaline purification of aminophosphonic acids  
A process for the purification of aminophosphonic acids under non-alkaline conditions is described. In particular, aminophosphonic acids are slurred in neutral or acidic water, heated to reflux,...
5468732 Phosphorus containing renin inhibitors  
Phosphorus containing polypeptides as renin inhibitors, useful as antihypertensive agents.
5414112 N-bis(phosphonomethyl) amino acids and their use as scale inhibitors  
Certain N-bis(phosphonomethyl) amino acids are novel compounds and are useful in preventing calcium carbonate scale.
5326906 Process for the extractive removal of phospho- and sulfobetaines from acidic reaction solutions  
The ampholytes are extracted from the reaction solution with a liquid cation exchanger which is immiscible with the acidic aqueous reaction solution, where the cation exchanger is dissolved in at...
5315035 Aniline derivatives useful as color formers  
The present invention is concerned with aniline derivatives of the general formula: ##STR1## wherein R1 is hydrogen or a lower alkyl or aryl, R2 is hydrogen or a lower alkyl which can be...
5312954 Bis- and tetrakis-phosphonates useful for treating calcium related disorders  
Novel bisphosphonates comprise compounds of the formula (I) ##STR1## wherein m and l are independently 1 or 2; R1 represents hydrogen, a lower alkyl group, or an alkali metal cation; R2 represents...
5312973 Process for producing n-phosphono-methyl-imino-diacetic acid  
Process for preparing N-phosphono-methyl-iminodiacetic acid by means of phosphonomethylation of iminodiacetic acid performed by reacting an aqueous solution of phosphoric acid and hydrochloric...
5281637 Flameproofed thermoplastic polyester molding material and its use  
Flameproofed thermoplastic polyester molding material comprising (A) one or more thermoplastic polyesters, (B) a nitrogen-containing diphosphinic acid compound of the formula (I), and (C) with or...
5256695 Acyl amidine and acyl guanidine substituted biphenyl derivatives  
Novel compounds are disclosed having the formula ##STR1## where A is ##STR2## and wherein R1, R2 and R3 are as defined herein. These compounds inhibit the action of angiotensin II and are useful,...
5208224 Phosphorus containing compounds as antihypercholesterolemic and antiatherosclerotic agents  
Novel phosphorus containing compounds are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of...
5167866 Control of corrosion in aqueous systems using certain phosphonomethyl amine oxides  
This invention relates to controlling corrosion in aqueous systems and more particularly to using certain calcium insensitive phosphonomethyl amine oxide compounds. The compounds of this invention...
5036058 N-substituted aminoalkanediphosphonic acids  
Compounds of the formula I ##STR1## in which R1 is an aromatic radical, n is 0, 1, 2 or 3, X is an oxy group, a thio group which can be oxidized or an imino group which is unsubstituted or has...
5008015 Purification of phosphorus compounds  
The content of hydrogen chloride and phosphorous acid of crude amino organic phosphonic acids, especially diethylenetriaminepentakis (methylene phosphonic acid) is reduced by solvent extraction...
5003097 Method for the sulfurization of phosphorous groups in compounds  
A method is disclosed for the sulfurization of a phosphorus containing compound, which comprises: solubilizing the phosphorous containing compound and then contacting the phosphorous containing...
4985591 Acid catalysts for low temperature cure of coating compositions  
Preparation of a semi-crystalline catalyst for curing coating compositions wherein an isocyanate-sulfonate or -phosphonate is made by a Michael addition followed by chain extension with an isocyanate.
4937333 Method for purifying aminomethylenephosphonic acids for pharmaceutical use  
High purity ethylenediaminetetra(methylenephosphonic acid) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylenephosp honic acid) are prepared by dissolving the aminomethylenephosphonic acid...
4918064 Phenyl glycines for use in reducing neurotoxic injury  
A class of phenyl glycine compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia....
