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8003820 Process for preparing bisphosphonic acids  
A process for preparing a bisphosphonate compound comprises reacting a carboxylic acid with a phosphonating agent, in a cresol solvent.
7833993 Immunomodulatory compounds and methods of use thereof  
The present invention is directed to methods of treating diseases and disorders related to immune responses by administering one or more immunomodulatory compounds. In particular, the invention is...
7081212 Solid free-flowing phosphonate composition  
Solid free-flowing compositions of a magnesium salt of bis(hexamethylene)triamino penta(methylenephosphonic) acid are disclosed. The compositions exhibit desirable scale inhibitor properties and...
7053138 Flame-proofing agents  
Compounds of formula (I) or (II), wherein R1 is C1–C18alkyl; C5–C12cycloalkyl that is unsubstituted or substituted by one or more C1–C6alkyl groups or C1–C6alkoxy groups; C5–C22aryl that is unsubs...
6590118 Aromatic compounds  
Disclosed are compounds of formula I wherein A, R1, R2, R3, R4 and R5 are described in the specification, pharmaceutical formulations comprising these compounds, the use of these compounds are...
6509324 Chelating compounds, their complexes with paramagnetic metals  
Compounds able to chelate bi- and trivalent paramagnetic metal ions, their chelated complexes with these metal ions and physiologically compatible salts thereof and therein magnetic resonance imaging.
6403826 Corrosion-inhibiting coating composition for metals  
A description is given of compounds of the formula in which the general symbols are as defined in claim 1, and of their zirconium, bismuth and calcium salts, and of the salts with the compounds of...
6388131 Benzene compounds as antiproliferative and cholesterol lowering agents  
The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular...
6372726 Methods of cancer treatment using NAALADase inhibitors  
The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to...
6284923 Substituted benzene compounds as antiproliferative and cholesterol lowering action  
The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular...
6005140 Process for making glyphosate by oxidizing N-substituted glyphosates  
This invention is directed to process for making a composition having the formula (I): ##STR1## wherein R3, R4, and R5 are independently hydrogen, substituted or unsubstituted hydrocarbyl, or an...
5962438 Estrogen derivative having carriers to bone  
A novel estrogen derivative represented by the formula: ##STR1## is useful for treating or preventing diseases caused by estrogen deficiency.
5672592 Certain phosphonomethyl-pentanedioic acid derivatives thereof  
The present disclosure relates to dipeptidase inhibitors, and more particularly, to N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme inhibitors which are proposed as novel agents for ...
5495042 Non-alkaline purification of aminophosphonic acids  
A process for the purification of aminophosphonic acids under non-alkaline conditions is described. In particular, aminophosphonic acids are slurred in neutral or acidic water, heated to reflux,...
5466682 Acylamino-alkyliden-hydroxy-bisphosphonic acids esters and salts thereof, wherein the acyl group is derived from an acid having antiinflammatory activity  
Compounds of formula (I) ##STR1## in which A is (CH2)n in which n is 1-10, preferably 3 or 5, and R is the acyl group from a known anti-inflammatory agent, exhibit high anti-inflammatory activity....
5414112 N-bis(phosphonomethyl) amino acids and their use as scale inhibitors  
Certain N-bis(phosphonomethyl) amino acids are novel compounds and are useful in preventing calcium carbonate scale.
5405601 Functionalized tripodal ligands for imaging applications  
The present invention provides new and structurally diverse compositions for diagnostic imaging comprising compounds of the general formula: ##STR1## wherein A is N or CR1, R1 is hydrogen, C1 -C8...
5326906 Process for the extractive removal of phospho- and sulfobetaines from acidic reaction solutions  
The ampholytes are extracted from the reaction solution with a liquid cation exchanger which is immiscible with the acidic aqueous reaction solution, where the cation exchanger is dissolved in at...
5315035 Aniline derivatives useful as color formers  
The present invention is concerned with aniline derivatives of the general formula: ##STR1## wherein R1 is hydrogen or a lower alkyl or aryl, R2 is hydrogen or a lower alkyl which can be...
