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4175203 Interphenylene 11,12-secoprostaglandins  
Novel interphenylene derivatives of 11,12-secoprostaglandins are prepared by the stepwise alkylation of the ethyl ester or the t-butyl ester of acetoacetic acid. One such method involves treatment...
4174460 Process for the hydroxylation of phenols and phenol ethers in the nucleus  
A process for the hydroxylation of phenols and phenol ethers in the nucleus with hydrogen peroxide wherein a phenol or a phenol ether is reacted at the start of the reaction with substantially...
4172950 ω-Aryl-13,14-didehydro-interphenylene-PGE compounds  
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical...
4169720 2-[4-(4-Chlorophenoxymethyl)-phenoxy]-propionic acid compounds as herbicides  
Compounds of the formula ##STR1## wherein R1 and R2 are each hydrogen, chlorine or fluorine; and R3 is --CH2 OH, --CH2 --O--COR4, --CH2 --O--CONHR5, --COOH, --COOCat, --COOR6, --CONR7 R8 or...
4168385 Hypolipemic phenylacetic acid derivatives  
This invention discloses α-aryloxy or α-arylthio para substituted phenyl acetic acid compounds that are useful in lowering sterol and triglyceride serum levels.
4168386 9-Deoxy-9 -methylene-inter-phenylene-13,14-didehydro-16-phenyl-17,18,19,20-tetranor -PGF1 compounds  
The present invention relates to novel 9-deoxy-9-methylene-inter-phenylene-13,14-didehydro-16-pheny l-17,18,19,20- tetranor-PGF1 compounds. These compounds are useful pharmacological agents, and...
4167489 Liquid crystalline compounds  
Liquid crystalline compounds of the formula: ##STR1## wherein X is an electron-repelling radical and Z is an electron-attracting radical, and rings A, B and C are each unsubstituted or...
4166912 9-Deoxy-9-methylene-inter-phenylene-16-phenyl-PGF compounds  
The present invention relates to novel 9-deoxy-9-methylene-inter-phenylene-16-phenyl-PGF compounds.These compounds are useful pharmacological agents, and are useful for the same purposes as the...
4163107 ω-Aryl-cis-13-PGF compounds  
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is of the cis configuration. Also provided in this invention, are novel chemical...
4159991 Acyloxy-N,N'-diacylmalonamides and methods for their preparation  
α-Acyloxy-N,N'-diacylmalonamides of the formula ##STR1## wherein R1, R2, R3, and R4 are the same or different and are hydrogen, straight chain or branched alkyl radicals having from one to eleven...
4156090 Polyene compounds  
15,15'-Didehydro-astaxanthin and ester derivatives thereof useful as coloring agents and intermediates for astaxanthin and a method for preparing astaxanthin from keto α-isophorone and...
4153803 Cholesterol-lowering phenoxyalkanoic acid esters  
Compounds possessing pharmaceutical activity as substances able to lower the level of fatty substances in the blood possess the following general formula: ##STR1## wherein R represents hydrogen,...
4148915 Bis(2-phenoxyalkane carboxylic acids) and derivatives thereof and their use as medicaments  
Bis (2-phenoxyalkane carboxylic acids) and their esters and salts, as well as a method for their preparation. These compounds are useful for the treatment of hyperlipemia and arteriosclerosis.
4138581 3(Hydroxy or hydroxymethyl)-4(hydroxy)-α-(aminomethyl)benzyl alcohols  
Mono-, di- and tri-esters of 3-(hydroxy or hydroxymethyl)-4-hydroxy-α-(aminomethyl)benzyl alcohols, obtained by methods involving reduction of the corresponding mono- and di-ester ketones, are...
4130720 9-Deoxy-9-methylene-PGF-p-substituted phenyl esters  
The present invention relates to novel 9-deoxy-9-methylene-p-substituted phenyl esters. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding...
4125732 2-Aryloxy-2-(phenoxyalkoxy)phenyl acetic acid and esters  
This disclosure describes substituted 2-aryloxy-2-(para-phenoxyalkoxy)phenylacetic acids and esters and salts thereof useful as hypolipidemic agents.
4124623 Inter-oxa-12,13(E)-didehydro-13,14-dihydro-PGD1 compounds  
Prostaglandin analogs with the following cyclopentane ring structure: ##STR1## are disclosed along with intermediates useful in their preparation and processes for their preparation. These analogs...
