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8097752 |
Antiprotozoal ring-substituted phospholipids
Disclosed are novel ring containing phospholipids represented by the structural formula A-X—PO3—W and physiologically acceptable salts thereof and a process for the preparation of these com...
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7833993 |
Immunomodulatory compounds and methods of use thereof
The present invention is directed to methods of treating diseases and disorders related to immune responses by administering one or more immunomodulatory compounds. In particular, the invention is...
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7767846 |
Fluorescent dyes for use in glucose sensing
A novel class of compounds that includes HPTS-Cys-MA, and methods of making them are disclosed herein. The class of compounds including HPTS-Cys-MA are useful as fluorescent dyes for analyte...
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7329778 |
Process and catalyst for dehydrogenating primary alcohols to make carboxylic acid salts
This invention is directed to a process for making a salt of a carboxylic acid. The process comprises contacting a catalyst with an alkaline mixture comprising a primary alcohol. In one embodiment,...
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7157092 |
Acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same
Compounds of the formula wherein the substitutents are defined as in the specification useful for modulating immune responses in warm-blooded animals.
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7087781 |
Polyaminomethylenephos phonate derivatives
In one embodiment, a scale inhibitor comprising at least one polymethylenephosphonate derivative having the following formula: wherein n is a number, wherein M is hydrogen or a cation, wherein R1,...
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7084298 |
Method for producing n-phosphonomethyl iminodiacetic acid
The present invention relates to a process for the preparation of N-phosphonomethyliminodiacetic acid by reacting an alkali metal salt of iminodiacetic acid with phosphorus trichloride in aqueous...
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7064234 |
Enantioselective cation-exchange materials
The present invention relates to an enantioselective cation-exchange material, comprising a chiral selector (1), composed of a chiral component (2) and at least one cation-exchange group (X), a...
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6759549 |
Method of preparing amino carboxylic acids
Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl
)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that ca...
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6692764 |
Wet granulation formulation for bisphosphonic acids
Pharmaceutical compositions of bisphosphonic acids, and salts thereof, are prepared by wet granulation tablet formulation. These pharmaceutical compositions are useful in the treatment of...
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6590118 |
Aromatic compounds
Disclosed are compounds of formula I wherein A, R1, R2, R3, R4 and R5 are described in the specification, pharmaceutical formulations comprising these compounds, the use of these compounds are...
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6576766 |
Signal transduction inhibitors, compositions containing them
This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediate by one or more molecular interactions involving a...
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6509324 |
Chelating compounds, their complexes with paramagnetic metals
Compounds able to chelate bi- and trivalent paramagnetic metal ions, their chelated complexes with these metal ions and physiologically compatible salts thereof and therein magnetic resonance imaging.
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6265605 |
Method of preparing amino carboxylic acids
Novel compounds, N,N'-bis(phosphonomethyl)-N,N'-bis(hydroxycarbonylmethyl)ure
a and N,N,N',N'-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that...
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6153775 |
Polydentate imines and their metal complexes
Tripodal chelating agents incorporating imine CN bonds are disclosed for the formation of lanthanide and other metal complexes which are relatively stable in the presence of water at neutral pH.
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6143776 |
Tosylproline analogs as thymidylate synthase inhibitors
Tosylproline analogs of formula I, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are thymidylate synthase inhibitors; and are useful...
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5990098 |
Therapeutic use of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid and its salts
Use of 1-amino-3-N,N-dimethylamino)-propyliden-1,1-bisphosphonic acid of the structural formula: ##STR1## or of its monosodium or other pharmaceutically acceptable salt, as a biological carrier for...
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5670493 |
Aminophenylphosphonic acid compounds
A compound of formula (I): ##STR1## in which: R1, R2, which may be identical or different, represent hydrogen or halogen, or alkyl, alkoxy, nitro or trihalomethyl, X represents CO, SO2 or CH2, A1...
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5606106 |
Hexamethlene phosphonate concentrate
Concentrated aqueous hexamethylene phonic acid solutions are described containing, in addition to high levels e.g. 40%-50% of phosphonic acid a narrowly defined level of non-oxidizing mineral acid,...
