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7626024 |
Processes and intermediates for the preparations of prostaglandins
The present invention provides novel processes for the preparation of a cyclopentanone of Formula II and a lactone of Formula I, which are useful in the production of prostaglandins:
wherein Z,...
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7598242 |
Compounds for the treatment of inflammatory disorders
This invention relates to compounds of the Formula (I):
or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions...
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7589228 |
Fluorine-containing compound
The present invention has an object to provide a fluorine-containing compound which can be used for applications such as additives making a transparent resin material low in a water absorbing ratio...
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7572829 |
Pharmaceutical compositions useful in prevention and treatment of Beta-amyloid protein-induced disease
The invention provides methods for treating beta-Amyloid protein-induced disease, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture...
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7368566 |
Process and intermediates for preparing benzazepines
Disclosed is a new process and intermediates for preparing benzazepines of Formula (I):
wherein R 1 and R 2 are as defined herein.
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7355081 |
Curcumin analogues and uses thereof
The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but...
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7332622 |
Process for preparing optically active nitro compounds and cyano compounds
A process for preparing optically active nitro compounds and cyano compounds using a metal complex, which is obtained by reaction of an optically active nitrogen-containing compound and a periodic...
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7161022 |
Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative
A 4-phenyl-4-oxo-2-butenoate derivative is stably supplied in a short period of time, at low cost, in high purity and on an industrial scale by a process for producing the...
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6946269 |
Alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid of use as intermediates
The invention relates to lower-alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid derivatives, and to processes for preparing the same.
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6911521 |
Polyhydroxyalkanoate that comprises unit having substituted or unsubstituted (phenylmethyl) sulfanyl structure in side chain thereof and process for producing the same
A polyhydroxyalkanoate that comprises a unit represented by the following chemical formula (1):
wherein R1 is a substituent of an aromatic ring selected from the group consisting of H, CH 3 ,...
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6861550 |
Polyhydroxyalkanoate containing 3-hydroxybenzoylalkanoic acid as monomer unit, and method for producing the same
Microorganisms capable of producing novel polyalkanoates having 3-hydroxybenzoylalkanoic acids as monomer units by utilizing benzoylalkanoic acids as starting materials are cultured in media...
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6858747 |
Process to prepare, 1,4-dihydropyridine intermediates and derivatives thereof
An improved catalyst is disclosed for a process involving the preparation of benzylidene intermediates useful in the preparation of 1,4-dihydropyridine compounds and derivatives thereof useful as...
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6670485 |
Prostanoic acid derivatives as agents for lowering intraocular pressure
The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective...
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6649172 |
Amphipathic aldehydes and their uses as adjuvants and immunoeffectors
This invention relates to novel aldehyde containing compounds and their uses as adjuvants and immunoeffectors.
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6639093 |
Process for the preparation of hydroxybenzoic benzyl esters
The invention relates to the preparation of hydroxybenzoic benzyl esters by reacting benzyl chloride with hydroxybenzoic acids in the presence of one or more amides.
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6635782 |
Polyhydroxyalkanoate and manufacturing method thereof
To provide a novel polyhydroxyalkanoate and a manufacturing method by a microorganism capable of substantially reducing unintended monomer units and obtaining the polyhydroxyalkanoate in a high...
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6593488 |
4-fluoro-3-oxocarboxylic esters and process for producing the same
The present invention is to provide 4-fluoro-3-oxocarboxylates represented by the following formula (1): wherein R 1 represents an alkyl group or an aryl group; R 2 and R 3 each represent a...
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6590119 |
Methods for the synthesis of dioxoalkanoic acid compounds
The invention relates to improved methods of producing aryl dioxoalkanoic acid compounds and derivatives useful as intermediates for diarylpyrrole therapeutic agents by the alcoholysis of...
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6586468 |
&ohgr -substituted phenyl-prostaglandin E derivatives and drugs containing the same as the active ingredient
A ω-substituted phenyl-prostaglandin of formula (I), a process for the preparation thereof, a mediciament comprising it as active ingredient (all symbols have the same meaning as described in the...
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6576784 |
Antiviral agents
Novel antiviral (including antiretroviral) compounds are mono- or dicarboxylic acid esters of hypericin in which one or both of the methyl groups of hypericin are substituted by carboxylic acid...
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6555287 |
Non-subliming, difunctionalized ultraviolet dyes for use in anti-reflective coatings
An improved light attenuating compound for use in the production of microdevices is provided. Broadly, the light attenuating compound is difunctional and can be directly incorporated (either...
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6541655 |
Catalytic compositions and methods for asymmetric allylic alkylation
Complexes of a selected class of chiral ligands with molybdenum, tungsten or chromium, preferably molybdenum, are effective as catalysts in highly enantioselective and regioselective alkylation of...
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6492550 |
Alpha-substituted thio, -oxo trifluoromethylketones as phospholipase inhibitors
Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general...
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6469200 |
Process for producing 2-alkylidene-4-bromoacetoacetic acid ester
A process for producing a 2-alkylidene-4-bromoacetoacetic acid ester of the formula (3): wherein R 1 and R 2 each independently represent a lower alkyl group having 1-5 carbon atoms, the...
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6417389 |
Process for the preparation of HPB esters
This invention relates to a novel advantageous process for the stereoselective preparation of 2-hydroxy-4-phenylbutyrates (HPB esters) and of their precursors. This is done by starting from readily...
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6380257 |
Aromatic di-keto derivatives, processes for their production and their use as a pharmaceutical
The present invention relates to new aromatic di-keto derivatives and to their pharmaceutically acceptable salts, esters, ethers and other chemical equivalents. The derivatives are...