5281637 Flameproofed thermoplastic polyester molding material and its use  
Flameproofed thermoplastic polyester molding material comprising (A) one or more thermoplastic polyesters, (B) a nitrogen-containing diphosphinic acid compound of the formula (I), and (C) with or...
5167866 Control of corrosion in aqueous systems using certain phosphonomethyl amine oxides  
This invention relates to controlling corrosion in aqueous systems and more particularly to using certain calcium insensitive phosphonomethyl amine oxide compounds. The compounds of this invention...
5051532 N,N-bis-phosphonomethyl taurine N-oxide and water-soluble salts thereof  
This invention relates to novel organic phosphonate compounds which can be used as water treatment agents. More specifically, this invention relates to the compound N,N-bis-phosphonomethyl taurine...
4973744 Ethoxylated N,N-bis-phosphonomethyl 2-(hydroxy)ethylamine N-oxides and water-soluble salts thereof  
This invention relates to novel organic phosphonate compounds, and more particularly to ethoxylated N,N-bis-phosphonomethyl 2-(hydroxy) ethylamine N-oxides and their water soluble salts. These...
4950474 Combination corrosion and scale inhibiting system containing phosphonate/amine reaction product  
A series of water-dispersible corrosion and scale inhibiting solutions are disclosed which contain the reaction product of a phosphonate compound containing at least two phosphonate groups of the...
4804499 Process for the preparation of N-substituted aminomethylphosphonic acids  
A process for the preparation of an N-substituted aminomethylphosphonic acid comprising reacting a 2,5-diketopiperazine compound with phosphorous acid and formaldehyde in an acidic medium.
4696920 Certain 2-substituted 1,3-propylidenediphosphonate derivatives, pharmaceutical compositions containing them and their use as antihypertensive agents  
2-Substituted-1,3-propylidenediphosphonates of formula (I), where A, R1 and R2 are defined in claim 1, are therapeutically active compounds, namely for the treatment of cardiovascular diseases....
4450116 3-Oxypropyleneimino-bis-(methylene phosphonic acids) and their salts, process for their manufacture and their use  
3-Alkoxypropylenimino-bis-(methylene phosphonic acids) of the formula ##STR1## wherein R is straight-chain or branched alkyl or alkenyl each having from 2 to 20, preferably 2 to 10, carbon atoms,...
4399817 Boron containing polyphosphonates for the treatment of calcific tumors  
Boron containing polyphosphonates of the formula ##STR1## wherein Z is a boron-containing radical; R2 is an alkyl group containing from 1 to about 10 carbon atoms; R3 is a geminal diphosphonate or...
4308147 Composition and treating aqueous solutions with N-carboxy alkyl amino alkane polyphosphonic acids and their alkali metal salts  
Disclosed are a composition and method for treating aqueous solutions with N-carboxy alkyl amino alkane polyphosphonic acids which have more than two carbon atoms in their carboxy alkyl group, and...
4307038 N-Carboxy alkyl amino alkane polyphosphonic acids  
Novel N-carboxy alkyl amino alkane polyphosphonic acids which have more than two carbon atoms in their carboxy alkyl group, and their alkali metal salts are prepared in a good yield by reacting...
4234562 Radiographic scanning  
A composition and method for the preparation of a technetium-99 m based scintigraphic scanning agent are disclosed. The agent is prepared by the addition of a pertechnetate-99 m solution to an...
4110100 Phosphinylmethylimino-acetic acid N-oxide compounds and the sucrose increasing use thereof  
This disclosure relates to phosphinylmethylimino-acetic acid N-oxide compounds and to sucrose increasing compositions and methods. The compounds and compositions are useful as sucrose increasing...
4098814 N-Phosphono methylene amino alkane phosphonic acid compounds, process of producing same, and method and compositions of using same  
Valuable and highly water soluble N-phosphono methylene mono- and di-amino alkane mono- and polyphosphonic acids which have not only an >N--CH2 --PO3 H2 group but also a C--PO3 H2 group in their...
