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7667070 |
Lipophilic compounds and uses thereof
The present invention has for an object a cationic lipophilic compound of the following general formula (I): wherein: a) R1 and R′1 each represent, independently from one another, an alkyl chain, a...
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7319163 |
Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders
This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac arrhythmias, thyrotoxicosis...
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7094928 |
Process for the synthesis of (±) 2-Amino-N-[2,(2,5-dimethoxy phenyl)-2-hydroxyethyl] acetamide monohydrochloride
This invention relates to an improved process for synthesizing (±)-2-Amino-N-[2-(2,5-dimethoxyphenyl]-2-hydroxyethyl acetamide monohydrochloride in good yield and in a cost effective manner from ...
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6737416 |
Phosphonic acid derivative having inhibitory activity against carboxypeptidase B
A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R1 represents hydrogen atom, an alkyl group, a substituted alkyl group and the...
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6288046 |
Phosphonic acid derivatives
The present invention relates to phosphonic acid derivatives that inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such ...
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6218563 |
Cyanophosphonamides and method for preparation
The present invention provides a process for preparing a cyanophosphonamide comprising contacting phosphoric anhydride and a cyanide, preferably in the presence of a Lewis base, to produce a...
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6071965 |
Phosphinic alkanoic acid derivatives
The present invention relate to phosphinic alkanoic acid derivatives that inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the ...
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6031091 |
Non-nucleotide linking reagents for nucleotide probes
A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a...
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5935947 |
Imidobisphosphoric acids, and use thereof
There are described compounds of the formula I ##STR1## in which R1 is (C1 -C10)-alkyl, (C1 -C8)-alkanoyl, (C6 -C10)-aryl or Het, each of which can be substituted by halogen, --OH, --NH2,...
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5908959 |
Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
A process is provided for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof which comprises of: a) reacting 4-aminobutyric acid with phosphorous acid and...
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5863536 |
Phosphoramidate derivatives
The present invention includes phosphoramidate derivatives, compositions containing the same, and methods of using them as NAALADase inhibitors, particularly for the treatment of glutamate...
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5760285 |
Phosphonyldipeptides useful in the treatment of cardiovascular diseases
Compounds of formula (II) ##STR1## wherein R is a biphenyl group optionally substituted by one or more substituents, the same or different, selected among halogen atoms, hydroxy groups, alkoxy,...
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5760021 |
Phosphonocarboxylate compounds pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
The present invention relates to compositions comprising pharnaceutically-acceptable carriers and a phosphonocarboxylate, or a pharmaceutically-acceptable salt thereof, having a structure according...
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5733897 |
Imidobisphosphoric acids, and use therefor
Imidobisphosphoric acids, process for their preparation, and use thereof.There are described compounds of the formula I ##STR1## in which R1 is (C1 -C10)-alkyl, (C1 -C8)-alkanoyl, (C6 -C10)-aryl or...
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5658897 |
Cyclopentane(ene) heptanoic or cyclopentane(ene) heptenoic acid, 2-hydrocarbyl phosphinyloxyalkyl or phosphonamidoalkyl as therapeutic agents
The present invention relates to cyclopentane (or cyclopentane) heptanoic or cyclopentane (or cyclopentene) heptenoic acid, 2-hydrocarbyl phosphinyloxyalkyl or phosphonamidoalkyl, 1-esters, and...
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5608045 |
Preparation of phosphoramidon
Compound of formula (I): ##STR1## in which: R1 represents a hydroxyl, alkoxy or amino (unsubstituted or substituted) group, R2 represents an unsubstituted or substituted alkyl group, X1 represents...
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5585481 |
Linking reagents for nucleotide probes
A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a...
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5510510 |
Inhibitors of farnesyl protein transferase
Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, and inhibition of cholesterol biosynthesis, are effected by compounds of the formula ##STR1## their...
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5442101 |
Methylenebisphosphonic acid derivatives
The invention relates to novel methylenebisphosphonic acid ester amide derivatives of general formula (I), in which formula W1, W2, W3 and W4 are independently the group OR1 or the group NR2 R3...
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5273969 |
Phosphorus-containing squalene synthetase inhibitors and method
Compounds which are inhibitors of cholesterol biosynthesis (by inhibiting de novo squalene biosynthesis), and thus are useful as hypocholesterolemic agents and antiatherosclerotic agents are...
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5212164 |
Phosphorus-containing squalene synthetase inhibitors
Compounds which are inhibitors of cholesterol biosynthesis (by inhibiting de novo squalene biosynthesis), and thus are useful as hypocholesterolemic agents and antiatherosclerotic agents are...
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5208224 |
Phosphorus containing compounds as antihypercholesterolemic and antiatherosclerotic agents
Novel phosphorus containing compounds are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of...
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5187266 |
Antitumor aldophosphamide glycoside and dideoxyuridine derivatives
A compound having the structure: ##STR1## wherein R is CH3, C2 H5, C3 H7, t-C4 H9 or C6 H5 ; R1 is NH2, NHCH3, NHC2 H5, NHC3 H7, NHC4 H9, NHCH2 CH2 Cl, NHC6 H5, N(CH3)2, N(C2 H5)2, N(C3 H7)2, NCH3...