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5495042 |
Non-alkaline purification of aminophosphonic acids
A process for the purification of aminophosphonic acids under non-alkaline conditions is described. In particular, aminophosphonic acids are slurred in neutral or acidic water, heated to reflux,...
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5468732 |
Phosphorus containing renin inhibitors
Phosphorus containing polypeptides as renin inhibitors, useful as antihypertensive agents.
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5414112 |
N-bis(phosphonomethyl) amino acids and their use as scale inhibitors
Certain N-bis(phosphonomethyl) amino acids are novel compounds and are useful in preventing calcium carbonate scale.
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5326906 |
Process for the extractive removal of phospho- and sulfobetaines from acidic reaction solutions
The ampholytes are extracted from the reaction solution with a liquid cation exchanger which is immiscible with the acidic aqueous reaction solution, where the cation exchanger is dissolved in at...
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5315035 |
Aniline derivatives useful as color formers
The present invention is concerned with aniline derivatives of the general formula: ##STR1## wherein R1 is hydrogen or a lower alkyl or aryl, R2 is hydrogen or a lower alkyl which can be...
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5312954 |
Bis- and tetrakis-phosphonates useful for treating calcium related disorders
Novel bisphosphonates comprise compounds of the formula (I) ##STR1## wherein m and l are independently 1 or 2; R1 represents hydrogen, a lower alkyl group, or an alkali metal cation; R2 represents...
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5312973 |
Process for producing n-phosphono-methyl-imino-diacetic acid
Process for preparing N-phosphono-methyl-iminodiacetic acid by means of phosphonomethylation of iminodiacetic acid performed by reacting an aqueous solution of phosphoric acid and hydrochloric...
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5281637 |
Flameproofed thermoplastic polyester molding material and its use
Flameproofed thermoplastic polyester molding material comprising (A) one or more thermoplastic polyesters, (B) a nitrogen-containing diphosphinic acid compound of the formula (I), and (C) with or...
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5256695 |
Acyl amidine and acyl guanidine substituted biphenyl derivatives
Novel compounds are disclosed having the formula ##STR1## where A is ##STR2## and wherein R1, R2 and R3 are as defined herein. These compounds inhibit the action of angiotensin II and are useful,...
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5208224 |
Phosphorus containing compounds as antihypercholesterolemic and antiatherosclerotic agents
Novel phosphorus containing compounds are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of...
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5167866 |
Control of corrosion in aqueous systems using certain phosphonomethyl amine oxides
This invention relates to controlling corrosion in aqueous systems and more particularly to using certain calcium insensitive phosphonomethyl amine oxide compounds. The compounds of this invention...
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5036058 |
N-substituted aminoalkanediphosphonic acids
Compounds of the formula I ##STR1## in which R1 is an aromatic radical, n is 0, 1, 2 or 3, X is an oxy group, a thio group which can be oxidized or an imino group which is unsubstituted or has...
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5008015 |
Purification of phosphorus compounds
The content of hydrogen chloride and phosphorous acid of crude amino organic phosphonic acids, especially diethylenetriaminepentakis (methylene phosphonic acid) is reduced by solvent extraction...
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5003097 |
Method for the sulfurization of phosphorous groups in compounds
A method is disclosed for the sulfurization of a phosphorus containing compound, which comprises: solubilizing the phosphorous containing compound and then contacting the phosphorous containing...
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4985591 |
Acid catalysts for low temperature cure of coating compositions
Preparation of a semi-crystalline catalyst for curing coating compositions wherein an isocyanate-sulfonate or -phosphonate is made by a Michael addition followed by chain extension with an isocyanate.
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4937333 |
Method for purifying aminomethylenephosphonic acids for pharmaceutical use
High purity ethylenediaminetetra(methylenephosphonic acid) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylenephosp
honic acid) are prepared by dissolving the aminomethylenephosphonic acid...
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4918064 |
Phenyl glycines for use in reducing neurotoxic injury
A class of phenyl glycine compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia....
