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7470807 |
Substituted arylalkanoic acid derivatives and use thereof
A compound represented by the formula (I):
[In the formula, Link represents a saturated or unsaturated straight hydrocarbon chain having 1 to 3 carbon atoms, C 2 to C 6 in the aromatic ring...
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7446222 |
Phenyl compounds
Compounds of formula (I) or derivatives thereof:
wherein A, B, Z, R 1 , R 2a , R 2b , R x , R 8 , and R 9 are as defined in the specification, a process for the preparation of such compounds,...
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7413782 |
Polymerizing binaphthalene derivatives
Provided are a polymerizing liquid-crystalline compound of formula (1).
In formula (1), Q 1 to Q 4 each independently represent a formula (2), a hydrogen atom, a halogen atom, an alkyl group...
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7358383 |
Polyphenol proteasome inhibitors, synthesis, and methods of use
The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present...
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7345189 |
Process for the preparation of adapalene
A process for the preparation of a compound of formula (I), or a salt thereof
wherein R is H, C 1 -C 8 alkyl, aryl or aryl-C 1 -C 8 alkyl; comprising the reaction between a compound of...
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7153548 |
Compound, retardation plate and method for forming optically anisotropic layer
A retardation plate having a high film strength and having an optical property is provided by using a biaxial liquid crystal compound, in which the direction having a minimum refractive index of...
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7074826 |
R-NSAID esters and their use
The present invention concerns esters of R-enantiomers of a non-steroidal anti-inflammatory drug, which is substantially free from the S-enantiomer. The compounds of the invention may be used in...
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7041845 |
Process for preparing optically active dihydropyrones
The invention relates to a process for preparing optically active 5-hydroxy-3-ketoesters of formula A1 or A2,
or one of the tautomers thereof,
the use thereof for preparing optically active...
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7019034 |
Compositions and methods for reducing serum glucose and triglyceride levels in diabetic mammals
Diabetic mammals are treated with compounds that are significantly more efficacious as agonists of RXR β retinoid receptors than as agonists of RXR α or RXR γ retinoid receptors. The...
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6939988 |
Tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them
Novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them.
The compounds have hypolipidemic, antihyperglycemic uses.
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6936636 |
5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity
Compounds of the formula:
where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side...
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6905739 |
Optically active materials
A compound is of formula (I), in which: A 1 to A 4 , E 1 and E 2 each independently represent hydrogen or an optionally-substituted hydrocarbon group; B 1 and B 2 each independently represent...
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6891072 |
Process for production of dimers or aromatic monohydroxyl compounds
The present invention provides a method for preparing dimer of a monohydroxy aromatic compound. In the method of the present invention, oxidative coupling reaction of a monohydroxy aromatic...
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6887896 |
7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity
Compounds of the formula
where the variations have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side...
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6884820 |
5,6,7,8-tetrahydronaphthalen-2-yl-7-fluoroalkyl-heptatrienoic acid derivatives having serum glucose reducing activity
Compounds of the formula
where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effect...
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6878842 |
Process for the enantioselective synthesis of propargyl alcohol derivatives of R configuration from the racemic mixtures thereof
The invention relates to a novel process for synthesizing organic compounds of general formula (I):
said process may be carried out on an industrial scale and makes it possible to obtain...
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6867320 |
Substituted phenylalkanoic acid derivatives and use thereof
A compound represented by the formula (I) or a salt thereof:
wherein n represents an integer of 1 to 3, R represents an alkyl group having 3 to 8 carbon atoms, a group represented by the...
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6849742 |
Binaphthol derivative and process for producing the same
The present invention provides a binaphthol compound represented by formula [1]:
and a salt thereof. The binaphthol compound of the present invention is useful for manufacturing antiseptic...
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6846890 |
Norbornene derivative and norbornene polymer obtained therefrom through ring opening polymerization
A novel norbornene derivative represented by a general formula (1m) shown below is provided. By conducting a ring opening polymerization of this norbornene derivative, or by performing a subsequent...
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6838574 |
Dicarba-closo-dodecarborane derivatives
A medicament comprising as an active ingredient a compound or a physiologically acceptable salt thereof represented by general formula (I):
wherein R 1 represents a...
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6835427 |
Optically active compound and liquid crystal composition containing the compound
An optically active compound containing 5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-bi-2-naphthol of the general formula (1) as an asymmetric source, wherein n is an integer of 1 to 10, Y is a...
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6825233 |
Compounds having retinoid-like activity
There are provided compounds represented by the formula I or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, wherein the various substituents...
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6790864 |
Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted...
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6759547 |
5,6,7,8-tetrahydronaphthalen-2-yl 2,6-difluoroheptatrienoic acid derivatives having serum glucose reducing activity
Compounds of the formula where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effect of...
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6756033 |
Method for delivering benzindene prostaglandins by inhalation
A method of delivering benzindene prostaglandins to a patient by inhalation is discussed. A benzindene prostaglandin known as UT-15 has unexpectedly superior results when administered by inhalation...
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6746729 |
Liquid crystal compounds
Compounds of formula I: wherein the variables are defined as explained in the disclosure. The invention also provides liquid crystalline mixtures and optical or electro-optical devices including...
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6740256 |
Chiral swallow-tailed liquid crystal and its fabrication method
A chiral swallow-tailed liquid crystal is provided. The present chiral swallow-tailed liquid crystal is synthesized from a chiral material. The present chiral swallow-tailed liquid crystal is...