4794197 All-cis-1,3,5-triamino-2,4,6,-cyclohexanetriol derivatives, their use, processes for their preparation and pharmaceutical preparations containing them  
All-cis-1,3,5-Triamino-2,4,6-trihydroxycyclohexane derivatives corresponding to the general formula I ##STR1## wherein the symbols R1, R2, R3, R4, R5 and R6 are identical or different and represent...
4728460 Aminomethylenephosphonic acid solutions  
Aqueous solutions of aminomethylenephosphonic acid selected from diethylenetriaminepenta(methylenephosphonic acid), diethylenetriaminetetra(methylenephosphonic acid),...
4702849 Method of increasing hydrocarbon production from subterranean formations  
A method of treating a carbonate-containing subterranean formation to increase the production of hydrocarbons therefrom. The formation is contacted with an aqueous solution of one or more of...
4696920 Certain 2-substituted 1,3-propylidenediphosphonate derivatives, pharmaceutical compositions containing them and their use as antihypertensive agents  
2-Substituted-1,3-propylidenediphosphonates of formula (I), where A, R1 and R2 are defined in claim 1, are therapeutically active compounds, namely for the treatment of cardiovascular diseases....
4582698 Process for imaging cardiac infarcts  
The imaging of cardiac infarcts with complexed radioactive metals is improved by employing as the complexing agent a compound of the formula ##STR1## wherein substituents A, B, X and Y are each...
4548757 Aqueous aminomethylenephosphonic acid solutions containing organic carboxylate stabilizing agent  
Aqueous solutions of aminomethylenephosphonic acid, chiefly diethylenetriaminepenta(methylenephosphonic acid), are disclosed containing a crystallization inhibitor which is an alkali-metal salt of...
4500469 Metal ion control compounds based on norbornane  
The bis(methylamine) of norbornane compounds which have at least one of the amine hydrogens substituted with hydroxyalkyl, methylenephosphonic, alkylenesulfonic, carboxylic acid radicals and salts...
4459241 Compounds containing quaternary ammonium and methylenephosphonic acid groups  
Compounds having improved properties of inhibiting the precipitation of metal ions when used in threshold amounts have been made which are derivatives of ammonia or di- or polyamines in which the...
4409151 N,N-Dimethylene phosphonic acids of alkylene diamines  
This invention relates to a process of preparing N,N'-disubstituted methylene phosphonic acids by reacting α,ω-alkylene diamines with essentially 2 equivalents of formaldehyde and phosphorus acid b...
4330487 N,N-Dimethylene phosponic acids of alkylene diamines  
This invention relates to a process of preparing N,N'-disubstituted methylene phosphonic acids by reacting α, ω-alkylene diamines with essentially 2 equivalents of formaldehyde and phosphorus a...
4239695 Method of preparing phosphonates from nitriles  
Amino-phosphonates typified by the general formula R--C(PO(OH)2)2 NH2 are prepared by reacting phosphorous acid with nitriles at elevated temperatures.
4234511 Dialkylamino-N,N-bis(phosphonoalkylene)alkylamines and use in aqueous systems as precipitation and corrosion inhibitors  
Dialkylamino-N,N-bis(phosphonoalkylene)alkylamines, salts, and specifically the hydrochlorides thereof prepared by reacting an unsymmetrical dimethylaminoalkylamine hydrochloride with phosphorous...
4213969 Phosphonous acid derivatives, processes for their preparation and their use in combatting microorganisms  
Phosphonous acid derivatives of the general formula I ##STR1## or the corresponding zwitterion form, in which R, R1, R2 and R3 have the meanings given hereinafter, are valuable microbicides. They...
4119430 N-(2-hydroxyalkyl) derivatives of N-phosphonomethylglycine and herbicidal compositions containing same  
Certain N-(2-hydroxyalkyl) derivatives of N-phosphonomethylglycine have been found to be useful as herbicides for the treatment of undesired plants.
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