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4794197 |
All-cis-1,3,5-triamino-2,4,6,-cyclohexanetriol derivatives, their use, processes for their preparation and pharmaceutical preparations containing them
All-cis-1,3,5-Triamino-2,4,6-trihydroxycyclohexane derivatives corresponding to the general formula I ##STR1## wherein the symbols R1, R2, R3, R4, R5 and R6 are identical or different and represent...
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4728460 |
Aminomethylenephosphonic acid solutions
Aqueous solutions of aminomethylenephosphonic acid selected from diethylenetriaminepenta(methylenephosphonic acid), diethylenetriaminetetra(methylenephosphonic acid),...
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4702849 |
Method of increasing hydrocarbon production from subterranean formations
A method of treating a carbonate-containing subterranean formation to increase the production of hydrocarbons therefrom. The formation is contacted with an aqueous solution of one or more of...
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4696920 |
Certain 2-substituted 1,3-propylidenediphosphonate derivatives, pharmaceutical compositions containing them and their use as antihypertensive agents
2-Substituted-1,3-propylidenediphosphonates of formula (I), where A, R1 and R2 are defined in claim 1, are therapeutically active compounds, namely for the treatment of cardiovascular diseases....
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4582698 |
Process for imaging cardiac infarcts
The imaging of cardiac infarcts with complexed radioactive metals is improved by employing as the complexing agent a compound of the formula ##STR1## wherein substituents A, B, X and Y are each...
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4548757 |
Aqueous aminomethylenephosphonic acid solutions containing organic carboxylate stabilizing agent
Aqueous solutions of aminomethylenephosphonic acid, chiefly diethylenetriaminepenta(methylenephosphonic acid), are disclosed containing a crystallization inhibitor which is an alkali-metal salt of...
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4500469 |
Metal ion control compounds based on norbornane
The bis(methylamine) of norbornane compounds which have at least one of the amine hydrogens substituted with hydroxyalkyl, methylenephosphonic, alkylenesulfonic, carboxylic acid radicals and salts...
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4459241 |
Compounds containing quaternary ammonium and methylenephosphonic acid groups
Compounds having improved properties of inhibiting the precipitation of metal ions when used in threshold amounts have been made which are derivatives of ammonia or di- or polyamines in which the...
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4409151 |
N,N-Dimethylene phosphonic acids of alkylene diamines
This invention relates to a process of preparing N,N'-disubstituted methylene phosphonic acids by reacting α,ω-alkylene diamines with essentially 2 equivalents of formaldehyde and phosphorus acid b...
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4330487 |
N,N-Dimethylene phosponic acids of alkylene diamines
This invention relates to a process of preparing N,N'-disubstituted methylene phosphonic acids by reacting α, ω-alkylene diamines with essentially 2 equivalents of formaldehyde and phosphorus a...
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4239695 |
Method of preparing phosphonates from nitriles
Amino-phosphonates typified by the general formula R--C(PO(OH)2)2 NH2 are prepared by reacting phosphorous acid with nitriles at elevated temperatures.
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4234511 |
Dialkylamino-N,N-bis(phosphonoalkylene)alkylamines and use in aqueous systems as precipitation and corrosion inhibitors
Dialkylamino-N,N-bis(phosphonoalkylene)alkylamines, salts, and specifically the hydrochlorides thereof prepared by reacting an unsymmetrical dimethylaminoalkylamine hydrochloride with phosphorous...
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4213969 |
Phosphonous acid derivatives, processes for their preparation and their use in combatting microorganisms
Phosphonous acid derivatives of the general formula I ##STR1## or the corresponding zwitterion form, in which R, R1, R2 and R3 have the meanings given hereinafter, are valuable microbicides. They...
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4119430 |
N-(2-hydroxyalkyl) derivatives of N-phosphonomethylglycine and herbicidal compositions containing same
Certain N-(2-hydroxyalkyl) derivatives of N-phosphonomethylglycine have been found to be useful as herbicides for the treatment of undesired plants.
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