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6380249 |
HIV integrase inhibitors
Certain six-membered aromatic and heteroaromatic-dioxobutyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the...
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6376546 |
Biphenyl-5-alkanoic acid derivatives and use thereof
Compounds represented by general formula I or salts thereof, wherein n is an integer of 2 or 3; R represents a straight-chain or branched saturated alkyl group having 4 or 4 carbon atoms, a...
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6369194 |
Vicinyl tricarbonyl compounds and combinatorial libraries containing same
The invention relates to compounds of formula where R is a structural diversity element selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, peptidyl,...
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6369026 |
Slow release of fragrant compounds in perfumery using 2-benzoyl benzoates, 2-alkanoyl benzoates or alpha-keto esters
The present invention describes a fragrance delivery system which releases fragrant alcohols upon exposure to light. Said system comprises 2-benzoyl benzoates of general formulae which can...
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6326369 |
Bicyclic quinone compounds, their production and use
A compound of the formula: ##STR1## wherein R 1 and R 2 each represents a lower alkyl, or R 1 and R 2 may be bonded together to form a ring; X represents a spacer of which the number of atoms...
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6313344 |
Organic compounds
Compounds of formula ##STR1## (I), wherein either X is CH or N, Y is OR 1 and Z is O, or X is N, Y is NHR 8 and Z is O, S or S(O); R 1 , R 2 and R 3 are as defined according to the...
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6262293 |
ω-Cycloalkly-prostaglandin e2 derivatives
ω-Cycloalkyl-prostaglandin E 2 derivatives of formula (I) ##STR1## (wherein all symbols are as defined in the description); and non-toxic salts thereof, prodrugs thereof and cyclodextrin...
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6258977 |
Alkyl3-oxoalkanoates
An alkyl 3-oxoalkanoate, a process for preparation and use for the synthesis of fatty hydroxylated amino acids, fatty amino alcohols and ceramides.
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6258843 |
4-oxy-3-(aryl)phenyl-arylcarbonyloxy compounds useful as phosphodiesterase inhibitors
(4-oxy-3-(aryl)phenyl)pyridine compounds, in free or acid addition salt form, are useful as pharmaceuticals for treatment and prophylaxis of inflammation, particularly inflammatory or obstructive...
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6232489 |
Preparation of arthropodicidal oxadiazines
A method for making arthropodicidal oxadiazines and intermediates which are racemic or enantiomerically enriched at their chiral center, the method for making the oxadiazines comprising reaction of...
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6232344 |
13-Oxa prostaglandins for the treatment of glaucoma and ocular hypertension
13-Oxa analogs of certain prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.
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6215016 |
Ketone derivatives and medical application thereof
The present invention relates to ketone derivatives represented by the following formula and medical agents containing the ketone derivatives or pharmacologically acceptable salts thereof as an...
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6090974 |
Alkyl 3-oxoalkanoate and process for the preparation thereof
This invention includes an alkyl 3-oxoalkanoate, and processes for its preparation and use for the synthesis of fatty hydroxylated amino acids, fatty amino alcohols and ceramides.
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6072072 |
Compounds for preparing modified hemoglobin
The present invention provides a chemically modified form of hemoglobin that is stabilized and can efficiently bind and release oxygen. In addition the chemically modified hemoglobin may be...
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6048660 |
Non-volatile phenylglyoxalic esters
Compounds of the formula I ##STR1## in which R 1 and R 2 independently of one another are, for example, a group of the formula II ##STR2## R 3 , R 4 , R 5 , R 6 and R 7 independently of one...
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6025516 |
Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes
The present invention provides an efficient route to the C-13 side chain of the anti-cancer drug paclitaxel (TAXOL) and its analogs. The process includes the resolution of racemic erythro...
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6018071 |
Preparation of arthropodicidal ozadiazines
A method for making arthropodicidal oxadiazines and intermediates which are racemic or enantiomerically enriched at their chiral center, the method for making the oxadiazines comprising reaction of...
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5990172 |
Peptidomimetics for the treatment of HIV infection
This invention provides peptidomimetics which bind to T4 or CD4 cell receptors and are useful in inhibiting viral infectivity by viruses which bind to T4 cell receptors. More specifically,...
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5973190 |
Process and intermediate compounds for the preparation of pesticidal fluoroolefin compounds
The present invention provides a process for the preparation of pesticidal fluoroolefin compounds having the structural formula I ##STR1## The present invention also provides intermediate compounds...
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5968482 |
α-hydroxyketoalkyl derivatives as light protection filters
The invention relates to the use of α-hydroxyketoalkyl derivatives as light protection filters for cosmetic or pharmaceutical products, the α-hydroxyketoalkyl group being linked, if appropriate...
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5962651 |
Modified hemoglobin and its use as a component of an artificial blood substitute
The present invention provides a chemically modified form of hemoglobin that is stabilized and can efficiently bind and release oxygen. In addition the chemically modified hemoglobin may be...
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5955635 |
Process for the preparation of 4-(6'-methoxy-2'-naphthyl) butan-2-one
An improved process for the preparation of Nabumetone, which comprises the following steps: a) condensation between 6-methoxy-naphthaldehyde I and t-butyl acetoacetate II, to give...
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5945561 |
Retinoid-like compounds
Certain novel substituted (5,6)-dihydroanthracenyl compounds of the general formula ##STR1## wherein A, n, p, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined in the specification...
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5942290 |
Molecular complex compounds of acylphosphine oxide and α-hydroxy ketones as photoinitiators
Molecular complex compounds comprising a mono-, bis- or trisacylphosphine oxide compound with an α-hydroxy ketone compound are suitable as photoinitiators for the photopolymerization of...
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