4119650 Thromboxane B dialkyl-acetal diol intermediates  
The present specification provides novel intermediates and novel processes for the synthesis of various side chain and skeletal analogs of Thromboxane B2 (11β-homo-11α-oxa-PGF2α). These analogs...
4113966 3,7-Inter-m-phenylene-3-oxa-4,5,6-trinor-13,14-didehydro-11-deoxy-PGF1 α compounds  
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical...
4113965 3,7-Inter-m-phenylene-3 -oxa-13,14-didehydro-11-deoxy-17-phenyl-4,5,6,18,19,20-hexanor-PGF1 α compounds  
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical...
4112225 16-CF3 prostaglandins  
A process for producing optically active 16-substituted prostaglandins and new 16-substituted prostaglandins produced thereby which are useful as cardiovascular agents and as agents for inducing...
4105792 Prostane dervatives  
Prostan-1-ol esters and intermediates for their preparation are described; the former compounds exhibit improved organ specificity and a longer duration of activity at lower dosages than the...
4098816 Polycyclic oxy-aromatic acid  
Pharmaceutical compositions having hypolipidaemic and/or hypoglycaemic activity, contain a substituted (4-carboxyphenoxy) phenyl alkane derivative.
4098805 9-Deoxy-9-methylene-PGF-type amides  
The present invention relates in part to novel amido, cycloamido, carbonylamido and sulfonylamido derivatives and p-substituted phenyl esters of 9-deoxy-9-methylene-PGF-type compounds. These novel...
4097678 Δ9 (11) -5α-D-homo-20-keto steroids  
3α-Hydroxy and 3α-acyloxy- Δ9(11) -5α-D-homo-20-ketopregnenes of the formula ##STR1## wherein R is hydrogen or acyl, R1 is hydrogen or methyl and R2 is methyl or ethyl, are produced by esterifying...
4090862 Novel phenoxycarboxylic acid aryloxy(thio)carbonylaminomethyl esters and their use for regulating plant growth  
Phenoxycarboxylic acid aryloxy(thio)carbonylaminomethyl ester compound of the formula ##STR1## wherein R1 is phenyl, substituted phenyl, benzyl, substituted benzyl, naphthyl or substituted...
4088674 Novel ester isocyanates  
This invention concerns novel ester isocyanates derived from acyloxyalkylamine hydrochlorides. The novel compounds may contain a hetero atom in either the acid or alkanolamine moiety and may...
4087617 Inter-M-phenylene-13,14-didehydro-PGF1 compounds  
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical...
RE29608 Benzoxazole derivatives  
The invention provides novel 5- and 6-benzoxazolyl alkanoic acids, optionally substituted in the 2-position, and derivatives thereof which possess anti-inflammatory, anti-pyretic and analgesic...
4080474 Hypolipidaemic compositions  
Allyloxy benzoic acid derivatives have hypolipidaemic activity, compositions for controlling or reducing serum lipid level in mammals, novel substituted phenoxy and phenylthio allyl compounds and...
4065432 Thermally stable, rigid polyesters from aromatic dibasic acids and thermally stable, rigid bisphenols  
Thermally stable, rigid bisphenols of the formula ##STR1## WHERE R is ##STR2## or ##STR3## where R2 is arylene or substituted arylene, and R1 is hydrogen or acyl,Are used to prepare thermally...
4064269 4-[(4-Phenoxy and benzyl)-phenoxy]-butyric acid esters  
New ethers of the formula ##STR1## wherein R1 represents cyano or the radical ##STR2## R2 = methoxy, ethoxy, propoxy, isopropoxy, n-, i-, sec.-, tert.-butoxy, propargyloxy, methylthio, ethylthio,...
4061672 Derivatives of 9-hydroxy-13-trans-prostenoic acid  
This disclosure describes certain 15-deoxy prostanoic acid derivatives having a hydroxy group further along in the beta-chain, useful as bronchodilators, hypotensive agents, anti-ulcer agents, or...
4056628 Insecticidal esters of alpha-phenoxy alkanoic acids with substituted benzyl alcohols  
Novel substituted α-aryloxycarboxylic acid esters and their preparation are described. The novel compounds are useful for the control of pests.