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5177240 |
o-Phosphono(alkyl)-N-sulfonyl-phenyl-alanine derivatives useful as intermediates for preparation of phosphono-hydroisoquinolines
A class of phosphono-hydroisoquinoline compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or...
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5175153 |
Substituted alpha-amino acids having pharmaceutical activity
The present invention is novel substituted α-amino acids, pharmaceutical compositions, method of use, and preparations therefore having utility for treating disorders which benefit from blockade ...
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5100654 |
Phosphorylated derivatives of L-dopa and compositions and methods for increasing the melanin content in mammalian skin and hair
A phosphorylated derivative of L-dopa of the formula ##STR1## wherein when X is ##STR2## wherein Z is --CH2, N, S or a linkage other than oxygen which renders the phosphate group resistant to...
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5091552 |
Novel antitumor aldophosphamide analogs
A compound having the structure: ##STR1## wherein R is CH3, C2 H5, C3 H7, t--C4 H9 or C6 H5 ; R1 is NH2, NHCH3, NHC2 H5, NHC3 H7, NHC4 H9, NHCH2 CH2 Cl, NHC6 H5, N(CH3)2, N(C2 H5)2, N(C3 H7)2, NCH3...
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5024691 |
Substituted phenoxy benzamide herbicides and methods of use
As new compounds, substituted aryloxyphenoxy benzamides having the formula ##STR1## in which X is CH or nitrogen; Y is chlorine, bromine, fluorine, iodine, methyl, cyano or hydrogen; Z is hydrogen,...
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4803157 |
Hydrolyzable fluorescent substrates for phosphatases and analytical use thereof
Hydrolyzable substrates for acid and alkaline phosphatases comprise blocked dye moieties which, when cleaved from the substrate during hydrolysis, provide fluorescent dyes having maximum...
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4568432 |
Process for preparing glyphosate and glyphosate derivatives
A process for preparing glyphosate and derivatives of related structure. A precursor primary or secondary amine, such as glycine, is condensed with a carbonyl compound, such as formylphosphonic...
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4432972 |
Phosphonamidate compounds
Phosphonamidates of the formula ##STR1## wherein X is an amino acid or ester. These compounds possess angiotensin converting enzyme inhibition activity and enkephalinase inhibition activity. Thus...
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4225491 |
Azo pyridone dyestuffs containing at least one reactive phosphoric or phosphonic acid group
Azo pyridone dyestuffs containing at least one reactive phosphoric or phosphonic acid group. The dyestuffs are characterized by the formula: A -- N N -- Rwherein A is an aromatic radical c...
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3997595 |
2-Chloroethanephosphonic acid derivatives
New and valuable 2-chloroethane-phosphonic acid derivatives having a strong biological action, agents for controlling the growth of plants containing these compounds as active ingredients, a...
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3977860 |
Herbicidal compositions and methods employing esters of N-phosphonomethylglycine
N-phosphonomethylglycine and novel derivatives thereof useful as phytotoxicants or herbicides.
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3969341 |
Method for the preparation of starch products and the compounds utilized therefor and the product thereof
Modified starch products are prepared by reacting a starch, in an aqueous slurry or dispersion, with a salt of the reaction product of a 2-alkyl-2-oxazoline and phosphorus oxychloride, under...
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3925456 |
Cyclic aminophosphonic acids
Cyclic aminophosphonic acids having the formula ##EQU1## wherein R is a member selected from the group consisting of hydrogen and alkyl having from 1 to 6 carbon atoms and n is an integer from 1 to...
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3901679 |
2-Chloroethane-phosphonic-(or thiono phosphonic) acid amido compounds as plant growth regulants
2-CHLOROETHANE-(THIONO)-PHOSPHONIC ACID AMIDO COMPOUNDS OF THE FORMULA ##EQU1## in which X is oxygen or sulfur; R is lower alkyl radical of from 1 to 6 carbon atoms or phenyl; and R' is hydrogen...
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3742040 |
ALKYLAMMONIUM ALKYLPHOSPHONAMIDATES
An organic phosphorus composition comprising: A. a major portion of an alkylammonium alkylphosphonoamidate of the formula: ##SPC1## Wherein R is a halo substituted alkyl of from one to eight carbon...
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3539625 |
PHOSPHOCREATINE SALTS
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3574793 |
IMINO PHOSPHORAMIDATES
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3849482 |
AMINE SALTS OF CIS-PROPENYLPHOSPHONIC ACID
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3702878 |
CYCLIC ORGANOPHOSPHORUS COMPOUNDS AND PROCESS FOR MAKING SAME
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3769406 |
TREATING HYPERGLYCEMIA WITH PHOSPHORYLATED GUANIDINES AND BIGUANIDINES
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3417098 |
Phosphoryl derivatives of 4-imidazolidones
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3405168 |
N-substituted monoamidotriphosphate and processes for their manufacture
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3296301 |
Nitrogenous organic compounds of phosphorus
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3253062 |
Phosphonamidic acids and esters
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3159669 |
Process for phosphoramidic acid derivatives
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3121731 |
Process for making mono (aminoalkyl) phosphite esters
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3036087 |
Process for the preparation of phosphocreatine and/or phosphocreatinine
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