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6720039 |
Liquid crystalline compounds and process for producing the same
A liquid crystalline compound having a novel structure and a process for producing the same are provided. The liquid crystalline compound is represented by the following general formula (I): ...
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6664411 |
Heterocyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their...
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6656384 |
Production of filaments via phase separation and polymerization
A polymerizable liquid crystalline monomer is described comprising a polymerizable first terminal group, a central portion, and a second terminal group, wherein the monomer is capable of filament...
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6620963 |
TRICYCLO&lsqb 6.2.202,7&rsqb DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-PHENYL AND TRICYCLO&lsqb 6.2.202,7&rsqb DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-HETEROARYL AND RELATED COMPOUNDS HAVING RARα RECEPTOR SELECTIVE BIOLOGICAL ACTIVITY
Compounds of the formula where the variables have the meaning defined in the specification, which bind specifically or selectively to to RARα retinoid receptors.
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6620813 |
Hydroxamate derivatives of non-steroidal anti-inflammatory drugs
In accordance with the present invention, there are provided novel chemical entities which have multiple utilities, e.g., as prodrugs of NSAIDs; as dual inhibitors of cyclooxygenase (COX) and...
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6610883 |
Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X...
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6610877 |
Aromatic carboxylic acid derivatives
Compounds of the formula wherein R 1 is a residue of the formula and R 2 -R 10 have the significance given in the specification can be used as pharmaceuticals, particularly for the repair of...
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6586463 |
C16 unsaturated FP-selective prostaglandins analogs
Compounds having the general structure: which are useful for the treatment of a variety of diseases and conditions, such as bone disorders.
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6569901 |
Alkynyl-substituted propionic acid derivatives, their preparation and use
The present invention relates to compounds of formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome...
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6555704 |
Process for the carbonylation of arylalkyl halides
A method is provided for the preparation of alpha-aryl-propionic acids such as ibuprofen by carbonylating the corresponding 1-arylethyl halide in an acidic aqueous medium containing a palladium...
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6548703 |
Toning agent
A toning agent for an azo pigment, an azo pigment with a modified tone, and process for preparing the same are provide. 2-hydroxynaphthalene-3,6-dicarboxylic acid or a derivative thereof is admixed...
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6509507 |
Polymerizable biaryls, process for their preparation and their use
A process for preparing polymerizable biaryl derivatives comprises reacting an aromatic comprising a 6-membered ring which bears ester or benzylic OH groups in the 1,4 position with a second...
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6479549 |
Carnosic acid derivatives for promoting synthesis of nerve growth factor
A novel carnosic acid derivative for promoting the synthesis of nerve growth factor (NGF), a composition comprising the carnosic acid derivative as an effective ingredient, as well as, a method of...
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6455585 |
Esters derived from substituted phennyl-cyclohexyl compounds
New esters derived from substituted phenyl-cyclohexyl compounds, which are derived from Tramadol, process for obtaining them and their use for preparing a drug with analgesic properties. These new...
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6444860 |
Naphthopyrans and phenanthropyrans annelated in C5-C6 with a bicyclic group, and compositions and (co) polymer matrices containing them
The invention relates to novel naphthopyran- and phenanthropyran-type compounds having a carbobicycle annelated in 5,6- position. These compounds have formula (I) given below: These compounds...
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6444850 |
Fungicidial compounds having a fluorovinyloxphyenyl moiety and process for the preparation thereof
A fungicidal compound of formula (I) having a fluorovinyloxyphenyl moiety and stereoisomers thereof are useful for protecting crops from fungal diseases: wherein: X is CH or N; Y is O or S; Z is...
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6403827 |
Crystal of 2-hydroxynaphthalene-3-carboxylic acid and process for the preparation thereof
The present invention provides crystalline 2-hydroxynaphthalene-3-carboxylic acid (BON) characterized in that the average particle size is equal to or more than 157 μm and the proportion of the...
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6326510 |
Bi-aromatic compounds, compositions containing them and uses
The invention relates to novel biaromatic compounds having general formula I ##STR1## and their use in pharmaceutical compositions for use in human and veterinary medicine, in particular for...
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6326369 |
Bicyclic quinone compounds, their production and use
A compound of the formula: ##STR1## wherein R 1 and R 2 each represents a lower alkyl, or R 1 and R 2 may be bonded together to form a ring; X represents a spacer of which the number of atoms...
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6323373 |
Polymerizable biaryls, method for the production and use thereof
A process for preparing polymerizable biaryl derivatives comprises reacting an aromatic comprising a 6-membered ring which bears ester or benzylic OH groups in the 1,4 position with a second...
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6284924 |
Compounds
A novel compound represented by the general formula (1) ##STR1## or salts thereof. The compound is useful as a structural component of polymers such as polyesters and polyamides. The compound...
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6252104 |
Naphthol derivatives and process for producing the same
A naphthol derivative represented by the general formula (I), [wherein Y and Y' indicate --(CONH) n --X or --COR; X is a phenyl group, a naphthyl group, an anthraquinonyl group, a benzimidazolonyl...
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6242635 |
Process for producing propionic acid derivatives
A process for producing a 2-aralkyl-3-hydroxypropionic acid (or its ester), comprising the steps of: reacting a 3-hydroxy-2-methylene-3-arylpropionic acid ester, easily obtained by the reaction of...
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