4055602 2-Decarboxy-2-hydroxy-methyl-5-oxa-17-phenyl-18,19,20-trinor-PGF-analogs  
This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in...
4052438 Process for preparing aromatic hydroxy-carboxylic acid alkyl esters  
An improved process for the preparation of aromatic hydroxycarboxylic acid alkyl esters had been found which avoids working with organic solvents and especially avoids the formation of alkyl ether...
4049823 Phenylbutanol derivatives and compositions containing them  
Phenylbutanol derivatives of the formula Z--C(CH3) (OH)--CH2 --Y wherein Z is 4-biphenyl or 4-phenoxyphenyl wherein the phenoxy group is unsubstituted or substituted by F, Cl or Br and Y is COOR2...
4046802 Process for making a high molecular weight alkylphenoxy substituted aliphatic carboxylic ester  
Alkylphenoxy alkanoic esters are made in high yield by reaction of a C50-200 alkylphenol with a halo-substituted alkanoic ester in the presence of a base. The reaction product contains little...
4045574 D-Homo-20-ketopregnanes  
D-homo-20-ketopregnanes of the formula ##STR1## wherein R1 is oxygen, ##STR2## in which R5 is hydrogen or lower acyl; R2 is hydrogen or methyl; R3 is oxygen, ##STR3## or two hydrogen atoms; R4 is...
4039574 13-Hydroxy-15-deoxy-prostaglandins  
This disclosure describes 13-hydroxy-15-deoxy-prostaglandins which exhibit multiple biological responses even at low doses.
4013714 Substituted bis-(dicarboxymethyl)-ethers  
Compounds represented by the formula ##EQU1## wherein Rx is ##EQU2## AND A is hydrogen, methyl, ethyl, CH2 OH or RxOH; M being alkali metal, ammonium, alkyl ammonium, or alkanol ammonium and Rz...
4001306 Prostaglandin Fα 15-monoacrylates  
Mono(carboxyacylates) of prostaglandins F1α, F2α, F3α, dihydro F1α, and their 15β isomers, at the C-15 position, and processes for preparing them. These compounds are useful for a variety of...
3992386 4(Quinolyl)phenoxy alkanoic acid derivatives  
Phenoxyacetic acids of the formula ##SPC1##Wherein R1 is H or alkyl of 1-4 carbon atoms; R2 is H, or when R4 is Q, also alkyl of 1-4 carbon atoms; R3 is methyl, phenyl or chlorophenyl; and R4 is...
3989737 2-Cyclohexene-1-one derivatives  
A compound of the formula ##SPC1##Wherein R1 is selected from the group consisting of phenyl and straight or branched chain alkyl; R2 is selected from the group consisting of straight or branched...
3985791 16-Phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives  
Novel racemic and 8R-antimeric 16-phenoxy- and 16-(o, m or p)-substituted phenoxy derivatives of 9α, 11α,15-trihydroxy-17,18,19,20-tetranorprosta-4,5,13-trans-tr ienoic acids, which may be further...
3980687 Intermediates for the preparation of 17-substituted-Δ4 -gonenes  
A process for the production of a Δ4 -gonenic steroid having the formula ##SPC1##Wherein R represents a member selected from the group consisting of hydrogen and the acyl of an organic carboxylic...
3978081 11H,12H-[1]benzopyrano[2,3-b][1]benzopyran-11,12-dione and derivatives  
Benzopyrano-benzopyranes and the sulfur analogs thereof, benzothiopyranobenzothiopyranes, useful as medicinal agents. Compositions of matter including...
3970684 Polyunsaturated prostaglandin derivatives  
Novel prostaglandin dehydro analogs of the PGA and PGB series and the 9-hydroxy-derivatives thereof, which possess a diethylenic unsaturation in the carboxylic acid chain and may be additionally...
3969368 2-Substituted benzodioxoles  
2-Substituted benzodioxoles are useful as pharmaceuticals having e.g. anti-inflammatory, analgesic, antipyrretic, antitussive, C.N.S. depressant, local anaesthetic, antiarrythmic, antihistaminic...
3968143 Phenoxypropionic acid derivatives  
Phenoxypropionic acid derivatives of the formula ##SPC1##Wherein Q is H or a halogen atom, R is H or CH3, Z is --OH, --O-alkyl of 1-4 carbon atoms, 1-methyl-4-piperidyloxy, or --NHCH2 CH2 OH, and...