4079006 Methods of scale inhibition  
The precipitation of scale forming salts in an aqueous system is inhibited by adding either stoichiometric or substoichiometric, including threshold, amounts to said system of a phosphonomethylene...
4072706 Oxidation of phosphonomethylamines  
Tertiary phosphonomethylamines are oxidized with oxygen, preferably in contact with activated carbon, to cause cleavage of a phosphonomethyl group and selective production of a secondary amine.
4033896 Method of corrosion inhibition and compositions therefor  
Phosphonomethyl amino carboxylates of the general formula ##STR1## wherein M1, M2 and M3 are each hydrogen, metal ion, ammonium ion or alkyl ammonium ion, Z is --CH2 PO3 M1 M2, C1-4 alkanol, C1-4...
4009204 Process of producing crystalline nitrilo tris-(methylene phosphonic acid)  
Pure, crystalline nitrilo tris-(methylene phosphonic acid) is produced in a high yield by reacting lower aliphatic acid amides with formaldehyde and phosphorus trihalogenide, preferably phosphorus...
3989772 N,N-bis-(phosphonomethyl)-acrylamides  
N,N-bis-(phosphonomethyl)-acrylamides of the formula ##EQU1## in which R represents hydrogen, methyl or ethyl and R1 and R2 represent C1 -C4 -alkyl, which is optionally substituted by halogen, or...
3974209 Substituted tertiary amines and processes for preparing the same  
Substituted tertiary amines of the general formula ##EQU1## wherein R1, R2, R3, R4, R5, X and Y are hereinafter defined and n is 1 - 20, and which are found useful as agents for complexing metal...
3959361 Process of producing amino methylene phosphonic acids  
Substantially pure amino methylene phosphonic acids, such as ethylene diamine tetra-(methylene phosphonic acid), nitrilo tris-(methylene phosphonic acid), and others are obtained in a high yield by...
3933944 αα'-Bis-(phosphono)dicarboxylic acid derivatives  
Derivatives of dicarboxylic acids containing a phosphono group in the alpha and alpha prime position have been made. These have a wide variety of uses as intermediates. Specifically, one of the new...
3925453 Quaternary aminoalkylene phosphonic acids and method of preparation  
Quaternary aminoalkylene phosphonic acids such as N-methyl aminotri(methylene phosphonic acid) of the formula ##EQU1## are prepared by reacting an aminoalkylene phosphonic acid with an alkyl halide...
3914162 COMPOSITIONS AND PROCESS FOR THE ELECTRODEPOSITION OF METALS  
An electrically conductive medium for the electrodeposition of metals comprises an aqueous solution of (a) a metal ion, (b) a carboxy alkylene amino di(methylene phosphonic acid) and optionally,...
3832393 PROCESS OF PRODUCING AMINO ALKYLENE PHOSPHONIC ACIDS  
Amino alkylene phosphonic acids such as ethylene diamine tetra-(methylene phosphonic acid), diethylene triamine penta-(methylene phosphonic acid), nitrilo tris-(methylene phosphonic acid), and...
3711577 NITRILO(ETHYLENEPHOSPHONIC ACID ESTERS)  
Compounds of the formula in which R is a hydrocarbon group or hydrogen atom and a process for preparing them by reacting tri(2-chloroethyl)amine with a phosphite of the formula MOP(OR)2 or P(OR)2...
3551339 BUILT DETERGENT COMPOSITIONS  
3536752 DIALKALI METAL SALTS OF AMINO TRI(ALKYLIDENEPHOSPHONIC ACIDS)  
3498969 PHOSPHONATE AMINE POLYOL COMPOUNDS AND A PROCESS FOR PREPARING SAME  
3567768 PROCESS FOR PREPARING AMINO ALKYLENEPHOSPHONIC ACIDS  
3770815 OIL-SOLUBLE PHOSPHONIC ACID COMPOSITION  
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